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Seung Jae Hyeon · SciRah

Researcher profile · Semantic Scholar

Seung Jae Hyeon

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Seung Jae Hyeon — researcher profile on SciRah

h-index: 22
Works: 62
Citations: 1,689

Most-cited papers

SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease
Junghee Lee, Yunha Kim, T. Liu, Y. Hwang +10 more
2017Aging Cell180 citations Open access
Semantic Scholar
Astrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALS
Junghee Lee, Seung Jae Hyeon, Hyeonjoo Im, H. Ryu +2 more
2016Experimental Neurobiology136 citations Open access
Semantic Scholar
Astrocytic urea cycle detoxifies Aβ-derived ammonia while impairing memory in Alzheimer’s disease
Ye-On-Ha Ju, Mridula Bhalla, Seung Jae Hyeon, Ju-Eun Oh +11 more
2021bioRxiv130 citations Open access
Semantic Scholar
Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease
Suhyun Kim, Heejung Chun, Yunha Kim, Yeyun Kim +18 more
2024Molecular Neurodegeneration117 citations Open access
Semantic Scholar
EWSR1, a multifunctional protein, regulates cellular function and aging via genetic and epigenetic pathways
Junghee Lee, P. T. Nguyen, Hyun-Soo Shim, Seung Jae Hyeon +6 more
2018Biochimica et Biophysica Acta - Molecular Basis of Disease89 citations Open access
Semantic Scholar
Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease
Min Young Lee, Junghee Lee, Seung Jae Hyeon, Hyesun Cho +8 more
2020Aging Cell73 citations Open access
Semantic Scholar
Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport
Heesun Choi, Haeng Jun Kim, Jisoo Kim, Soohyun Kim +8 more
2017Molecular Neurodegeneration67 citations Open access
Semantic Scholar
Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage
Yun-Hee Bae, Hyejin Joo, Jinhyun Bae, Seung Jae Hyeon +7 more
2018Cell Death and Disease64 citations Open access
Semantic Scholar
UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation
Manivannan Subramanian, Seung Jae Hyeon, Tanuza Das, Yoon Seok Suh +5 more
2021Nature Communications62 citations Open access
Semantic Scholar
Visualizing reactive astrocyte-neuron interaction in Alzheimer's disease using 11C-acetate and 18F-FDG.
Min-Ho Nam, H. Ko, Dongwoo Kim, Sangwon Lee +27 more
2023Brain : a journal of neurology56 citations Open access
Semantic Scholar
Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy
Jeong-Sun Seo, Seungbok Lee, Jong-Yeon Shin, Y. Hwang +20 more
2017Experimental &Molecular Medicine54 citations Open access
Semantic Scholar
"Turn-On" Quinoline-Based Fluorescent Probe for Selective Imaging of Tau Aggregates in Alzheimer's Disease: Rational Design, Synthesis, and Molecular Docking.
Ahmed A. Elbatrawy, Seung Jae Hyeon, Nan Yue, E. E. A. Osman +6 more
2021ACS Sensors47 citations
Semantic Scholar
A Difluoroboron β-Diketonate Probe Shows "Turn-on" Near-Infrared Fluorescence Specific for Tau Fibrils.
Kwang-Su Park, M. K. Kim, Yujin Seo, Taewoong Ha +7 more
2017ACS Chemical Neuroscience45 citations
Semantic Scholar
Lipocalin-2 Is a Key Regulator of Neuroinflammation in Secondary Traumatic and Ischemic Brain Injury
Jae-Hong Kim, Ri-Jin Kang, Seung Jae Hyeon, Ho-Cheol Ryu +4 more
2022Neurotherapeutics44 citations Open access
Semantic Scholar
Neurotoxic Microglial Activation via IFNγ‐Induced Nrf2 Reduction Exacerbating Alzheimer's Disease
You-Jung Kang, Seung Jae Hyeon, Amanda McQuade, Jiwoon Lim +9 more
2024Advancement of science43 citations Open access
Semantic Scholar
Remodeling of heterochromatin structure slows neuropathological progression and prolongs survival in an animal model of Huntington’s disease
Junghee Lee, Y. Hwang, Yunha Kim, Min Young Lee +12 more
2017Acta Neuropathologica38 citations
Semantic Scholar
Visualization of soluble tau oligomers in TauP301L-BiFC transgenic mice demonstrates the progression of tauopathy.
Seulgi Shin, Dohee Kim, Ji-Ye-On Song, Hyeanjeong Jeong +6 more
