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H. Hwang · SciRah

Researcher profile · Semantic Scholar

H. Hwang

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H. Hwang — researcher profile on SciRah

h-index: 19
Works: 82
Citations: 2,243

Most-cited papers

Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans
Hiroshi Watanabe, Nagesh Chopra, D. Laver, H. Hwang +6 more
2009Nature Medicine610 citations Open access
Semantic Scholar
SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence
G. Salazar, Abigail E Cullen, Jingwen Huang, Yi-Tong Zhao +5 more
2019Autophagy167 citations Open access
Semantic Scholar
Comparable Calcium Handling Of Human iPSC-derived Cardiomyocytes Generated By Multiple Laboratories
H. Hwang, D. Kryshtal, T. Feaster, V. Sanchez-Freire +5 more
2015Journal of Molecular and Cellular Cardiology166 citations Open access
Semantic Scholar
Inhibition of Cardiac Ca2+ Release Channels (RyR2) Determines Efficacy of Class I Antiarrhythmic Drugs in Catecholaminergic Polymorphic Ventricular Tachycardia
H. Hwang, C. Hasdemir, D. Laver, Divya Mehra +4 more
2011Circulation: Arrhythmia and Electrophysiology152 citations Open access
Semantic Scholar
Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis and causes pause-dependent Ca triggered arrhythmia
T. Schober, Sabine Huke, R. Venkataraman, O. Gryshchenko +4 more
2012Circulation Research143 citations Open access
Semantic Scholar
Divergent Regulation of Ryr2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants
H. Hwang, Florentin R. Nitu, Yi Yang, K. Walweel +9 more
2014Circulation Research142 citations Open access
Semantic Scholar
Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin (CaM) Variants in Long QT Syndrome (LQTS) and Functional Characterization of a Novel LQTS-Associated CaM Missense Variant, E141G
N. Boczek, Nieves Gómez-Hurtado, D. Ye, Melissa L Calvert +12 more
2016Circulation: Cardiovascular Genetics126 citations Open access
Semantic Scholar
Echocardiographic assessment of age-associated changes in systolic and diastolic function of the female F344 rat heart.
M. Boluyt, K. Converso, H. Hwang, Agdas Mikkor +1 more
2004Journal of applied physiology95 citations
Semantic Scholar
Accelerated Sinus Rhythm Prevents Catecholaminergic Polymorphic Ventricular Tachycardia in Mice and in Patients
M. Faggioni, H. Hwang, C. van der Werf, I. Nederend +3 more
2013Circulation Research59 citations Open access
Semantic Scholar
Focal Energy Deprivation Underlies Arrhythmia Susceptibility in Mice with Calcium-Sensitized Myofilaments
Sabine Huke, R. Venkataraman, M. Faggioni, Sirish C. Bennuri +3 more
2013Circulation Research57 citations Open access
Semantic Scholar
Suppression of Spontaneous Ca Elevations Prevents Atrial Fibrillation in Casq2 Null Hearts
M. Faggioni, E. Savio-Galimberti, R. Venkataraman, H. Hwang +3 more
2014Circulation: Arrhythmia and Electrophysiology53 citations Open access
Semantic Scholar
Inhibition of the biosynthesis of prostaglandin E2 by low dose aspirin: implications for adenocarcinoma metastasis
O. Boutaud, I. Sosa, Taneem Amin, D. Oram +11 more
2016Cancer Prevention Research49 citations Open access
Semantic Scholar
Parameter sensitivity analysis of stochastic models provides insights into cardiac calcium sparks.
Young-Seon Lee, Ona Z Liu, H. Hwang, B. Knollmann +1 more
2013Biophysical Journal49 citations Open access
Semantic Scholar
Coordinated Regulation of Murine Cardiomyocyte Contractility by Nanomolar (−)-Epigallocatechin-3-Gallate, the Major Green Tea Catechin
W. Feng, H. Hwang, D. Kryshtal, Tao Yang +5 more
2012Molecular Pharmacology34 citations Open access
Semantic Scholar
Catecholaminergic Polymorphic Ventricular Tachycardia Release Channels ( RyR 2 ) Determines Efficacy of Class I 2 + Inhibition of Cardiac Ca
H. Hwang, C. Hasdemir, D. Laver, Divya Mehra +4 more
201132 citations
Semantic Scholar
Effects of Hawthorn on Cardiac Remodeling and Left Ventricular Dysfunction after 1 Month of Pressure Overload-induced Cardiac Hypertrophy in Rats
H. Hwang, B. Bleske, Michael M. J. Ghannam, K. Converso +3 more
2008Cardiovascular Drugs and Therapy30 citations
