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R. Sakemura · SciRah

Researcher profile · Semantic Scholar

R. Sakemura

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R. Sakemura — researcher profile on SciRah

h-index: 17
Works: 93
Citations: 1,652

Most-cited papers

GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts.
Rosalie M. Sterner, R. Sakemura, M. Cox, Nan Yang +19 more
2019Blood579 citations Open access
Semantic Scholar
CAR T cell therapy and the tumor microenvironment: Current challenges and opportunities
L. K. Kankeu Fonkoua, Olivia Sirpilla, R. Sakemura, E. Siegler +1 more
2022Molecular Therapy: Oncolytics247 citations Open access
Semantic Scholar
Targeting Cancer-Associated Fibroblasts in the Bone Marrow Prevents Resistance to CART-Cell Therapy in Multiple Myeloma.
R. Sakemura, M. Hefazi, E. Siegler, M. Cox +19 more
2022Blood128 citations Open access
Semantic Scholar
GM-CSF Neutralization With Lenzilumab in Severe COVID-19 Pneumonia
Z. Temesgen, Mariam Assi, F. Shweta, Paschalis Vergidis +17 more
2020Mayo Clinic proceedings85 citations Open access
Semantic Scholar
Leukemic Extracellular Vesicles Induce Chimeric Antigen Receptor T Cell Dysfunction in Chronic Lymphocytic Leukemia.
M. Cox, F. Lucien, R. Sakemura, Justin C. Boysen +21 more
2020Molecular Therapy74 citations Open access
Semantic Scholar
Management of cytokine release syndrome: an update on emerging antigen-specific T cell engaging immunotherapies.
Roman H. Khadka, R. Sakemura, S. Kenderian, Aaron J. Johnson
2019Immunotherapy60 citations Open access
Semantic Scholar
IL-4 drives exhaustion of CD8+ CART cells
C. Stewart, E. Siegler, R. Sakemura, M. Cox +17 more
2024Nature Communications43 citations Open access
Semantic Scholar
Using CRISPR/Cas9 to Knock Out GM-CSF in CAR-T Cells.
Rosalie M. Sterner, M. Cox, R. Sakemura, S. Kenderian
2019Journal of Visualized Experiments43 citations
Semantic Scholar
Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression
Olivia Sirpilla, R. Sakemura, M. Hefazi, Truc N. Huynh +20 more
2024Nature Biomedical Engineering41 citations
Semantic Scholar
GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity
M. Cox, C. Roman, E. Tapper, E. Siegler +18 more
2022Leukemia33 citations Open access
Semantic Scholar
Treatment strategies for relapse after CAR T-cell therapy in B cell lymphoma
Shuto Negishi, James H. Girsch, E. Siegler, Evandro D. Bezerra +2 more
2024Frontiers in Pediatrics28 citations Open access
Semantic Scholar
In vivo CART cell imaging: Paving the way for success in CART cell therapy
R. Sakemura, I. Can, E. Siegler, Saad S. Kenderian
2021Molecular Therapy: Oncolytics26 citations Open access
Semantic Scholar
CD19 occupancy with tafasitamab increases therapeutic index of CART19 cell therapy and diminishes severity of CRS
R. Sakemura, Claudia Manriquez Roman, Paulina Horvei, E. Siegler +27 more
2023Blood23 citations Open access
Semantic Scholar
Development of a Clinically Relevant Reporter for Chimeric Antigen Receptor T-Cell Expansion, Trafficking, and Toxicity
R. Sakemura, Aditya Bansal, E. Siegler, M. Hefazi +23 more
2021Cancer immunology research22 citations Open access
Semantic Scholar
Host-Viral Interactions at the Maternal-Fetal Interface. What We Know and What We Need to Know
James H. Girsch, Maria Mejia-Plazas, A. Olivier, M. Farah +9 more
2022Frontiers in Virology19 citations Open access
Semantic Scholar
Resistance to CART cell therapy: lessons learned from the treatment of hematological malignancies
R. Sakemura, M. Cox, M. Hefazi, E. Siegler +1 more
2021Leukemia and Lymphoma19 citations
Semantic Scholar
Targeting of CD19 By Tafasitamab Does Not Impair CD19 Directed Chimeric Antigen Receptor T Cell Activity in Vitro
Paulina Horvei, R. Sakemura, M. Cox, M. Ruff +10 more
2019Biology of Blood and Marrow Transplantation19 citations Open access
Semantic Scholar
Targeting Cancer Associated Fibroblasts in the Bone Marrow Prevents Resistance to Chimeric Antigen Receptor T Cell Therapy in Multiple Myeloma
R. Sakemura, M. Cox, Michael J. Hansen, M. Hefazi +9 more
2019Blood17 citations
Semantic Scholar
AXL inhibition improves the anti-tumor activity of chimeric antigen receptor T cells
R. Sakemura, M. Hefazi, M. Cox, E. Siegler +27 more
2023Cancer immunology research13 citations Open access
Semantic Scholar
First Clinical Use of Lenzilumab to Neutralize GM-CSF in Patients with Severe and Critical COVID-19 Pneumonia
