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S. Pilkis · SciRah

Researcher profile · Semantic Scholar

S. Pilkis

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S. Pilkis — researcher profile on SciRah

h-index: 54
Works: 198
Citations: 9,734

Most-cited papers

Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis.
S. Pilkis, D. Granner
1992Annual Review of Physiology880 citations
Semantic Scholar
Hormonal regulation of hepatic gluconeogenesis and glycolysis.
S. Pilkis, M. el-Maghrabi, T. Claus
1988Annual Review of Biochemistry373 citations
Semantic Scholar
Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families
G. Velho, H. Blanché, M. Vaxillaire, C. Bellanné-Chantelot +11 more
1997Diabetologia273 citations Open access
Semantic Scholar
The genes of hepatic glucose metabolism.
D. Granner, S. Pilkis
1990Journal of Biological Chemistry260 citations Open access
Semantic Scholar
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme.
S. Pilkis, T. Claus, I. Kurland, A. Lange
1995Annual Review of Biochemistry256 citations
Semantic Scholar
Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus.
M. Stoffel, P. Froguel, J. Takeda, H. Zouali +6 more
1992Proceedings of the National Academy of Sciences of the United States of America233 citations Open access
Semantic Scholar
Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships.
M. Gidh-Jain, J. Takeda, Liang Z. Xu, A. Lange +16 more
1993Proceedings of the National Academy of Sciences of the United States of America219 citations Open access
Semantic Scholar
Regulation of Rat Liver Glucose-6-Phosphatase Gene Expression in Different Nutritional and Hormonal States: Gene Structure and 5′-Flanking Sequence
D. Argaud, Qing Zhang, W. Pan, S. Maitra +2 more
1996Diabetes177 citations
Semantic Scholar
The amino acid sequence of rat liver glucokinase deduced from cloned cDNA.
T. Andreone, R. Printz, S. Pilkis, M. Magnuson +1 more
1989Journal of Biological Chemistry131 citations
Semantic Scholar
Hepatic Gluconeogenesis/Glycolysis: Regulation and Structure/Function Relationships of Substrate Cycle Enzymes
S. Pilkis, T. Claus
1991129 citations
Semantic Scholar
Isolation of a cDNA for the catalytic subunit of rat liver glucose-6-phosphatase: regulation of gene expression in FAO hepatoma cells by insulin, dexamethasone and cAMP.
A. Lange, D. Argaud, M. el-Maghrabi, W. Pan +2 more
1994Biochemical and Biophysical Research Communications - BBRC125 citations
Semantic Scholar
Identification of Glucokinase Mutations in Subjects With Gestational Diabetes Mellitus
M. Stoffel, Katherine L Bell, Christine L. Blackburn, K. Powell +8 more
1993Diabetes114 citations Open access
Semantic Scholar
Glucokinase mutations, insulin secretion, and diabetes mellitus.
G. Bell, S. Pilkis, I. Weber, K. Polonsky
1996Annual Review of Physiology100 citations
Semantic Scholar
Studies on the regulation of yeast phosphofructo-1-kinase: its role in aerobic and anaerobic glycolysis.
D. Reibstein, J. den Hollander, S. Pilkis, R. Shulman
1986Biochemistry77 citations
Semantic Scholar
Human fructose-1,6-bisphosphatase gene (FBP1): exon-intron organization, localization to chromosome bands 9q22.2-q22.3, and mutation screening in subjects with fructose-1,6-bisphosphatase deficiency.
M. el-Maghrabi, A. Lange, Wei Jiang, K. Yamagata +7 more
1995Genomics72 citations Open access
Semantic Scholar
Glucokinase: structural analysis of a protein involved in susceptibility to diabetes.
S. Pilkis, I. Weber, R. Harrison, Graeme I. Bell
1994Journal of Biological Chemistry72 citations Open access
Semantic Scholar
Induction of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase mRNA by refeeding and insulin.
Ann D. Colosia, A. Marker, A. Lange, M. el-Maghrabi +4 more
1988Journal of Biological Chemistry72 citations Open access
Semantic Scholar
Evolution of a bifunctional enzyme: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