Semantic Scholar
Ryanodine receptor inhibition potentiates the activity of Na channel blockers against spontaneous calcium elevations and delayed afterdepolarizations in Langendorff-perfused rabbit ventricles
Young-Soo Lee, M. Maruyama, P. Chang, H. Park +9 more
2012Heart Rhythm21 citations Open access
Semantic Scholar
Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function
Maicon Landim-Vieira, Weikang Ma, Taejeong Song, Hosna Rastegarpouyani +13 more
2023Proceedings of the National Academy of Sciences of the United States of America19 citations Open access
Semantic Scholar
Essential roles of the dystrophin-glycoprotein complex in different cardiac pathologies.
I. Valera, A. Wacker, H. Hwang, Christina Holmes +3 more
2020Advances in Medical Sciences19 citations Open access
Semantic Scholar
Myofilament calcium de-sensitization and contractile uncoupling prevents pause-triggered ventricular tachycardia in mouse hearts with chronic myocardial infarction
R. Venkataraman, M. Baldo, H. Hwang, Tiago Veltri +3 more
2013Journal of Molecular and Cellular Cardiology19 citations Open access
Semantic Scholar
Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia.
D. Steele, H. Hwang, B. Knollmann
2013Cardiovascular Research19 citations Open access
Semantic Scholar
Functional consequences of stably expressing a mutant calsequestrin (CASQ2D307H) in the CASQ2 null background.
Anuradha Kalyanasundaram, S. Viatchenko‐Karpinski, A. Belevych, V. Lacombe +4 more
2012American Journal of Physiology. Heart and Circulatory Physiology19 citations Open access
Semantic Scholar
Effect of N-2-mercaptopropionyl glycine on exercise-induced cardiac adaptations.
M. Nelson, M. B. Harris, M. Boluyt, H. Hwang +1 more
2011American Journal of Physiology. Regulatory Integrative and Comparative Physiology19 citations
Semantic Scholar
Effects of Hawthorn on the Progression of Heart Failure in a Rat Model of Aortic Constriction
H. Hwang, M. Boluyt, K. Converso, M. Russell +1 more
2009Pharmacotherapy16 citations Open access
Semantic Scholar
Efficacy of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia Is Mutation-Independent but Reduced by Calcium Overload
H. Hwang, M. Baldo, J. Rodríguez, M. Faggioni +1 more
2019Frontiers in Physiology14 citations Open access
Semantic Scholar
Human induced pluripotent stem cell (hiPSC) derived cardiomyocytes to understand and test cardiac calcium handling: A glass half full.
H. Hwang, D. Kryshtal, T. Feaster, V. Sanchez-Freire +5 more
2015Journal of Molecular and Cellular Cardiology12 citations
Semantic Scholar
Alpha B-crystallin prevents ventricular arrhythmia by attenuating inflammation and oxidative stress in rat with autoimmune myocarditis.
Hyewon Park, Hyelim Park, Hyeonseo Hwang, H. Hwang +6 more
2015International Journal of Cardiology12 citations Open access
Semantic Scholar
Divergent Regulation of Ryanodine Receptor 2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants
H. Hwang, Florentin R. Nitu, Yi Yang, K. Walweel +9 more
10 citations
Semantic Scholar
Pathogenic Troponin T Mutants with Opposing Effects on Myofilament Ca2+ Sensitivity Attenuate Cardiomyopathy Phenotypes in Mice
Karissa M. Dieseldorff Jones, Yeojung Koh, R. Weller, Rajdeep S. Turna +5 more
2018Archives of Biochemistry and Biophysics9 citations Open access
Semantic Scholar
Accelerated junctional rhythm and non-alternans repolarization lability precede ventricular tachycardia in Casq2−/− mice
Ure L Mezu, P. Singh, V. Shusterman, H. Hwang +2 more
2012Cardiovascular Electrophysiology9 citations Open access
Semantic Scholar
3-HMG-Coenzyme A Reductase Inhibition and Extracellular Matrix Gene Expression in the Pressure-Overloaded Rat Heart
Georgina M. Cirrincione, M. Boluyt, H. Hwang, B. Bleske
2006Journal of Cardiovascular Pharmacology9 citations Open access
Semantic Scholar
High-dose vitamin D administration and resistance exercise training attenuate the progression of obesity and improve skeletal muscle function in obese p62-deficient mice.
Do-Houn Kim, Alex O. Klemp, G. Salazar, H. Hwang +3 more
2020Nutrition Research7 citations
Semantic Scholar