Zelalem Temesgen, Mariam Assi, Paschalis Vergidis, S. A. Rizza +16 more
2020medRxiv13 citations Open access
Semantic Scholar
Improved Anti-Tumor Response of Chimeric Antigen Receptor T Cell (CART) Therapy after GM-CSF Inhibition Is Mechanistically Supported By a Novel Direct Interaction of GM-CSF with Activated Carts
M. Cox, C. Kuhlmann, Rosalie M. Sterner, R. Sakemura +15 more
2019Biology of Blood and Marrow Transplantation13 citations Open access
Semantic Scholar
Identification of IL-4 As a Key Regulator of CAR T-Cell Exhaustion Using Functional Genomics and Correlates of the Zuma-1 Clinical Trial
C. Stewart, M. Cox, R. Sakemura, E. Ogbodo +12 more
2022Blood11 citations Open access
Semantic Scholar
Differential susceptibility and role for senescence in CART cells based on costimulatory domains
I. Can, E. Siegler, Olivia Sirpilla, Claudia Manriquez-Roman +18 more
2025Molecular Cancer10 citations Open access
Semantic Scholar
Efficient Gene Editing of CART Cells with CRISPR-Cas12a for Enhanced Antitumor Efficacy
E. Siegler, Brandon W. Simone, R. Sakemura, E. Tapper +9 more
202010 citations Open access
Semantic Scholar
Is CD19-directed chimeric antigen receptor T cell therapy a smart strategy to combat central nervous system lymphoma?
Kotaro Miyao, H. Yokota, R. Sakemura
2023Frontiers in Oncology8 citations Open access
Semantic Scholar
Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography.
R. Sakemura, M. Cox, Aditya Bansal, C. Roman +7 more
2022Journal of Visualized Experiments7 citations
Semantic Scholar
Intrinsic immunosuppressive features of monocytes suppress CAR-T19 through IL-1 pathway modulation in mantle cell lymphoma
Kun Yun, R. Sakemura, I. Can, Omar Gutierrez Ruiz +22 more
2024Molecular therapy. Oncology6 citations Open access
Semantic Scholar
Chimeric Antigen Receptor Engineering of Mesenchymal Stromal Cells (CAR-MSC) Enhance Immunosuppression and Outcomes in Graft Versus Host Disease (GvHD) Preclinical Models
Olivia Sirpilla, R. Sakemura, M. Hefazi, James H. Girsch +10 more
2022Blood6 citations Open access
Semantic Scholar
GM-CSF Blockade during Chimeric Antigen Receptor T-Cell (CART) Therapy Reduces Cytokine Release Syndrome and Neurotoxicity and May Enhance CART Effector Functions
Rosalie M. Sterner, R. Sakemura, Nan Yang, M. Cox +21 more
2019Biology of Blood and Marrow Transplantation6 citations Open access
Semantic Scholar
The Impact of Prior Treatment with a CD19 Targeting Monoclonal Antibody on Subsequent Treatment with CD19 Targeting CART Cell Therapy in Preclinical Models
R. Sakemura, Paulina Horvei, Claudia Manriquez-Roman, E. Ogbodo +23 more
2021Blood5 citations Open access
Semantic Scholar
Circulating Extracellular Vesicles Induce Chimeric Antigen Receptor T Cell Dysfunction in Chronic Lymphocytic Leukemia (CLL)
M. Cox, F. Lucien-Matteoni, R. Sakemura, Justin C. Boysen +12 more
2019Biology of Blood and Marrow Transplantation5 citations Open access
Semantic Scholar
CD19 Antigen Occupancy on Cancer Cells with the CD19 Monoclonal Antibody Tafasitamab Improves the Activation, Antitumor Efficacy, and Safety Profile of CART19 Cell Therapy
R. Sakemura, Claudia Manriquez-Roman, Paulina Horvei, M. Cox +22 more
2022Blood4 citations Open access
Semantic Scholar
Favorable Modulation of Chimeric Antigen Receptor T Cells Safety and Efficacy By the Non-Covalent BTK Inhibitor Vecabrutinib
Mohamad M Adada, R. Sakemura, M. Cox, Caludia Manriquez-Roman +18 more
2021Blood3 citations Open access
Semantic Scholar
Development of a Sensitive and Efficient Reporter Platform for the Detection of Chimeric Antigen Receptor T Cell Expansion, Trafficking, and Toxicity
R. Sakemura, L. Suksanpaisan, Roman H. Khadka, Alysha N. Newsom +13 more
2019Biology of Blood and Marrow Transplantation3 citations Open access
Semantic Scholar
Axl-RTK Inhibition Modulates T Cell Functions and Synergizes with Chimeric Antigen Receptor T Cell Therapy in B Cell Malignancies
R. Sakemura, Nan Yang, M. Cox, S. Sinha +14 more
2018Biology of Blood and Marrow Transplantation3 citations Open access
Semantic Scholar
GM-CSF Blockade during Chimeric Antigen Receptor T Cell Therapy Reduces Cytokine Release Syndrome and Neurotoxicity and May Enhance Their Effector Functions
Rosalie M. Sterner, R. Sakemura, Nan Yang, M. Cox +21 more
2018Blood3 citations
Semantic Scholar