J. Bazan, R. Fletterick, S. Pilkis
1989Proceedings of the National Academy of Sciences of the United States of America71 citations Open access
Semantic Scholar
The allosteric site of human liver fructose-1,6-bisphosphatase. Analysis of six AMP site mutants based on the crystal structure.
M. Gidh-Jain, Y. Zhang, P. Vanpoelje, J.-Y. Liang +6 more
1995Journal of Biological Chemistry68 citations
Semantic Scholar
Isolation of a human liver fructose-1,6-bisphosphatase cDNA and expression of the protein in Escherichia coli. Role of ASP-118 and ASP-121 in catalysis.
M. el-Maghrabi, M. Gidh-Jain, L. R. Austin, S. Pilkis
1993Journal of Biological Chemistry61 citations Open access
Semantic Scholar
Compensation in Pancreatic β-Cell Function in Subjects With Glucokinase Mutations
J. Sturis, I. Kurland, M. Byrne, E. Mosekilde +4 more
1994Diabetes60 citations
Semantic Scholar
Rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Properties of phospho- and dephospho- forms and of two mutants in which Ser32 has been changed by site-directed mutagenesis.
I. Kurland, M. el-Maghrabi, J. Correia, S. Pilkis
1992Journal of Biological Chemistry59 citations Open access
Semantic Scholar
cDNA sequence of rat liver fructose-1,6-bisphosphatase and evidence for down-regulation of its mRNA by insulin.
M. el-Maghrabi, J. Pilkis, A. Marker, A. Colosia +3 more
1988Proceedings of the National Academy of Sciences of the United States of America58 citations Open access
Semantic Scholar
Fructose-2,6-Bisphosphate in Control of Hepatic Gluconeogenesis: From Metabolites to Molecular Genetics
S. Pilkis, M. el-Maghrabi, T. Claus
1990Diabetes Care57 citations
Semantic Scholar
Hepatic gluconeogenesis/glycolysis: regulation and structure/function relationships of substrate cycle enzymes.
S. Pilkis, T. Claus
1991Annual review of nutrition56 citations
Semantic Scholar
The rat fructose-1,6-bisphosphatase gene. Structure and regulation of expression.
M. el-Maghrabi, A. Lange, L. Kümmel, S. Pilkis
1991Journal of Biological Chemistry55 citations Open access
Semantic Scholar
Human beta-cell glucokinase. Dual role of Ser-151 in catalysis and hexose affinity.
Liang Z. Xu, R. Harrison, I. Weber, S. Pilkis
1995Journal of Biological Chemistry52 citations Open access
Semantic Scholar
Hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Use of site-directed mutagenesis to evaluate the roles of His-258 and His-392 in catalysis.
A. Tauler, K. Lin, S. Pilkis
1990Journal of Biological Chemistry52 citations
Semantic Scholar
Sugar specificity of human beta-cell glucokinase: correlation of molecular models with kinetic measurements.
Liang Z. Xu, I. Weber, R. Harrison, M. Gidh-Jain +1 more
1995Biochemistry48 citations
Semantic Scholar
The role of cyclic AMP in rapid and long-term regulation of gluconeogenesis and glycolysis.
S. Pilkis, T. Claus, M. el-Maghrabi
1988Advances in second messenger and phosphoprotein research48 citations
Semantic Scholar
Complete amino acid sequence of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
Mark O. Lively, M. el-Maghrabi, J. Pilkis, G. D'Angelo +4 more
1988Journal of Biological Chemistry48 citations Open access
Semantic Scholar
Covalent control of 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase: Insights into autoregulation of a bifunctional enzyme
I. Kurland, S. Pilkis
1995Protein Science47 citations Open access
Semantic Scholar
Carbon metabolism in leaves of transgenic tobacco (Nicotiana tabacum L.) containing elevated fructose 2,6-bisphosphate levels.
Peter Scott, Alex J. Lange, S. Pilkis, Nicholas J. Kruger
1995The Plant Journal45 citations Open access
Semantic Scholar
Crystal structure of the rat liver fructose-2,6-bisphosphatase based on selenomethionine multiwavelength anomalous dispersion phases.
Y. Lee, C. Ogata, J. Pflugrath, David G. Levitt +3 more
1996Biochemistry44 citations
Semantic Scholar
Molecular Model of Human β-Cell Glucokinase Built by Analogy to the Crystal Structure of Yeast Hexokinase B
