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M. Umetani · SciRah

Researcher profile · Semantic Scholar

M. Umetani

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M. Umetani — researcher profile on SciRah

h-index: 29
Works: 69
Citations: 4,820

Most-cited papers

27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology
Erik R. Nelson, S. Wardell, Jeff S. Jasper, SungHee Park +9 more
2013Science798 citations Open access
Semantic Scholar
27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen
M. Umetani, H. Domoto, Andrew K. Gormley, I. Yuhanna +5 more
2007Nature Medicine389 citations
Semantic Scholar
27-Hydroxycholesterol Promotes Cell-autonomous ER-positive Breast Cancer Growth
Qian Wu, Tomonori Ishikawa, R. Sirianni, Hao Tang +10 more
2013Cell Reports329 citations Open access
Semantic Scholar
Sterol Intermediates from Cholesterol Biosynthetic Pathway as Liver X Receptor Ligands*
Chen-Dong Yang, J. McDonald, Amit N. Patel, Yuan Zhang +7 more
2006Journal of Biological Chemistry308 citations Open access
Semantic Scholar
Identification of a hormonal basis for gallbladder filling
Mihwa Choi, A. Moschetta, A. Bookout, Li Peng +8 more
2006Nature Medicine290 citations
Semantic Scholar
The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling.
Tingting Li, Sam R. Holmstrom, Serkan Kir, M. Umetani +3 more
2011Molecular Endocrinology250 citations Open access
Semantic Scholar
Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice.
K. Chambliss, Qian Wu, Sarah C. Oltmann, Eddy S. Konaniah +15 more
2010Journal of Clinical Investigation244 citations Open access
Semantic Scholar
27-hydroxycholesterol is an endogenous selective estrogen receptor modulator.
Carolyn D. DuSell, M. Umetani, P. Shaul, D. Mangelsdorf +1 more
2008Molecular Endocrinology233 citations Open access
Semantic Scholar
Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor
B. Goodwin, K. Gauthier, M. Umetani, M. Watson +6 more
2002Proceedings of the National Academy of Sciences of the United States of America205 citations Open access
Semantic Scholar
The Cholesterol Metabolite 27-Hydroxycholesterol Promotes Atherosclerosis via Proinflammatory Processes Mediated by Estrogen Receptor Alpha
M. Umetani, P. Ghosh, Tomonori Ishikawa, Junko Umetani +3 more
2014Cell Metabolism181 citations Open access
Semantic Scholar
Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA
Keiko Horiuchi, M. Umetani, T. Minami, H. Okayama +7 more
2006Proceedings of the National Academy of Sciences of the United States of America152 citations Open access
Semantic Scholar
The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors.
Erik R. Nelson, Carolyn D. DuSell, Xiaojuan Wang, Matthew K. Howe +7 more
2011Endocrinology122 citations Open access
Semantic Scholar
27-Hydroxycholesterol: the First Identified Endogenous SERM
M. Umetani, P. Shaul
2011Trends in endocrinology and metabolism122 citations Open access
Semantic Scholar
Non-nuclear Estrogen Receptor Signaling in the Endothelium*
Qian Wu, K. Chambliss, M. Umetani, C. Mineo +1 more
2011Journal of Biological Chemistry106 citations Open access
Semantic Scholar
The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis.
Carolyn D. DuSell, Erik R. Nelson, Xiaojuan Wang, J. Abdo +6 more
2010Endocrinology105 citations Open access
Semantic Scholar
Neutralizing Aptamers Block S/RBD‐ACE2 Interactions and Prevent Host Cell Infection
Xiaohui Liu, Yi-Ling Wang, Jacky Wu, J. Qi +16 more
2021Angewandte Chemie94 citations Open access
Semantic Scholar
Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells.
S. Morikawa, M. Umetani, S. Nakagawa, Hiroyuki Yamazaki +6 more
2000Journal of atherosclerosis and thrombosis75 citations Open access
Semantic Scholar
