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Mark A Eckardt · SciRah

Researcher profile · Semantic Scholar

Mark A Eckardt

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Mark A Eckardt — researcher profile on SciRah

h-index: 21
Works: 48
Citations: 1,127

Most-cited papers

PD-0332991, a potent and selective inhibitor of cyclin-dependent kinase 4/6, demonstrates inhibition of proliferation in renal cell carcinoma at nanomolar concentrations and molecular markers predict for sensitivity.
Joshua E. Logan, Nikayeh Mostofizadeh, Amrita J. Desai, E. von Euw +13 more
2013Anticancer Research110 citations
Semantic Scholar
Effective molecular targeting of CDK4/6 and IGF-1R in a rare FUS-ERG fusion CDKN2A-deletion doxorubicin-resistant Ewing's sarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model
T. Murakami, Arun S. Singh, Tasuku Kiyuna, S. Dry +18 more
2016OncoTarget104 citations Open access
Semantic Scholar
Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: decoy, trap and kill chemotherapy moves toward the clinic
K. Igarashi, Kei Kawaguchi, Tasuku Kiyuna, K. Miyake +19 more
2018Cell Cycle77 citations Open access
Semantic Scholar
Recombinant methioninase in combination with doxorubicin (DOX) overcomes first-line DOX resistance in a patient-derived orthotopic xenograft nude-mouse model of undifferentiated spindle-cell sarcoma.
K. Igarashi, Kei Kawaguchi, Shu-Kuan Li, Qinghong Han +19 more
2018Cancer Letters72 citations
Semantic Scholar
Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention
Kei Kawaguchi, Qinghong Han, Shu-Kuan Li, Yu-Ying Tan +14 more
2018Cell Cycle56 citations Open access
Semantic Scholar
Clinical and radiographic outcomes of concentrated bone marrow aspirate with allograft and demineralized bone matrix for posterolateral and interbody lumbar fusion in elderly patients
Remi M. Ajiboye, Jason Hamamoto, Mark A Eckardt, Jeffrey C. Wang
2015European spine journal50 citations
Semantic Scholar
The combination of temozolomide-irinotecan regresses a doxorubicin-resistant patient-derived orthotopic xenograft (PDOX) nude-mouse model of recurrent Ewing’s sarcoma with a FUS-ERG fusion and CDKN2A deletion: Direction for third-line patient therapy
K. Miyake, T. Murakami, Tasuku Kiyuna, K. Igarashi +17 more
2017OncoTarget42 citations Open access
Semantic Scholar
Metabolic targeting with recombinant methioninase combined with palbociclib regresses a doxorubicin-resistant dedifferentiated liposarcoma.
K. Igarashi, Kei Kawaguchi, Tasuku Kiyuna, K. Miyake +18 more
2018Biochemical and Biophysical Research Communications - BBRC40 citations
Semantic Scholar
Giant Cell Tumor of Bone: Are We Stratifying Results Appropriately?
Thomas J. Jr Kremen, N. Bernthal, Mark A Eckardt, J. Eckardt
2012Clinical Orthopaedics and Related Research40 citations Open access
Semantic Scholar
Intra-tumor L-methionine level highly correlates with tumor size in both pancreatic cancer and melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse models
Kei Kawaguchi, Qinghong Han, Shu-Kuan Li, Yu-Ying Tan +14 more
2018OncoTarget39 citations Open access
Semantic Scholar
Growth of doxorubicin‐resistant undifferentiated spindle‐cell sarcoma PDOX is arrested by metabolic targeting with recombinant methioninase
K. Igarashi, Shu-Kuan Li, Qinghong Han, Yu-Ying Tan +18 more
2018Journal of Cellular Biochemistry38 citations Open access
Semantic Scholar