2020Progress in neurobiology28 citations Open access
Semantic Scholar
Power Failure of Mitochondria and Oxidative Stress in Neurodegeneration and Its Computational Models
Junhyuk Woo, Hyesun Cho, YunHee Seol, Soon Ho Kim +5 more
2021Antioxidants27 citations Open access
Semantic Scholar
Distinct dual roles of p-Tyr42 RhoA GTPase in tau phosphorylation and ATP citrate lyase activation upon different Aβ concentrations
K. Cap, Yeon-Joo Jung, Boram Choi, Seung Jae Hyeon +8 more
2020Redox Biology26 citations Open access
Semantic Scholar
The rise of astrocytes: are they guardians or troublemakers of the brain disorder?
Hee-Yeon Kim, Seungchan Kim, Asli Nur Akaydin, Suhyun Kim +3 more
2026Experimental and Molecular Medicine25 citations
Semantic Scholar
Aβ-induced mitochondrial dysfunction in neural progenitors controls KDM5A to influence neuronal differentiation
Dong Kyu Kim, Hyobin Jeong, Jingi Bae, Moon-Yong Cha +14 more
2022Experimental and Molecular Medicine24 citations Open access
Semantic Scholar
Alterations of transcriptome signatures in head trauma-related neurodegenerative disorders
Hyesun Cho, Seung Jae Hyeon, Jong-Yeon Shin, Victor E. Alvarez +6 more
2020Scientific Reports24 citations Open access
Semantic Scholar
Hevin–calcyon interaction promotes synaptic reorganization after brain injury
Jong-Heon Kim, Hyun-Gug Jung, A. Kim, H. Shim +9 more
2021Cell Death and Differentiation23 citations Open access
Semantic Scholar
SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer’s disease
Mridula Bhalla, Jinhyeong Joo, Daeun Kim, Jeong-Im Shin +9 more
2025Molecular Neurodegeneration19 citations Open access
Semantic Scholar
Dysfunction of striatal MeCP2 is associated with cognitive decline in a mouse model of Alzheimer's disease
Sangjoon Lee, T. Kim, J. Choi, Yunjung Choi +8 more
2022Theranostics19 citations Open access
Semantic Scholar
Antioxidant and Neuroprotective Effects of Paeonol against Oxidative Stress and Altered Carrier-Mediated Transport System on NSC-34 Cell Lines
S. Latif, Seung-Hye Choi, Asmita Gyawali, Seung Jae Hyeon +2 more
2022Antioxidants18 citations Open access
Semantic Scholar
L-Citrulline Level and Transporter Activity Are Altered in Experimental Models of Amyotrophic Lateral Sclerosis
Asmita Gyawali, S. Gautam, Seung Jae Hyeon, H. Ryu +1 more
2020Molecular Neurobiology18 citations
Semantic Scholar
Dysfunction of X-linked inhibitor of apoptosis protein (XIAP) triggers neuropathological processes via altered p53 activity in Huntington’s disease
Seung Jae Hyeon, Jinyoung Park, Junsang Yoo, Suhyun Kim +16 more
2021Progress in neurobiology17 citations Open access
Semantic Scholar
Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington’s disease mouse model
Y. Hwang, Seung Jae Hyeon, Younghee Kim, Sung-Su Lim +13 more
2021Journal of Enzyme Inhibition and Medicinal Chemistry15 citations Open access
Semantic Scholar
Quantitative Proteomic Analysis Reveals Impaired Axonal Guidance Signaling in Human Postmortem Brain Tissues of Chronic Traumatic Encephalopathy
Baibin Bi, Han-Pil Choi, Seung Jae Hyeon, Sheng-Nan Sun +7 more
2019Experimental Neurobiology15 citations Open access
Semantic Scholar
Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction.
Hyungsup Kim, Hyesu Kim, L. Nguyen, Taewoong Ha +14 more
2022Progress in neurobiology14 citations
Semantic Scholar
Modulation of histone H3K4 dimethylation by spermidine ameliorates motor neuron survival and neuropathology in a mouse model of ALS
Seung-Hye Choi, Ali Yousefian-Jazi, Seung Jae Hyeon, Phuong Thi Tuyet Nguyen +7 more
2022Journal of Biomedical Sciences14 citations Open access
Semantic Scholar
Genetic Ablation of EWS RNA Binding Protein 1 (EWSR1) Leads to Neuroanatomical Changes and Motor Dysfunction in Mice
Yeojun Yoon, Hasang Park, Sangyeon Kim, P. T. Nguyen +6 more
2018Experimental Neurobiology14 citations Open access
Semantic Scholar
Tau accumulation is cleared by the induced expression of VCP via autophagy
