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Petr Vachal · SciRah

Researcher profile · Semantic Scholar

Petr Vachal

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Petr Vachal — researcher profile on SciRah

h-index: 23
Works: 52
Citations: 3,898

Most-cited papers

The medicinal chemist's toolbox for late stage functionalization of drug-like molecules.
T. Cernak, Kevin D. Dykstra, S. Tyagarajan, Petr Vachal +1 more
2016Chemical Society Reviews754 citations
Semantic Scholar
Nanomole-scale high-throughput chemistry for the synthesis of complex molecules
Alexander Buitrago Santanilla, E. Regalado, T. Pereira, M. Shevlin +13 more
2015Science488 citations
Semantic Scholar
Structure-based analysis and optimization of a highly enantioselective catalyst for the strecker reaction.
Petr Vachal, E. Jacobsen
2002Journal of the American Chemical Society454 citations
Semantic Scholar
Late-stage functionalization of biologically active heterocycles through photoredox catalysis.
D. DiRocco, Kevin D. Dykstra, S. Krska, Petr Vachal +2 more
2014Angewandte Chemie368 citations
Semantic Scholar
A General Catalyst for the Asymmetric Strecker Reaction This work was supported by the NIH (GM-43214). A postdoctoral fellowship to M.S.S. (NIH), and a predoctoral fellowship to P.V. sponsored by Alfred Bader are gratefully acknowledged.
M. Sigman, Petr Vachal, Eric N. Jacobsen
2000Angewandte Chemie320 citations
Semantic Scholar
Enantioselective catalytic addition of HCN to ketoimines. Catalytic synthesis of quaternary amino acids.
Petr Vachal, Eric N. Jacobsen
2000Organic Letters234 citations
Semantic Scholar
A General Small-Scale Reactor To Enable Standardization and Acceleration of Photocatalytic Reactions
C. Le, M. Wismer, Zhi-Cai Shi, Rui Zhang +5 more
2017ACS Central Science207 citations Open access
Semantic Scholar
Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods
Peter S. Kutchukian, J. Dropinski, Kevin D. Dykstra, Bing Li +8 more
2016Chemical Science119 citations Open access
Semantic Scholar
Chemoselective Peptide Modification via Photocatalytic Tryptophan β-Position Conjugation.
Younong Yu, Li-Kang Zhang, A. Buevich, Guo-Qing Li +4 more
2018Journal of the American Chemical Society94 citations
Semantic Scholar
Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor
D. Johns, Louis-Charles Campeau, Puja Banka, A. Bautmans +37 more
2023Circulation89 citations Open access
Semantic Scholar
Profiling and Application of Photoredox C(sp3)-C(sp2) Cross-Coupling in Medicinal Chemistry.
Rui Zhang, Guo-Qing Li, M. Wismer, Petr Vachal +2 more
2018ACS Medicinal Chemistry Letters78 citations Open access
Semantic Scholar
Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors.
T. Cernak, N. Gesmundo, Kevin D. Dykstra, Yang Yu +23 more
2017Journal of Medicinal Chemistry70 citations Open access
Semantic Scholar
1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.
Petr Vachal, S. Miao, J. Pierce, D. Guiadeen +27 more
2012Journal of Medicinal Chemistry57 citations Open access
Semantic Scholar
Practical Synthesis of a Soluble Schiff Base Catalyst for the Asymmetric Strecker Reaction
J. Su, Petr Vachal, E. Jacobsen
200156 citations
Semantic Scholar
General facile synthesis of 2,5-diarylheteropentalenes
Petr Vachal, L. Toth
200453 citations
Semantic Scholar
Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench-Stable Organozinc Reagents.
