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P. Kasper · SciRah

Researcher profile · Semantic Scholar

P. Kasper

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P. Kasper — researcher profile on SciRah

h-index: 25
Works: 74
Citations: 2,648

Most-cited papers

How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.
D. Kirkland, S. Pfuhler, D. Tweats, M. Aardema +21 more
2007Mutation research433 citations
Semantic Scholar
Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium
F. Dieterle, F. Sistare, F. Goodsaid, M. Papaluca +62 more
2010Nature Biotechnology400 citations
Semantic Scholar
Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: a follow-up to an ECVAM workshop.
D. Kirkland, P. Kasper, L. Müller, R. Corvi +1 more
2008Mutation research174 citations
Semantic Scholar
Updated recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests.
D. Kirkland, P. Kasper, H. Martus, L. Müller +3 more
2016Mutation Research. Genetic Toxicology and Environmental Mutagenesis167 citations Open access
Semantic Scholar
Towards consensus practices to qualify safety biomarkers for use in early drug development
F. Sistare, F. Dieterle, Sean P. Troth, D. Holder +33 more
2010Nature Biotechnology127 citations
Semantic Scholar
Human biological relevance and the use of threshold-arguments in regulatory genotoxicity assessment: experience with pharmaceuticals.
L. Müller, P. Kasper
2000Mutation research103 citations
Semantic Scholar
Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities-Report from an ECVAM workshop.
S. Pfuhler, D. Kirkland, P. Kasper, M. Hayashi +13 more
2009Mutation research93 citations
Semantic Scholar
The utility of genetically modified mouse assays for identifying human carcinogens: a basic understanding and path forward. The Alternatives to Carcinogenicity Testing Committee ILSI HESI.
J. Macdonald, J. French, R. J. Gerson, J. Goodman +10 more
2004Toxicological Sciences87 citations Open access
Semantic Scholar
Interlaboratory evaluation of genomic signatures for predicting carcinogenicity in the rat.
M. Fielden, Alex Y. Nie, M. McMillian, C. S. Elangbam +31 more
2008Toxicological Sciences86 citations Open access
Semantic Scholar
The 3T3 neutral red uptake phototoxicity test: practical experience and implications for phototoxicity testing--the report of an ECVAM-EFPIA workshop.
M. Ceridono, Pär Tellner, D. Bauer, J. Barroso +31 more
2012Regulatory toxicology and pharmacology : RTP83 citations
Semantic Scholar
The application of the micronucleus test in Chinese hamster V79 cells to detect drug-induced photogenotoxicity.
Birgit Kersten, J. Zhang, S. Brendler-Schwaab, P. Kasper +1 more
1999Mutation research71 citations
Semantic Scholar
Compilation and use of genetic toxicity historical control data.
M. Hayashi, K. Dearfield, P. Kasper, D. Lovell +2 more
2011Mutation research66 citations
Semantic Scholar
Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? I. Reports of individual databases presented at an EURL ECVAM Workshop.
D. Kirkland, E. Zeiger, F. Madia, N. Gooderham +13 more
2014Mutation Research. Genetic Toxicology and Environmental Mutagenesis64 citations Open access
Semantic Scholar
Moving forward in carcinogenicity assessment: Report of an EURL ECVAM/ESTIV workshop
R. Corvi, F. Madia, K. Guyton, P. Kasper +4 more
2017Toxicology in Vitro59 citations Open access
Semantic Scholar
Critical issues with the in vivo comet assay: A report of the comet assay working group in the 6th International Workshop on Genotoxicity Testing (IWGT).
G. Speit, H. Kojima, B. Burlinson, A. Collins +12 more
