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H. van Dam · SciRah

Researcher profile · Semantic Scholar

H. van Dam

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H. van Dam — researcher profile on SciRah

h-index: 48
Works: 107
Citations: 7,165

Most-cited papers

ATF‐2 is preferentially activated by stress‐activated protein kinases to mediate c‐jun induction in response to genotoxic agents.
H. van Dam, D. Wilhelm, I. Herr, A. Steffen +2 more
1995EMBO Journal643 citations Open access
Semantic Scholar
Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis
H. van Dam, M. Castellazzi
2001Oncogene490 citations
Semantic Scholar
Heterodimer formation of cJun and ATF‐2 is responsible for induction of c‐jun by the 243 amino acid adenovirus E1A protein.
H. van Dam, M. C. A. Duyndam, R. Rottier, A. Bosch +5 more
1993EMBO Journal373 citations Open access
Semantic Scholar
Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif.
I. Matic, J. Schimmel, I. Hendriks, Maria A. van Santen +5 more
2010Molecules and Cells331 citations Open access
Semantic Scholar
Growth factors can activate ATF2 via a two‐step mechanism: phosphorylation of Thr71 through the Ras–MEK–ERK pathway and of Thr69 through RalGDS–Src–p38
D. Ouwens, Nancy D. de Ruiter, G. van der Zon, Andrew P. Carter +6 more
2002EMBO Journal238 citations Open access
Semantic Scholar
The TGF-β/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system
E. Wiercinska, H. P. H. Naber, E. Pardali, G. van der Pluijm +2 more
2011Breast Cancer Research and Treatment213 citations Open access
Semantic Scholar
TGF-&bgr; signaling in cancer metastasis
Feng Xie, Li Ling, H. van Dam, Fang-Fang Zhou +1 more
2018Acta Biochimica et Biophysica Sinica187 citations
Semantic Scholar
YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKKɛ-mediated phosphorylation
Shuai Wang, Feng Xie, Feng Chu, Zheng-Kui Zhang +10 more
2017Nature Immunology185 citations
Semantic Scholar
Inflammation induces endothelial‐to‐mesenchymal transition and promotes vascular calcification through downregulation of BMPR2
G. Sánchez-Duffhues, Amaya García de Vinuesa, V. van de Pol, M. Geerts +6 more
2019Journal of Pathology178 citations Open access
Semantic Scholar
Tumor-derived exosomes antagonize innate antiviral immunity
Liang Gao, Lin Wang, Tong Dai, Ke Jin +9 more
2018Nature Immunology177 citations
Semantic Scholar
OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ.
Zheng-Kui Zhang, Jinjin Du, Shuai Wang, L. Shao +14 more
2019Molecules and Cells169 citations Open access
Semantic Scholar
Genome-wide assessment of differential roles for p300 and CBP in transcription regulation
Yolande F M Ramos, M. Hestand, M. Verlaan, Elise Krabbendam +7 more
2010Nucleic Acids Research163 citations Open access
Semantic Scholar
Epithelial–mesenchymal-transition-inducing transcription factors: new targets for tackling chemoresistance in cancer?
J. van Staalduinen, David A. Baker, P. ten Dijke, H. van Dam
2018Oncogene153 citations
Semantic Scholar
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling
Feng Xie, Xiaoxue Zhou, Peng Su, Heyu Li +13 more
2022Nature Communications148 citations Open access
Semantic Scholar
Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression
J. Ren, M. Smid, J. Iaria, D. Salvatori +4 more
2019Breast Cancer Research132 citations Open access
Semantic Scholar
c-Myb Enhances Breast Cancer Invasion and Metastasis through the Wnt/β-Catenin/Axin2 Pathway.
Yihao Li, Ke Jin, G. V. van Pelt, H. van Dam +5 more
2016Cancer Research131 citations
Semantic Scholar
ULTRAVIOLET‐RADIATION INDUCED c‐jun GENE TRANSCRIPTION: TWO AP‐1 LIKE BINDING SITES MEDIATE THE RESPONSE
