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S. Hansen · SciRah

Researcher profile · Semantic Scholar

S. Hansen

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S. Hansen — researcher profile on SciRah

h-index: 24
Works: 59
Citations: 3,787

Most-cited papers

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations
S. Hansen, G. Sulzenbacher, T. Huxford, P. Marchot +2 more
2005EMBO Journal645 citations Open access
Semantic Scholar
Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2
S. Hansen, X. Tao, R. MacKinnon
2011Nature614 citations Open access
Semantic Scholar
Crystal structure of a Cbtx–AChBP complex reveals essential interactions between snake α‐neurotoxins and nicotinic receptors
Y. Bourne, T. Talley, S. Hansen, P. Taylor +1 more
2005EMBO Journal303 citations Open access
Semantic Scholar
Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol
Hao Wang, Joshua A. Kulas, Chao Wang, D. Holtzman +2 more
2020Proceedings of the National Academy of Sciences of the United States of America277 citations Open access
Semantic Scholar
Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel
C. Bouzat, Fernanda Gumilar, G. Spitzmaul, Hai-Long Wang +4 more
2004Nature274 citations Open access
Semantic Scholar
Studies on the mechanism of general anesthesia
M. A. Pavel, E. Petersen, Hao Wang, R. Lerner +1 more
2018Proceedings of the National Academy of Sciences of the United States of America189 citations Open access
Semantic Scholar
Structural and Ligand Recognition Characteristics of an Acetylcholine-binding Protein from Aplysia californica*
S. Hansen, T. Talley, Z. Radić, P. Taylor
2004Journal of Biological Chemistry147 citations Open access
Semantic Scholar
Agonist-mediated Conformational Changes in Acetylcholine-binding Protein Revealed by Simulation and Intrinsic Tryptophan Fluorescence*
Fan Gao, N. Bren, T. Burghardt, S. Hansen +4 more
2005Journal of Biological Chemistry144 citations Open access
Semantic Scholar
Galanthamine and non-competitive inhibitor binding to ACh-binding protein: evidence for a binding site on non-alpha-subunit interfaces of heteromeric neuronal nicotinic receptors.
S. Hansen, P. Taylor
2007Journal of Molecular Biology138 citations Open access
Semantic Scholar
Lipid Agonism, The PIP2 Paradigm of Ligand-Gated Ion Channels
S. Hansen
2015Biochimica et Biophysica Acta133 citations Open access
Semantic Scholar
The role of high cholesterol in age-related COVID19 lethality.
Hao Wang, Zixuan Yuan, M. A. Pavel, Sonia Mediouni Jablonski +5 more
2020bioRxiv115 citations Open access
Semantic Scholar
Tryptophan Fluorescence Reveals Conformational Changes in the Acetylcholine Binding Protein*
S. Hansen, Z. Radić, T. Talley, B. Molles +3 more
2002Journal of Biological Chemistry105 citations Open access
Semantic Scholar
Tools for understanding nanoscale lipid regulation of ion channels
C. Robinson, T. Rohacs, S. Hansen
2019TIBS -Trends in Biochemical Sciences. Regular ed81 citations Open access
Semantic Scholar
An Ion Selectivity Filter in the Extracellular Domain of Cys-loop Receptors Reveals Determinants for Ion Conductance*
S. Hansen, Hai-Long Wang, P. Taylor, S. Sine
2008Journal of Biological Chemistry69 citations Open access
Semantic Scholar
A Soluble Fluorescent Binding Assay Reveals PIP2 Antagonism of TREK-1 Channels
C. Cabanos, Miao Wang, Xian-Lin Han, S. Hansen
2017Cell Reports63 citations Open access
Semantic Scholar
The shared role of cholesterol in neuronal and peripheral inflammation.
S. Hansen, Hao Wang
2023Pharmacology and Therapeutics55 citations Open access
Semantic Scholar
Homogeneous Oligomers of Pro-Apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization
Zachary J. Hauseman, Edward P. Harvey, C. Newman, T. Wales +15 more
2020Molecules and Cells46 citations Open access
Semantic Scholar
Curariform Antagonists Bind in Different Orientations to Acetylcholine-binding Protein*
Fan Gao, Nina Bern, A. Little, Hai-Long Wang +4 more
2003Journal of Biological Chemistry46 citations Open access
Semantic Scholar
Structure-guided drug design: conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes.
P. Taylor, T. Talley, Z. Radić, S. Hansen +2 more
2007Biochemical Pharmacology45 citations Open access
Semantic Scholar
Solution NMR of Acetylcholine Binding Protein Reveals Agonist-Mediated Conformational Change of the C-Loop
Fan Gao, G. Mer, M. Tonelli, S. Hansen +3 more
2006Molecular Pharmacology43 citations
Semantic Scholar
The role of high cholesterol in SARS-CoV-2 infectivity
Hao Wang, Zixuan Yuan, M. A. Pavel, Sonia Mediouni Jablonski +5 more
2023Journal of Biological Chemistry35 citations Open access
Semantic Scholar
Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture
Zixuan Yuan, M. A. Pavel, Hao Wang, Jerome C. Kwachukwu +6 more
2022Communications Biology34 citations Open access
Semantic Scholar
Cholesterol and COVID19 lethality in elderly.
Hao Wang, Zixuan Yuan, M. A. Pavel, S. Hansen
