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Jean-Marie Würtz · SciRah

Researcher profile · Semantic Scholar

Jean-Marie Würtz

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Jean-Marie Würtz — researcher profile on SciRah

h-index: 35
Works: 90
Citations: 5,947

Most-cited papers

A canonical structure for the ligand-binding domain of nuclear receptors
Jean-Marie Würtz, W. Bourguet, J. Renaud, Valérie Vivat +3 more
1996Nature Structural Biology983 citations
Semantic Scholar
The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand.
N. Rochel, Jean-Marie Würtz, A. Mitschler, B. Klaholz +1 more
2000Molecules and Cells779 citations Open access
Semantic Scholar
Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains.
W. Bourguet, Valérie Vivat, Jean-Marie Würtz, P. Chambon +2 more
2000Molecules and Cells397 citations Open access
Semantic Scholar
The bromodomain revisited.
F. Jeanmougin, Jean-Marie Würtz, Bertrand Le Douarin, Pierre Chambon +1 more
1997TIBS -Trends in Biochemical Sciences. Regular ed316 citations
Semantic Scholar
Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3.
H. Greschik, Jean-Marie Würtz, Sarah Sanglier, W. Bourguet +3 more
2002Molecules and Cells288 citations Open access
Semantic Scholar
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes.
D. Helmlinger, Sara Hardy, S. Sasorith, Fabrice A. C. Klein +9 more
2004Human Molecular Genetics252 citations
Semantic Scholar
Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands
G. Tocchini-Valentini, N. Rochel, Jean-Marie Würtz, A. Mitschler +1 more
2001Proceedings of the National Academy of Sciences of the United States of America204 citations Open access
Semantic Scholar
A transcriptional silencing domain in DAX-1 whose mutation causes adrenal hypoplasia congenita.
E. Lalli, Barbara Bardoni, Emmanuel Zazopoulos, Jean-Marie Würtz +3 more
1997Molecular Endocrinology204 citations Open access
Semantic Scholar
Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors.
E. Leproult, S. Barluenga, D. Moras, Jean-Marie Würtz +1 more
2011Journal of Medicinal Chemistry184 citations Open access
Semantic Scholar
Antagonism in the human mineralocorticoid receptor
J. Fagart, Jean-Marie Würtz, A. Souque, C. Hellal-Levy +2 more
1998EMBO Journal172 citations Open access
Semantic Scholar
Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1alpha,25(OH)2-vitamin D3 signaling.
Mathew T. Mizwicki, Donald Keidel, C. Bula, J. Bishop +4 more
2004Proceedings of the National Academy of Sciences of the United States of America157 citations Open access
Semantic Scholar
Crystal Structure of a Mutant hERα Ligand-binding Domain Reveals Key Structural Features for the Mechanism of Partial Agonism*
M. Gangloff, M. Ruff, S. Eiler, S. Duclaud +2 more
2001Journal of Biological Chemistry139 citations Open access
Semantic Scholar
A mutation mimicking ligand‐induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers
Valérie Vivat, C. Zechel, Jean-Marie Würtz, William Bourguet +6 more
1997EMBO Journal132 citations Open access
Semantic Scholar
X‐ray structure of the orphan nuclear receptor RORβ ligand‐binding domain in the active conformation
C. Stehlin, Jean-Marie Würtz, A. Steinmetz, E. Greiner +3 more
2001EMBO Journal120 citations Open access
Semantic Scholar
Specific Recognition of Androgens by Their Nuclear Receptor
N. Poujol, Jean-Marie Würtz, B. Tahiri, S. Lumbroso +3 more
2000Journal of Biological Chemistry120 citations Open access
Semantic Scholar
The TBP-like factor: an alternative transcription factor in metazoa?
J. Dantonel, Jean-Marie Würtz, O. Poch, D. Moras +1 more
1999TIBS -Trends in Biochemical Sciences. Regular ed113 citations
Semantic Scholar
Net (ERP/SAP2) one of the Ras‐inducible TCFs, has a novel inhibitory domain with resemblance to the helix‐loop‐helix motif.
S. Maira, Jean-Marie Würtz, B. Wasylyk
1996EMBO Journal97 citations Open access
Semantic Scholar
Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists.
Martine Géhin, Valérie Vivat, Jean-Marie Würtz, R. Losson +3 more
1999Chemistry and Biology87 citations Open access
Semantic Scholar
The structure of cyclin H: common mode of kinase activation and specific features
G. Andersen, D. Busso, A. Poterszman, J. R. Hwang +5 more
1997EMBO Journal86 citations Open access
Semantic Scholar
Critical Role of Desolvation in the Binding of 20-Hydroxyecdysone to the Ecdysone Receptor*