The Gene Expression Profile of Human Umbilical Vein Endothelial Cells Stimulated by Tumor Necrosis Factor a Using DNA Microarray Analysis
T. Murakami, C. Mataki, C. Nagao, M. Umetani +8 more
200071 citations Open access
Semantic Scholar
Function of GATA Transcription Factors in Induction of Endothelial Vascular Cell Adhesion Molecule-1 by Tumor Necrosis Factor-&agr;
M. Umetani, C. Mataki, N. Minegishi, Masayuki Yamamoto +2 more
2001Arteriosclerosis, Thrombosis and Vascular Biology65 citations Open access
Semantic Scholar
A novel cell adhesion inhibitor, K-7174, reduces the endothelial VCAM-1 induction by inflammatory cytokines, acting through the regulation of GATA.
M. Umetani, H. Nakao, T. Doi, Akio Iwasaki +5 more
2000Biochemical and Biophysical Research Communications - BBRC65 citations
Semantic Scholar
A comparison of gene expression in murine cardiac allografts and isografts by means DNA microarray analysis.
A. Saiura, C. Mataki, T. Murakami, M. Umetani +10 more
2001Transplantation61 citations Open access
Semantic Scholar
LXRβ/estrogen receptor-α signaling in lipid rafts preserves endothelial integrity.
Tomonori Ishikawa, I. Yuhanna, Junko Umetani, Wan-Ru Lee +3 more
2013Journal of Clinical Investigation53 citations Open access
Semantic Scholar
27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy.
Hideyuki Oguro, J. McDonald, Zhi-Yu Zhao, M. Umetani +2 more
2017Journal of Clinical Investigation49 citations Open access
Semantic Scholar
The gene expression profile of human umbilical vein endothelial cells stimulated by tumor necrosis factor alpha using DNA microarray analysis.
T. Murakami, C. Mataki, C. Nagao, M. Umetani +8 more
2000Journal of atherosclerosis and thrombosis40 citations
Semantic Scholar
Estrogen Receptor Beta-Mediated Modulation of Lung Cancer Cell Proliferation by 27-Hydroxycholesterol
Shiro Hiramitsu, Tomonori Ishikawa, Wan-Ru Lee, Tamor Khan +9 more
2018Frontiers in Endocrinology38 citations Open access
Semantic Scholar
The interaction between metabolism, cancer and cardiovascular disease, connected by 27-hydroxycholesterol
Wan-Ru Lee, Tomonori Ishikawa, M. Umetani
2014Clinical Lipidology38 citations Open access
Semantic Scholar
Obesity and Cancer: 27-Hydroxycholesterol, the Missing Link
Arvand Asghari, M. Umetani
2020International Journal of Molecular Sciences33 citations Open access
Semantic Scholar
Nonnuclear Estrogen Receptor Activation Improves Hepatic Steatosis in Female Mice.
K. Chambliss, Jose A. Barrera, M. Umetani, Junko Umetani +7 more
2016Endocrinology31 citations Open access
Semantic Scholar
Coupling of FcγRI to FcγRIIB by Src Kinase Mediates C-reactive Protein Impairment of Endothelial Function
N. Sundgren, Wei-Fei Zhu, I. Yuhanna, K. Chambliss +5 more
2011Circulation Research30 citations Open access
Semantic Scholar
An In Vitro Coculture Model of Transmigrant Monocytes and Foam Cell Formation
M. Takaku, Y. Wada, K. Jinnouchi, M. Takeya +12 more
199929 citations Open access
Semantic Scholar
Physical activity protects NLRP3 inflammasome‐associated coronary vascular dysfunction in obese mice
Jonghae Lee, Yang Lee, E. Lavoy, M. Umetani +2 more
2018Physiological Reports25 citations Open access
Semantic Scholar
An in vitro coculture model of transmigrant monocytes and foam cell formation.
M. Takaku, Y. Wada, Katsunori Jinnouchi, Motohiro Takeya +12 more
2000Arteriosclerosis, Thrombosis and Vascular Biology25 citations
Semantic Scholar
Contribution of Transcription Factor EB to AdipoRon-induced Inhibition of Arterial Smooth Muscle Cell Proliferation and Migration.
Yun-Ting Wang, Jiajie Chen, Xiang Li, M. Umetani +3 more
2019American Journal of Physiology - Cell Physiology24 citations Open access
Semantic Scholar
27-Hydroxycholesterol Promotes Adiposity and Mimics Adipogenic Diet-induced Inflammatory Signaling.