B. Stein, P. Angel, H. van Dam, H. Ponta +3 more
1992Photochemistry and Photobiology119 citations
Semantic Scholar
Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion
A. Sundqvist, A. Zięba, E. Vasilaki, C. Hidalgo +7 more
2013Oncogene118 citations Open access
Semantic Scholar
Autocrine growth and anchorage independence: two complementing Jun-controlled genetic programs of cellular transformation.
H. van Dam, S. Huguier, K. Kooistra, J. Baguet +5 more
1998Genes & Development118 citations Open access
Semantic Scholar
Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7
Zheng-Kui Zhang, Yao-Min Fan, Feng Xie, Hang Zhou +16 more
2017Nature Communications115 citations Open access
Semantic Scholar
The regulation of TGF-β/SMAD signaling by protein deubiquitination
Juan Zhang, Xiao-Fei Zhang, Feng Xie, Zheng-Kui Zhang +3 more
2014Protein & Cell107 citations Open access
Semantic Scholar
JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion
A. Sundqvist, M. Morikawa, J. Ren, E. Vasilaki +8 more
2017Nucleic Acids Research101 citations Open access
Semantic Scholar
RNF12 controls embryonic stem cell fate and morphogenesis in zebrafish embryos by targeting Smad7 for degradation.
Long Zhang, Hui-Zhe Huang, Fang-Fang Zhou, J. Schimmel +11 more
2012Molecules and Cells101 citations Open access
Semantic Scholar
Binding of promoter-associated AP-1 is not altered during induction and subsequent repression of the c-jun promoter by TPA and UV irradiation.
Ingrid Herr, H. van Dam, Peter Angel
1994Carcinogenesis95 citations
Semantic Scholar
UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination
Xiao-Fei Zhang, Juan Zhang, Long Zhang, H. van Dam +1 more
2013Cell Research94 citations Open access
Semantic Scholar
Ubiquitin-specific Protease 4 Mitigates Toll-like/Interleukin-1 Receptor Signaling and Regulates Innate Immune Activation*
Fang-Fang Zhou, Xiao-Fei Zhang, H. van Dam, P. ten Dijke +2 more
2012Journal of Biological Chemistry94 citations Open access
Semantic Scholar
TGFβ and EGF signaling orchestrates the AP-1- and p63 transcriptional regulation of breast cancer invasiveness
A. Sundqvist, E. Vasilaki, O. Voytyuk, Yu Bai +6 more
2020Oncogene90 citations Open access
Semantic Scholar
Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2
Jaap Kool, Mohamed Hamdi, P. Cornelissen-Steijger, A. J. van der Eb +2 more
2003Oncogene90 citations Open access
Semantic Scholar
Ras-Dependent Regulation of c-Jun Phosphorylation Is Mediated by the Ral Guanine Nucleotide Exchange Factor-Ral Pathway
Nancy D. de Ruiter, R. Wolthuis, H. van Dam, B. Burgering +1 more
2000Molecular and Cellular Biology89 citations Open access
Semantic Scholar
DNA damage in transcribed genes induces apoptosis via the JNK pathway and the JNK-phosphatase MKP-1
Mohamed Hamdi, Jaap Kool, P. Cornelissen-Steijger, F. Carlotti +8 more
2005Oncogene86 citations
Semantic Scholar
Tamoxifen Inhibits TGF‐β‐Mediated Activation of Myofibroblasts by Blocking Non‐Smad Signaling Through ERK1/2
J. Carthy, A. Sundqvist, Angelos Heldin, H. van Dam +3 more
2015Journal of Cellular Physiology75 citations
Semantic Scholar
Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination
Feng Xie, Zheng-Kui Zhang, H. van Dam, Long Zhang +1 more
2014Cells68 citations Open access
Semantic Scholar
Transcription factor ATF3 partially transforms chick embryo fibroblasts by promoting growth factor-independent proliferation
Sandrine Perez, E. Vial, H. van Dam, M. Castellazzi
2001Oncogene66 citations
Semantic Scholar
Restriction to Fos family members of Trip6-dependent coactivation and glucocorticoid receptor-dependent trans-repression of activator protein-1.