C. Browning, Elyette Martin, C. Loch, Jean-Marie Würtz +4 more
2007Journal of Biological Chemistry77 citations Open access
Semantic Scholar
Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.
D. Stolfa, M. Marek, Julien Lancelot, Alexander-Thomas Hauser +10 more
2014Journal of Molecular Biology69 citations Open access
Semantic Scholar
Defining and characterizing protein surface using alpha shapes
Laurent-Philippe Albou, B. Schwarz, O. Poch, Jean-Marie Würtz +1 more
2009Proteins: Structure, Function, and Bioinformatics68 citations Open access
Semantic Scholar
A new model for 20‐hydroxyecdysone and dibenzoylhydrazine binding: A homology modeling and docking approach
Jean-Marie Würtz, B. Guillot, J. Fagart, D. Moras +2 more
2000Protein Science68 citations Open access
Semantic Scholar
Crucial role of the H11-H12 loop in stabilizing the active conformation of the human mineralocorticoid receptor.
C. Hellal-Levy, J. Fagart, A. Souque, Jean-Marie Würtz +2 more
2000Molecular Endocrinology58 citations Open access
Semantic Scholar
Characterization of the DNA-Binding and Dimerization Properties of the Nuclear Orphan Receptor Germ Cell Nuclear Factor
H. Greschik, Jean-Marie Würtz, P. Hublitz, Fabian Köhler +2 more
1999Molecular and Cellular Biology58 citations Open access
Semantic Scholar
Three-dimensional models of estrogen receptor ligand binding domain complexes, based on related crystal structures and mutational and structure-activity relationship data.
Jean-Marie Würtz, Ursula Egner, N. Heinrich, D. Moras +1 more
1998Journal of Medicinal Chemistry58 citations
Semantic Scholar
A New Class of Transcription Initiation Factors, Intermediate between TATA Box-binding Proteins (TBPs) and TBP-like Factors (TLFs), Is Present in the Marine Unicellular Organism, the Dinoflagellate Crypthecodinium cohnii *
D. Guillebault, S. Sasorith, É. Derelle, Jean-Marie Würtz +4 more
2002Journal of Biological Chemistry52 citations Open access
Semantic Scholar
Reappraisal of the role of heat shock proteins as regulators of steroid receptor activity.
T. Ylikomi, Jean-Marie Würtz, H. Syvälä, S. Passinen +5 more
1998Critical reviews in biochemistry and molecular biology50 citations
Semantic Scholar
Structure-function analysis reveals the molecular determinants of the impaired biological function of DAX-1 mutants in AHC patients.
Sylvia G. Lehmann, Jean-Marie Würtz, J. Renaud, P. Sassone-Corsi +1 more
2003Human Molecular Genetics49 citations
Semantic Scholar
Human TAFII55 Interacts with the Vitamin D3 and Thyroid Hormone Receptors and with Derivatives of the Retinoid X Receptor That Have Altered Transactivation Properties
A. Lavigne, G. Mengus, Yann-Gaël Gangloff, Jean-Marie Würtz +1 more
1999Molecular and Cellular Biology47 citations Open access
Semantic Scholar
Raloxifene and ICI182,780 increase estrogen receptor-alpha association with a nuclear compartment via overlapping sets of hydrophobic amino acids in activation function 2 helix 12.
M. Lupien, M. Jeyakumar, E. Hébert, Khalid Hilmi +9 more
2007Molecular Endocrinology46 citations Open access
Semantic Scholar
Structural insight into arginine methylation by the mouse protein arginine methyltransferase 7: a zinc finger freezes the mimic of the dimeric state into a single active site.
V. Cura, N. Troffer‐Charlier, Jean-Marie Würtz, L. Bonnefond +1 more
2014Acta Crystallographica Section D: Biological Crystallography44 citations
Semantic Scholar
Structure-based analysis of the ultraspiracle protein and docking studies of putative ligands
S. Sasorith, I. Billas, T. Iwema, D. Moras +1 more
2002Journal of Insect Science41 citations Open access
Semantic Scholar
Unfaithfulness and promiscuity of a mutant androgen receptor in a hormone-refractory prostate cancer
A. Monge, Monika Jagla, Gäelle Lapouge, S. Sasorith +5 more
2006Cellular and Molecular Life Sciences (CMLS)38 citations Open access
Semantic Scholar
Residues in the ligand binding domain that confer progestin or glucocorticoid specificity and modulate the receptor transactivation capacity.
Catherine Robin-Jagerschmidt, Jean-Marie Würtz, B. Guillot, Dominique Gofflo +5 more
2000Molecular Endocrinology35 citations Open access
Semantic Scholar
A single amino acid mutation of ala-773 in the mineralocorticoid receptor confers agonist properties to 11beta-substituted spirolactones.
