Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

C. O'Rourke · SciRah

Researcher profile · Semantic Scholar

C. O'Rourke

Share profile

C. O'Rourke — researcher profile on SciRah

h-index: 22
Works: 68
Citations: 1,606

Most-cited papers

Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma
A. Lapitz, M. Azkargorta, P. Milkiewicz, P. Olaizola +31 more
2023Journal of Hepatology171 citations Open access
Semantic Scholar
A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily
A. Korkut, S. Zaidi, R. Kanchi, Shuyun Rao +41 more
2018Cell Systems155 citations Open access
Semantic Scholar
Genomic Perturbations Reveal Distinct Regulatory Networks in Intrahepatic Cholangiocarcinoma
Chirag Nepal, C. O'Rourke, D. V. Oliveira, Andrzej Taranta +10 more
2018Hepatology116 citations Open access
Semantic Scholar
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms
Aitor Esparza-Baquer, I. Labiano, O. Sharif, Aloña Agirre-Lizaso +22 more
2020Gut113 citations Open access
Semantic Scholar
Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis
A. Lapitz, A. Arbelaiz, C. O'Rourke, J. Lavín +22 more
2020Cells92 citations Open access
Semantic Scholar
SOX17 Regulates Cholangiocyte Differentiation and Acts as a Tumor Suppressor in Cholangiocarcinoma
Maite Merino-Azpitarte, E. Lozano, M. J. Perugorria, Aitor Esparza-Baquer +21 more
2017Journal of Hepatology90 citations Open access
Semantic Scholar
Differential effects of FXR or TGR5 activation in cholangiocarcinoma progression.
O. Erice, I. Labiano, A. Arbelaiz, A. Santos-Laso +20 more
2017Biochimica et Biophysica Acta - Molecular Basis of Disease70 citations Open access
Semantic Scholar
Integrative molecular characterization of gallbladder cancer reveals microenvironment-associated subtypes
Chirag Nepal, Bin Zhu, C. O'Rourke, D. Bhatt +23 more
2020Journal of Hepatology69 citations Open access
Semantic Scholar
E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment
Francisco González-Romero, Daniela Mestre, Igor Aurrekoetxea, C. O'Rourke +31 more
2021Cancer Research54 citations Open access
Semantic Scholar
miR‐21‐5p promotes NASH‐related hepatocarcinogenesis
P. Rodrigues, M. B. Afonso, A. Simão, T. Islam +16 more
2023Liver international (Print)48 citations Open access
Semantic Scholar
Causes of hOCT1‐Dependent Cholangiocarcinoma Resistance to Sorafenib and Sensitization by Tumor‐Selective Gene Therapy
E. Lozano, R. Macías, M. Monte, M. Asensio +13 more
2019Hepatology48 citations Open access
Semantic Scholar
Integrating biomarkers across omic platforms: an approach to improve stratification of patients with indolent and aggressive prostate cancer
K. Murphy, B. Murphy, Susie Boyce, L. Flynn +15 more
2018Molecular Oncology48 citations Open access
Semantic Scholar
Epigenetic events involved in organic cation transporter 1‐dependent impaired response of hepatocellular carcinoma to sorafenib
Ruba Al-Abdulla, E. Lozano, R. Macías, M. Monte +9 more
2019British Journal of Pharmacology42 citations Open access
Semantic Scholar
Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models.
P. Olaizola, P. Lee-Law, M. G. Fernandez-Barrena, Laura Álvarez +21 more
2022Journal of Hepatology40 citations Open access
Semantic Scholar
Epigenome dysregulation in cholangiocarcinoma.
C. O'Rourke, Patricia Muñoz-Garrido, Esmeralda L Aguayo, J. Andersen
2017Biochimica et Biophysica Acta - Molecular Basis of Disease39 citations Open access
Semantic Scholar
Mucosal‐associated invariant T‐cell tumor infiltration predicts long‐term survival in cholangiocarcinoma
C. Zimmer, Iva Filipovic, M. Cornillet, C. O'Rourke +16 more
2021Hepatology38 citations Open access
Semantic Scholar
IDENTIFICATION OF A PAN-GAMMA-SECRETASE INHIBITOR RESPONSE SIGNATURE FOR NOTCH-DRIVEN CHOLANGIOCARCINOMA
C. O'Rourke, M. Matter, Chirag Nepal, Rui Caetano-Oliveira +3 more
2019Hepatology34 citations Open access
Semantic Scholar
Molecular Targets in Cholangiocarcinoma
C. O'Rourke, Patricia Muñoz-Garrido, J. Andersen
2020Hepatology33 citations
Semantic Scholar