202031 citations
Semantic Scholar
On the Origin of Ion Selectivity in the Cys-Loop Receptor Family
S. Sine, Hai-Long Wang, S. Hansen, P. Taylor
2010Journal of Molecular Neuroscience24 citations Open access
Semantic Scholar
Cholesterol Regulation of Membrane Proteins Revealed by Two-Color Super-Resolution Imaging
Zixuan Yuan, S. Hansen
2023Membranes23 citations Open access
Semantic Scholar
Structural characterization of agonist and antagonist-bound acetylcholine-binding protein from Aplysia Californica
S. Hansen, G. Sulzenbacher, T. Huxford, P. Marchot +2 more
2007Journal of Molecular Neuroscience21 citations
Semantic Scholar
Crystal structure of a Cbtx–AChBP complex reveals essential interactions between snake α‐neurotoxins and nicotinic receptors
Y. Bourne, T. Talley, S. Hansen, P. Taylor +1 more
201319 citations Open access
Semantic Scholar
An ACAT inhibitor suppresses SARS-CoV-2 replication and boosts antiviral T cell activity
P. Wing, N. Schmidt, R. Peters, Maximilian Erdmann +14 more
2023PLoS Pathogens17 citations Open access
Semantic Scholar
Hydroxychloroquine: mechanism of action inhibiting SARS-CoV2 entry.
Zixuan Yuan, M. A. Pavel, Hao Wang, S. Hansen
2020bioRxiv13 citations Open access
Semantic Scholar
Structural dynamics of the alpha-neurotoxin-acetylcholine-binding protein complex: hydrodynamic and fluorescence anisotropy decay analyses.
R. Hibbs, David A. Johnson, Jianxin Shi, S. Hansen +1 more
2005Biochemistry13 citations
Semantic Scholar
Regulation of neuroinflammation by astrocyte-derived cholesterol
Hao Wang, Joshua A. Kulas, Yang Yu, Joshua L. Milstein +11 more
2026bioRxiv10 citations Open access
Semantic Scholar
Structural comparison of three crystalline complexes of a peptidic toxin with a synaptic acetylcholine recognition protein
Y. Bourne, S. Hansen, G. Sulzenbacher, T. Talley +3 more
2007Journal of Molecular Neuroscience7 citations Open access
Semantic Scholar
Measuring anesthetic resistance in Drosophila by VAAPR
E. Petersen, Katherine R. Clowes, S. Hansen
2019bioRxiv6 citations Open access
Semantic Scholar
Cholesterol’s Function and Origin in the Alzheimer’s Disease Brain
S. Hansen
2023Journal of Alzheimer's Disease4 citations
Semantic Scholar
Getting in on the action: New tools to see SARS-CoV-2 infect a cell
S. Hansen, Zixuan Yuan
2023Cell Chemical Biology1 citations Open access
Semantic Scholar
An ACAT inhibitor regulates SARS-CoV-2 replication and antiviral T cell activity
N. Schmidt, P. Wing, R. Peters, Rachel Brown +12 more
2022bioRxiv1 citations Open access
Semantic Scholar
Contemporary paradigms for cholinergic ligand design guided by biological structure.
P. Taylor, S. Hansen, T. Talley, R. Hibbs +1 more
2004Bioorganic & Medicinal Chemistry Letters1 citations Open access
Semantic Scholar
Author Correction: Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture
Zixuan Yuan, M. A. Pavel, Hao Wang, Jerome C. Kwachukwu +6 more
2022Communications Biology0 citations Open access
Semantic Scholar
Reply to van Swinderen and Hines: Drosophila model establishes the lipid membrane as a target of anesthetics
S. Hansen, R. Lerner, M. A. Pavel, E. Petersen
2020Proceedings of the National Academy of Sciences of the United States of America0 citations Open access
Semantic Scholar
Astrocyte cholesterol is essential for amyloid beta production
Joshua A. Kulas, Hao Wang, S. Hansen, Heather A. Ferris
20200 citations Open access
Semantic Scholar
Cholesterol‐dependent regulation of amyloid processing in neurons
Hao Wang, Joshua A. Kulas, Heather A. Ferris, S. Hansen
2020Alzheimer's & Dementia0 citations Open access
Semantic Scholar
Inward rectifier potassium channel Kir2.2 in complex with PIP2
S. Hansen, X. Tao, R. MacKinnon
20110 citations
Semantic Scholar
Inward rectifier potassium channel Kir2.2 in complex with dioctanoylglycerol pyrophosphate (DGPP)
S. Hansen, X. Tao, R. MacKinnon
20110 citations
Semantic Scholar
Inward rectifier potassium channel Kir2.2 I223L mutant in complex with PIP2
S. Hansen, X. Tao, R. MacKinnon
20110 citations
Semantic Scholar
Crystal structure of acetylcholine binding protein complexed with metocurine
T. Talley, M. Harel, G. Yamauchi, Z. Radić +3 more
20110 citations
Semantic Scholar
Crystal Structure of the Complex of Acetylcholine Binding Protein and d-tubocurarine
T. Talley, M. Harel, John G. Yamauchi, Z. Radić +3 more
20110 citations
Semantic Scholar
Apo inward rectifier potassium channel Kir2.2 I223L mutant
S. Hansen, X. Tao, R. MacKinnon
20110 citations
Semantic Scholar
Sulfates bound in the vestibule of AChBP
S. Hansen, P. Taylor
20090 citations
Semantic Scholar
Galanthamine bound to an ACh-binding Protein
S. Hansen, P. Taylor
20070 citations
Semantic Scholar
Crystal structure of Cocaine bound to an ACh-Binding Protein
S. Hansen, P. Taylor
20070 citations
Semantic Scholar

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R. MacKinnon — researcher profile on SciRah