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R. Young · SciRah

Researcher profile · Semantic Scholar

R. Young

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R. Young — researcher profile on SciRah

h-index: 39
Works: 107
Citations: 13K

Most-cited papers

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
J. Fraietta, S. Lacey, Elena J. Orlando, Iulian Pruteanu-Malinici +33 more
2018Nature Medicine1,598 citations Open access
Semantic Scholar
CRISPR-engineered T cells in patients with refractory cancer
E. Stadtmauer, J. Fraietta, M. Davis, A. Cohen +37 more
2020Science1,308 citations Open access
Semantic Scholar
Disruption of TET2 Promotes the Therapeutic Efficacy of CD19-targeted T-cells
J. Fraietta, Christopher L. Nobles, Morgan A. Sammons, Stefan Lundh +34 more
2018Nature796 citations Open access
Semantic Scholar
Decade-long leukaemia remissions with persistence of CD4+ CAR T cells
J. Melenhorst, Gregory M. Chen, Meng Wang, D. Porter +30 more
2022Nature789 citations Open access
Semantic Scholar
B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma.
Adam D. Cohen, A. Garfall, Edward A. Stadtmauer, J. Melenhorst +18 more
2019Journal of Clinical Investigation645 citations Open access
Semantic Scholar
Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell
M. Ruella, Jun Xu, D. Barrett, J. Fraietta +22 more
2018Nature Medicine614 citations Open access
Semantic Scholar
Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma
A. Posey, Robert D Schwab, Alina C. Boesteanu, C. Steentoft +18 more
2016Immunity559 citations Open access
Semantic Scholar
Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation.
S. Guedan, A. Posey, Carolyn E Shaw, A. Wing +13 more
2018JCI Insight527 citations Open access
Semantic Scholar
Affinity-tuned ErbB2 or EGFR chimeric antigen receptor T cells exhibit an increased therapeutic index against tumors in mice
Xiao-Jun Liu, Shuguang Jiang, C. Fang, Shiyu Yang +11 more
2015Cancer Research516 citations Open access
Semantic Scholar
Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18
Bi-Liang Hu, Jiangtao Ren, Yanping Luo, Brian Keith +4 more
2017Cell Reports470 citations Open access
Semantic Scholar
Safety and efficacy of intratumoral injections of chimeric antigen receptor (CAR) T cells in metastatic breast cancer
J. Tchou, Yang-Bing Zhao, B. Levine, Paul J. L. Zhang +22 more
2017Cancer immunology research360 citations Open access
Semantic Scholar
An NK-like CAR T cell transition in CAR T cell dysfunction
Charly R. Good, M. A. Aznar, Shunichiro Kuramitsu, Parisa Samareh +26 more
2021Cell335 citations Open access
Semantic Scholar
Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses.
Keisuke Watanabe, Yanping Luo, Tong Da, S. Guedan +11 more
2018JCI Insight258 citations Open access
Semantic Scholar
Improving CART-Cell Therapy of Solid Tumors with Oncolytic Virus–Driven Production of a Bispecific T-cell Engager
A. Wing, C. A. Fajardo, A. Posey, Carolyn E Shaw +5 more
2018Cancer immunology research228 citations Open access
Semantic Scholar
Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress.
R. Young, D. Ackerman, Zachary Quinn, A. Mancuso +7 more
2013Genes & Development209 citations Open access
Semantic Scholar
Deletion of the inhibitory co-receptor CTLA4 enhances and invigorates chimeric antigen receptor T cells
Sangya Agarwal, M. A. Aznar, Andrew J. Rech, Charly R. Good +16 more
2023Immunity171 citations Open access
Semantic Scholar
Single residue in CD28-costimulated CAR T cells limits long-term persistence and antitumor durability.
S. Guedan, Aviv Madar, Victoria Casado-Medrano, Carolyn E Shaw +5 more
2020Journal of Clinical Investigation157 citations Open access
Semantic Scholar