[Next-generation CAR gene-modified cell therapy: overcoming resistance and exploring novel applications].
R. Sakemura
2025[Rinsho ketsueki] The Japanese journal of clinical hematology2 citations
Semantic Scholar
The Identification of IL-4 as a Regulator of Chimeric Antigen Receptor T Cell Exhaustion
C. Stewart, E. Siegler, R. Sakemura, M. Cox +17 more
2023bioRxiv2 citations Open access
Semantic Scholar
Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-derived Xenograft Mouse Model
Claudia Manriquez Roman, R. Sakemura, F. Jin, Roman H. Khadka +4 more
2023Journal of Visualized Experiments2 citations Open access
Semantic Scholar
324 Sensitizing poorly differentiated thyroid cancers to TSHR-CART cell therapy with MEK inhibitors
J. Copland, K. Schick, J. Gleba, T. Huynh +20 more
2022Regular and Young Investigator Award Abstracts2 citations Open access
Semantic Scholar
TNFR2 As a Target to Improve CD19-Directed CART Cell Fitness and Antitumor Activity in Large B Cell Lymphoma
Claudia Manriquez Roman, M. Cox, R. Sakemura, Kun Yun +23 more
2021Blood2 citations Open access
Semantic Scholar
Vesicular Stomatitis Virus (VSV) Engineered to Express CD19 Stimulates Anti-CD19 Chimeric Antigen Receptor Modified T Cells and Promotes Their Anti-Tumor Effects
R. Sakemura, Elizabeth C. Eckert, Sydney B. Crotts, Linh D Pham +17 more
2020Transplantation and Cellular Therapy2 citations Open access
Semantic Scholar
EXTH-32. DEVELOPMENT OF EPHA3 DIRECTED CHIMERIC ANTIGEN RECEPTOR T CELL THERAPY FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME
M. Ruff, R. Sakemura, M. Cox, Mehrdad Hefazi-Torghabeh +4 more
2019Neuro-Oncology2 citations Open access
Semantic Scholar
Abstract 1525: Optimized CART cell therapy to remodel the tumor microenvironment and eliminate GI malignancies
Omar L. Gutierrez Ruiz, J. Feigin, Brooke L. Kimball, R. Sakemura +24 more
2026Cancer Research1 citations
Semantic Scholar
Targeting CSF1R to overcome myeloid cell suppression in CART therapy
Grace DeFranco, Kun Yun, Claudia Manriquez Roman, J. Feigin +31 more
2025Blood1 citations
Semantic Scholar
Overexpression of CD103 on regulatory T cells mitigates acute graft-versus-host disease via promotion of tolerogenic dendritic cell networks
Mehrdad Hefazi-Torghabeh, R. Sakemura, Hong Xia, Brooke L. Kimball +22 more
2025Blood1 citations
Semantic Scholar
Ibrutinib enhances 41BB-costimulated CART19 function and persistence through immune reprogramming: Insights from the phase 3 ECOG-ACRIN E1912 clinical Trial
Truc N. Huynh, Victoria Wang, J. Feigin, E. Siegler +26 more
2025Blood1 citations
Semantic Scholar
Tumor-derived microRNA-125a impairs CART cell function and predicts treatment failure in B cell malignancies
Olivia Sirpilla, I. Can, Kun Yun, Grace DeFranco +19 more
2025Blood1 citations
Semantic Scholar
Identification of T Cell Senescence As a Cell Fate Limiting the Antitumor Activity of 41BB-Costimulated CART Cells
I. Can, R. Sakemura, Olivia Sirpilla, Claudia Manriquez Roman +17 more
2024Blood1 citations
Semantic Scholar
Abstract 3841: Tumor-derived microRNA125a induces CART cell apoptosis and failure in B cell malignancies
Olivia Sirpilla, R. Sakemura, I. Can, Truc N. Huynh +22 more
2024Cancer Research1 citations
Semantic Scholar

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S. Kenderian×34
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S. Kenderian — researcher profile on SciRah
M. Cox×30
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M. Hefazi×29
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M. Hefazi — researcher profile on SciRah
E. Siegler×29
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I. Can — researcher profile on SciRah

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K. Schick — researcher profile on SciRah

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C. Stewart — researcher profile on SciRah

Claudia Manriquez Roman×20

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Claudia Manriquez Roman — researcher profile on SciRah

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M. Ruff — researcher profile on SciRah

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N. Kay — researcher profile on SciRah

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S. Parikh — researcher profile on SciRah

Olivia Sirpilla×17

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Olivia Sirpilla — researcher profile on SciRah