Longitudinal analysis of individual cfDNA methylome patterns in metastatic prostate cancer
Romina Silva, B. Moran, A. Baird, C. O'Rourke +6 more
2021Clinical Epigenetics27 citations Open access
Semantic Scholar
Serum IL6 as a Prognostic Biomarker and IL6R as a Therapeutic Target in Biliary Tract Cancers
D. Høgdall, C. O'Rourke, C. Dehlendorff, O. Larsen +12 more
2020Clinical Cancer Research27 citations Open access
Semantic Scholar
Whole blood microRNAs capture systemic reprogramming and have diagnostic potential in patients with biliary tract cancer.
D. Høgdall, C. O'Rourke, F. Larsen, Shahryar Zarforoushan +6 more
2022Journal of Hepatology23 citations Open access
Semantic Scholar
Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy
C. O'Rourke, M. Salati, Colin Rae, G. Carpino +31 more
2023Gut22 citations Open access
Semantic Scholar
MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells
Lea Duwe, Patricia Muñoz-Garrido, Monika Lewinska, Juan F. Lafuente-Barquero +15 more
2022Journal of Hepatology22 citations Open access
Semantic Scholar
Molecular Pathogenesis and Current Therapy in Intrahepatic Cholangiocarcinoma
D. Høgdall, C. O'Rourke, Andrzej Taranta, D. V. Oliveira +1 more
2016Digestive Diseases21 citations
Semantic Scholar
Manipulating the epigenome for the treatment of urological malignancies,
C. O'Rourke, Vinicius Knabben, E. Bolton, D. Moran +3 more
2013Pharmacology and Therapeutics21 citations Open access
Semantic Scholar
Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis
C. Czauderna, A. Poplawski, C. O'Rourke, D. Castven +16 more
2021JCI Insight20 citations Open access
Semantic Scholar
Mutational signatures and processes in hepatobiliary cancers
Ekaterina Zhuravleva, C. O'Rourke, J. Andersen
2022Nature reviews: Gastroenterology & hepatology15 citations
Semantic Scholar
DNA Methylation in Ovarian Tumors—a Comparison Between Fresh Tissue and FFPE Samples
Douglas N. P. Oliveira, Julie L. Hentze, C. O'Rourke, J. Andersen +2 more
2021Reproductive Sciences15 citations Open access
Semantic Scholar
Genome-wide meta-analysis identifies nine loci associated with higher risk of hepatocellular carcinoma development
J. Ghouse, H. Gellert-Kristensen, C. O'Rourke, A. Seidelin +44 more
2025JHEP Reports14 citations Open access
Semantic Scholar
Targeting protein hyper-SUMOylation halts cholangiocarcinoma progression by impairing cancer cell viability and tumor-stroma cross talk
P. Olaizola, I. Olaizola, Marta Fernandez de Ara, A. Lapitz +22 more
2025Hepatology11 citations Open access
Semantic Scholar
PARP-1 selectively impairs KRAS-driven phenotypic and molecular features in intrahepatic cholangiocarcinoma
F. Keggenhoff, D. Castven, D. Becker, S. Stojković +23 more
2024Gut11 citations Open access
Semantic Scholar
Structural aberrations are associated with poor survival in patients with clonal cytopenia of undetermined significance
S. U. Mikkelsen, S. Safavi, K. Dimopoulos, C. O'Rourke +6 more
2020Haematologica9 citations Open access
Semantic Scholar
Mutational signatures define immune and Wnt-associated subtypes of ampullary carcinoma
Ekaterina Zhuravleva, Monika Lewinska, C. O'Rourke, A. Pea +8 more
2024Gut6 citations Open access
Semantic Scholar
Developing a DNA Methylation Signature to Differentiate High-Grade Serous Ovarian Carcinomas from Benign Ovarian Tumors
Douglas N. P. Oliveira, Edyta Biskup, C. O'Rourke, Julie L. Hentze +3 more
2024Molecular Diagnosis & Therapy6 citations Open access
Semantic Scholar
Preoperative immunological plasma markers TRAIL, CSF1 and TIE2 predict survival after resection for biliary tract cancer
H. Jansson, M. Cornillet, Dan Sun, Iva Filipovic +5 more
2023Frontiers in Oncology6 citations Open access
Semantic Scholar
Genetic and epigenetic analysis of hepatocellular adenomas with atypical morphological features
S. Haefliger, J. Hench, C. O'Rourke, Nathalie Meyer-Schaller +10 more
2022Histopathology5 citations Open access
Semantic Scholar
Molecular and cellular consequences of tumour-autonomous IL-6 signalling in intrahepatic cholangiocarcinoma