Antigen-independent activation enhances the efficacy of 41BB co-stimulated CD22 CAR T cells
Nathan Singh, N. Frey, Boris Engels, D. Barrett +32 more
2021Nature Medicine156 citations Open access
Semantic Scholar
Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma.
A. Garfall, E. Stadtmauer, W. Hwang, S. Lacey +25 more
2019JCI Insight151 citations Open access
Semantic Scholar
Next-generation CAR T Cell Therapies
R. Young, N. Engel, U. Uslu, N. Wellhausen +1 more
2022Cancer Discovery126 citations Open access
Semantic Scholar
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy
N. Wellhausen, Ryan P. O'Connell, S. Lesch, N. Engel +8 more
2023Science Translational Medicine111 citations Open access
Semantic Scholar
Potentiating adoptive cell therapy using synthetic IL-9 receptors
A. Kalbasi, M. Siurala, L. Su, M. Tariveranmoshabad +19 more
2022Nature107 citations Open access
Semantic Scholar
Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers
Josephine R. Giles, Sasikanth Manne, Elizabeth Freilich, D. Oldridge +18 more
2022Immunity105 citations Open access
Semantic Scholar
Two Cases of Severe Pulmonary Toxicity from Highly Active Mesothelin-Directed CAR T Cells.
A. Haas, Ryan J. Golden, L. Litzky, Boris Engels +29 more
2023Molecular Therapy91 citations Open access
Semantic Scholar
BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia.
Weimin Kong, Alexander J. Dimitri, Wen-Lian Wang, In-Young Jung +29 more
2021Journal of Clinical Investigation75 citations Open access
Semantic Scholar
B-Cell Maturation Antigen (BCMA)-Specific Chimeric Antigen Receptor T Cells (CART-BCMA) for Multiple Myeloma (MM): Initial Safety and Efficacy from a Phase I Study
Adam D. Cohen, A. Garfall, Edward A. Stadtmauer, S. Lacey +19 more
201673 citations Open access
Semantic Scholar
Pre-clinical validation of B cell maturation antigen (BCMA) as a target for T cell immunotherapy of multiple myeloma
De-Xiu Bu, Reshma Singh, Eugene Choi, M. Ruella +18 more
2018OncoTarget71 citations Open access
Semantic Scholar
Anti-BCMA/CD19 CAR T Cells with Early Immunomodulatory Maintenance for Multiple Myeloma Responding to Initial or Later-Line Therapy
A. Garfall, A. Cohen, S. Susanibar-Adaniya, W. Hwang +35 more
2022Blood Cancer Discovery68 citations Open access
Semantic Scholar
CAR T Cell Therapy of Non-hematopoietic Malignancies: Detours on the Road to Clinical Success
Kristen B. Long, R. Young, Alina C. Boesteanu, M. Davis +5 more
2018Frontiers in Immunology68 citations Open access
Semantic Scholar
Efficacy of Humanized CD19-Targeted Chimeric Antigen Receptor (CAR)-Modified T Cells in Children and Young Adults with Relapsed/Refractory Acute Lymphoblastic Leukemia
S. Maude, D. Barrett, S. Rheingold, R. Aplenc +17 more
201666 citations
Semantic Scholar
Chimeric antigen receptor T cells as adjuvant therapy for unresectable adenocarcinoma
U. Uslu, Tong Da, C. Assenmacher, J. Scholler +3 more
2023Science Advances63 citations Open access
Semantic Scholar
Safety and Efficacy of B-Cell Maturation Antigen (BCMA)-Specific Chimeric Antigen Receptor T Cells (CART-BCMA) with Cyclophosphamide Conditioning for Refractory Multiple Myeloma (MM)
A. Cohen, A. Garfall, E. Stadtmauer, S. Lacey +20 more
201762 citations
Semantic Scholar
The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion
U. Uslu, Lijun Sun, Sofia Castelli, Amanda V. Finck +4 more
2024Nature Communications54 citations Open access
Semantic Scholar
Future perspectives on engineered T cells for cancer.
A. Posey, R. Young, Carl H. June
2024Trends in Cancer50 citations Open access
Semantic Scholar
Identifying highly active anti-CCR4 CAR T cells for the treatment of T-cell lymphoma
Keisuke Watanabe, Ángela M. Gómez, Shunichiro Kuramitsu, M. Siurala +11 more