Arvand Asghari, Tomonori Ishikawa, Shiro Hiramitsu, Wan-Ru Lee +4 more
2019Endocrinology24 citations Open access
Semantic Scholar
27-Hydroxycholesterol regulates human SLC22A12 gene expression through estrogen receptor action
Masaya Matsubayashi, Yoshihiko M. Sakaguchi, Yoshiki Sahara, H. Nanaura +18 more
2020The FASEB Journal18 citations Open access
Semantic Scholar
Vascular Protection by Exercise in Obesity: Inflammasome-associated Mechanisms
Jonghae Lee, Junyoung Hong, M. Umetani, E. Lavoy +2 more
2020Medicine & Science in Sports & Exercise17 citations
Semantic Scholar
Tricyclic antidepressant amitriptyline inhibits autophagic flux and prevents tube formation in vascular endothelial cells
Ying-Chao Guan, Xiang Li, M. Umetani, Krishna M. Boini +2 more
2018Basic & Clinical Pharmacology & Toxicology16 citations Open access
Semantic Scholar
Re-adopting classical nuclear receptors by cholesterol metabolites
M. Umetani
2015Journal of Steroid Biochemistry and Molecular Biology16 citations Open access
Semantic Scholar
Neutralizing Aptamers Block S/RBD‐ACE2 Interactions and Prevent Host Cell Infection
Xiaohui Liu, Yi-Ling Wang, Jacky Wu, J. Qi +16 more
2021Angewandte Chemie13 citations Open access
Semantic Scholar
A novel zinc finger protein mRNA in human umbilical vein endothelial cells is profoundly induced by tumor necrosis factor alpha.
C. Mataki, T. Murakami, M. Umetani, Y. Wada +5 more
2000Journal of atherosclerosis and thrombosis13 citations Open access
Semantic Scholar
A novel group of genes that cause endocrine resistance in breast cancer identified by dynamic gene expression analysis
Arvand Asghari, Katherine Wall, M. Gill, Natascha Del Vecchio +7 more
2022OncoTarget8 citations Open access
Semantic Scholar
Gene expression dynamic analysis reveals co-activation of Sonic Hedgehog and epidermal growth factor followed by dynamic silencing
Vahed Maroufy, Pankil Shah, Arvand Asghari, N. Deng +6 more
2020OncoTarget4 citations Open access
Semantic Scholar
An Inhibitor of VCAM-1 Expression and Its Implication as a Novel Treatment of Inflammatory Diseases
H. Nakao, T. Doi, M. Suda, M. Umetani +3 more
19984 citations Open access
Semantic Scholar
A Novel Mouse Model to Analyze Non-Genomic ERα Physiological Actions.
Y. Arao, A. Gruzdev, Greg J Scott, Manas K. Ray +17 more
2022Journal of the Endocrine Society2 citations Open access
Semantic Scholar
Editorial: Cholesterol and Oxysterols as Signal Molecules in Human Pathophysiology and Cancer: Implications for New Therapeutic Strategies
R. Sirianni, M. Umetani, V. Pezzi
2019Frontiers in Endocrinology2 citations Open access
Semantic Scholar
Abstract 18427: 27-Hydroxycholesterol, the First Identified endogenous SERM, Promotes Atherogenesis in Mice
M. Umetani, D. Mangelsdorf, P. Shaul
20102 citations
Semantic Scholar
Affinity improvement of the high-affinity immunoglobulin E receptor by phage display.
A. Iwasaki, T. Doi, M. Umetani, Masanao Watanabe +3 more
2002Biochemical and Biophysical Research Communications - BBRC2 citations
Semantic Scholar
The relative induction of mRNA for HMGCoA and LDL receptor by five different HMGCoA reductase inhibitors in cultured human cells
S. Morikawa, M. Umetani, S. Nakagawa, H. Yamazaki +6 more
20002 citations
Semantic Scholar
Exercise‐mediated Wall Shear Stress Attenuates NLRP3 Inflammasome‐induced Endothelial Dysfunction in Obesity
Jonghae Lee, Junyoung Hong, M. Umetani, Aishwarya Juttu +1 more
2020The FASEB Journal1 citations
Semantic Scholar
Human URAT1/SLC22A12 gene promoter is regulated by 27-hydroxycholesterol through estrogen response elements
Masaya Matsubayashi, Yoshihiko M. Sakaguchi, Yoshiki Sahara, H. Nanaura +18 more
2019bioRxiv1 citations Open access
Semantic Scholar

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