2015Mutation Research. Genetic Toxicology and Environmental Mutagenesis55 citations
Semantic Scholar
Evaluation studies on the in vitro rat hepatocyte micronucleus assay.
Kerstin Müller-Tegethoff, P. Kasper, L. Müller
1995Mutation research49 citations
Semantic Scholar
Relevance and follow-up of positive results in in vitro genetic toxicity assays: an ILSI-HESI initiative.
V. Thybaud, M. Aardema, D. Casciano, V. Dellarco +8 more
2007Mutation research43 citations
Semantic Scholar
OSWG Recommendations for Genotoxicity Testing of Novel Oligonucleotide-Based Therapeutics
Cindy L. Berman, Scott A. Barros, S. Galloway, P. Kasper +5 more
2016Nucleic Acid Therapeutics42 citations
Semantic Scholar
Strategy for genotoxicity testing and stratification of genotoxicity test results--report on initial activities of the IWGT Expert Group.
L. Müller, D. Blakey, K. Dearfield, S. Galloway +11 more
2003Mutation research39 citations
Semantic Scholar
Critical analysis of carcinogenicity study outcomes. Relationship with pharmacological properties
J. W. van der Laan, P. Kasper, Beatriz Silva Lima, David R. Jones +1 more
2016Critical Reviews in Toxicology38 citations
Semantic Scholar
A critical appraisal of the sensitivity of in vivo genotoxicity assays in detecting human carcinogens
A. Zeller, S. Pfuhler, S. Albertini, F. Bringezu +6 more
2018Mutagenesis32 citations
Semantic Scholar
Follow-up testing of rodent carcinogens not positive in the standard genotoxicity testing battery: IWGT workgroup report.
P. Kasper, Y. Uno, R. J. Mauthe, N. Asano +7 more
2007Mutation research29 citations
Semantic Scholar
Photochemical genotoxicity and photochemical carcinogenesis--two sides of a coin?
L. Müller, P. Kasper, Birgit Kersten, Juan Zhang
1998Toxicology Letters27 citations
Semantic Scholar
Regulatory Acceptance of Alternative Methods in the Development and Approval of Pharmaceuticals.
S. Beken, P. Kasper, J. W. van der Laan
2016Advances in Experimental Medicine and Biology26 citations
Semantic Scholar
The Genetic Diversification of the HIV Type 1 gag p17 Gene in Patients Infected from a Common Source
P. Kasper, Peter Simmonds, K. Schneweis, R. Kaiser +4 more
1995AIDS Research and Human Retroviruses26 citations
Semantic Scholar
In vitro mutagenicity studies on cyproterone acetate using female rat hepatocytes for metabolic activation and as indicator cells.
P. Kasper, K. Tegethoff, L. Mueller
1995Carcinogenesis23 citations
Semantic Scholar
Genotoxicity assessment of peptide/protein-related biotherapeutics: points to consider before testing.
V. Thybaud, P. Kasper, Z. Sobol, A. Elhajouji +5 more
2016Mutagenesis20 citations
Semantic Scholar
Further investigations on the clastogenicity of paracetamol and acetylsalicylic acid in vitro.
L. Müller, P. Kasper, S. Madle
1991Mutation research17 citations
Semantic Scholar
Parallel Evolution in the V3 Region of HIV Type 1 after Infection of Hemophiliacs from a Homogeneous Source
P. Kasper, R. Kaiser, J. Oldenburg, H. Brackmann +2 more
1994AIDS Research and Human Retroviruses16 citations
Semantic Scholar
The Relevance of Photomutagenicity Testing as a Predictor of Photocarcinogenicity
L. Müller, P. Kasper
199814 citations
Semantic Scholar
Summary of major conclusions from the 6th International Workshop on Genotoxicity Testing (IWGT), Foz do Iguaçu, Brazil.
H. Martus, M. Hayashi, M. Honma, P. Kasper +5 more
2015Mutation Research. Genetic Toxicology and Environmental Mutagenesis12 citations
Semantic Scholar
SHORT COMMUNICATION: Time-Related introduction of DNA repair synthesis in rat hepatocytes following in vivo treatment with cyproterone acetate
P. Kasper, L. Mueller
