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A. Mhyre · SciRah

Researcher profile · Semantic Scholar

A. Mhyre

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A. Mhyre — researcher profile on SciRah

h-index: 12
Works: 34
Citations: 670

Most-cited papers

Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function
A. Marcondes, A. Mhyre, D. Stirewalt, Soohyun Kim +2 more
2008Proceedings of the National Academy of Sciences of the United States of America133 citations Open access
Semantic Scholar
Estrogen activates rapid signaling in the brain: role of estrogen receptor alpha and estrogen receptor beta in neurons and glia.
A. Mhyre, D. Dorsa
2006Neuroscience102 citations
Semantic Scholar
Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
Zachary R. Crook, Gregory P. Sevilla, D. Friend, Mi-Youn K. Brusniak +8 more
2017Nature Communications72 citations Open access
Semantic Scholar
Disease-causing Mutation in GPR54 Reveals the Importance of the Second Intracellular Loop for Class A G-protein-coupled Receptor Function*
Jennifer L. Wacker, David B. Feller, Xiao-Bo Tang, Mia Defino +6 more
2008Journal of Biological Chemistry68 citations Open access
Semantic Scholar
Optimal therapeutic targeting by HDAC inhibition in biopsy-derived treatment-naïve diffuse midline glioma models.
N. Vitanza, M. Biery, Carrie Myers, E. Ferguson +19 more
2020Neuro-Oncology67 citations Open access
Semantic Scholar
Stroma-dependent apoptosis in clonal hematopoietic precursors correlates with expression of PYCARD.
A. Mhyre, A. Marcondes, Emily Spaulding, H. Deeg
2009Blood39 citations Open access
Semantic Scholar
A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure
Michelle L. Cook Sangar, Emily J. Girard, Gene Hopping, Chun-Feng Yin +15 more
2020Science Translational Medicine36 citations
Semantic Scholar
The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties.
Cheng Guo, Min Hu, R. Deorazio, A. Usyatinsky +10 more
2014Bioorganic & Medicinal Chemistry32 citations Open access
Semantic Scholar
A TfR-binding cystine-dense peptide promotes blood-brain barrier penetration of bioactive molecules
Zachary R. Crook, Emily J. Girard, Gregory P. Sevilla, Morgan M. Merrill +13 more
2020Journal of Molecular Biology31 citations Open access
Semantic Scholar
Medulloblastoma Recurrence and Metastatic Spread are Independent of Colony-Stimulating Factor 1 Receptor Signaling and Macrophage Survival
Erin E. Crotty, Stephanie M. C. Smith, K. Brasel, Fiona Pakiam +6 more
2021Journal of Neuro-Oncology18 citations Open access
Semantic Scholar
Estradiol reduces nonclassical transcription at cyclic adenosine 3',5'-monophosphate response elements in glioma cells expressing estrogen receptor alpha.
A. Mhyre, R. Shapiro, D. Dorsa
2006Endocrinology16 citations
Semantic Scholar
Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1.
C. Cioffi, Shuang Liu, M. Wolf, P. Guzzo +26 more
2016Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar
Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager
Zachary R. Crook, Emily J. Girard, Gregory P. Sevilla, Mi-Youn K. Brusniak +14 more
2022Science Translational Medicine9 citations Open access
Semantic Scholar
Versatile tissue‐injectable hydrogels capable of the extended hydrolytic release of bioactive protein therapeutics
Eric S. Nealy, Steveni . Reed, Steven M. Adelmund, Barry A. Badeau +10 more
2024Bioengineering & Translational Medicine7 citations Open access
Semantic Scholar
Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1.
C. Cioffi, M. Wolf, P. Guzzo, K. Sadalapure +17 more
2013Bioorganic & Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Mammalian Surface Display Screening of Diverse Cystine-Dense Peptide Libraries for Difficult-to-Drug Targets.
Zachary R. Crook, Gregory P. Sevilla, A. Mhyre, James M. Olson
2020Methods in molecular biology6 citations
Semantic Scholar
A modified gene trap approach for improved high-throughput cancer drug discovery
S. Morris, A. Mhyre, Savanna S. Carmack, Carrie Myers +5 more
