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T. Willson · SciRah

Researcher profile · Semantic Scholar

T. Willson

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T. Willson — researcher profile on SciRah

h-index: 45
Works: 98
Citations: 14K

Most-cited papers

A family of cytokine-inducible inhibitors of signalling
R. Starr, T. Willson, E. Viney, Leecia J. L. Murray +7 more
1997Nature2,216 citations
Semantic Scholar
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells
R.Lindsay Williams, D. Hilton, S. Pease, T. Willson +6 more
1988Nature2,084 citations
Semantic Scholar
SOCS3 negatively regulates IL-6 signaling in vivo
B. Croker, D. Krebs, Jian-Guo Zhang, Sam Wormald +11 more
2003Nature Immunology918 citations
Semantic Scholar
Twenty proteins containing a C-terminal SOCS box form five structural classes.
D. Hilton, R. Richardson, W. Alexander, E. Viney +6 more
1998Proceedings of the National Academy of Sciences of the United States of America797 citations Open access
Semantic Scholar
Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells.
T. Gainsford, T. Willson, D. Metcalf, E. Handman +5 more
1996Proceedings of the National Academy of Sciences of the United States of America782 citations Open access
Semantic Scholar
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.
J.-G. Zhang, A. Farley, S. Nicholson, T. Willson +13 more
1999Proceedings of the National Academy of Sciences of the United States of America680 citations Open access
Semantic Scholar
Gigantism in mice lacking suppressor of cytokine signalling-2
D. Metcalf, C. Greenhalgh, E. Viney, T. Willson +4 more
2000Nature533 citations
Semantic Scholar
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130.
S. Nicholson, D. D. de Souza, L. Fabri, J. Corbin +10 more
2000Proceedings of the National Academy of Sciences of the United States of America508 citations Open access
Semantic Scholar
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.
R. Starr, D. Metcalf, A. Elefanty, M. Brysha +4 more
1998Proceedings of the National Academy of Sciences of the United States of America488 citations Open access
Semantic Scholar
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL‐6 signal transduction
S. Nicholson, T. Willson, A. Farley, R. Starr +6 more
1999EMBO Journal475 citations Open access
Semantic Scholar
Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor.
D. Hilton, Jian-Guo Zhang, D. Metcalf, W. Alexander +2 more
1996Proceedings of the National Academy of Sciences of the United States of America446 citations Open access
Semantic Scholar
ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity
Matthew D. Young, T. Willson, M. Wakefield, Evelyn Trounson +4 more
2011Nucleic Acids Research297 citations Open access
Semantic Scholar
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells
Stephen J. Loughran, E. Kruse, D. Hacking, C. D. de Graaf +9 more
2008Nature Immunology280 citations
Semantic Scholar
Cloning of a murine IL‐11 receptor alpha‐chain; requirement for gp130 for high affinity binding and signal transduction.
D. Hilton, Adrienne A. Hilton, A. Raicevic, S. Rakar +6 more
1994EMBO Journal271 citations Open access
Semantic Scholar
SOCS2 negatively regulates growth hormone action in vitro and in vivo.
C. Greenhalgh, Elizabeth Rico-Bautista, M. Lorentzon, Anne L Thaus +13 more
2005Journal of Clinical Investigation268 citations Open access
Semantic Scholar
Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling.
Marina R. Carpinelli, D. Hilton, Donald Metcalf, J. Antonchuk +9 more
2004Proceedings of the National Academy of Sciences of the United States of America196 citations Open access
Semantic Scholar
The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo
Jian-Guo Zhang, D. Metcalf, S. Rakar, Maria Asimakis +8 more
2001Proceedings of the National Academy of Sciences of the United States of America187 citations Open access
Semantic Scholar
Biological Evidence That SOCS-2 Can Act Either as an Enhancer or Suppressor of Growth Hormone Signaling*
C. Greenhalgh, D. Metcalf, Anne L Thaus, J. Corbin +11 more
2002Journal of Biological Chemistry183 citations Open access
Semantic Scholar
The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.
J. Babon, Edward J. Mcmanus, S. Yao, D. D. de Souza +8 more
2006Molecules and Cells179 citations Open access
Semantic Scholar
HBO1 is required for the maintenance of leukaemia stem cells
Laura MacPherson, Juliana Anokye, Miriam M. Yeung, E. Lam +44 more
2019Nature158 citations Open access
Semantic Scholar
Identification, Purification, and Characterization of a Soluble Interleukin (IL)-13-binding Protein
Jian-Guo Zhang, D. Hilton, T. Willson, Clare McFarlane +6 more
1997Journal of Biological Chemistry134 citations Open access
Semantic Scholar
Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction
W. S. Alexander, R. Starr, D. Metcalf, S. Nicholson +17 more
1999Journal of Leukocyte Biology132 citations
Semantic Scholar
ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification.
S. Taoudi, Thomas Bee, Adrienne A. Hilton, K. Knezevic +9 more
2011Genes & Development116 citations Open access
Semantic Scholar
Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia.
B. Kile, Athanasia D. Panopoulos, R. Stirzaker, D. Hacking +10 more
2007Blood115 citations Open access
Semantic Scholar
Leukemia Inhibitory Factor: A Novel Bone-Active Cytokine*
I. Reid, C. Lowe, J. Cornish, S. Skinner +4 more
1990104 citations
Semantic Scholar
The SPRY domain–containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation
Zhihe Kuang, Rowena S. Lewis, J. Curtis, Y. Zhan +11 more
