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L. Haertle · SciRah

Researcher profile · Semantic Scholar

L. Haertle

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L. Haertle — researcher profile on SciRah

h-index: 10
Works: 46
Citations: 425

Most-cited papers

Single and double hit events in genes encoding for immune targets before and after T cell engaging antibody therapy in MM.
M. Truger, J. Duell, Xiang Zhou, Larissa Heimeshoff +17 more
2021Blood Advances78 citations Open access
Semantic Scholar
IKZF1/3 and CRL4CRBN E3 ubiquitin ligase mutations and resistance to immunomodulatory drugs in multiple myeloma
S. Barrio, U. Munawar, Yuan-Xiao Zhu, N. Giesen +21 more
2020Haematologica65 citations Open access
Semantic Scholar
CIC Mutation as a Molecular Mechanism of Acquired Resistance to Combined BRAF-MEK Inhibition in Extramedullary Multiple Myeloma with Central Nervous System Involvement.
M. da Via, Antonio Giovanni Solimando, Andoni Garitano-Trojaola, S. Barrio +11 more
2019The Oncologist56 citations Open access
Semantic Scholar
Cereblon Enhancer Methylation and IMiD Resistance in Multiple Myeloma.
L. Haertle, S. Barrio, U. Munawar, Seung-Bin Han +22 more
2021Blood46 citations Open access
Semantic Scholar
All-trans retinoic acid works synergistically with the γ-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T cells
Estefanía García-Guerrero, L. G. Rodríguez-Lobato, Belén Sierro-Martínez, Sophia Danhof +11 more
2022Haematologica30 citations Open access
Semantic Scholar
Actin cytoskeleton deregulation confers midostaurin resistance in FLT3-mutant acute myeloid leukemia
Andoni Garitano-Trojaola, Ana Sancho, Ralph Götz, Patrick Eiring +17 more
2021Communications Biology22 citations Open access
Semantic Scholar
Single Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma.
L. Haertle, S. Barrio, U. Munawar, Seung-Bin Han +25 more
2022Clinical Cancer Research15 citations Open access
Semantic Scholar
Genetic Alterations in Members of the Proteasome 26S Subunit, AAA-ATPase (PSMC) Gene Family in the Light of Proteasome Inhibitor Resistance in Multiple Myeloma
L. Haertle, N. Buenache, Hipólito Nicolás Cuesta Hernández, M. Šimíček +18 more
2023Cancers11 citations Open access
Semantic Scholar
Hypermethylation of the non-imprinted maternal MEG3 and paternal MEST alleles is highly variable among normal individuals
L. Haertle, Anna Maierhofer, Julia Böck, H. Lehnen +7 more
2017PLoS ONE11 citations Open access
Semantic Scholar
Hierarchy of mono- and bi-allelic TP53 alterations in Multiple Myeloma cell fitness.
U. Munawar, L. Rasche, N. Müller, C. Vogt +16 more
2019Blood10 citations Open access
Semantic Scholar
High-dose carfilzomib achieves superior anti-tumor activity over low-dose and recaptures response in relapsed/refractory multiple myeloma resistant to low-dose carfilzomib by co-inhibiting the β2 and β1 subunits of the proteasome complex
Xiang Zhou, A. Besse, J. Peter, M. Steinhardt +19 more
2023Haematologica9 citations Open access
Semantic Scholar
Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1
Xiang Zhou, Seung-Bin Han, N. Cebulla, L. Haertle +22 more
2023Biomarker Research9 citations Open access
Semantic Scholar
The Link between Cytogenetics/Genomics and Imaging Patterns of Relapse and Progression in Patients with Relapsed/Refractory Multiple Myeloma: A Pilot Study Utilizing 18F-FDG PET/CT
Xiang Zhou, A. Dierks, O. Kertels, S. Samnick +14 more
2020Cancers9 citations Open access
Semantic Scholar
Epigenetic Modifications As a Mechanism of Resistance to BCMA-Directed Immunotherapies in Multiple Myeloma: Insights from Multi-Omic Profiling
L. Haertle, Natalia Buenache Cuenda, Isabel Espejo Diaz, Paula Lázaro del Campo +13 more
2024Blood7 citations
Semantic Scholar
Functional Characterization of GPRC5D alteration and Its Impact on Talquetamab Resistance in Relapsed/ Refractory Multiple Myeloma
Seung-Bin Han, U. Munawar, L. Haertle, C. Vogt +15 more
2023Blood7 citations
Semantic Scholar