T. Greshock, Keith P. Moore, R. McClain, A. Bellomo +10 more
2016Angewandte Chemie47 citations
Semantic Scholar
High-throughput purification platform in support of drug discovery.
Min Liu, Kuanchang Chen, Denny Christian, Tazeen Fatima +9 more
2012ACS Combinatorial Science43 citations
Semantic Scholar
Supporting Information Synthesis and Study of Alendronate Derivatives as Potential Prodrugs of Alendronate Sodium; for the Treatment of Low Bone Density and Osteoporosis
Petr Vachal, J. Hale, Z. Lu, E. Streckfuss +8 more
200641 citations
Semantic Scholar
Discovery of Novel Indoline Cholesterol Ester Transfer Protein Inhibitors (CETP) through a Structure-Guided Approach.
Jonathan E. Wilson, Ravi Kurukulasuriya, Mikhail Y. Reibarkh, M. Reiter +13 more
2016ACS Medicinal Chemistry Letters37 citations Open access
Semantic Scholar
Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor.
Petr Vachal, L. Toth, J. Hale, Lin Yan +7 more
2006Bioorganic & Medicinal Chemistry Letters34 citations Open access
Semantic Scholar
SYNTHESIS AND ANALGESIC ACTIVITY OF SOME 1-BENZOFURANS, 1-BENZOTHIOPHENES AND INDOLES
S. Rádl, Petr Hezký, J. Urbankova, Petr Vachal +1 more
200026 citations
Semantic Scholar
A new approach to the synthesis of benzofuro[3,2-b]quinolines, benzothieno[3,2-b]quinolines and indolo[3,2-b]quinolines†
S. Rádl, Petr Konvička, Petr Vachal
200025 citations
Semantic Scholar
Thieno[3,2- b ]benzofuran - Synthesis and Reactions
Petr Vachal, P. Pihera, J. Svoboda
199725 citations
Semantic Scholar
New heterocyclic core structure for chiral liquid crystals
Petr Vachal, J. Svoboda, I. Stibor, M. Glogarová
199921 citations
Semantic Scholar
Synthesis of HDAC Inhibitor Libraries via Microscale Workflow.
Kevin D. Dykstra, E. Streckfuss, Min Liu, Jian Liu +8 more
2021ACS Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties.
Petr Vachal, Joseph James Duffy, Louis-Charles Campeau, Rupesh P. Amin +27 more
2021Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Effects of anacetrapib on plasma lipids, apolipoproteins and PCSK9 in healthy, lean rhesus macaques.
T. Roddy, David G. McLaren, Ying Chen, Dan Xie +17 more
2014European Journal of Pharmacology15 citations
Semantic Scholar
Fluorescence Properties and Dipole Moments of Novel Fused Thienobenzofurans. Solvent and Structural Effects
J. Aaron, C. Párkányi, A. Adenier, Caroline Potin +5 more
2011Journal of Fluorescence14 citations
Semantic Scholar
A General Catalyst for the Asymmetric Strecker Reaction.
M. Sigman, Petr Vachal, E. Jacobsen
200014 citations
Semantic Scholar
Selective functionalization of complex heterocycles via an automated strong base screening platform
S. B. Boga, Melodie Christensen, Nicholas Perrotto, S. Krska +11 more
201713 citations
Semantic Scholar
Harnessing the Power of C–H Functionalization Chemistry to Accelerate Drug Discovery
Bing Li, S. Tyagarajan, Kevin D. Dykstra, T. Cernak +2 more
2023Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry11 citations
Semantic Scholar
Discovery Process of Enlicitide, a Highly Engineered Macrocyclic Peptide Therapeutic, through Issue-Driven Fragment-Based Synthetic Assembly and SAR.
Hubert Josien, Anilkumar G. Nair, Fa-Xiang Ding, Yan Guo +38 more
2026Journal of Medicinal Chemistry10 citations
Semantic Scholar
1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity.
Petr Vachal, Joan M. Fletcher, T. Fong, C. Huang +20 more
