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Si-Ming Man · SciRah

Researcher profile · Semantic Scholar

Si-Ming Man

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Si-Ming Man — researcher profile on SciRah

h-index: 34
Works: 51
Citations: 6,434

Most-cited papers

Regulation of inflammasome activation
Si-Ming Man, T. Kanneganti
2015Immunological Reviews980 citations Open access
Semantic Scholar
Converging roles of caspases in inflammasome activation, cell death and innate immunity
Si-Ming Man, T. Kanneganti
2015Nature reviews. Immunology642 citations Open access
Semantic Scholar
Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex
Si-Ming Man, Lee J. Hopkins, E. Nugent, S. Cox +6 more
2014Proceedings of the National Academy of Sciences of the United States of America332 citations Open access
Semantic Scholar
AIM2 inflammasome in infection, cancer and autoimmunity: role in DNA sensing, inflammation and innate immunity
Si-Ming Man, Rajendra Karki, T. Kanneganti
2015European Journal of Immunology323 citations Open access
Semantic Scholar
Inflammasomes and Cancer
Rajendra Karki, Si-Ming Man, T. Kanneganti
2017Cancer immunology research319 citations Open access
Semantic Scholar
Critical role for the DNA sensor AIM2 in stem-cell proliferation and cancer
Si-Ming Man, Qi-Fan Zhu, Liqin Zhu, Zhiping Liu +15 more
2015Cell314 citations Open access
Semantic Scholar
IRGB10 liberates bacterial ligands for sensing by the AIM2 and caspase-11–NLRP3 inflammasomes
Si-Ming Man, Rajendra Karki, Miwa Sasai, David E. Place +11 more
2016Cell288 citations Open access
Semantic Scholar
Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection
Rajendra Karki, Si-Ming Man, R. K. Subbarao Malireddi, Prajwal Gurung +3 more
2015Cell Host and Microbe258 citations Open access
Semantic Scholar
The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation.
J. Vince, D. De Nardo, Wenqing Gao, Angelina J. Vince +16 more
2018Cell Reports218 citations Open access
Semantic Scholar
IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases
Yvette Wooff, Si-Ming Man, Riemke Aggio-Bruce, R. Natoli +1 more
2019Frontiers in Immunology204 citations Open access
Semantic Scholar
NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer
Rajendra Karki, Si-Ming Man, R. K. Subbarao Malireddi, Sannula Kesavardhana +8 more
2016Nature201 citations Open access
Semantic Scholar
Campylobacter concisus and other Campylobacter species in children with newly diagnosed Crohn's disease
Si-Ming Man, Li Zhang, A. Day, S. Leach +2 more
2010Inflammatory Bowel Diseases189 citations Open access
Semantic Scholar
Regulation of lysosomal dynamics and autophagy by CTSB/cathepsin B
Si-Ming Man, T. Kanneganti
2016Autophagy187 citations Open access
Semantic Scholar
Detection and Isolation of Campylobacter Species Other than C. jejuni from Children with Crohn's Disease
Li Zhang, Si-Ming Man, A. Day, S. Leach +8 more
2008Journal of Clinical Microbiology155 citations Open access
Semantic Scholar
Cutting Edge: STING Mediates Protection against Colorectal Tumorigenesis by Governing the Magnitude of Intestinal Inflammation
Qi-Fan Zhu, Si-Ming Man, Prajwal Gurung, Zhiping Liu +3 more
2014Journal of Immunology151 citations Open access
Semantic Scholar
Gasdermin D: the long-awaited executioner of pyroptosis
Si-Ming Man, T. Kanneganti
2015Cell Research146 citations Open access
Semantic Scholar
Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection
M. Zaki, Si-Ming Man, P. Vogel, M. Lamkanfi +1 more
2013Proceedings of the National Academy of Sciences of the United States of America143 citations Open access
Semantic Scholar
Differential roles of caspase-1 and caspase-11 in infection and inflammation
Si-Ming Man, Rajendra Karki, B. Briard, A. Burton +3 more
2017Scientific Reports138 citations Open access
Semantic Scholar
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway
Daniel S. Simpson, J. Pang, Ashley Weir, Isabella Y. Kong +32 more