Changes in T‐cell subsets, preexisting cytopenias and hyperferritinaemia correlate with cytopenias after BCMA targeted CAR T‐cell therapy in relapsed/refractory multiple myeloma: Results from a prospective comprehensive biomarker study
Xiang Zhou, Vivien Wagner, Lukas Scheller, E. Stanojkovska +21 more
2024British Journal of Haematology5 citations Open access
Semantic Scholar
Clonal competition assays identify fitness signatures in cancer progression and resistance in multiple myeloma
L. Haertle, U. Munawar, Hipólito N. C. Hernández, Andrés Arroyo-Barea +19 more
2024HemaSphere5 citations Open access
Semantic Scholar
Mechanisms of Proteasome Inhibitor Resistance Selected By Clonal Evolution in Multiple Myeloma
L. Haertle, S. Barrio, M. Šimíček, U. Munawar +15 more
2019Blood5 citations Open access
Semantic Scholar
Advanced Risk Stratification in Multiple Myeloma Beyond Traditional FISH: The First Prospective Real-World Evidence for SKY92 Gene Expression Profiling
Xiang Zhou, A. Hofmann, C. Vogt, S. Nerreter +18 more
2022Blood4 citations Open access
Semantic Scholar
Differential CD38 Expression on Daratumumab-Naïve Vs. Resistant Multiple Myeloma - a Direct Stochastic Optical Reconstruction Microscopy ( dSTORM) Analysis in 53 Patients
M. Steinhardt, Patrick Eiring, C. Vogt, U. Munawar +13 more
2023Blood3 citations
Semantic Scholar
Impaired FADD/BID signaling mediates cross-resistance to immunotherapy in Multiple Myeloma
U. Munawar, Xiang Zhou, Sabrina Prommersberger, S. Nerreter +27 more
2023Communications Biology3 citations Open access
Semantic Scholar
Secondary Genetic Events Impact the Expression of Key Immunotargets on the Surface of Multiple Myeloma Cells
U. Munawar, Patrick Eiring, C. Vogt, L. Haertle +11 more
2023Blood3 citations Open access
Semantic Scholar
Minimally invasive characterization of peripheral blood measurable residual disease in multiple myeloma using high‐sensitivity detection of ctDNA by next‐generation sequencing
N. Buenache, M. Lasa, Andrés Arroyo, Carmen González +28 more
2026HemaSphere2 citations Open access
Semantic Scholar
Focusing PI and IMiD Resistance in Multiple Myeloma: Impact of DNA Methylation
L. Haertle, M. Bittrich, R. Potabattula, M. da Via +11 more
2018Blood2 citations Open access
Semantic Scholar
Promoter hypomethylation drives ABCB1-mediated carfilzomib resistance in multiple myeloma
Seung-Bin Han, L. Haertle, U. Munawar, M. Truger +24 more
2026Clinical Epigenetics1 citations Open access
Semantic Scholar
Multi-Omics Analysis of Proteasome Inhibitor Resistance in Multiple Myeloma
Seung-Bin Han, Chien-Yun Lee, L. Besse, U. Munawar +13 more
2024Blood1 citations
Semantic Scholar
P52 RISK STRATIFICATION COMBINING SKY92 GENE EXPRESSION PROFILING AND TRADITIONAL FISH IN MULTIPLE MYELOMA: THE FIRST PROSPECTIVE EVIDENCE IN THE R2-ISS ERA
Xiaoping Zhou, A. Hofmann, C. Vogt, S. Nerreter +20 more
2023HemaSphere1 citations Open access
Semantic Scholar
P44 DETECTION OF SOLUBLE BCMA IN TEARS OF MM PATIENTS TREATED WITH BELANTAMAB MAFODOTIN
U. Munawar, J. Theuersbacher, L. Haertle, X. Zhou +13 more
2023HemaSphere1 citations Open access
Semantic Scholar
Multiomic Analysis of CD38 Expression Levels in 209 Untreated and Daratumumab-Resistant Patients
M. Steinhardt, Patrick Eiring, U. Munawar, L. Haertle +18 more
2022Blood1 citations Open access
Semantic Scholar
Immune Checkpoint CD200/CD200R Decreases T Cell-Mediated Cytotoxicity Via Dok2 and Is Regulated By P53 in Multiple Myeloma
P. Shah, Thorsten Stuehmer, L. Haertle, Daniela Bruennert +11 more
2022Blood1 citations Open access
Semantic Scholar
Genetic Alterations in Members of the Proteasome 26S Subunit, AAA-Atpase (PSMC) Gene Family Transmit Proteasome Inhibitor Resistance in Multiple Myeloma By Impacting the ADP/ATP Binding Pocket
L. Haertle, Hipolito Nicolas Cuesta Hernandez, N. Buenache, M. Šimíček +15 more
2022Blood1 citations
Semantic Scholar
Impaired Death Receptor Signaling Mediates Cross-Resistance to Immunotherapy in MM
U. Munawar, Xiang Zhou, Sabrina Prommersberger, M. Steinhardt +24 more
2022Blood1 citations Open access
Semantic Scholar