V. Gehl, C. O'Rourke, M. Cornillet, O. Nousias +8 more
2026Gut4 citations Open access
Semantic Scholar
Clinical, radiological, and molecular insights into extracranial metastases from adult gliomas
J. Jacobsen, A. Locallo, C. O'Rourke, J. Carlsen +13 more
2025Neuro-Oncology4 citations Open access
Semantic Scholar
Multimodal single-cell profiling reveals crosstalk between macrophages and stromal cells in poor prognostic cholangiocarcinoma patients
Lara Heij, S. Hayat, Konrad Reichel, Sidrah Maryam +29 more
2026npj Precision Oncology3 citations Open access
Semantic Scholar
MARCO promotes cholangiocarcinogenesis by inducing immunosuppression and its targeting reduces tumor growth
Aloña Agirre-Lizaso, Maider Huici-Izagirre, C. O'Rourke, Ekaterina Zhuravleva +23 more
2026Signal Transduction and Targeted Therapy3 citations Open access
Semantic Scholar
Validation of Two Prognostic Gene Scores in Patients Undergoing Liver Resection for Hepatocellular Carcinoma
S. D. Schnabl, J. Klubien, C. O'Rourke, Sophie Bull Nordkild +4 more
2025Journal of Clinical and Experimental Hepatology3 citations Open access
Semantic Scholar
Genetic and epigenetic bases of the relationship between reduced OCT1 expression and poor response to sorafenib in hepatocellular carcinoma and cholangiocarcinoma
Ruba Al-Abdulla, E. Lozano, R. Macías, C. O'Rourke +11 more
20173 citations
Semantic Scholar
Targeted therapies in biliary tract cancer—when precision becomes imprecise
C. O'Rourke, J. V. Schou, J. B. Andersen, D. Høgdall
2024ESMO gastrointestinal oncology2 citations Open access
Semantic Scholar
Molecular therapeutic targets for cholangiocarcinoma: Present challenges and future possibilities.
D. Høgdall, C. O'Rourke, J. Andersen
2022Advances in Cancer Research2 citations
Semantic Scholar
Mining methylome databases.
C. O'Rourke, Therese M. Murphy, D. Hollywood, A. Perry
2013Trends in Genetics2 citations
Semantic Scholar
Personalized neoadjuvant chemotherapy for gastrointestinal cancers - shaping imprecision to be precise.
D. Høgdall, J. V. Schou, Julia Johanna Almer Bromann, J. B. Andersen +1 more
2025Clinical Cancer Research1 citations
Semantic Scholar
Molecularly redefining small bowel adenocarcinoma to accelerate precision patient care – protocol of a multicenter observational cohort biomarker study
R.H. Døssing, Julia Broman, C. O'Rourke, E. Tabaksblat +6 more
2025BMC Cancer1 citations Open access
Semantic Scholar
Landscape of (epi-)genetic alterations during malignant transformation in liver cancer
C. Czauderna, A. Poplawski, D. Castven, S. Heilmann-Heimbach +11 more
2019Zeitschrift für Gastroenterologie - German Journal of Gastroenterology1 citations
Semantic Scholar
Abstract 3413: A pan-cancer atlas of genomic, epigenomic and transcriptomic alterations in the TGF-β pathway
A. Korkut, S. Zaidi, R. Kanchi, Ashton C. Berger +38 more
2018Molecular and Cellular Biology / Genetics1 citations
Semantic Scholar
Molecular Subtypes of Cholangiocarcinoma and their Translational Implications
C. Braconi, C. O'Rourke, J. B. Andersen, L. Roberts
2026Gastroenterology0 citations Open access
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

J. Andersen×31
Invite
J. Andersen — researcher profile on SciRah
J. Banales×14
Invite
J. Banales — researcher profile on SciRah
M. J. Perugorria×9
Invite
M. J. Perugorria — researcher profile on SciRah
J. B. Andersen×9
Invite
J. B. Andersen — researcher profile on SciRah

×9

Invite

D. Høgdall — researcher profile on SciRah

R. Jiménez-Agüero×7

Invite

R. Jiménez-Agüero — researcher profile on SciRah

Invite

L. Bujanda — researcher profile on SciRah

Patricia Muñoz-Garrido×6

Invite

Patricia Muñoz-Garrido — researcher profile on SciRah

Ekaterina Zhuravleva×5

Invite

Ekaterina Zhuravleva — researcher profile on SciRah

Invite

A. La Casta — researcher profile on SciRah

P. Rodrigues×5

Invite

P. Rodrigues — researcher profile on SciRah

P. Aspichueta×5

Invite

P. Aspichueta — researcher profile on SciRah