2010Journal of Cell Biology103 citations Open access
Semantic Scholar
Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling.
S. Nicholson, D. Metcalf, N. Sprigg, Ruth Columbus +8 more
2005Proceedings of the National Academy of Sciences of the United States of America99 citations Open access
Semantic Scholar
Production of Leukemia Inhibitory Factor in Escherichia coli by a Novel Procedure and Its Use in Maintaining Embryonic Stem Cells in Culture
D. Gearing, N. Nicola, D. Metcalf, S. Foote +3 more
1989Nature Biotechnology92 citations
Semantic Scholar
The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4–binding residues
S. Masters, S. Yao, T. Willson, Jian-Guo Zhang +6 more
2006Nature Structural &Molecular Biology85 citations
Semantic Scholar
Suckling defect in mice lacking the soluble haemopoietin receptor NR6.
W. S. Alexander, S. Rakar, L. Robb, A. Farley +14 more
1999Current Biology80 citations Open access
Semantic Scholar
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
J. Hildebrand, Maria Kauppi, I. Majewski, Zi-Kou Liu +66 more
2020Nature Communications77 citations Open access
Semantic Scholar
Regulation of hematopoietic stem cells by their mature progeny
C. D. de Graaf, Maria Kauppi, T. Baldwin, Craig D. Hyland +6 more
2010Proceedings of the National Academy of Sciences of the United States of America75 citations Open access
Semantic Scholar
Development of hydrocephalus in mice lacking SOCS7.
D. Krebs, D. Metcalf, T. Merson, A. Voss +10 more
2004Proceedings of the National Academy of Sciences of the United States of America74 citations Open access
Semantic Scholar
The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo.
Kristy Boyle, P. Egan, S. Rakar, T. Willson +7 more
2007Blood71 citations Open access
Semantic Scholar
Leukemia inhibitory factor: a novel bone-active cytokine.
L. R. Reid, C. Lowe, J. Cornish, S. Skinner +4 more
1990Endocrinology70 citations
Semantic Scholar
Smchd1 Targeting to the Inactive X Is Dependent on the Xist-HnrnpK-PRC1 Pathway.
N. Jansz, T. Nesterova, A. Keniry, Megan Iminitoff +14 more
2018Cell Reports68 citations Open access
Semantic Scholar
TLR Regulation of SPSB1 Controls Inducible Nitric Oxide Synthase Induction
Rowena S. Lewis, T. B. Kolesnik, Zhihe Kuang, A. D’Cruz +6 more
2011Journal of Immunology59 citations Open access
Semantic Scholar
Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4.
B. Kile, E. Viney, T. Willson, T. Brodnicki +7 more
2000Gene56 citations
Semantic Scholar
Distinct Roles for Leukemia Inhibitory Factor Receptor α-Chain and gp130 in Cell Type-specific Signal Transduction*
R. Starr, U. Novak, T. Willson, M. Inglese +6 more
1997Journal of Biological Chemistry56 citations Open access
Semantic Scholar
Absence of Suppressor of Cytokine Signalling 3 Reduces Self‐Renewal and Promotes Differentiation in Murine Embryonic Stem Cells
A. Forrai, Kristy Boyle, Adam H. Hart, L. Hartley +7 more
2006Stem Cells55 citations
Semantic Scholar
An Erg-driven transcriptional program controls B cell lymphopoiesis
Ashley P Ng, H. Coughlan, S. Hediyeh-zadeh, K. Behrens +24 more
2020Nature Communications54 citations Open access
Semantic Scholar
Suppressor of Cytokine Signaling (SOCS) 5 Utilises Distinct Domains for Regulation of JAK1 and Interaction with the Adaptor Protein Shc-1
E. Linossi, I. Chandrashekaran, T. B. Kolesnik, James M. Murphy +8 more
2013PLoS ONE51 citations Open access
Semantic Scholar
Structural Analysis of the Gene Encoding the Murine Interleukin-11 Receptor α-Chain and a Related Locus*
L. Robb, D. Hilton, T. Willson, C. Begley
1996Journal of Biological Chemistry51 citations Open access
Semantic Scholar
Production of hematopoietic regulatory factors in cultures of adult and fetal mouse organs: measurement by specific bioassays.
D. Metcalf, T. Willson, D. Hilton, L. Di Rago +1 more
1995Leukemia51 citations
Semantic Scholar
Ankyrin Repeat and Suppressors of Cytokine Signaling Box Protein Asb-9 Targets Creatine Kinase B for Degradation*
M. Debrincat, Jian-Guo Zhang, T. Willson, J. Silke +6 more
2007Journal of Biological Chemistry50 citations Open access
Semantic Scholar
SPRY domain-containing SOCS box protein 2: crystal structure and residues critical for protein binding.
Zhihe Kuang, S. Yao, Yibin Xu, Rowena S. Lewis +7 more
2009Journal of Molecular Biology42 citations
Semantic Scholar
Negative regulation of cytokine signaling by the SOCS proteins.
N. Nicola, S. Nicholson, D. Metcalf, Jian-Guo Zhang +6 more
1999Cold Spring Harbor Symposia on Quantitative Biology38 citations
Semantic Scholar
Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome
Matthew T. Witkowski, Yifang Hu, K. Roberts, J. Boer +14 more
2017Journal of Experimental Medicine37 citations Open access
Semantic Scholar
Clonal multi-omics reveals Bcor as a negative regulator of emergency dendritic cell development.
L. Tian, S. Tomei, J. Schreuder, T. Weber +22 more
2021Immunity36 citations Open access
Semantic Scholar
Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia
Matthew T. Witkowski, L. Cimmino, Yifang Hu, Thomas Trimarchi +10 more
2015Leukemia35 citations Open access
Semantic Scholar

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M. Baca — researcher profile on SciRah

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B. Kile — researcher profile on SciRah

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S. Rakar — researcher profile on SciRah

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E. Viney — researcher profile on SciRah

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A. Farley — researcher profile on SciRah