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Wen-Wen Huang · SciRah

Researcher profile · Semantic Scholar

Wen-Wen Huang

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Wen-Wen Huang — researcher profile on SciRah

h-index: 27
Works: 69
Citations: 2,251

Most-cited papers

Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells.
Wen-Wen Huang, Yu-Jen Chiu, Ming-Jen Fan, Hsu-Feng Lu +5 more
2010Molecular Nutrition & Food Research176 citations
Semantic Scholar
Kaempferol induces autophagy through AMPK and AKT signaling molecules and causes G2/M arrest via downregulation of CDK1/cyclin B in SK-HEP-1 human hepatic cancer cells.
Wen-Wen Huang, S. Tsai, Shu-Fen Peng, Meng-Wei Lin +5 more
2013International Journal of Oncology147 citations Open access
Semantic Scholar
Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways.
Wen-Wen Huang, Shih-Wei Ko, H. Tsai, Jing-Gung Chung +6 more
2011International Journal of Oncology125 citations Open access
Semantic Scholar
Kaempferol suppresses cell metastasis via inhibition of the ERK-p38-JNK and AP-1 signaling pathways in U-2 OS human osteosarcoma cells.
Hui-Jye Chen, Chung-Ming Lin, Chao-Ying Lee, Nai-Chen Shih +5 more
2013Oncology Report124 citations Open access
Semantic Scholar
MJ-29 Inhibits Tubulin Polymerization, Induces Mitotic Arrest, and Triggers Apoptosis via Cyclin-Dependent Kinase 1-Mediated Bcl-2 Phosphorylation in Human Leukemia U937 Cells
Jai-Sing Yang, Mann J. Hour, Wen-Wen Huang, K. Lin +2 more
2010Journal of Pharmacology and Experimental Therapeutics97 citations
Semantic Scholar
Rhein induced apoptosis through the endoplasmic reticulum stress, caspase- and mitochondria-dependent pathways in SCC-4 human tongue squamous cancer cells.
Wan-Wen Lai, Jai-Sing Yang, Kuang-Chi Lai, Chao-Lin Kuo +8 more
2009In Vivo85 citations
Semantic Scholar
Bufalin increases sensitivity to AKT/mTOR-induced autophagic cell death in SK-HEP-1 human hepatocellular carcinoma cells.
S. Tsai, Jai-Sing Yang, Shu-Fen Peng, Chi-Cheng Lu +9 more
2012International Journal of Oncology84 citations Open access
Semantic Scholar
(-)-Epigallocatechin gallate induced apoptosis in human adrenal cancer NCI-H295 cells through caspase-dependent and caspase-independent pathway.
Ping-Ping Wu, S. Kuo, Wen-Wen Huang, Jai-Sing Yang +6 more
2009Anticancer Research73 citations
Semantic Scholar
Cucurbitacin E Induces G2/M Phase Arrest through STAT3/p53/p21 Signaling and Provokes Apoptosis via Fas/CD95 and Mitochondria-Dependent Pathways in Human Bladder Cancer T24 Cells
Wen-Wen Huang, Jai-Sing Yang, Meng-Wei Lin, Po-Yuan Chen +7 more
2012Evidence-Based Complementary and Alternative Medicine72 citations Open access
Semantic Scholar
Diallyl disulfide inhibits WEHI-3 leukemia cells in vivo.
Jai-Sing Yang, Lai-Fong Kok, Yu-Hsuan Lin, Tzu-Ching Kuo +6 more
2006Anticancer Research71 citations
Semantic Scholar
Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling pathway.
Chao-Ying Lee, Yu Chien, Tai-Hui Chiu, Wen-Wen Huang +3 more
2012Oncology Report69 citations Open access
Semantic Scholar
Novel Quinazolinone MJ-29 Triggers Endoplasmic Reticulum Stress and Intrinsic Apoptosis in Murine Leukemia WEHI-3 Cells and Inhibits Leukemic Mice
Chi-Cheng Lu, Jai-Sing Yang, Jo-Hua Chiang, Mann J. Hour +6 more
2012PLoS ONE69 citations Open access
Semantic Scholar
ERK-modulated intrinsic signaling and G(2)/M phase arrest contribute to the induction of apoptotic death by allyl isothiocyanate in MDA-MB-468 human breast adenocarcinoma cells.
S. Tsai, Wen-Wen Huang, Wei-Chien Huang, Chi-Cheng Lu +7 more
2012International Journal of Oncology69 citations Open access
Semantic Scholar
AKT serine/threonine protein kinase modulates baicalin-triggered autophagy in human bladder cancer T24 cells.
Chin-Fen Lin, S. Tsai, Michael T. Tseng, Shu-Fen Peng +8 more
