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E. Sotelo · SciRah

Researcher profile · Semantic Scholar

E. Sotelo

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E. Sotelo — researcher profile on SciRah

h-index: 28
Works: 142
Citations: 2,482

Most-cited papers

3D printing of a heterogeneous copper-based catalyst
C. R. Tubio, J. Azuaje, L. Escalante, Alberto Coelho +3 more
2016191 citations
Semantic Scholar
Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs
Giovanni Graziano, A. Stefanachi, M. Contino, Rubén Prieto-Díaz +5 more
2023International Journal of Molecular Sciences114 citations Open access
Semantic Scholar
Three-Dimensional Printing in Catalysis: Combining 3D Heterogeneous Copper and Palladium Catalysts for Multicatalytic Multicomponent Reactions
Antonio S. Díaz-Marta, C. R. Tubio, Carlos Carbajales, Carmen Fernández +6 more
2018102 citations Open access
Semantic Scholar
An efficient and recyclable 3D printed α-Al2O3 catalyst for the multicomponent assembly of bioactive heterocycles
J. Azuaje, C. R. Tubio, L. Escalante, Mónica Gómez +5 more
201794 citations
Semantic Scholar
Structural Mapping of Adenosine Receptor Mutations: Ligand Binding and Signaling Mechanisms.
W. Jespers, Anke C. Schiedel, L. Heitman, R. Cooke +6 more
2018TIPS - Trends in Pharmacological Sciences73 citations Open access
Semantic Scholar
Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes.
Abdelaziz El Maatougui, J. Azuaje, M. González-Gómez, G. Miguez +6 more
2016Journal of Medicinal Chemistry73 citations Open access
Semantic Scholar
Polymer‐Supported 1,5,7‐Triazabicyclo[4.4.0]dec‐5‐ene as Polyvalent Ligands in the Copper‐Catalyzed Huisgen 1,3‐Dipolar Cycloaddition
Alberto Coelho, Paula M. Diz, Olga Caamaño, E. Sotelo
201069 citations
Semantic Scholar
Discovery of 3,4-Dihydropyrimidin-2(1H)-ones As a Novel Class of Potent and Selective A2B Adenosine Receptor Antagonists.
A. Crespo, Abdelaziz El Maatougui, Pierfrancesco Biagini, J. Azuaje +7 more
2013ACS Medicinal Chemistry Letters61 citations Open access
Semantic Scholar
Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists.
Vicente Yaziji, D. Rodríguez, H. Gutiérrez-de-Terán, Alberto Coelho +6 more
2011Journal of Medicinal Chemistry59 citations Open access
Semantic Scholar
Clinical validation of blood/brain glutamate grabbing in acute ischemic stroke
A. da Silva-Candal, Amparo Pérez-Díaz, María Santamaría, C. Correa-Paz +11 more
2018Annals of Neurology44 citations Open access
Semantic Scholar
3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition.
Maria Majellaro, W. Jespers, A. Crespo, M. J. Núñez +20 more
2020Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
A Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A2B Adenosine Receptor Antagonists.
Ana Mallo-Abreu, R. Prieto-Díaz, W. Jespers, J. Azuaje +8 more
2020Journal of Medicinal Chemistry33 citations Open access
Semantic Scholar
A2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models
A. Tay, Rubén Prieto-Díaz, Shiyong Neo, L. Tông +14 more
2022Journal for ImmunoTherapy of Cancer32 citations Open access
Semantic Scholar
X‐Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A2A Adenosine Receptor Antagonists
W. Jespers, G. Verdon, J. Azuaje, Maria Majellaro +12 more
2019Angewandte Chemie32 citations Open access
Semantic Scholar
Structure-Based Design of Potent and Selective Ligands at the Four Adenosine Receptors
W. Jespers, Ana Oliveira, R. Prieto-Díaz, Maria Majellaro +3 more
2017Molecules31 citations Open access
Semantic Scholar
Integrated Ugi-based assembly of functionally, skeletally, and stereochemically diverse 1,4-benzodiazepin-2-ones.
J. Azuaje, José M. Pérez-Rubio, Vicente Yaziji, Abdelaziz El Maatougui +6 more
2015Journal of Organic Chemistry31 citations Open access
Semantic Scholar
Structure-Based Rational Design of Adenosine Receptor Ligands.
H. Gutiérrez-de-Terán, Jessica Sallander, E. Sotelo
2016Current Topics in Medicinal Chemistry29 citations
Semantic Scholar
Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Abeta1-40 aggregation in vitro.
S. Cellamare, A. Stefanachi, D. Stolfa, Teodora Basile +5 more
2008Bioorganic & Medicinal Chemistry28 citations
Semantic Scholar
Enantiospecific Recognition at the A2B Adenosine Receptor by Alkyl 2-Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates.
Carlos Carbajales, J. Azuaje, Ana Oliveira, M. Loza +6 more
2017Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
8-Substituted-9-deazaxanthines as adenosine receptor ligands: design, synthesis and structure-affinity relationships at A2B.
A. Carotti, A. Stefanachi, E. Raviña, E. Sotelo +4 more
2004European journal of medicinal chemistry26 citations
Semantic Scholar
Multicomponent assembly of diverse pyrazin-2(1H)-one chemotypes.
J. Azuaje, Abdelaziz El Maatougui, José M. Pérez-Rubio, Alberto Coelho +2 more
2013Journal of Organic Chemistry24 citations
Semantic Scholar
1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor.
A. Stefanachi, J. Bréa, M. Cadavid, Nuria B. Centeno +10 more
2008Bioorganic & Medicinal Chemistry24 citations Open access
Semantic Scholar
Parallel regulation by olanzapine of the patterns of expression of 5-HT2A and D3 receptors in rat central nervous system and blood cells.
J. Padín, M. A. Rodríguez, E. Domínguez, Iria M. Gonzalez Dopeso-Reyes +8 more
2006Neuropharmacology24 citations
Semantic Scholar
Similarities and differences upon binditng of naturally occurring Δ9-tetrahydrocannabinol-derivatives to cannabinoid CB1 and CB2 receptors.
RaichIu Raïch, Rafael Rivas-Santisteban, Alejandro Lillo, Jaume Lillo +8 more
2021Pharmacological Research23 citations Open access
Semantic Scholar
Design, synthesis, and structure-activity relationships of a novel series of 5-alkylidenepyridazin-3(2H)-ones with a non-cAMP-based antiplatelet activity.
Alberto Coelho, E. Raviña, N. Fraiz, M. Yáñez +3 more
2007Journal of Medicinal Chemistry23 citations
Semantic Scholar
Ugi-based approaches to quinoxaline libraries.
J. Azuaje, Abdelaziz El Maatougui, X. García‐Mera, E. Sotelo
2014ACS Combinatorial Science21 citations
Semantic Scholar
Copper-catalyzed Huisgen 1,3-dipolar cycloaddition under oxidative conditions: polymer-assisted assembly of 4-acyl-1-substituted-1,2,3-triazoles.
Paula M. Diz, Alberto Coelho, Abdelaziz El Maatougui, J. Azuaje +3 more
2013Journal of Organic Chemistry21 citations
Semantic Scholar
The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling.
Martha E. Sommer, J. Selent, Jens Carlsson, C. de Graaf +12 more
2020ACS Pharmacology & Translational Science19 citations Open access
Semantic Scholar
Sol–gel entrapped Cu in a silica matrix: An efficient heterogeneous nanocatalyst for Huisgen and Ullmann intramolecular coupling reactions
Paula M. Diz, P. Pernas, Abdelaziz El Maatougui, C. R. Tubio +5 more
201519 citations
Semantic Scholar
Three-component assembly of structurally diverse 2-aminopyrimidine-5-carbonitriles.
Cristina Val, A. Crespo, Vicente Yaziji, Alberto Coelho +4 more
2013ACS Combinatorial Science18 citations
Semantic Scholar
Gemcitabine-Vitamin E Prodrug-Loaded Micelles for Pancreatic Cancer Therapy
Miguel Pereira-Silva, Darío Miranda-Pastoriza, Luis Díaz-Gómez, E. Sotelo +4 more
2024Pharmaceutics17 citations Open access
Semantic Scholar
Exploring the Effect of Halogenation in a Series of Potent and Selective A2B Adenosine Receptor Antagonists
Rubén Prieto-Díaz, M. González-Gómez, Hugo Fojo-Carballo, J. Azuaje +17 more
2022Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
Supported p-toluenesulfonic acid as a highly robust and eco-friendly isocyanide scavenger.
J. Azuaje, Alberto Coelho, Abdelaziz El Maatougui, J. Blanco +1 more
2011ACS Combinatorial Science17 citations
Semantic Scholar
Pyridazines part 41: synthesis, antiplatelet activity and SAR of 2,4,6-substituted 5-(3-oxo-3-phenylprop-1-en-1-yl)- or 5-(3-phenylprop-2-enoyl)pyridazin-3(2H)-ones.
A. Crespo, C. Meyers, Alberto Coelho, M. Yáñez +7 more
