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Xi-Qin Ding · SciRah

Researcher profile · Semantic Scholar

Xi-Qin Ding

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Xi-Qin Ding — researcher profile on SciRah

h-index: 26
Works: 93
Citations: 1,989

Most-cited papers

Expression of cone-photoreceptor-specific antigens in a cell line derived from retinal tumors in transgenic mice.
Elaine Tan, Xi-Qin Ding, Anisse Saadi, N. Agarwal +2 more
2004Investigative Ophthalmology and Visual Science338 citations Open access
Semantic Scholar
The R172W mutation in peripherin/rds causes a cone-rod dystrophy in transgenic mice.
Xi-Qin Ding, M. Nour, L. M. Ritter, A. Goldberg +2 more
2004Human Molecular Genetics105 citations
Semantic Scholar
Ocular Delivery of Compacted DNA-Nanoparticles Does Not Elicit Toxicity in the Mouse Retina
Xi-Qin Ding, A. Quiambao, J. Fitzgerald, M. Cooper +2 more
2009PLoS ONE80 citations Open access
Semantic Scholar
Comparative mechanistic study of RPE cell death induced by different oxidative stresses
Yao Tong, Yin-Ga Wu, Jing Ma, M. Ikeda +4 more
2023Redox Biology79 citations Open access
Semantic Scholar
The Cys214-->Ser mutation in peripherin/rds causes a loss-of-function phenotype in transgenic mice.
Heidi M. Stricker, Xi-Qin Ding, A. Quiambao, S. Fliesler +1 more
2005Biochemical Journal79 citations Open access
Semantic Scholar
Impaired cone function and cone degeneration resulting from CNGB3 deficiency: down-regulation of CNGA3 biosynthesis as a potential mechanism.
Xi-Qin Ding, C. S. Harry, Y. Umino, A. V. Matveev +2 more
2009Human Molecular Genetics78 citations Open access
Semantic Scholar
Modulating expression of peripherin/rds in transgenic mice: critical levels and the effect of overexpression.
M. Nour, Xi-Qin Ding, Heidi M. Stricker, S. Fliesler +1 more
2004Investigative Ophthalmology and Visual Science72 citations Open access
Semantic Scholar
cGMP Accumulation Causes Photoreceptor Degeneration in CNG Channel Deficiency: Evidence of cGMP Cytotoxicity Independently of Enhanced CNG Channel Function
Jian-Hua Xu, Lynsie Morris, Arjun Thapa, Hong-Wei Ma +6 more
2013Journal of Neuroscience69 citations Open access
Semantic Scholar
Suppressing thyroid hormone signaling preserves cone photoreceptors in mouse models of retinal degeneration
Hong-Wei Ma, Arjun Thapa, Lynsie Morris, T Michael Redmond +2 more
2014Proceedings of the National Academy of Sciences of the United States of America64 citations Open access
Semantic Scholar
Differential requirements for retinal degeneration slow intermolecular disulfide-linked oligomerization in rods versus cones.
D. Chakraborty, Xi-Qin Ding, Shannon M. Conley, S. Fliesler +1 more
2009Human Molecular Genetics62 citations Open access
Semantic Scholar
Endoplasmic Reticulum Stress-associated Cone Photoreceptor Degeneration in Cyclic Nucleotide-gated Channel Deficiency*
Arjun Thapa, Lynsie Morris, Jian-Hua Xu, Hong-Wei Ma +3 more
2012Journal of Biological Chemistry54 citations Open access
Semantic Scholar
Inhibition of thyroid hormone signaling protects retinal pigment epithelium and photoreceptors from cell death in a mouse model of age-related macular degeneration
Hong-Wei Ma, Fan Yang, Xi-Qin Ding
2020Cell Death and Disease51 citations Open access
Semantic Scholar
Role of the second intradiscal loop of peripherin/rds in homo and hetero associations.
Xi-Qin Ding, Heidi M. Stricker, M. Naash
2005Biochemistry50 citations Open access
Semantic Scholar
Outer segment oligomerization of Rds: evidence from mouse models and subcellular fractionation.
D. Chakraborty, Xi-Qin Ding, S. Fliesler, M. Naash
2008Biochemistry49 citations Open access
Semantic Scholar
Native Cone Photoreceptor Cyclic Nucleotide-Gated Channel Is A Heterotetrameric Complex Comprising both CNGA3 and CNGB3: A Study Using the Cone-Dominant Retina of Nrl−/− Mice
A. V. Matveev, A. Quiambao, J. Fitzgerald, Xi-Qin Ding
2008Journal of Neurochemistry47 citations Open access
Semantic Scholar
Early-onset, slow progression of cone photoreceptor dysfunction and degeneration in CNG channel subunit CNGB3 deficiency.
Jian-Hua Xu, Lynsie Morris, S. Fliesler, D. M. Sherry +1 more