Robert St Charles, R. Harrison, G. Bell, S. Pilkis +1 more
1994Diabetes44 citations
Semantic Scholar
Indirect versus direct routes of hepatic glycogen synthesis 1
I. Kurland, S. Pilkis
1989The FASEB Journal41 citations
Semantic Scholar
Adenovirus-mediated Overexpression of Liver 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase in Gluconeogenic Rat Hepatoma Cells
Doriane Argaud, A. Lange, Thomas C. Becker, D. Okar +3 more
1995Journal of Biological Chemistry38 citations Open access
Semantic Scholar
Cloning and sequencing of a cDNA encoding 2,3-bisphosphoglycerate-independent phosphoglycerate mutase from maize. Possible relationship to the alkaline phosphatase family.
Xavier Graña, L. de Lecea, M. el-Maghrabi, Jesús M. Ureña +5 more
1992Journal of Biological Chemistry38 citations Open access
Semantic Scholar
Erratum: Human glucokinase gene: Isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin- dependent (type 2) diabetes mellitus (Proc. Natl. Acad. Sci. USA (August 15, 1992) 89 (7698-7702))
M. Stoffel, P. Froguel, J. Takeda, H. Zouali +13 more
199231 citations
Semantic Scholar
Bovine brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Evidence for a neural-specific isozyme.
F. Ventura, J. L. Rosa, Santiago Ambrosio, S. Pilkis +1 more
1992Journal of Biological Chemistry31 citations Open access
Semantic Scholar
Site-directed mutagenesis studies on the determinants of sugar specificity and cooperative behavior of human beta-cell glucokinase.
Liang Z. Xu, Wen Zhang, I. T. Weber, Robert W. Harrison +1 more
1994Journal of Biological Chemistry30 citations Open access
Semantic Scholar
Regulation of gene expression of rat skeletal muscle/liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Isolation and characterization of a glucocorticoid response element in the first intron of the gene.
A. Lange, Carme Espinet, R. Hall, M. el-Maghrabi +4 more
1992Journal of Biological Chemistry30 citations Open access
Semantic Scholar
Glu327 is part of a catalytic triad in rat liver fructose-2,6-bisphosphatase.
K. Lin, Lin Li, J. Correia, S. Pilkis
1992Journal of Biological Chemistry29 citations Open access
Semantic Scholar
1 Enzymes of the Fructose 6-Phosphate-Fructose 1, 6-Bisphosphate Substrate Cycle
S. Pilkis, T. Claus, P. D. Kountz, M. el-Maghrabi
198729 citations
Semantic Scholar
Cloning and expression of a catalytic core bovine brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
F. Ventura, Santiago Ambrosio, R. Bartrons, M. el-Maghrabi +2 more
1995Biochemical and Biophysical Research Communications - BBRC27 citations
Semantic Scholar
Active site sequence of hepatic fructose-2,6-bisphosphatase. Homology in primary structure with phosphoglycerate mutase.
S. Pilkis, Mark O. Lively, M. el-Maghrabi
1987Journal of Biological Chemistry27 citations Open access
Semantic Scholar
Expression and site-directed mutagenesis of hepatic glucokinase.
A. Lange, Liang Z. Xu, F. van Poelwijk, Kai Lin +2 more
1991Biochemical Journal26 citations Open access
Semantic Scholar
Mutations of the human glucokinase gene and diabetes mellitus.
Graeme I. Bell, P. Froguel, S. Nishi, S. Pilkis +4 more
1993Trends in endocrinology and metabolism25 citations
Semantic Scholar
Arg-257 and Arg-307 of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase bind the C-2 phospho group of fructose-2,6-bisphosphate in the fructose-2,6-bisphosphatase domain.
K. Lin, Lin Li, J. Correia, S. Pilkis
1992Journal of Biological Chemistry25 citations Open access
Semantic Scholar
Isolation of a cDNA clone for rat liver 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase.
Ann D. Colosia, Mark Lively, M. el-Maghrabi, S. Pilkis
1987Biochemical and Biophysical Research Communications - BBRC24 citations
Semantic Scholar

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A. Lange×11
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