Evaluation of Immunomodulatory Biomarkers in a Pressure Overload Model of Heart Failure
B. Bleske, H. Hwang, I. Zineh, Michael G. Ghannam +1 more
2007Pharmacotherapy7 citations Open access
Semantic Scholar
Sarcospan Deficiency Increases Oxidative Stress and Arrhythmias in Hearts after Acute Ischemia-Reperfusion Injury
H. Hwang, Aida R. Kahmini, Julia Prascak, Alexis Cejas-Carbonell +5 more
2023International Journal of Molecular Sciences5 citations Open access
Semantic Scholar
Aldosterone antagonism fails to attenuate age-associated left ventricular fibrosis.
H. Hwang, Georgina M. Cirrincione, D. Thomas, R. McCormick +1 more
2007The journals of gerontology. Series A, Biological sciences and medical sciences5 citations
Semantic Scholar
Divergent Regulation of Ryr2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants
H. Hwang, Florentin R. Nitu, Yi Yang, K. Walweel +11 more
20144 citations
Semantic Scholar
CALMODULIN MUTATION (CALM1-E141G) ASSOCIATED WITH LONG QT SYNDROME DISRUPTS CALMODULIN CALCIUM BINDING AND IMPAIRS L-TYPE CA CHANNEL INACTIVATION
Nieves Gómez-Hurtado, D. Kryshtal, H. Hwang, Christopher N. Johnson +7 more
20144 citations
Semantic Scholar
Evaluation of hawthorn extract on immunomodulatory biomarkers in a pressure overload model of heart failure.
B. Bleske, I. Zineh, H. Hwang, G. Welder +2 more
2007Medical Science Monitor4 citations
Semantic Scholar
Abstract 14157: Calmodulin Mutations in Human Genetic Arrhythmia Disorders Exhibit Divergent Functional Effects on Ryanodine Receptor Ca Release Channels
H. Hwang, Florentin R. Nitu, Yi Yang, Christopher N. Johnson +6 more
20133 citations
Semantic Scholar
Effect Of (-)-epigallocatechin Gallate (EGCG), A Green Tea Extract, On Excitation-contraction Coupling Of Murine Cardiomyocytes
H. Hwang, W. Feng, Tao Yang, I. Pessah +1 more
20093 citations Open access
Semantic Scholar
Divergent Regulation of Cardiomyocyte Cav1.2 Currents by Calmodulin Mutants Associated with Human Sudden Death Syndromes
D. Kryshtal, H. Hwang, Christopher N. Johnson, W. Chazin +2 more
20152 citations Open access
Semantic Scholar
Suppression of Spontaneous Ca Elevations Prevents Atrial Fibrillation in Casq 2 Null Hearts
M. Faggioni, E. Savio-Galimberti, R. Venkataraman, H. Hwang +3 more
20142 citations
Semantic Scholar
Abstract 351: Role of Ketoaldehyde Protein Adducts in Ischemic Cardiomyopathy
H. Hwang, S. Davies, M. Hill, I. Pessah +3 more
20082 citations
Semantic Scholar
Calcium Overload Reduces Flecainide Efficacy Against Spontaneous Calcium Release
H. Hwang, B. Knollmann
20121 citations Open access
Semantic Scholar
Slow Diffusion Across Cell Membrane Delays Onset of RyR2-Channel Block and Ca Wave Suppression by Flecainide in Intact Myocytes
H. Hwang, E. S. Galimberti, B. Knollmann
20111 citations Open access
Semantic Scholar
Dissecting the mechanisms by which a pathogenic variant in cardiac TnT tail domain leads to disturbed myofilament performance.
Maicon Landim-Vieira, Weikang Ma, Taejeong Song, Hosna Rastegarpouyani +10 more
2023Biophysical Journal0 citations Open access
Semantic Scholar
The HCM I79N pathogenic variant in cardiac TNT induces thick filament malfunction and myofilament lattice rearrangement
Maicon Landim-Vieira, Weikang Ma, Taejeong Song, C. Ottenheijm +8 more
2022Biophysical Journal0 citations Open access
Semantic Scholar
Abstract P417: Cardiomyopathy-associated Variant In Troponin T Tail Domain Promotes Disruption Of Both Frank-starling Mechanism And Cardiac Myofilament Performance
Maicon Landim-Vieira, Weikang Ma, Taejeong Song, C. Ottenheijm +6 more
2021Circulation Research0 citations
Semantic Scholar
Osmotic Compression Influences Cross-Bridge Detachment Rate in Transgenic Hypertrophic Cardiomyopathy Variant Hctnt-I79N and Non-Transgenic Mouse Cardiac Muscle
Maicon Landim Vieira, B. Knollmann, H. Hwang, C. Ottenheijm +2 more
20200 citations Open access
Semantic Scholar
Effects Of Vitamin D And Resistance Training On Insulin Sensitivity And Neuromuscular Health In Obesity
Do-Houn Kim, Alex O. Klemp, G. Salazar, H. Hwang +3 more
20200 citations Open access
Semantic Scholar

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