2011Investigative Ophthalmology and Visual Science42 citations Open access
Semantic Scholar
cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice*
Hong-Wei Ma, Michael R. Butler, Arjun Thapa, Josh Belcher +5 more
2015Journal of Biological Chemistry40 citations Open access
Semantic Scholar
Gene Therapy Fully Restores Vision to the All-Cone Nrl−/−Gucy2e−/− Mouse Model of Leber Congenital Amaurosis-1
Sanford L. Boye, James J. Peterson, S. Choudhury, Seok-Hong Min +9 more
2015Human Gene Therapy39 citations Open access
Semantic Scholar
Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel–associated retinopathy
Markus Burkard, S. Kohl, T. Krätzig, N. Tanimoto +30 more
2018Journal of Clinical Investigation36 citations Open access
Semantic Scholar
Retinal abnormalities associated with the G90D mutation in opsin
M. Naash, Ting-huai Wu, D. Chakraborty, S. Fliesler +7 more
2004The Journal of comparative neurology33 citations
Semantic Scholar
Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency
Michael R. Butler, Hong-Wei Ma, Fan Yang, Josh Belcher +7 more
2017Journal of Biological Chemistry31 citations Open access
Semantic Scholar
Loss of cone cyclic nucleotide-gated channel leads to alterations in light response modulating system and cellular stress response pathways: a gene expression profiling study.
Hong-Wei Ma, Arjun Thapa, Lynsie Morris, S. Michalakis +4 more
2013Human Molecular Genetics29 citations Open access
Semantic Scholar
CNGA3 deficiency affects cone synaptic terminal structure and function and leads to secondary rod dysfunction and degeneration.
Jian-Hua Xu, Lynsie Morris, S. Michalakis, M. Biel +3 more
2012Investigative Ophthalmology and Visual Science29 citations Open access
Semantic Scholar
Cones Respond to Light in the Absence of Transducin β Subunit
S. Nikonov, A. Lyubarsky, Marie E. Fina, E. S. Nikonova +7 more
2013Journal of Neuroscience27 citations Open access
Semantic Scholar
cGMP Signaling in Photoreceptor Degeneration
Shujuan Li, Hong-Wei Ma, Fan Yang, Xi-Qin Ding
2023International Journal of Molecular Sciences26 citations Open access
Semantic Scholar
Thyroid Hormone Signaling in Retinal Development, Survival, and Disease.
Fan Yang, Hong-Wei Ma, Xi-Qin Ding
2018Vitamins and hormones26 citations
Semantic Scholar
Vitreal delivery of AAV vectored Cnga3 restores cone function in CNGA3-/-/Nrl-/- mice, an all-cone model of CNGA3 achromatopsia.
W. Du, Ye Tao, Wen-Tao Deng, Ping Zhu +14 more
2015Human Molecular Genetics26 citations Open access
Semantic Scholar
Targeting iodothyronine deiodinases locally in the retina is a therapeutic strategy for retinal degeneration
Fan Yang, Hong-Wei Ma, Josh Belcher, Michael R. Butler +4 more
2016The FASEB Journal24 citations Open access
Semantic Scholar
Deficiency of thyroid hormone receptor protects retinal pigment epithelium and photoreceptors from cell death in a mouse model of age-related macular degeneration
Hong-Wei Ma, Fan Yang, Xi-Qin Ding
2022Cell Death and Disease23 citations Open access
Semantic Scholar
Functional activity of photoreceptor cyclic nucleotide-gated channels is dependent on the integrity of cholesterol- and sphingolipid-enriched membrane domains.
Xi-Qin Ding, J. Fitzgerald, A. V. Matveev, Mark E. McClellan +1 more
2008Biochemistry22 citations
Semantic Scholar
The Disease-Causing Mutations in the Carboxyl-Terminus of Cone Cyclic Nucleotide-Gated Channel CNGA3 Subunit Alter the Local Secondary Structure and Interfere with the Channel Active Conformational Change
A. V. Matveev, J. Fitzgerald, Jian-Hua Xu, A. Malykhina +2 more
2010Biochemistry20 citations Open access
Semantic Scholar
Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration
Hong-Wei Ma, Fan Yang, Michael R. Butler, Josh Belcher +4 more
2017The FASEB Journal19 citations Open access
Semantic Scholar
Deficiency of type 2 iodo‐ thyronine deiodinase reduces necroptosis activity and oxidative stress responses in retinas of Leber congenital amaurosis model mice
Fan Yang, Hong-Wei Ma, Michael R. Butler, Xi-Qin Ding
2018The FASEB Journal17 citations Open access
Semantic Scholar
