Benjamin F. Vieira

Most-cited papers

1. Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34+ Hematopoietic Stem and Progenitor Cells

   Kai-Hsin Chang, Sarah Smith, T. Sullivan, Kai Chen +16 more

   2017Molecular Therapy: Methods & Clinical Development146 citations Open access

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2. Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease.

   S. Krishnamoorthy, B. Pace, Dipti Gupta, Sarah Sturtevant +10 more

   2017JCI Insight42 citations Open access

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3. Zinc finger nuclease-mediated gene editing in hematopoietic stem cells results in reactivation of fetal hemoglobin in sickle cell disease

   S. Lessard, Pauline Rimmelé, Hui Ling, Kevin Moran +24 more

   2024Scientific Reports18 citations Open access

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4. MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease.

   M. Demers, Sarah Sturtevant, K. Guertin, Dipti Gupta +14 more

   2021Blood Advances8 citations Open access

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5. Ex Vivo Gene-Edited Cell Therapy for Sickle Cell Disease: Disruption of the BCL11A Erythroid Enhancer with Zinc Finger Nucleases Increases Fetal Hemoglobin in Plerixafor Mobilized Human CD34+ Cells

   Kevin Moran, H. Ling, Samuel Lessard, Benjamin F. Vieira +7 more

   2018Blood7 citations Open access

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6. Zinc Finger Nuclease-Mediated Disruption of the BCL11A Erythroid Enhancer Results in Enriched Biallelic Editing, Increased Fetal Hemoglobin, and Reduced Sickling in Erythroid Cells Derived from Sickle Cell Disease Patients

   Samuel Lessard, P. Rimmelé, H. Ling, Kevin Moran +10 more

   2019Blood6 citations Open access

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7. Characterization of a Genetically Engineered HUDEP2 Cell Line Harboring a Sickle Cell Disease Mutation As a Potential Research Tool for Preclinical Sickle Cell Disease Drug Discovery

   Dipti Gupta, Sarah Sturtevant, Benjamin F. Vieira, Yukio Nakamura +2 more

   2019Blood4 citations Open access

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8. Clonal Analysis of Human Bone Marrow CD34+ Cells Edited By BCL11A-Targeting Zinc Finger Nucleases Reveals Clinically Relevant Levels of Fetal Globin Expression in Edited Erythroid Progeny

   Kai-Hsin Chang, T. Sullivan, Mei Liu, Xiao Yang +12 more

   20154 citations

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9. MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease

   M. Demers, Sarah Sturtevant, K. Guertin, Dipti Gupta +13 more

   2019Blood1 citations Open access

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10. Nrf2 Activation and Fetal Hemoglobin Induction in Sickle Cell Disease

    S. Krishnamoorthy, Dipti Gupta, W. Hobbs, C. Loh +7 more

    20161 citations

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11. PF736 ZINC FINGER NUCLEASE-MEDIATED DISRUPTION OF THE BCL11A ERYTHROID ENHANCER IN PLERIXAFOR MOBILIZED CD34+ CELLS RESULTS IN ENRICHED BIALLELEIC EDITING AND ALLELE-ADDITIVE INCREASES IN FETAL HEMOGLOBIN

    Pauline Rimmelé, H. Ling, Samuel Lessard, Kevin Moran +7 more

    2019HemaSphere0 citations Open access

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12. LC-MS Analysis of Anti-Sickling Compounds in Cord Blood Derived RBCs Demonstrates Modification of Fetal Hemoglobin and Globin Chain Binding Preferences

    Benjamin F. Vieira, Vu P. Hong, K. Desai, M. Safo +1 more

    2018Blood0 citations Open access

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