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I. A. Chaim · SciRah

Researcher profile · Semantic Scholar

I. A. Chaim

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I. A. Chaim — researcher profile on SciRah

h-index: 16
Works: 29
Citations: 2,074

Most-cited papers

Complex oscillatory waves emerging from cortical organoids model early human brain network development
C. A. Trujillo, Richard Gao, Priscilla D. Negraes, Jing Gu +12 more
2019Cell Stem Cell820 citations Open access
Semantic Scholar
Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9
Ranjan Batra, David A. Nelles, Elaine Pirie, Steven M. Blue +12 more
2017Cell242 citations Open access
Semantic Scholar
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer
J. Einstein, Mark Perelis, I. A. Chaim, Jitendra Kumar Meena +10 more
2021Molecules and Cells160 citations Open access
Semantic Scholar
Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis
Z. Nagel, C. Margulies, I. A. Chaim, S. McRee +6 more
2014Proceedings of the National Academy of Sciences of the United States of America142 citations Open access
Semantic Scholar
Robust single-cell discovery of RNA targets of RNA binding proteins and ribosomes
Kristopher W Brannan, I. A. Chaim, Ryan J. Marina, Brian A. Yee +7 more
2021Nature Methods140 citations Open access
Semantic Scholar
Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment
C. A. Trujillo, E. Rice, Nathan K. Schaefer, I. A. Chaim +23 more
2021Science124 citations Open access
Semantic Scholar
DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme
Z. Nagel, G. Kitange, Shiv K. Gupta, B. Joughin +5 more
2016Cancer Research110 citations Open access
Semantic Scholar
Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair research.
Z. Nagel, I. A. Chaim, L. Samson
2014DNA Repair84 citations Open access
Semantic Scholar
In vivo measurements of interindividual differences in DNA glycosylases and APE1 activities
I. A. Chaim, Z. Nagel, J. Jordan, P. Mazzucato +2 more
2017Proceedings of the National Academy of Sciences of the United States of America53 citations Open access
Semantic Scholar
Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells
Tomoyuki Koga, I. A. Chaim, J. Benitez, Sebastian J. Markmiller +17 more
2020Nature Communications51 citations Open access
Semantic Scholar
Nested oscillatory dynamics in cortical organoids model early human brain network development
C. A. Trujillo, Richard Gao, Priscilla D. Negraes, I. A. Chaim +6 more
2018bioRxiv34 citations Open access
Semantic Scholar
MECP2-related pathways are dysregulated in a cortical organoid model of myotonic dystrophy
K. H. Morelli, Wenhao Jin, Shashank Shathe, Assael A. Madrigal +8 more
2022Science Translational Medicine24 citations Open access
Semantic Scholar
Nitric oxide induced S-nitrosation causes base excision repair imbalance
Marcus C. Parrish, I. A. Chaim, Z. Nagel, S. Tannenbaum +2 more
2018DNA Repair20 citations Open access
Semantic Scholar
A novel role for transcription-coupled nucleotide excision repair for the in vivo repair of 3,N4-ethenocytosine
I. A. Chaim, Alycia Gardner, Jie Wu, T. Iyama +2 more
2017Nucleic Acids Research20 citations Open access
Semantic Scholar
CometChip Analysis of Human Primary Lymphocytes Enables Quantification of Inter-Individual Differences in the Kinetics of Repair of DNA Oxidation Damage
Le P. Ngo, S. Kaushal, I. A. Chaim, P. Mazzucato +4 more
2021Free Radical Biology & Medicine18 citations Open access
Semantic Scholar
Mapping the future of oxidative RNA damage in neurodegeneration: Rethinking the status quo with new tools
Hailey B Wheeler, Assael A. Madrigal, I. A. Chaim
2024Proceedings of the National Academy of Sciences of the United States of America16 citations Open access
Semantic Scholar
Alkylation induced cerebellar degeneration dependent on Aag and Parp1 does not occur via previously established cell death mechanisms
C. Margulies, I. A. Chaim, Aprotim Mazumder, June Criscione +1 more
2017PLoS ONE6 citations Open access
Semantic Scholar
Robust single-cell discovery of RNA targets of RNA binding proteins and ribosomes
Kristopher W Brannan, I. A. Chaim, Brian A. Yee, Ryan J. Marina +4 more
20204 citations Open access
Semantic Scholar
Comprehensive Measurement of Inter‐Individual Variation in DNA Repair Capacity in Healthy Individuals
Ting Zhai, P. Mazzucato, Catherine Ricciardi, D. Christiani +4 more
2025Advancement of science3 citations Open access
Semantic Scholar
Glioblastomas derived from genetically modified pluripotent stem cells recapitulate pathobiology
Tomoyuki Koga, J. Benitez, I. A. Chaim, Sebastian J. Markmiller +16 more
20192 citations Open access
Semantic Scholar
Assessing BER Capacity in the Human Population
I. A. Chaim, Z. Nagel
20172 citations
Semantic Scholar
Author Correction: Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells
Tomoyuki Koga, I. A. Chaim, Jorge A. Benitez, Sebastian J. Markmiller +17 more
2020Nature Communications1 citations Open access
Semantic Scholar
Cancer avatars derived from genetically engineered pluripotent stem cells allow for longitudinal assessment of tumor development
Tomoyuki Koga, I. A. Chaim, J. Benitez, Sebastian J. Markmiller +17 more
2019bioRxiv1 citations Open access
Semantic Scholar
Comprehensive Measurement of Inter-Individual Variation in DNA Repair Capacity in Healthy Individuals
Ting Zhai, P. Mazzucato, Catherine Ricciardi, D. Christiani +4 more
2025medRxiv0 citations Open access
Semantic Scholar
OTEH-9. scRNA sequencing of proneural GBM avatar model reveals acquisition of oncogenic transcriptional programming and infers a developmental path towards a genomically unstable state
B. Taylor, I. A. Chaim, Tomoyuki Koga, Shunichiro Miki +3 more
2021Neuro-Oncology Advances0 citations Open access
Semantic Scholar
1 Robust single-cell discovery of RNA targets of RNA binding proteins and ribosomes 2 3
Kristopher W Brannan, I. A. Chaim, Brian A. Yee, Ryan J. Marina +5 more
20200 citations
Semantic Scholar
TMOD-28. AUTHENTIC HUMAN GLIOMA MODELING USING GENETICALLY ENGINEERED INDUCED PLURIPOTENT STEM CELLS
Tomoyuki Koga, I. A. Chaim, Sebastian J. Markmiller, J. Benitez +11 more
2019Neuro-Oncology0 citations Open access
Semantic Scholar
Functional DNA repair capacity assays : a focus on base excision repair
I. A. Chaim
20160 citations
Semantic Scholar
Multiplexed Dna Repair Assays for Multiple Lesions and Multiple Doses via Transcription Inhibition and Transcriptional Mutagenesis Multiplexed Dna Repair Assays for Multiple Lesions and Multiple Doses via Transcription Inhibition and Accessed Terms of Use Detailed Terms
C. Nagel, C. Margulies, I. A. Chaim, S. McRee +6 more
0 citations
Semantic Scholar

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Gene W. Yeo×9
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