2023Blood Advances49 citations Open access
Semantic Scholar
Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma.
A. Garfall, E. Stadtmauer, Wei-Ting Hwang, S. Lacey +25 more
2018JCI Insight45 citations Open access
Semantic Scholar
Quadruple adenine base–edited allogeneic CAR T cells outperform CRISPR/Cas9 nuclease–engineered T cells
N. Engel, Israel Steinfeld, Daniel E. Ryan, Kusala Anupindi +14 more
2025Proceedings of the National Academy of Sciences of the United States of America32 citations Open access
Semantic Scholar
Clinical and molecular dissection of CAR T cell resistance in pancreatic cancer
M. A. Aznar, Charly R. Good, J. Barber-Rotenberg, Sangya Agarwal +28 more
2025Cell Reports Medicine30 citations Open access
Semantic Scholar
Proton radiation boosts the efficacy of mesothelin-targeting chimeric antigen receptor T cell therapy in pancreatic cancer
U. Amit, U. Uslu, Ioannis I. Verginadis, Michele M. Kim +9 more
2024Proceedings of the National Academy of Sciences of the United States of America28 citations Open access
Semantic Scholar
Efficacy and Safety of Humanized Chimeric Antigen Receptor (CAR)-Modified T Cells Targeting CD19 in Children with Relapsed/Refractory ALL
S. Maude, D. Barrett, David E. Ambrose, S. Rheingold +21 more
201528 citations
Semantic Scholar
Efficacy of humanized CD19-targeted chimeric antigen receptor (CAR)-modified T cells in children with relapsed ALL.
S. Maude, D. Barrett, S. Rheingold, R. Aplenc +16 more
201627 citations
Semantic Scholar
Durable Remissions with Humanized CD19-Targeted Chimeric Antigen Receptor (CAR)-Modified T Cells in CAR-Naive and CAR-Exposed Children and Young Adults with Relapsed/Refractory Acute Lymphoblastic Leukemia
S. Maude, G. Hucks, C. Callahan, D. Baniewicz +19 more
201726 citations
Semantic Scholar
TET2 regulates early and late transitions in exhausted CD8+ T cell differentiation and limits CAR T cell function
Alexander J. Dimitri, A. Baxter, Gregory M. Chen, Caitlin R. Hopkins +38 more
2024Science Advances23 citations Open access
Semantic Scholar
Enhancing chimeric antigen receptor T cell therapy by modulating the p53 signaling network with Δ133p53α
Christopher Roselle, Izumi Horikawa, Linhui Chen, Andre R. Kelly +11 more
2024Proceedings of the National Academy of Sciences of the United States of America23 citations Open access
Semantic Scholar
Off-the-shelf CAR T cells to treat cancer
Sofia Castelli, R. Young, C. June
2022Cell Research23 citations Open access
Semantic Scholar
Author Correction: Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
J. Fraietta, S. Lacey, Elena J. Orlando, Iulian Pruteanu-Malinici +33 more
2021Nature Medicine21 citations Open access
Semantic Scholar
PD-1 Inhibitor Combinations As Salvage Therapy for Relapsed/Refractory Multiple Myeloma (MM) Patients Progressing after Bcma-Directed CAR T Cells
L. Bernabei, A. Garfall, J. Melenhorst, S. Lacey +10 more
2018Blood20 citations Open access
Semantic Scholar
TET2 regulates early and late transitions in exhausted CD8+ T-cell differentiation and limits CAR T-cell function
Alexander J. Dimitri, A. Baxter, Gregory M. Chen, Caitlin R. Hopkins +36 more
2024bioRxiv19 citations Open access
Semantic Scholar
Biomarkers of Response to Anti-CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy in Patients with Chronic Lymphocytic Leukemia
J. Fraietta, S. Lacey, Nicholas Wilcox, Felipe Bedoya +14 more
201618 citations
Semantic Scholar
IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing antitumor efficacy.
Sofia Castelli, Wesley V. Wilson, U. Uslu, Amanda V. Finck +7 more
2025Immunity17 citations Open access
Semantic Scholar

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