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Y. Sakane · SciRah

Researcher profile · Semantic Scholar

Y. Sakane

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Y. Sakane — researcher profile on SciRah

h-index: 12
Works: 28
Citations: 695

Most-cited papers

Identification of protease 3.4.24.11 as the major atrial natriuretic factor degrading enzyme in the rat kidney.
J. L. Sonnenberg, Y. Sakane, Arco Y. Jeng, J. Koehn +3 more
1988Peptides154 citations
Semantic Scholar
Degradation of atrial natriuretic factor by kidney cortex membranes. Isolation and characterization of the primary proteolytic product.
J. Koehn, J. A. Norman, B. N. Jones, L. Lesueur +2 more
1987Journal of Biological Chemistry86 citations Open access
Semantic Scholar
Dicarboxylic acid dipeptide neutral endopeptidase inhibitors.
G. Ksander, R. Ghai, R. deJesus, C. Diefenbacher +4 more
1995Journal of Medicinal Chemistry79 citations Open access
Semantic Scholar
N-Phosphonomethyl dipeptides and their phosphonate prodrugs, a new generation of neutral endopeptidase (NEP, EC 3.4.24.11) inhibitors.
S. Delombaert, M. Erion, Jenny Tan, L. Blanchard +5 more
1994Journal of Medicinal Chemistry67 citations Open access
Semantic Scholar
Non-peptidic inhibitors of neutral endopeptidase 24.11 1. Discovery and optimization of potency
S. Delombaert, L. Blanchard, Jenny Tan, Y. Sakane +2 more
199554 citations
Semantic Scholar
Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13.
L. Monovich, R. Tommasi, R. Fujimoto, V. Blancuzzi +32 more
2009Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
Differential Structure‐Activity Relationships of Phosphoramidon Analogues for Inhibition of Three Metalloproteases: Endothelin‐Converting Enzyme, Neutral Endopeptidase, and Angiotensin‐Converting Enzyme
Paivi J. Kukkola, P. Savage, Y. Sakane, J. Berry +3 more
1995Journal of Cardiovascular Pharmacology41 citations Open access
Semantic Scholar
Heterocyclic lactam derivatives as dual angiotensin converting enzyme and neutral endopeptidase 24.11 inhibitors.
J. L. Stanton, Donald M. Sperbeck, A. Trapani, Donald Cote +3 more
1993Journal of Medicinal Chemistry26 citations
Semantic Scholar
Design and synthesis of an orally active macrocyclic neutral endopeptidase 24.11 inhibitor.
L. J. Macpherson, Erol K. Bayburt, M. Capparelli, R. Bohacek +6 more
1993Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.
Cynthia A. Fink, Ying Qiao, C. Berry, Y. Sakane +2 more
1995Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Characterisation of neutral endopeptidase 3.4.24.11 (NEP) in the kidney: comparison between normotensive, genetically hypertensive and experimentally hypertensive rats.
R. Schulz, Y. Sakane, Carol R. Berry, R. Ghai
1991Journal of enzyme inhibition (Print)14 citations
Semantic Scholar
Enkephalinase inhibitors. 1. 2,4-Dibenzylglutaric acid derivatives.
G. Ksander, Clive G. Diefenbacher, A. Yuan, F. Clark +2 more
1989Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar
Development of an Assay Suitable for High-Throughput Screening to Measure Matrix Metalloprotease Activity
J. Peppard, Quynhchi Pham, Am Clark, D. Farley +4 more
2003Assay and drug development technologies12 citations
Semantic Scholar
4-Substituted proline derivatives that inhibit angiotensin converting enzyme and neutral endopeptidase 24.11.
S. Bhagwat, Cynthia A. Fink, C. Gude, Kenneth Chan +4 more
199411 citations
Semantic Scholar
α-Mercaptoacyl dipeptides that inhibit angiotensin converting enzyme and neutral endopeptidase 24.11
S. Bhagwat, Cynthia A. Fink, C. Gude, Kenneth Chan +4 more
19958 citations
Semantic Scholar
Dual inhibition of neutral endopeptidase and angiotensin-converting enzyme by N-phosphonomethyl and N-carboxyalkyl dipeptides
S. Delombaert, Jenny Tan, Lisa J. Stamford, Y. Sakane +2 more
19946 citations
Semantic Scholar
Inhibition of thromboxane biosynthesis in splanchnic ischemia shock.
H. H. Oei, H. Zoganas, Y. Sakane, R. D. Robson +1 more
1986Circulatory shock5 citations
Semantic Scholar
New α-Thiol Dipeptide Dual Inhibitors of Angiotensin-I Converting Enzyme (ACE) and Neutral Endopeptidase (NEP) EC 3.4.24.11.
Cynthia A. Fink, Ying Qiao, C. Berry, Y. Sakane +2 more
19964 citations
Semantic Scholar
Disposition of thiorphan in DOCA-salt and spontaneously hypertensive rats.
Y. Sakane, C. Berry, M. Hopkins, Kuldeep Singh +1 more
1993Research communications in chemical pathology and pharmacology4 citations
Semantic Scholar
Dazoxiben, UK 38,485 and aspirin: duration of effect for preventing thrombotic sudden death in rabbits.
L. A. Lindsay, R. W. Olson, Y. Sakane, R. Ghai +1 more
1986Thrombosis Research4 citations
Semantic Scholar
IDENTIFICATION OF WHALE SPECIES BY LIQUID CHROMATOGRAPHIC ANALYSIS OF SARCOPLASMIC PROTEINS
Y. Ukishima, Y. Sakane, A. Fukuda, S. Wada +1 more
19953 citations
Semantic Scholar
Dual inhibition of angiotensin-converting enzyme and neutral endopeptidase by tricyclic benzazepinone thiols
S. Delombaert, L. Blanchard, Lisa B. Stamford, Y. Sakane +3 more
19961 citations
Semantic Scholar
4‐Substituted Proline Derivatives that Inhibit Angiotesin Converting Enzyme and Neutral Endopeptidase 24.11.
S. Bhagwat, Cynthia A. Fink, C. Gude, Kenneth Chan +4 more
19951 citations
Semantic Scholar
A rapid indirect method to determine the plasma concentrations of neutral endopeptidase inhibitors.
R. Ghai, S. Delombaert, G. Ksander, C. Berry +2 more
1995Research Communications in Molecular Pathology and Pharmacology1 citations
Semantic Scholar
The biological activity of atrial natriuretic factor cleaved by endoprotease 3.4.24.11.
R. Ghai, R. Webb, J. L. Sonnenberg, Y. Sakane +1 more
1991Journal of enzyme inhibition (Print)1 citations
Semantic Scholar
Non‐Peptidic Inhibitos of Neutral Endopeptidase 24.11. Part 1. Discovery and Optimization of Potency.
S. Delombaert, L. Blanchard, Jenny Tan, Y. Sakane +2 more
19950 citations
Semantic Scholar
Differential Cleavage of Urodilatin and Atrial Natriuretic Factor by Thrombin and Protease 3.4.24.11
C. Berry, Y. Sakane, Radhika Ramannan, C. Krulan +2 more
19930 citations
Semantic Scholar
Properties of hepatic and pancreatic cyclic AMP phosphodiesterase in the cat.
Y. Sakane, P. Morgan, T. Glenn
1981Research communications in chemical pathology and pharmacology0 citations
Semantic Scholar

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R. Ghai×23
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A. Trapani×8
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S. Delombaert×5
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Cynthia A. Fink

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Ying Qiao — researcher profile on SciRah

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G. Ksander — researcher profile on SciRah

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S. Bhagwat — researcher profile on SciRah

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