Labeling the Stroma of a Patient‐Derived Orthotopic Xenograft (PDOX) Mouse Model of Undifferentiated Pleomorphic Soft‐Tissue Sarcoma With Red Fluorescent Protein for Rapid Non‐Invasive Imaging for Drug Screening
Tasuku Kiyuna, T. Murakami, Y. Tome, K. Igarashi +11 more
2017Journal of Cellular Biochemistry38 citations Open access
Semantic Scholar
Combination therapy of tumor-targeting Salmonella typhimurium A1-R and oral recombinant methioninase regresses a BRAF-V600E-negative melanoma.
Kei Kawaguchi, T. Higuchi, Shu-Kuan Li, Qinghong Han +22 more
2018Biochemical and Biophysical Research Communications - BBRC36 citations
Semantic Scholar
Recombinant methioninase combined with doxorubicin (DOX) regresses a DOX-resistant synovial sarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model
K. Igarashi, Kei Kawaguchi, Shu-Kuan Li, Qinghong Han +20 more
2018OncoTarget33 citations Open access
Semantic Scholar
Tumor-targeting Salmonella typhimurium A1-R is a highly effective general therapeutic for undifferentiated soft tissue sarcoma patient-derived orthotopic xenograft nude-mouse models.
K. Igarashi, Kei Kawaguchi, Tasuku Kiyuna, K. Miyake +15 more
2018Biochemical and Biophysical Research Communications - BBRC32 citations
Semantic Scholar
Image-guided Percutaneous Core Needle Biopsy of Musculoskeletal Tumors in Children
Bryan A. Mitton, L. Seeger, Mark A Eckardt, K. Motamedi +4 more
2014Journal of pediatric hematology/oncology27 citations
Semantic Scholar
AMG 900, pan-Aurora kinase inhibitor, preferentially inhibits the proliferation of breast cancer cell lines with dysfunctional p53
O. Kalous, D. Conklin, Amrita J. Desai, J. Dering +10 more
2013Breast Cancer Research and Treatment27 citations
Semantic Scholar
Temozolomide combined with irinotecan regresses a cisplatinum-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model
K. Igarashi, Kei Kawaguchi, Tasuku Kiyuna, K. Miyake +15 more
2017OncoTarget25 citations Open access
Semantic Scholar
A combination of irinotecan/cisplatinum and irinotecan/temozolomide or tumor-targeting Salmonella typhimurium A1-R arrest doxorubicin- and temozolomide-resistant myxofibrosarcoma in a PDOX mouse model.
Tasuku Kiyuna, Y. Tome, T. Murakami, K. Miyake +22 more
2018Biochemical and Biophysical Research Communications - BBRC23 citations
Semantic Scholar
Outcomes of Demineralized Bone Matrix Enriched with Concentrated Bone Marrow Aspirate in Lumbar Fusion
Remi M. Ajiboye, Mark A Eckardt, Jason Hamamoto, B. Plotkin +2 more
2016The International Journal of Spine Surgery22 citations Open access
Semantic Scholar
Oncologic Accuracy of Image-guided Percutaneous Core-Needle Biopsy of Peripheral Nerve Sheath Tumors at a High-volume Sarcoma Center
D. Graham, T. Russell, Mark A Eckardt, K. Motamedi +9 more
2019American Journal of Clinical Oncology21 citations
Semantic Scholar
Does “Low-Grade” Dedifferentiated Liposarcoma Exist? The Role of Mitotic Index in Separating Dedifferentiated Liposarcoma From Cellular Well-differentiated Liposarcoma
D. Graham, A. Qorbani, Mark A Eckardt, Kyle D. Klingbeil +4 more
2023American Journal of Surgical Pathology20 citations
Semantic Scholar
Eribulin regresses a doxorubicin‐resistant Ewing's sarcoma with a FUS‐ERG fusion and CDKN2A‐deletion in a patient‐derived orthotopic xenograft (PDOX) nude mouse model
K. Miyake, T. Murakami, Tasuku Kiyuna, K. Igarashi +12 more
2018Journal of Cellular Biochemistry16 citations
Semantic Scholar
Temozolomide regresses a doxorubicin‐resistant undifferentiated spindle‐cell sarcoma patient‐derived orthotopic xenograft (PDOX): precision‐oncology nude‐mouse model matching the patient with effective therapy