2022Immunity132 citations Open access
Semantic Scholar
Host attachment, invasion, and stimulation of proinflammatory cytokines by Campylobacter concisus and other non-Campylobacter jejuni Campylobacter species.
Si-Ming Man, N. Kaakoush, S. Leach, Lily Nahidi +5 more
2010Journal of Infectious Diseases119 citations
Semantic Scholar
Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection
Xiao-Peng Qi, Si-Ming Man, R. K. Subbarao Malireddi, Rajendra Karki +6 more
2016Journal of Experimental Medicine99 citations Open access
Semantic Scholar
Actin polymerization as a key innate immune effector mechanism to control Salmonella infection
Si-Ming Man, A. Ekpenyong, Panagiotis Tourlomousis, Sarra Achouri +8 more
2014Proceedings of the National Academy of Sciences of the United States of America97 citations Open access
Semantic Scholar
Interferon‐inducible guanylate‐binding proteins at the interface of cell‐autonomous immunity and inflammasome activation
Si-Ming Man, David E. Place, T. Kuriakose, T. Kanneganti
2017Journal of Leukocyte Biology96 citations Open access
Semantic Scholar
Innate immune sensing of cell death in disease and therapeutics
Si-Ming Man, T. Kanneganti
2024Nature Cell Biology83 citations Open access
Semantic Scholar
The secretome of Campylobacter concisus
N. Kaakoush, Si-Ming Man, Sarah Lamb, M. Raftery +3 more
2010The FEBS Journal71 citations
Semantic Scholar
Role of Emerging Campylobacter Species in Inflammatory Bowel Diseases
N. Kaakoush, H. Mitchell, Si-Ming Man
2014Inflammatory Bowel Diseases62 citations Open access
Semantic Scholar
Bacterial infection of macrophages induces decrease in refractive index
A. Ekpenyong, Si-Ming Man, Sarra Achouri, C. Bryant +2 more
2013Journal of Biophotonics60 citations
Semantic Scholar
Detection of Enterohepatic and Gastric Helicobacter Species in Fecal Specimens of Children with Crohn's Disease
Si-Ming Man, Li Zhang, A. Day, S. Leach +1 more
2008Helicobacter58 citations
Semantic Scholar
Transcriptomic and Proteomic Analyses Reveal Key Innate Immune Signatures in the Host Response to the Gastrointestinal Pathogen Campylobacter concisus
N. Kaakoush, N. Deshpande, Si-Ming Man, Jose A. Burgos-Portugal +4 more
2014Infection and Immunity57 citations Open access
Semantic Scholar
Is Campylobacter to esophageal adenocarcinoma as Helicobacter is to gastric adenocarcinoma?
N. Kaakoush, N. Castaño-Rodríguez, Si-Ming Man, H. Mitchell
2015Trends in Microbiology56 citations
Semantic Scholar
Detrimental Type I Interferon Signaling Dominates Protective AIM2 Inflammasome Responses during Francisella novicida Infection
Qi-Fan Zhu, Si-Ming Man, Rajendra Karki, R. K. Subbarao Malireddi +1 more
2018Cell Reports49 citations Open access
Semantic Scholar
The Internal Transcribed Spacer Region, a New Tool for Use in Species Differentiation and Delineation of Systematic Relationships within the Campylobacter Genus
Si-Ming Man, N. Kaakoush, S. Octavia, H. Mitchell
2010Applied and Environmental Microbiology47 citations Open access
Semantic Scholar
Detection of Helicobacteraceae in Intestinal Biopsies of Children with Crohn’s Disease
N. Kaakoush, J. Holmes, S. Octavia, Si-Ming Man +10 more
2010Helicobacter42 citations
Semantic Scholar
DNA-sensing inflammasomes: regulation of bacterial host defense and the gut microbiota.
Si-Ming Man, Rajendra Karki, T. Kanneganti
2016Pathogens and Disease39 citations Open access
Semantic Scholar
DOCK2 confers immunity and intestinal colonization resistance to Citrobacter rodentium infection
Zhiping Liu, Si-Ming Man, Qi-Fan Zhu, P. Vogel +3 more
2016Scientific Reports23 citations Open access
Semantic Scholar
MicroRNA-223 Regulates Retinal Function and Inflammation in the Healthy and Degenerating Retina
Nilisha Fernando, Josephine H. C. Wong, Shannon J. Das, C. Dietrich +12 more
2020Frontiers in Cell and Developmental Biology22 citations Open access
Semantic Scholar
A20 is a regulator of necroptosis