2013International Journal of Oncology68 citations Open access
Semantic Scholar
Triptolide induces apoptosis in human adrenal cancer NCI-H295 cells through a mitochondrial-dependent pathway.
Ping-Ping Wu, Kuo-Ching Liu, Wen-Wen Huang, Chia‐Yu Ma +3 more
2011Oncology Report64 citations Open access
Semantic Scholar
Bufalin induces G0/G1 phase arrest through inhibiting the levels of cyclin D, cyclin E, CDK2 and CDK4, and triggers apoptosis via mitochondrial signaling pathway in T24 human bladder cancer cells.
Wen-Wen Huang, Jai-Sing Yang, S. Pai, Ping-Ping Wu +9 more
2012Mutation research63 citations
Semantic Scholar
Pycnogenol induces differentiation and apoptosis in human promyeloid leukemia HL-60 cells.
Wen-Wen Huang, Jai-Sing Yang, Chin-Fen Lin, W. Ho +1 more
2005Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis48 citations
Semantic Scholar
Diallyl trisulfide (DATS) inhibits mouse colon tumor in mouse CT-26 cells allograft model in vivo.
Ping-Ping Wu, Kuo-Ching Liu, Wen-Wen Huang, F. Chueh +6 more
2011Phytomedicine47 citations
Semantic Scholar
Combinational treatment of all-trans retinoic acid (ATRA) and bisdemethoxycurcumin (BDMC)-induced apoptosis in liver cancer Hep3B cells.
Ting-Yi Huang, Shu-Fen Peng, Yi-Ping Huang, Chang-Hai Tsai +8 more
2019Journal of food biochemistry46 citations Open access
Semantic Scholar
Lupeol suppresses migration and invasion via p38/MAPK and PI3K/Akt signaling pathways in human osteosarcoma U-2 OS cells
Ming-Jie Hsu, Shu-Fen Peng, F. Chueh, Chang-Hai Tsai +7 more
2019Bioscience, biotechnology and biochemistry43 citations
Semantic Scholar
Berberine Inhibits Human Melanoma A375.S2 Cell Migration and Invasion via Affecting the FAK, uPA, and NF-κB Signaling Pathways and Inhibits PLX4032 Resistant A375.S2 Cell Migration In Vitro
Jia-Fan Liu, Kuang-Chi Lai, Shu-Fen Peng, Pornsuda Maraming +5 more
2018Molecules43 citations Open access
Semantic Scholar
Emodin Induces Apoptotic Death in Murine Myelomonocytic Leukemia WEHI-3 Cells In Vitro and Enhances Phagocytosis in Leukemia Mice In Vivo
Yuan Chang, T. Lai, Chun-Shu Yu, Hung-Yi Chen +7 more
2011Evidence-Based Complementary and Alternative Medicine42 citations Open access
Semantic Scholar
Activations of Both Extrinsic and Intrinsic Pathways in HCT 116 Human Colorectal Cancer Cells Contribute to Apoptosis through p53-Mediated ATM/Fas Signaling by Emilia sonchifolia Extract, a Folklore Medicinal Plant
Y. Lan, Jo-Hua Chiang, Wen-Wen Huang, Chi-Cheng Lu +8 more
2012Evidence-Based Complementary and Alternative Medicine41 citations Open access
Semantic Scholar
Curcumin inhibits WEHI-3 leukemia cells in BALB/c mice in vivo.
C. Su, Jai-Sing Yang, Shuw-Yuan Lin, Hsu-Feng Lu +6 more
2008In Vivo36 citations
Semantic Scholar
Bufalin Induces Apoptotic Cell Death in Human Nasopharyngeal Carcinoma Cells through Mitochondrial ROS and TRAIL Pathways.
En-Ming J. Su, Yung-Lin Chu, F. Chueh, Yi-Shih Ma +5 more
2019The American Journal of Chinese Medicine35 citations
Semantic Scholar
Novel quinazoline HMJ‐30 induces U‐2 OS human osteogenic sarcoma cell apoptosis through induction of oxidative stress and up‐regulation of ATM/p53 signaling pathway
Yu-Jen Chiu, Mann J. Hour, Chi-Cheng Lu, Jing-Gung Chung +5 more
2011Journal of Orthopaedic Research34 citations Open access
Semantic Scholar
Anticancer effects of cantharidin in A431 human skin cancer (Epidermoid carcinoma) cells in vitro and in vivo
Chi-Chuan Li, Fu-Shun Yu, Ming-Jen Fan, Ya-Yin Chen +7 more
2017Environmental Toxicology30 citations
Semantic Scholar
Melittin suppresses epithelial-mesenchymal transition and metastasis in human gastric cancer AGS cells via regulating Wnt/BMP and associated pathway.
Jye-Yu Huang, Shu-Fen Peng, F. Chueh, Po-Yuan Chen +3 more
2021Bioscience, biotechnology and biochemistry27 citations