Potential Contribution of Ryanodine Receptor 2 Upregulation to cGMP/PKG Signaling-induced Cone Degeneration in Cyclic Nucleotide-gated Channel Deficiency
Fan Yang, Hong-Wei Ma, Michael R. Butler, Xi-Qin Ding
2020The FASEB Journal16 citations Open access
Semantic Scholar
Biochemical Characterization of Cone Cyclic Nucleotide-gated (CNG) Channel Using the Infrared Fluorescence Detection System
Xi-Qin Ding, A. V. Matveev, Anil Singh, N. Komori +1 more
2012Advances in Experimental Medicine and Biology16 citations Open access
Semantic Scholar
Molecular characterization of the skate peripherin/rds gene: relationship to its orthologues and paralogues.
Chibo Li, Xi-Qin Ding, J. O'Brien, M. Al-Ubaidi +1 more
2003Investigative Ophthalmology and Visual Science16 citations Open access
Semantic Scholar
Molecular Pathogenesis of Achromatopsia Associated with Mutations in the Cone Cyclic Nucleotide-Gated Channel CNGA3 Subunit
Xi-Qin Ding, J. Fitzgerald, A. Quiambao, C. S. Harry +1 more
2010Advances in Experimental Medicine and Biology14 citations Open access
Semantic Scholar
Excessive Thyroid Hormone Signaling Induces Photoreceptor Degeneration in Mice
Hong-Wei Ma, Fan Yang, Lilliana R. York, Shujuan Li +1 more
2023eNeuro13 citations Open access
Semantic Scholar
Functional expression of cone cyclic nucleotide-gated channel in cone photoreceptor-derived 661W cells.
J. Fitzgerald, A. Malykhina, M. Al-Ubaidi, Xi-Qin Ding
2008Advances in Experimental Medicine and Biology13 citations
Semantic Scholar
Ryanodine Receptor 2 Contributes to Impaired Protein Localization in Cyclic Nucleotide-Gated Channel Deficiency
Hong-Wei Ma, Fan Yang, Michael R. Butler, Jacob Rapp +2 more
2019eNeuro12 citations Open access
Semantic Scholar
Thyroid Hormone Signaling and Cone Photoreceptor Viability.
Hong-Wei Ma, Xi-Qin Ding
2016Advances in Experimental Medicine and Biology12 citations
Semantic Scholar
The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the Cnga3-Deficient Mouse Model of Achromatopsia
M. Koch, Constanze Scheel, Hong-Wei Ma, Fan Yang +8 more
2020International Journal of Molecular Sciences11 citations Open access
Semantic Scholar
RDS in Cones Does Not Interact with the Beta Subunit of the Cyclic Nucleotide Gated Channel
Shannon M. Conley, Xi-Qin Ding, M. Naash
2010Advances in Experimental Medicine and Biology10 citations Open access
Semantic Scholar
Detection of cGMP in the degenerating retina.
S. Michalakis, Jian-Hua Xu, M. Biel, Xi-Qin Ding
2013Methods in molecular biology8 citations
Semantic Scholar
Overexpression of Type 3 Iodothyronine Deiodinase Reduces Cone Death in the Leber Congenital Amaurosis Model Mice.
Fan Yang, Hong-Wei Ma, Sanford L. Boye, W. Hauswirth +1 more
2018Advances in Experimental Medicine and Biology7 citations
Semantic Scholar
Overexpression of ROM-1 in the cone-dominant retina.
D. Chakraborty, Shannon M. Conley, Zack A. Nash, Xi-Qin Ding +1 more
2012Advances in Experimental Medicine and Biology7 citations
Semantic Scholar
Transgenic animal studies of human retinal disease caused by mutations in peripherin/rds.
Xi-Qin Ding, M. Naash
2006Advances in Experimental Medicine and Biology7 citations Open access
Semantic Scholar
Promotion of endoplasmic reticulum retrotranslocation by overexpression of E3 ubiquitin-protein ligase synoviolin 1 reduces endoplasmic reticulum stress and preserves cone photoreceptors in cyclic nucleotide-gated channel deficiency
Fan Yang, Hong-Wei Ma, Sanford L. Boye, Shannon E. Boye +1 more
2024The FASEB Journal6 citations
Semantic Scholar
Preservation of endoplasmic reticulum (ER) Ca2+ stores by deletion of inositol-1,4,5-trisphosphate receptor type 1 promotes ER retrotranslocation, proteostasis and protein outer segment localization in cyclic nucleotide-gated channel-deficient cone photoreceptors
Fan Yang, Hong-Wei Ma, Michael R. Butler, Xi-Qin Ding
2021The FASEB Journal5 citations Open access
Semantic Scholar
Erratum: Retinal abnormalities associated with the G90D mutation in opsin (The Journal of Comparative Neurology (2004) 478 (149-163))
M. Naash, T.-H. Wu, D. Chakraborty, S. Fliesler +7 more
20045 citations Open access
Semantic Scholar

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