Prajwal Gurung, Si-Ming Man, T. Kanneganti
2015Nature Immunology19 citations
Semantic Scholar
Campylobacter concisus: a New Character in the Crohn's Disease Story?
M. Guslandi, Li Zhang, Si-Ming Man, A. Day +9 more
2009Journal of Clinical Microbiology6 citations Open access
Semantic Scholar
STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation
Qi-Fan Zhu, Si-Ming Man, Prajwal Gurung, Zhiping Liu +3 more
2014Journal of Immunology5 citations Open access
Semantic Scholar
Functional relationship between Campylobacter concisus and the stomach ecosystem in health and disease
N. Kaakoush, Si-Ming Man, H. Mitchell
2013The ISME Journal4 citations Open access
Semantic Scholar
Downloads: Stats for papers let authors track impact
Si-Ming Man
2011Nature3 citations
Semantic Scholar
Inflammasome-independent role of AIM2 in mediating protection against colorectal tumorogenesis
Rajendra Karki, Si-Ming Man, Qi-Fan Zhu, T. Kanneganti
2016Journal of Immunology2 citations
Semantic Scholar
Multi-omics of the esophageal microenvironment identifies signatures associated with progression of Barrett’s esophagus
N. Deshpande, S. Riordan, Claire J. Gorman, S. Nielsen +9 more
2021Genome Medicine1 citations Open access
Semantic Scholar
Modeling and Multi Source Signal Processing of High Precision Perception Sensing System in Intelligent Robots
Si-Ming Man
2025Transactions on Computer Science and Intelligent Systems Research0 citations Open access
Semantic Scholar
A multi-component bacterial toxin incites host inflammation via the NLRP3 inflammasome
A. Mathur, Shou-Ya Feng, Jenni A. Hayward, Chinh Ngo +2 more
2020Journal of Immunology0 citations
Semantic Scholar
The Mitochondrial Apopto tic Effectors BAX / BAK Activate Caspase-3 and-7 to Trigger NLRP 3 Inflammasome and Caspase-8 Driven IL-1 b Activation Graphical
J. Vince, D. De Nardo, Wenqing Gao, Angelina J. Vince +16 more
20180 citations
Semantic Scholar
Type I Interferon Keeps IL-1β in Check.
Si-Ming Man, T. Kanneganti
2016Cell Host and Microbe0 citations Open access
Semantic Scholar
Opposing roles of AIM2 inflammasome and type I interferon signaling in Francisella infection
Qi-Fan Zhu, Si-Ming Man, Rajendra Karki, T. Kanneganti
2016Journal of Immunology0 citations
Semantic Scholar
Guanylate-binding proteins and other interferon-inducible proteins are essential for the activation of the inflammasomes
Si-Ming Man, Rajendra Karki, T. Kanneganti
2016Journal of Immunology0 citations
Semantic Scholar
AIM2 and NLRP3 inflammasome activation provide dual surveillance to confer protection against Aspergillus infection (MPF4P.728)
Rajendra Karki, Si-Ming Man, T. Kanneganti
2015Journal of Immunology0 citations
Semantic Scholar

Frequent co-authors

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T. Kanneganti×26
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T. Kanneganti — researcher profile on SciRah
Rajendra Karki×14
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Rajendra Karki — researcher profile on SciRah
H. Mitchell×12
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H. Mitchell — researcher profile on SciRah
Qi-Fan Zhu×9
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Qi-Fan Zhu — researcher profile on SciRah

×9

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N. Kaakoush — researcher profile on SciRah

Prajwal Gurung×6

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P. Vogel — researcher profile on SciRah

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Li Zhang — researcher profile on SciRah

R. K. Subbarao Malireddi×5

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R. K. Subbarao Malireddi — researcher profile on SciRah

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M. Lamkanfi — researcher profile on SciRah

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A. Day — researcher profile on SciRah

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S. Leach — researcher profile on SciRah