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J. Jenkins · SciRah

Researcher profile · Semantic Scholar

J. Jenkins

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J. Jenkins — researcher profile on SciRah

h-index: 42
Works: 104
Citations: 6,711

Most-cited papers

Large Scale Prediction and Testing of Drug Activity on Side-Effect Targets
Eugen Lounkine, Michael J. Keiser, S. Whitebread, D. Mikhailov +8 more
2012Nature829 citations Open access
Semantic Scholar
Integrating high-content screening and ligand-target prediction to identify mechanism of action.
Daniel W. Young, A. Bender, Jonathan Hoyt, E. Mcwhinnie +7 more
2008Nature Chemical Biology347 citations
Semantic Scholar
Analysis of Pharmacology Data and the Prediction of Adverse Drug Reactions and Off‐Target Effects from Chemical Structure
A. Bender, J. Scheiber, Meir Glick, J. Davies +5 more
2007ChemMedChem310 citations
Semantic Scholar
Prediction of Biological Targets for Compounds Using Multiple-Category Bayesian Models Trained on Chemogenomics Databases
Nidhi, Meir Glick, J. Davies, J. Jenkins
2006Journal of Chemical Information and Modeling289 citations
Semantic Scholar
How Similar Are Similarity Searching Methods? A Principal Component Analysis of Molecular Descriptor Space
A. Bender, J. Jenkins, J. Scheiber, S. C. K. Sukuru +2 more
2009Journal of Chemical Information and Modeling285 citations
Semantic Scholar
From in silico target prediction to multi-target drug design: current databases, methods and applications.
Alexios Koutsoukas, Benjamin Simms, J. Kirchmair, P. Bond +7 more
2011Journal of Proteomics262 citations
Semantic Scholar
Phenotypic landscape of intestinal organoid regeneration
I. Lukonin, Denise Serra, Ludivine Challet Meylan, K. Volkmann +8 more
2020Nature244 citations Open access
Semantic Scholar
DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery
Chao-Yang Ye, D. Ho, Marilisa Neri, Chian Yang +13 more
2018Nature Communications199 citations Open access
Semantic Scholar
Bridging chemical and biological space: "target fishing" using 2D and 3D molecular descriptors.
J. Nettles, J. Jenkins, A. Bender, Z. Deng +2 more
2006Journal of Medicinal Chemistry186 citations
Semantic Scholar
In silico target fishing: Predicting biological targets from chemical structure
J. Jenkins, A. Bender, J. Davies
2006175 citations
Semantic Scholar
Modeling Promiscuity Based on in vitro Safety Pharmacology Profiling Data
Kamal Azzaoui, Jacques Hamon, B. Faller, S. Whitebread +4 more
2007ChemMedChem170 citations
Semantic Scholar
Mapping adverse drug reactions in chemical space.
J. Scheiber, J. Jenkins, S. C. K. Sukuru, A. Bender +8 more
2009Journal of Medicinal Chemistry156 citations
Semantic Scholar
Rethinking molecular similarity: comparing compounds on the basis of biological activity.
P. Petrone, Benjamin Simms, Florian Nigsch, Eugen Lounkine +6 more
2012ACS Chemical Biology151 citations
Semantic Scholar
Gaining Insight into Off-Target Mediated Effects of Drug Candidates with a Comprehensive Systems Chemical Biology Analysis
J. Scheiber, Bin Chen, M. Milik, S. C. K. Sukuru +9 more
2009Journal of Chemical Information and Modeling150 citations
Semantic Scholar
Identifying compound efficacy targets in phenotypic drug discovery.
M. Schirle, J. Jenkins
2016Drug Discovery Today147 citations
Semantic Scholar
A 3D similarity method for scaffold hopping from known drugs or natural ligands to new chemotypes.
J. Jenkins, Meir Glick, J. Davies
2004Journal of Medicinal Chemistry113 citations
Semantic Scholar
"Bayes Affinity Fingerprints" Improve Retrieval Rates in Virtual Screening and Define Orthogonal Bioactivity Space: When Are Multitarget Drugs a Feasible Concept?
A. Bender, J. Jenkins, Meir Glick, Z. Deng +2 more
2006Journal of Chemical Information and Modeling109 citations Open access
Semantic Scholar
A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity
Richard Y. T. Kao, J. Jenkins, K. Olson, M. Key +2 more
2002Proceedings of the National Academy of Sciences of the United States of America108 citations Open access
Semantic Scholar
Ligand-Target Prediction Using Winnow and Naive Bayesian Algorithms and the Implications of Overall Performance Statistics
Florian Nigsch, A. Bender, J. Jenkins, John B. O. Mitchell
2008Journal of Chemical Information and Modeling97 citations
Semantic Scholar
Enrichment of High-Throughput Screening Data with Increasing Levels of Noise Using Support Vector Machines, Recursive Partitioning, and Laplacian-Modified Naive Bayesian Classifiers
Meir Glick, J. Jenkins, J. Nettles, Hamilton Hitchings +1 more
2006Journal of Chemical Information and Modeling97 citations
Semantic Scholar
Virtual screening to enrich hit lists from high‐throughput screening: A case study on small‐molecule inhibitors of angiogenin
J. Jenkins, Richard Y. T. Kao, R. Shapiro
2002Proteins: Structure, Function, and Bioinformatics91 citations
Semantic Scholar
Chemogenomic data analysis: prediction of small-molecule targets and the advent of biological fingerprint.
A. Bender, Daniel W. Young, J. Jenkins, M. Serrano +3 more
2007Combinatorial chemistry & high throughput screening90 citations
Semantic Scholar
Using Information from Historical High-Throughput Screens to Predict Active Compounds
Sereina Riniker, Yuan Wang, J. Jenkins, G. Landrum
2014Journal of Chemical Information and Modeling80 citations
Semantic Scholar
Streamlining lead discovery by aligning in silico and high-throughput screening.
J. Davies, Meir Glick, J. Jenkins
2006Current Opinion in Chemical Biology79 citations
Semantic Scholar
CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma
N. T. Ross, F. Lohmann, Seth Carbonneau, A. Fazal +38 more
2019Nature Chemical Biology76 citations Open access
Semantic Scholar
Plate-Based Diversity Selection Based on Empirical HTS Data to Enhance the Number of Hits and Their Chemical Diversity
S. C. K. Sukuru, J. Jenkins, Rohan E. J. Beckwith, J. Scheiber +4 more
2009Journal of biomolecular screening74 citations Open access
Semantic Scholar
Activation of human STING by a molecular glue-like compound
Jie Li, Stephen M. Canham, Huan-Yu Wu, Martin Hénault +31 more
2023Nature Chemical Biology71 citations Open access
Semantic Scholar
Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length
Shi-Xuan Liu, M. Ginzberg, N. Patel, M. Hild +12 more
2017bioRxiv70 citations Open access
Semantic Scholar
Understanding False Positives in Reporter Gene Assays: in Silico Chemogenomics Approaches To Prioritize Cell-Based HTS Data
Thomas J. Crisman, C. Parker, J. Jenkins, J. Scheiber +7 more
2007Journal of Chemical Information and Modeling67 citations Open access
Semantic Scholar
Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.
F. Bassilana, Adam Carlson, Jennifer Dasilva, Bianka L. Grosshans +26 more
2014Nature Chemical Biology64 citations
Semantic Scholar
Discovery of a ZIP7 inhibitor from a Notch pathway screen
Erin Nolin, S. Gans, Luis A Llamas, S. Bandyopadhyay +39 more
2019Nature Chemical Biology61 citations Open access
Semantic Scholar
Cheminformatics tools for analyzing and designing optimized small molecule collections and libraries
Nienke Moret, Nicholas A. Clark, M. Hafner, Yuan Wang +6 more
2019Cell Chemical Biology58 citations Open access
Semantic Scholar
Small Molecule-facilitated Degradation of ANO1 Protein
A. Bill, M. Hall, J. Borawski, C. Hodgson +9 more
2014Journal of Biological Chemistry55 citations Open access
Semantic Scholar
Biodiversity of small molecules--a new perspective in screening set selection.
P. Petrone, A. Wassermann, Eugen Lounkine, Peter S. Kutchukian +4 more
2013Drug Discovery Today55 citations
Semantic Scholar
Recent trends and observations in the design of high-quality screening collections.
Steffen Renner, Maxim Popov, A. Schuffenhauer, Hans-Joerg Roth +7 more