M. Diefenbacher, S. Sekula, Christine Heilbock, J. Maier +5 more
2008Molecular Endocrinology63 citations Open access
Semantic Scholar
Increased activity of activator protein-1 transcription factor components ATF2, c-Jun, and c-Fos in human and mouse autosomal dominant polycystic kidney disease.
N. H. Le, A. van der Wal, P. van der Bent, I. S. Lantinga-van Leeuwen +4 more
2005Journal of the American Society of Nephrology62 citations
Semantic Scholar
GSK3β inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb
Fang-Fang Zhou, Long Zhang, T. van Laar, H. van Dam +1 more
2011Molecular Biology of the Cell61 citations Open access
Semantic Scholar
BMP-7 inhibits TGF-β-induced invasion of breast cancer cells through inhibition of integrin β3 expression
H. P. H. Naber, E. Wiercinska, E. Pardali, T. van Laar +8 more
2011Cellular Oncology61 citations Open access
Semantic Scholar
Molecular insights into tumour metastasis: tracing the dominant events
Ke Jin, Tong Li, H. van Dam, Fang-Fang Zhou +1 more
2017Journal of Pathology59 citations
Semantic Scholar
Control of endothelial sprouting by a Tel–CtBP complex
M. G. Roukens, Mariam Alloul-Ramdhani, B. Baan, Kazuki Kobayashi +4 more
2010Nature Cell Biology58 citations
Semantic Scholar
Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models
Yihao Li, Yvette Drabsch, P. Pujuguet, J. Ren +5 more
2015Breast Cancer Research55 citations Open access
Semantic Scholar
A RNA Interference Screen Identifies the Protein Phosphatase 2A Subunit PR55γ as a Stress-Sensitive Inhibitor of c-SRC
P. Eichhorn, M. Creyghton, Kevin Wilhelmsen, H. van Dam +1 more
2007PLoS Genetics54 citations Open access
Semantic Scholar
Increased cyclin A and decreased cyclin D levels in adenovirus 5 E1A-transformed rodent cell lines.
T. Buchou, O. Kranenburg, H. van Dam, D. Roelen +3 more
1993Oncogene54 citations
Semantic Scholar
Overexpression of Activating Transcription Factor-2 Is Required for Tumor Growth and Progression in Mouse Skin Tumors
Paraskevi Papassava, V. Gorgoulis, Dimitra Papaevangeliou, S. Vlahopoulos +2 more
2004Cancer Research52 citations Open access
Semantic Scholar
FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection.
Tong Dai, Li-Ming Wu, Shuai Wang, Jing Wang +14 more
2018Cell Host and Microbe51 citations Open access
Semantic Scholar
FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis
Feng Xie, Ke Jin, L. Shao, Yao-Min Fan +12 more
2017Nature Communications50 citations Open access
Semantic Scholar
Transcription Factor ATF2 Cooperates with v-Jun To Promote Growth Factor-Independent Proliferation In Vitro and Tumor Formation In Vivo
S. Huguier, J. Baguet, Sandrine Perez, H. van Dam +1 more
1998Molecular and Cellular Biology50 citations Open access
Semantic Scholar
Aberrant Polycystin-1 Expression Results in Modification of Activator Protein-1 Activity, whereas Wnt Signaling Remains Unaffected*
N. H. Le, P. van der Bent, G. Huls, M. L. Van De Wetering +7 more
2004Journal of Biological Chemistry48 citations Open access
Semantic Scholar
Key signaling nodes in mammary gland development and cancer: Smad signal integration in epithelial cell plasticity
A. Sundqvist, P. ten Dijke, H. van Dam
2012Breast Cancer Research46 citations Open access
Semantic Scholar
ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responses.
Mohamed Hamdi, H. Popeijus, F. Carlotti, J. Janssen +6 more
2008DNA Repair44 citations
Semantic Scholar
Both ATF-2 and c-Jun are phosphorylated by stress-activated protein kinases in response to UV irradiation.
D. Wilhelm, H. van Dam, Ingrid Herr, Bernd Baumann +2 more
1995Immunobiology43 citations
Semantic Scholar

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