G. Auzou, J. Fagart, A. Souque, C. Hellal-Levy +3 more
2000Molecular Pharmacology31 citations
Semantic Scholar
Different ligands–different receptor conformations: Modeling of the hERα LBD in complex with agonists and antagonists
U. Egner, N. Heinrich, M. Ruff, M. Gangloff +2 more
2001Medicinal research reviews (Print)30 citations
Semantic Scholar
Histone H3 Tails Containing Dimethylated Lysine and Adjacent Phosphorylated Serine Modifications Adopt a Specific Conformation during Mitosis and Meiosis
A. Eberlin, Cédric Grauffel, M. Oulad-Abdelghani, Flavie Robert +10 more
2008Molecular and Cellular Biology28 citations Open access
Semantic Scholar
Functional insights from high resolution structures of mouse protein arginine methyltransferase 6.
L. Bonnefond, J. Stojko, J. Mailliot, N. Troffer‐Charlier +4 more
2015Journal of Structural Biology25 citations
Semantic Scholar
Sequences in the ligand-binding domains of the human androgen and progesterone receptors which determine their distinct ligand identities.
Valérie Vivat, D. Gofflo, Teresa García, Jean-Marie Würtz +3 more
1997Journal of Molecular Endocrinology22 citations
Semantic Scholar
Investigation of the binding interactions of progesterone using muteins of the human progesterone receptor ligand binding domain designed on the basis of a three-dimensional protein model.
M. Letz, P. Bringmann, Mario Mann, A. Mueller-Fahrnow +4 more
1999Biochimica et Biophysica Acta19 citations
Semantic Scholar
Amino Acids Specifying MHC Class Preference in TCR Vα2 Regions
M. Correia-Neves, C. Waltzinger, Jean-Marie Würtz, C. Benoist +1 more
1999Journal of Immunology16 citations Open access
Semantic Scholar
The monomeric orphan nuclear receptor Schistosoma mansoni Ftz-F1 dimerizes specifically and functionally with the schistosome RXR homologue, SmRXR1.
B. Bertin, Stéphanie Caby, F. Oger, S. Sasorith +2 more
2005Biochemical and Biophysical Research Communications - BBRC15 citations
Semantic Scholar
Unique functional properties of a member of the Fushi Tarazu-Factor 1 family from Schistosoma mansoni.
B. Bertin, S. Sasorith, Stéphanie Caby, F. Oger +3 more
2004Biochemical Journal14 citations Open access
Semantic Scholar
Erratum: A canonical structure for the ligand-binding domain of nuclear receptors
Jean-Marie Würtz, W. Bourguet, J. Renaud, Valérie Vivat +3 more
1996Nature Structural Biology12 citations Open access
Semantic Scholar
The loss of transcriptional inhibition by the photoreceptor-cell specific nuclear receptor (NR2E3) is not a necessary cause of enhanced S-cone syndrome
Mathias Fradot, O. Lorentz, Jean-Marie Würtz, J. Sahel +1 more
2007Molecular Vision11 citations
Semantic Scholar
The macrotricyclic receptors SC24, SC24,nH+ and their cryptates: molecular mechanics and molecular dynamics studies
G. Wipff, Jean-Marie Würtz
19899 citations
Semantic Scholar
Amino acids specifying MHC class preference in TCR V alpha 2 regions.
M. Correia-Neves, C. Waltzinger, Jean-Marie Würtz, C. Benoist +1 more
1999Journal of Immunology8 citations
Semantic Scholar
Common characteristics of the human and rhesus macaque CD1e molecules: conservation of biochemical and biological properties during primate evolution
C. Angénieux, J. Salamero, D. Fricker, Jean-Marie Würtz +4 more
2003Immunogenetics7 citations
Semantic Scholar
Dynamic Views of Macrocyclic Receptors: Molecular Dynamics Simulations and Normal Modes Analysis
G. Wipff, Jean-Marie Würtz
19887 citations
Semantic Scholar

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D. Moras×21
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S. Sasorith×6
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J. Renaud×5
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Valérie Vivat×5
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H. Gronemeyer×4

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L. Tora — researcher profile on SciRah

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D. Moras — researcher profile on SciRah

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J. Fagart — researcher profile on SciRah

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P. Chambon — researcher profile on SciRah

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A. Souque — researcher profile on SciRah

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C. Hellal-Levy — researcher profile on SciRah