Proteome Profiling Reveals NQO2 Activity Contributing to Proteasome Inhibitor Resistance in Multiple Myeloma Cell Lines
Chien-Yun Lee, Seung-Bin Han, L. Haertle, U. Munawar +9 more
2026Molecular & Cellular Proteomics0 citations Open access
Semantic Scholar
Abstract 3079: Uncovering novel molecular mechanisms of PI resistance in multiple myeloma through multi-omics analysis
Seung-Bin Han, Chien-Yun Lee, L. Besse, U. Munawar +17 more
2025Cancer Research0 citations
Semantic Scholar
Uncovering molecular trajectories in follicular lymphoma using hidden markov models of ctdna dynamics
Ana Jiménez Ubieto, Alejandro Martín-Muñoz, Davide Di Lernia, M. Poza +18 more
2025Blood0 citations
Semantic Scholar
P45 HIGH-DOSE CARFILZOMIB ACHIEVES SUPERIOR ANTI-TUMOR ACTIVITY OVER LOW-DOSE AND RECAPTURES RESPONSE IN RELAPSED/REFRACTORY MULTIPLE MYELOMA RESISTANT TO LOW-DOSE CARFILZOMIB BY CO-INHIBITING THE B2 AND B1 PROTEASOME SUBUNITS
Xiaoping Zhou, A. Besse, J. Peter, M. Steinhardt +19 more
2023HemaSphere0 citations Open access
Semantic Scholar
P-417 SKY92 gene expression profiling and cytogenetics according to R2-ISS for multiple myeloma risk classification
Xiang Zhou, B. Engel, A. Hofmann, C. Vogt +13 more
2023Clinical Lymphoma, Myeloma & Leukemia0 citations
Semantic Scholar
Intracytoplasmatic BCMA Point Mutation and Teclistamab Resistance: Genomic Assessment of a Multidrug-Resistant Multiple Myeloma Patient
Natalia Buenache Cuenda, Hipolito Nicolas Cuesta Hernández, Alicia Giménez Sánchez, Laura Carneros Blanco +12 more
2023Blood0 citations Open access
Semantic Scholar
P890: COMBINING SKY92 GENE EXPRESSION PROFILING WITH CYTOGENETICS ACCORDING TO R2-ISS FOR MULTIPLE MYELOMA RISK CLASSIFICATION: THE FIRST PROSPECTIVE EVIDENCE
Xiang Zhou, B. Engel, A. Hofmann, C. Vogt +16 more
2023HemaSphere0 citations Open access
Semantic Scholar
Impact of ABCB1 Promoter Methylation on PI-Resistance in Multiple Myeloma
Seung-Bin Han, L. Haertle, L. Besse, Chien-Yun Lee +20 more
2022Blood0 citations
Semantic Scholar
P-075: CD200 expression in multiple myeloma is regulated by P53 and exerts its function as immune checkpoint on T cells via DOK2
P. Shah, T. Stühmer, L. Haertle, D. Brünnert +13 more
2022Clinical Lymphoma, Myeloma & Leukemia0 citations
Semantic Scholar
High-Dose Carfilzomib Recaptures Response in Relapsed/Refractory Multiple Myeloma Resistant to Low-Dose Carfilzomib By Co-Inhibiting β2 Subunit of Proteasome Complex: The First in Human Evidence
Xiang Zhou, A. Besse, J. Peter, M. Mendez-Lopez +10 more
2021Blood0 citations Open access
Semantic Scholar
Clonal Competition Models to Understand Progression and Resistance in Myeloma
S. Barrio, L. Haertle, U. Munawar, L. Martin +10 more
2019Blood0 citations Open access
Semantic Scholar
PS1357 FITNESS SIGNATURES IN MULTIPLE MYELOMA PROGRESSION AND RESISTANCE
S. Barrio, U. Munawar, L. Haertle, M. Davia +10 more
2019HemaSphere0 citations Open access
Semantic Scholar
RAC1 Inhibitor EHT1864 and Venetoclax Overcome Midostaurin Resistance in Acute Myeloid Leukemia
Andoni Garitano-Trojaola, Ana Sancho, Ralph Goetz, S. Walz +17 more
2019Blood0 citations Open access
Semantic Scholar
PS1001 HACE1, A NOVEL TUMOR SUPPRESSOR GENE WHICH REGULATE THE RESPONSE OF VENETOCLAX, GANT61 AND NECROPTOSIS ACTIVATORS BY CONTROLLING C-FLIP, GLI2 AND BCL2 GENES IN ACUTE MYELOID LEUKEMIA
A. Garitano, E. Teufel, Jennifer Kreckel, R. Nadine +12 more
2019HemaSphere0 citations Open access
Semantic Scholar

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U. Munawar×35
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U. Munawar — researcher profile on SciRah
L. Rasche×34
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C. Vogt×31
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K. Kortüm×28
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H. Einsele — researcher profile on SciRah

Seung-Bin Han×23

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S. Barrio — researcher profile on SciRah

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M. Truger — researcher profile on SciRah