K. Igarashi, Kei Kawaguchi, Tasuku Kiyuna, K. Miyake +15 more
2018Journal of Cellular Biochemistry16 citations
Semantic Scholar
A child with gemcitabine-induced severe radiation recall myositis resulting in a compartment syndrome.
Mark A Eckardt, A. Bean, M. Selch, N. Federman
2013Journal of pediatric hematology/oncology16 citations
Semantic Scholar
Chemotherapy and Survival in Patients with Primary High-Grade Extremity and Trunk Soft Tissue Sarcoma
D. Graham, R. van Dams, N. Jackson, M. Onyshchenko +8 more
2020Cancers12 citations Open access
Semantic Scholar
Pathologic Response to Neoadjuvant Therapy is Associated With Improved Long-term Survival in High-risk Primary Localized Malignant Peripheral Nerve Sheath Tumors
Elizabeth Shurell-Linehan, B. Dipardo, Irmina A. Elliott, D. Graham +8 more
2019American Journal of Clinical Oncology12 citations
Semantic Scholar
Tumor-targeting Salmonella typhimurium A1-R arrests a doxorubicin-resistant PDGFRA-amplified patient-derived orthotopic xenograft (PDOX) mouse model of pleomorphic liposarcoma
Tasuku Kiyuna, Y. Tome, T. Murakami, Ming Zhao +15 more
2018Journal of Cellular Biochemistry12 citations Open access
Semantic Scholar
Aggressive osteoblastoma with a secondary aneurysmal bone cyst treated with denosumab
Karlton Wong, J. Chantharasamee, S. Nelson, Mark A Eckardt +3 more
2021Rare Tumors11 citations Open access
Semantic Scholar
Does Age Influence the Efficacy of Demineralized Bone Matrix Enriched with Concentrated Bone Marrow Aspirate in Lumbar Fusions?
Remi M. Ajiboye, Mark A Eckardt, Jason Hamamoto, Akshay Sharma +2 more
2018Clinical Spine Surgery11 citations
Semantic Scholar
Lifelong Imaging Surveillance is Indicated for Patients with Primary Retroperitoneal Liposarcoma
Mark A Eckardt, D. Graham, Kyle D. Klingbeil, Serena Y. Lofftus +13 more
2022Annals of Surgical Oncology10 citations
Semantic Scholar
Clinical Factors That Affect the Establishment of Soft Tissue Sarcoma Patient-Derived Orthotopic Xenografts: A University of California, Los Angeles, Sarcoma Program Prospective Clinical Trial
T. Russell, Mark A Eckardt, T. Murakami, Irmina A. Elliott +15 more
2017JCO Precision Oncology9 citations Open access
Semantic Scholar
Low Rates of Chemotherapy Use for Primary, High-Grade Soft Tissue Sarcoma: A National Cancer Database Analysis.
D. Graham, M. Onyshchenko, Mark A Eckardt, B. Dipardo +7 more
2020The Journal of the National Comprehensive Cancer Network8 citations Open access
Semantic Scholar
Translating Knowledge About the Immune Microenvironment of Gastrointestinal Stromal Tumors into Effective Clinical Strategies
J. Chantharasamee, J. Adashek, Karlton Wong, Mark A Eckardt +4 more
2021Current Treatment Options in Oncology7 citations
Semantic Scholar
Pathologic discordance in sarcomas: Prospective comparison of external and sarcoma center pathologic diagnosis.
Mark A Eckardt, D. Graham, Arun S. Singh, B. Chmielowski +14 more
2019Journal of Clinical Oncology4 citations
Semantic Scholar
Bayesian sequential learning for prognostication in extremity soft tissue sarcoma (BayeSarc): a retrospective, multicentre cohort study.
D. Callegaro, G. Tine', S. Pasquali, S. Stacchiotti +14 more
2026The Lancet Oncology3 citations
Semantic Scholar
Dedicated review of sarcoma pathology is necessary for corroborative diagnosis in nearly one half of referred patients.
Mark A Eckardt, Nicholas M Siena, Amy R. Copeland, Tyler R. McCaw +15 more
2025Surgery3 citations