2018Oncogene5 citations Open access
Semantic Scholar
DIPG-35. A NOVEL HDAC INHIBITOR IN NEW PATIENT-DERIVED DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) MODELS
M. Biery, Carrie Myers, Emily J. Girard, S. Morris +8 more
2018Neuro-Oncology4 citations Open access
Semantic Scholar
Publisher Correction: Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
Zachary R. Crook, Gregory P. Sevilla, D. Friend, Mi-Youn K. Brusniak +8 more
2018Nature Communications2 citations Open access
Semantic Scholar
Abstract 3200: Targeting PHF5A for the treatment of glioblastoma and other Myc-driven cancers
A. Mhyre, Shanon M Turnbaugh, S. Morris, Xin Hu +3 more
20172 citations
Semantic Scholar
Fully human anti-FOLR1 T-cell engager demonstrates potent activity in CBFA2T3::GLIS2 acute megakaryoblastic leukemia
Shelli M Morris, K. Pilat, Emily J. Girard, A. Noll +15 more
2026Blood neoplasia1 citations Open access
Semantic Scholar
Abstract LB-231: An optide (optimized knottin-peptide) that inhibits tumor cell growth In vitro and accumulates in sarcoma flank tumors in vivo
T. Sottero, Emily J. Girard, C. Correnti, M. Stroud +3 more
20161 citations
Semantic Scholar
Abstract 1613: Expanded therapeutic window of potent bispecific PD-L1:CD3 T cell engager using a novel best-in-class CD3 binder
A. Mhyre, Emily J. Girard, Sinduja K. Marx, Shelli M Morris +10 more
2026Cancer Research0 citations
Semantic Scholar
Intratumoral B7H3:CD3 Bispecific T-cell Engager Drives Localized T-cell Accumulation in Canine Sarcoma Patients
Yusuke Suita, Lisa S. Ang, Ken Brasel, Shelli M Morris +12 more
2026bioRxiv0 citations Open access
Semantic Scholar
Abstract 1628: A bispecific PDL1:CD3 T-cell engager potently kills intractable primary and metastatic intracranial tumors
Emily J. Girard, Shelli M Morris, K. Pilat, Alison M. Williams +11 more
2026Cancer Research0 citations
Semantic Scholar
Versatile Tissue-Injectable Hydrogels with Extended Hydrolytic Release of Bioactive Protein Therapeutics
Eric S. Nealy, Steveni . Reed, Steven M. Adelmund, Barry A. Badeau +9 more
2023bioRxiv0 citations Open access
Semantic Scholar
Abstract 1043: Advances in cystine-dense peptide (CDP) screening and therapeutic applications
Zachary R. Crook, Emily J. Girard, Gregory P. Sevilla, Mi-Youn K. Brusniak +13 more
2022Cancer Research0 citations
Semantic Scholar
EXTH-58. THERAPEUTIC HDAC INHIBITION IN HYPERMUTANT DIFFUSE INTRINSIC PONTINE GLIOMA
A. Noll, M. Biery, Carrie Myers, Danyelle Paine +13 more
2021Neuro-Oncology0 citations Open access
Semantic Scholar
DIPG-10. OPTIMAL HDAC INHIBITION IN DIFFUSE INTRINSIC PONTINE GLIOMA
N. Vitanza, M. Biery, Carrie Myers, E. Ferguson +9 more
2020Neuro-Oncology0 citations Open access
Semantic Scholar
MODL-28. IMMUNE PRIMING WITH INTERFERON-Γ COMBINED WITH EPIGENETIC MODULATION IN PEDIATRIC BRAIN TUMORS
Erin E. Crotty, S. Morris, K. Brasel, Emily J. Girard +3 more
2020Neuro-Oncology0 citations Open access
Semantic Scholar
Pacifastin-derived Peptides Target Tumors for Use in In Vivo Imaging.
T. Sottero, Emily J. Girard, Carrie Myers, Gene Hopping +2 more
2018Anticancer Research0 citations
Semantic Scholar
Abstract 5573: A high-affinity Optide (optimized peptide) inhibitor of the Hippo pathway’s YAP-TEAD interaction
Zachary R. Crook, P. Bradley, Gregory P. Sevilla, D. Friend +5 more
20170 citations
Semantic Scholar
Abstract 4023: The SABRE platform: A novel, unbiased technology for drug discovery and prioritization
S. Morris, A. Mhyre, Savanna S. Carmack, Connor Burns +4 more
20170 citations
Semantic Scholar
Abstract 2971: Optides (optimized knottin peptides) computationally designed to target the oncogenic HIPPO pathway
Zachary R. Crook, P. Bradley, Christopher R. King, A. Mhyre +2 more
20160 citations
Semantic Scholar

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James M. Olson×16
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Emily J. Girard×14
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Zachary R. Crook×11
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