Hoi-Khoanh Giong, Seung Jae Hyeon, Jae-Geun Lee, Hyun-Ju Cho +6 more
2024Acta Neuropathologica13 citations Open access
Semantic Scholar
Monocarboxylate transporter functions and neuroprotective effects of valproic acid in experimental models of amyotrophic lateral sclerosis
Asmita Gyawali, S. Latif, Seung-Hye Choi, Seung Jae Hyeon +2 more
2022Journal of Biomedical Sciences11 citations Open access
Semantic Scholar
Acceleration of somatic cell reprogramming into the induced pluripotent stem cell using a mycosporine-like amino acid, Porphyra 334
Junsang Yoo, Junyeop Kim, J. Lee, Hyein Kim +7 more
2020Scientific Reports11 citations Open access
Semantic Scholar
PyrPeg, a Blood-Brain Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, not Tau Aggregates.
Ji-Woo Choi, Ye-On-Ha Ju, Yunsook Choi, Seung Jae Hyeon +10 more
2020ACS Chemical Neuroscience11 citations
Semantic Scholar
Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice
Ali Yousefian-Jazi, Suhyun Kim, Jiyeon Chu, Seung-Hye Choi +14 more
2025Molecular Neurodegeneration9 citations
Semantic Scholar
Astrocytic gamma-aminobutyric acid dysregulation as a therapeutic target for posttraumatic stress disorder
Sujung Yoon, Woojin Won, Su-Ji Lee, Kayoung Han +15 more
2025Signal Transduction and Targeted Therapy9 citations Open access
Semantic Scholar
Crosstalk between lipocalin-2 and IL-6 in traumatic brain injury: Closely related biomarkers.
Jae-Hong Kim, Han-Gil Jeong, Seung Jae Hyeon, Uiyeol Park +8 more
2024Experimental Neurology9 citations
Semantic Scholar
The Alteration of L-Carnitine Transport and Pretreatment Effect under Glutamate Cytotoxicity on Motor Neuron-Like NSC-34 Lines
Asmita Gyawali, Seung Jae Hyeon, H. Ryu, Young-Sook Kang
2021Pharmaceutics8 citations Open access
Semantic Scholar
Decreased FAK activity and focal adhesion dynamics impair proper neurite formation of medium spiny neurons in Huntington's disease
Hae Nim Lee, Seung Jae Hyeon, Heejung Kim, K. Sim +6 more
2022Acta Neuropathologica7 citations
Semantic Scholar
Visualization of reactive astrocytes in living brain of Alzheimer’s disease patient
Min-Ho Nam, H. Ko, Sangwon Lee, Yongmin Mason Park +18 more
2021bioRxiv7 citations Open access
Semantic Scholar
Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice
Ali Yousefian-Jazi, Suhyun Kim, Seung-Hye Choi, Jiyeon Chu +13 more
2024bioRxiv5 citations Open access
Semantic Scholar
Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism
J. Heo, Ah Hyung Park, Min Joung Lee, M. Ryu +17 more
2023Molecular Psychiatry4 citations
Semantic Scholar
Targeting the microglial phosphatidylethanolamine synthesis pathway promotes GABARAP-associated phagocytosis and Aβ clearance in Alzheimer’s disease
Seung Jae Hyeon, Seungchan Kim, Jiyeon Chu, Yeonseo Kim +17 more
2026Signal Transduction and Targeted Therapy2 citations Open access
Semantic Scholar
Publisher Correction: UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation
Manivannan Subramanian, Seung Jae Hyeon, Tanuza Das, Yoon Seok Suh +5 more
2021Nature Communications2 citations Open access
Semantic Scholar
Mitochondrial dysfunction-induced KDM5A degradation impairs adult hippocampal neurogenesis in Alzheimer’s disease
Dong Kyu Kim, Hyobin Jeong, Jingi Bae, Moon-Yong Cha +14 more
20202 citations Open access
Semantic Scholar
Astrocytic noncanonical WNT5B signaling modulates extracellular matrix remodeling and neuropathology in Huntington’s disease
Phuong Thi-Thanh Nguyen, Ali Yousefian-Jazi, Seung Jae Hyeon, Soomin Lee +13 more
2026Signal Transduction and Targeted Therapy1 citations Open access
Semantic Scholar
Neurotoxic Microglial Activation via IFNγ‐Induced Nrf2 Reduction Exacerbating Alzheimer's Disease (Adv. Sci. 20/2024)
You-Jung Kang, Seung Jae Hyeon, Amanda McQuade, Jiwoon Lim +9 more
2024Advancement of science1 citations Open access
Semantic Scholar

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