Semantic Scholar
18F-FLT PET/CT as a Prognostic Imaging Biomarker of Disease-Specific Survival in Patients with Primary Soft-Tissue Sarcoma
J. Crompton, W. Armstrong, Mark A Eckardt, Ameen Seyedroudbari +8 more
2021Journal of Nuclear Medicine3 citations Open access
Semantic Scholar
Not All Hemangiomas are Benign—Epithelioid Hemangioendothelioma: An Aggressive Vascular Lesion in Children
Mark A Eckardt, Vivian Y. Chang, S. Nelson, N. Federman
2011Pediatric Hematology & Oncology2 citations
Semantic Scholar
612 PD-0332991, AN INHIBITOR OF CYCLIN-DEPENDENT KINASE 4/6, DEMONSTRATES INHIBITION OF PROLIFERATION IN RENAL CELL CARCINOMA AT NANOMOLAR CONCENTRATIONS AND MOLECULAR MARKERS PREDICT FOR SENSITIVITY
Joshua E. Logan, Nikayeh Mostofizadeh, Amrita J. Desai, E. von Euw +12 more
20131 citations
Semantic Scholar
Coexistence of Translocation(1,19) and the Philadelphia Chromosome in a Child's First Presentation of Chronic Myeloid Leukemia in Blast Crisis Treated with Dasatinib
Mark A Eckardt, Vivian Y. Chang, N. Rao, N. Federman
2011Pediatric Hematology & Oncology1 citations
Semantic Scholar
Robot-Assisted Transduodenal Sphincteroplasty for Ampullary Stenosis After Roux-en-Y-Gastric Bypass
Raja R. Narayan, Mark A Eckardt, Bonnie O. Wang, Z. Fong +2 more
2025Annals of Surgical Oncology0 citations
Semantic Scholar
ASO Visual Abstract: Lifelong Imaging Surveillance is Indicated for Patients with Primary Retroperitoneal Liposarcoma
Mark A Eckardt, D. Graham, Kyle D. Klingbeil, Serena Y. Lofftus +13 more
2023Annals of Surgical Oncology0 citations
Semantic Scholar
Recurrence and disease-specific survival after 10-year disease-free interval in patients with primary retroperitoneal liposarcoma: Implications for long-term surveillance.
Mark A Eckardt, D. Graham, B. Kadera, Kyle D. Klingbeil +8 more
20210 citations
Semantic Scholar
Concentrated Bone Marrow Aspirate in Lumbar Fusion Outcomes of Demineralized Bone Matrix Enriched with
C. Wang, Remi M. Ajiboye, Mark A Eckardt, Jason Hamamoto +2 more
20190 citations
Semantic Scholar
Growth of doxorubicin-resistant undifferentiated spindle-cell sarcoma PDOX is arrested metabolic targeting with recombinant methioninase † Running title : Recombinant methioninase arrests a doxorubicin-resistant spindle-cell sarcoma
K. Igarashi, Shu-Kuan Li, Qinghong Han, Yu-Ying Tan +18 more
20170 citations
Semantic Scholar
Effect of PD-0332991, a potent and selective inhibitor of cyclin-dependent kinase 4/6, on proliferation in renal cell carcinoma at nanomolar concentrations and prediction of sensitivity by molecular markers.
Joshua E. Logan, Nikayeh Mostofizadeh, Amrita J. Desai, E. von Euw +12 more
2013Journal of Clinical Oncology0 citations
Semantic Scholar
Cell cycle effects of CDK 4/6 inhibitor PD 0332991 in diffuse large B-cell lymphoma cell lines in vitro.
Herbert A. Eradat, Mark A Eckardt, E. Dorfman, Habib Hamidi +6 more
2011Journal of Clinical Oncology0 citations
Semantic Scholar

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F. Eilber×32
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Arun S. Singh×29
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S. Dry×27
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Tasuku Kiyuna — researcher profile on SciRah

K. Igarashi×19

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T. Russell — researcher profile on SciRah

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K. Miyake — researcher profile on SciRah

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