2011Future Medicinal Chemistry54 citations
Semantic Scholar
Design of potent antimalarials with generative chemistry
W. Godinez, Eric J. Ma, Alexander T. Chao, Lu-Ying Pei +6 more
2022Nature Machine Intelligence52 citations Open access
Semantic Scholar
Systematic Chemogenetic Library Assembly
Stephen M. Canham, Yuan Wang, A. Cornett, D. Auld +23 more
2020bioRxiv52 citations Open access
Semantic Scholar
Evidence-Based and Quantitative Prioritization of Tool Compounds in Phenotypic Drug Discovery.
Yuan Wang, A. Cornett, Fred J. King, Yi Mao +4 more
2016Cell Chemical Biology50 citations Open access
Semantic Scholar
Which aspects of HTS are empirically correlated with downstream success?
A. Bender, D. Bojanic, J. Davies, Thomas J. Crisman +8 more
2008Current opinion in drug discovery & development49 citations
Semantic Scholar
Clustering and Rule-Based Classifications of Chemical Structures Evaluated in the Biological Activity Space
A. Schuffenhauer, Nathan Brown, P. Ertl, J. Jenkins +2 more
2007Journal of Chemical Information and Modeling48 citations
Semantic Scholar
Flexible 3D pharmacophores as descriptors of dynamic biological space.
J. Nettles, J. Jenkins, Chris Williams, A. Clark +4 more
2007Journal of Molecular Graphics and Modelling44 citations
Semantic Scholar
Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK.
Ceryl Tan, M. Ginzberg, Rachel Webster, Seshu Iyengar +12 more
2021Developmental Cell41 citations Open access
Semantic Scholar
"Virtual fragment linking": an approach to identify potent binders from low affinity fragment hits.
Thomas J. Crisman, A. Bender, M. Milik, J. Jenkins +6 more
2008Journal of Medicinal Chemistry41 citations Open access
Semantic Scholar
Identification of small-molecule inhibitors of human angiogenin and characterization of their binding interactions guided by computational docking.
J. Jenkins, R. Shapiro
2003Biochemistry38 citations
Semantic Scholar
“Plate Cherry Picking”: A Novel Semi-Sequential Screening Paradigm for Cheaper, Faster, Information-Rich Compound Selection
Thomas J. Crisman, J. Jenkins, C. Parker, W. Hill +5 more
2007Journal of biomolecular screening36 citations Open access
Semantic Scholar
Recurrent ubiquitin B silencing in gynecological cancers establishes dependence on ubiquitin C
Alexia T. Kedves, S. Gleim, Xiao-You Liang, D. Bonal +12 more
2017Journal of Clinical Investigation33 citations Open access
Semantic Scholar
DRUG-seq Provides Unbiased Biological Activity Readouts for Neuroscience Drug Discovery
Jingyao Li, D. Ho, Martin Hénault, Chian Yang +17 more
2022ACS Chemical Biology32 citations Open access
Semantic Scholar
Indolyl-Pyridinyl-Propenone-Induced Methuosis through the Inhibition of PIKFYVE
Hyelim Cho, Erin Geno, Maude Patoor, Adam Reid +3 more
2018ACS Omega32 citations Open access
Semantic Scholar
The Multidimensional Perturbation Value
Janna E. Hutz, Thomas Nelson, Hua-Lang Wu, G. McAllister +7 more
2013Journal of biomolecular screening29 citations Open access
Semantic Scholar
Computational methods for early predictive safety assessment from biological and chemical data
Florian Nigsch, Eugen Lounkine, P. McCarren, B. Cornett +8 more
2011Expert Opinion on Drug Metabolism & Toxicology29 citations
Semantic Scholar

Frequent co-authors

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Meir Glick×20
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J. Davies×19
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A. Bender×18
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J. Scheiber×8
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Florian Nigsch×7

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D. Mikhailov×6

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Jacques Hamon×6

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J. Tallarico×6

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