2006Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Pyridazine derivatives. Part 39: Reactivity of 5-iodopyridazin-3(2H)-ones in palladium-catalysed reactions
Alberto Coelho, E. Sotelo, H. Novoa, O. Peeters +2 more
200417 citations
Semantic Scholar
Pyridazine derivatives. Part 38: Efficient Heck alkenylation at position 5 of the 6-phenyl-3(2H)-pyridazinone system ☆
Alberto Coelho, E. Sotelo, H. Novoa, O. Peeters +2 more
200417 citations
Semantic Scholar
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase.
F. Intranuovo, Leonardo Brunetti, P. Delre, G. Mangiatordi +15 more
2022Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases
Leen Kalash, Cristina Val, J. Azuaje, M. Loza +8 more
2017Journal of Cheminformatics16 citations Open access
Semantic Scholar
Catalytic performance of a metal-free graphene oxide-Al2O3 composite assembled by 3D printing
J. Azuaje, Adrián Rama, Ana Mallo-Abreu, Mónica G. Boado +7 more
202115 citations
Semantic Scholar
Effect of Nitrogen Atom Substitution in A3 Adenosine Receptor Binding: N-(4,6-Diarylpyridin-2-yl)acetamides as Potent and Selective Antagonists.
J. Azuaje, W. Jespers, Vicente Yaziji, A. Mallo +8 more
2017Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Development of Fluorescent Probes that Target Serotonin 5-HT2B Receptors
J. Azuaje, P. López, A. Iglesias, Rocío A. de la Fuente +10 more
2017Scientific Reports15 citations Open access
Semantic Scholar
Pharmacological insights emerging from the characterization of a large collection of synthetic cannabinoid receptor agonists designer drugs.
Claudia Gioé-Gallo, Sandra Ortigueira, J. Brea, Iu Raïch +8 more
2023Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie14 citations Open access
Semantic Scholar
Synthesis, adenosine receptor binding and 3D-QSAR of 4-substituted 2-(2'-furyl)-1,2,4-triazolo[1,5-a]quinoxalines.
Ana Martínez, H. Gutiérrez-de-Terán, J. Bréa, E. Raviña +6 more
2008Bioorganic & Medicinal Chemistry14 citations Open access
Semantic Scholar
Trifluorinated Pyrimidine-Based A2B Antagonists: Optimization and Evidences of Stereospecific Recognition.
Ana Mallo-Abreu, Maria Majellaro, W. Jespers, J. Azuaje +6 more
2019Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar
Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold.
Vicente Yaziji, D. Rodríguez, Alberto Coelho, X. García‐Mera +6 more
2013European journal of medicinal chemistry12 citations Open access
Semantic Scholar
Silica-supported aluminum chloride-assisted solution phase synthesis of pyridazinone-based antiplatelet agents.
Abdelaziz El Maatougui, J. Azuaje, E. Sotelo, Olga Caamaño +1 more
2011ACS Combinatorial Science12 citations
Semantic Scholar
Discovery and preliminary SAR of 5-arylidene-2,2-dimethyl-1,3-dioxane- 4,6-diones as platelet aggregation inhibitors.
Abdelaziz El Maatougui, J. Azuaje, Alberto Coelho, E. Cano +5 more
2012Combinatorial chemistry & high throughput screening11 citations
Semantic Scholar
Click chemistry approach to assembly proline mimetic libraries containing 1,4-substituted 1,2,3-triazoles.
J. Rodríguez-Borges, S. Gonçalves, M. L. D. Do Vale, X. García‐Mera +2 more
2008Journal of combinatorial chemistry11 citations
Semantic Scholar
Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists
Cristina Val, C. Rodríguez-García, Rubén Prieto-Díaz, A. Crespo +13 more
2022Journal of Medicinal Chemistry10 citations Open access
Semantic Scholar
Potent and Subtype-Selective Dopamine D2 Receptor Biased Partial Agonists Discovered via an Ugi-Based Approach
Ana Mallo-Abreu, Irene Reyes-Resina, J. Azuaje, R. Franco +8 more
2021Journal of Medicinal Chemistry10 citations Open access
Semantic Scholar

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Alberto Coelho×19
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M. Loza×19
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X. García‐Mera×18
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H. Gutiérrez-de-Terán

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