199612 citations
Semantic Scholar
Inter-laboratory Evaluation of Genomic Signatures for Predicting Carcinogenicity in the Rat Predictive Safety Testing Consortium, Carcinogenicity Working Group
M. Fielden, Alex Y. Nie, M. McMillian, C. S. Elangbam +29 more
200811 citations
Semantic Scholar
Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells.
R. Frötschl, Sandra Weickardt, S. Staszewski, G. Kaufmann +1 more
2005Mutation research10 citations
Semantic Scholar
Considerations on photochemical genotoxicity. II: report of the 2009 International Workshop on Genotoxicity Testing Working Group.
A. Lynch, P. Guzzie, D. Bauer, E. Gocke +6 more
2011Mutation research9 citations
Semantic Scholar
OTC pharmaceuticals and genotoxicity testing: the paracetamol, anthraquinone, and griseofulvin cases.
L. Müller, P. Kasper
1995Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement9 citations
Semantic Scholar
Diversification of HIV-1 Strains after Infection from a Unique Source
P. Kasper, R. Kaiser, J. Kleim, J. Oldenburg +3 more
1993AIDS Research and Human Retroviruses9 citations
Semantic Scholar
Joint EFPIA/CHMP SWP workshop: the Emerging Use of Omic Technologies for Regulatory Non-Clinical Safety Testing.
P. Kasper, Gerry Oliver, B. Lima, T. Singer +1 more
2005Pharmacogenomics (London)8 citations
Semantic Scholar
Induction of chromosomal aberrations in Chinese hamster ovary cells by the restriction endonuclease Dra I: dose-effect relationships and effect of substitution of chromosomal DNA with bromodeoxyuridine.
G. Obe, Christian Johannes, V. Vasudev, P. Kasper +1 more
1987Mutation research8 citations
Semantic Scholar
Sex-specific induction of apoptosis by cyproterone acetate in primary rat hepatocytes.
P. Kasper, L. Mueller
1999Carcinogenesis7 citations
Semantic Scholar
Tumor promoter-like activity of the molluscicidal latex of 'Crown-of-Thorns' (Euphorbia milii var. hislopii) in the V79 metabolic cooperation assay.
C. M. Cruz, P. Kasper, A. Cataldo, H. Zamith +1 more
1996Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas6 citations
Semantic Scholar
Time-related induction of DNA repair synthesis in rat hepatocytes following in vivo treatment with cyproterone acetate.
P. Kasper, L. Mueller
1996Carcinogenesis6 citations
Semantic Scholar
ICH Guidances on Genotoxicity and Carcinogenicity: Scientific Background and Regulatory Practice
P. Kasper, L. Schechtman, Lutz M√ºller
20015 citations
Semantic Scholar
Assessment and acceptance of thresholds of genotoxic Impurities in New Drug substances: A regulatory perspective
P. Kasper
20044 citations
Semantic Scholar
Effect of diallyl trisulfide on induction of UDS by mutagenic drugs in primary rat hepatocytes.
Da-Jun Deng, K. Mueller, P. Kasper, L. Mueller
1994Biomedical and environmental sciences : BES4 citations
Semantic Scholar
International Workshop on Qualification and Control of Impurities
L. van Aerts, P. Kasper, O. Queckenberg, Lutz Mueller +1 more
20063 citations
Semantic Scholar
Effects of visible light absorbing chemicals in the photomicronucleus test in Chinese hamster V79 cells
J. Zhang, B. Kersten, P. Kasper, L. Müller
20013 citations
Semantic Scholar
Genotoxic Impurities in Pharmaceuticals
P. Kasper, L. Müller
20152 citations
Semantic Scholar
Assessment and Acceptance of Thresholds of Genotoxic Impurities in New Drug Substances
P. Kasper
2012International Journal of Pharmaceutical Medicine2 citations
Semantic Scholar
Microarrays in drug development: regulatory perspective
R. Frötschl, P. Kasper
20082 citations
Semantic Scholar

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