2009Journal of Medicinal Chemistry8 citations Open access
Semantic Scholar
A direct functionalization of tertiary alkyl bromides with O-, N-, and C-nucleophiles
Petr Vachal, Joan M. Fletcher, W. Hagmann
20078 citations
Semantic Scholar
Rapid Affinity and Microsomal Stability Ranking of Crude Mixture Libraries of Histone Deacetylase Inhibitors.
S. Tyagarajan, Christine L. Andrews, D. Beshore, A. Buevich +19 more
2024ACS Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Cholesteryl ester transfer protein (CETP) inhibitors based on cyclic urea, bicyclic urea and bicyclic sulfamide cores.
Jian Liu, Patrick P Shao, D. Guiadeen, Arto D Krikorian +9 more
2020Bioorganic & Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC).
Yang Yu, Zhicai Wu, Zhi-Cai Shi, Shu-Wen He +27 more
2019Bioorganic & Medicinal Chemistry Letters6 citations Open access
Semantic Scholar
Highly Selective and Potent Agonists of Sphingosine‐1‐phosphate 1 (S1P1) Receptor.
Petr Vachal
20063 citations
Semantic Scholar
Development of indazole mineralocorticoid receptor antagonists and investigation into their selective late-stage functionalization.
Kun Liu, Ravi Kurukulasuriya, Kevin D. Dykstra, Lisa DiMichelle +18 more
2019Bioorganic & Medicinal Chemistry Letters2 citations Open access
Semantic Scholar
Structure‐Based Analysis and Optimization of a Highly Enantioselective Catalyst for the Strecker Reaction.
Petr Vachal, E. Jacobsen
20032 citations
Semantic Scholar
A New Approach to the Synthesis of Benzofuro[3,2‐b]quinolines, Benzothieno[3,2‐b]quinolines and Indolo[3,2‐b]quinolines.
S. Rádl, Petr Konvička, Petr Vachal
20012 citations
Semantic Scholar
Late-Stage Functionalization for the Optimization of Reversible BTK Inhibitors
S. Krska, S. Tyagarajan, D. Guiadeen, E. Streckfuss +5 more
2022Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry1 citations
Semantic Scholar
Correction: The medicinal chemist's toolbox for late stage functionalization of drug-like molecules.
T. Cernak, Kevin D. Dykstra, S. Tyagarajan, Petr Vachal +1 more
2017Chemical Society Reviews1 citations Open access
Semantic Scholar
A Direct Functionalization of Tertiary Alkyl Bromides with O-, N-, and C-Nucleophiles.
Petr Vachal, Joan M. Fletcher, W. Hagmann
20071 citations
Semantic Scholar
Thieno[3,2-b]benzofuran — Synthesis and Reactions.
Petr Vachal, P. Pihera, J. Svoboda
19981 citations
Semantic Scholar
OD PROTIZANETLIVYCH LATEK K HETEROPENTALENUM
Petr Vachal, Pavel Pihera, Jiří Svoboda, J. Paleček
19981 citations
Semantic Scholar
Employing Late-Stage Functionalization Strategies to Address Metabolic Challenges in Drug Discovery
Kevin D. Dykstra, A. McCracken, Melodie Christensen, Cheol K. Chung +20 more
2026Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry0 citations
Semantic Scholar
Correction to "Discovery Process of Enlicitide, a Highly Engineered Macrocyclic Peptide Therapeutic, Through Issue Driven Fragment-Based Synthetic Assembly and SAR".
Hubert Josien, Anilkumar G. Nair, Fa-Xiang Ding, Yan Guo +38 more
2026Journal of Medicinal Chemistry0 citations
Semantic Scholar
Prof. Eric Jacobsen and #MSDChemistry: Past, present and future
Rebecca T. Ruck, Petr Vachal
2025Tetrahedron0 citations
Semantic Scholar
CETP condensed bicyclic oxazolidinone
P. Shao, Feng Ye, Petr Vachal, De-You Sha +3 more
20120 citations
Semantic Scholar

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