Semantic Scholar
Casticin Induces DNA Damage and Affects DNA Repair Associated Protein Expression in Human Lung Cancer A549 Cells (Running Title: Casticin Induces DNA Damage in Lung Cancer Cells)
Zheng-Yu Cheng, Yung-Ting Hsiao, Yi-Ping Huang, Shu-Fen Peng +5 more
2020Molecules24 citations Open access
Semantic Scholar
Bufalin induced apoptosis in SCC-4 human tongue cancer cells by decreasing Bcl-2 and increasing Bax expression via the mitochondria-dependent pathway
Han-Yu Chou, F. Chueh, Yi-Shih Ma, Rick Sai-Chuen Wu +5 more
2017Molecular Medicine Reports24 citations Open access
Semantic Scholar
Curcuminoids combined with gefitinib mediated apoptosis and autophagy of human oral cancer SAS cells in vitro and reduced tumor of SAS cell xenograft mice in vivo
Yung-Ting Hsiao, Chao-Lin Kuo, Jen-Jyh Lin, Wen-Wen Huang +4 more
2018Environmental Toxicology22 citations
Semantic Scholar
Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates
Y. Bi, Jinyi Xu, Fei Sun, Xiao-Ming Wu +3 more
2012Molecules22 citations Open access
Semantic Scholar
Norcantharidin-induced Apoptosis of AGS Human Gastric Cancer Cells Through Reactive Oxygen Species Production, and Caspase- and Mitochondria-dependent Signaling Pathways.
Li-Cheng Zheng, Mei-Due Yang, Chao-Lin Kuo, Chiashin Lin +6 more
2016Anticancer Research20 citations Open access
Semantic Scholar
Induction of Cell Cycle Arrest and Apoptosis in Human Osteosarcoma U-2 OS Cells by Solanum lyratum Extracts
Yi-Ting Lin, An-Cheng Huang, Chao-Lin Kuo, Jai-Sing Yang +4 more
2013Nutrition and Cancer19 citations
Semantic Scholar
Combination Treatment of Sorafenib and Bufalin Induces Apoptosis in NCI-H292 Human Lung Cancer Cells In Vitro
JUNG-YU Kuo, Ching-Lung Liao, Yi-Shih Ma, Chao-Lin Kuo +5 more
2022In Vivo18 citations Open access
Semantic Scholar
Casticin Promotes Immune Responses, Enhances Macrophage and NK Cell Activities, and Increases Survival Rates of Leukemia BALB/c Mice.
Kuang-Chi Lai, Hsu-Feng Lu, Kuen-Bao Chen, Shu-Ching Hsueh +4 more
2019The American Journal of Chinese Medicine18 citations
Semantic Scholar
Investigation of anti-leukemia molecular mechanism of ITR-284, a carboxamide analog, in leukemia cells and its effects in WEHI-3 leukemia mice.
Yen-Fang Wen, Jai-Sing Yang, S. Kuo, Chrong-Shiong Hwang +6 more
2010Biochemical Pharmacology18 citations
Semantic Scholar
Chitosan promotes immune responses, ameliorating total mature white blood cell numbers, but increases glutamic oxaloacetic transaminase and glutamic pyruvic transaminase, and ameliorates lactate dehydrogenase levels in leukemia mice in vivo
Ming-Yang Yeh, Yung-Lu-En Shih, Hsueh-Yu Chung, Jason Chou +7 more
2017Molecular Medicine Reports15 citations Open access
Semantic Scholar
Synthesis and biological activity of 28-amide derivatives of 23-hydroxy betulinic Acid as antitumor agent candidates.
Y. Bi, Jinyi Xu, Fei Sun, Xiao-Ming Wu +3 more
2013Medicinal chemistry14 citations
Semantic Scholar
Cantharidin decreased viable cell number in human osteosarcoma U-2 OS cells through G2/M phase arrest and induction of cell apoptosis
Chia-Ching Chen, F. Chueh, Shu-Fen Peng, Wen-Wen Huang +9 more
2019Bioscience, biotechnology and biochemistry12 citations
Semantic Scholar
Bisdemethoxycurcumin suppresses human osteosarcoma U‑2 OS cell migration and invasion via affecting the PI3K/Akt/NF‑κB, PI3K/Akt/GSK3β and MAPK signaling pathways in vitro.
Yi-Shih Ma, Shu-Fen Peng, Rick Sai-Chuen Wu, F. Chueh +6 more
2022Oncology Report11 citations Open access
Semantic Scholar
Combinational treatment of 5-fluorouracil and casticin induces apoptosis in mouse leukemia WEHI-3 cells in vitro.
Zheng-Yu Cheng, F. Chueh, Shu-Fen Peng, Chiashin Lin +5 more
2020Environmental Toxicology10 citations
Semantic Scholar
Chitosan promotes immune responses, ameliorates glutamic oxaloacetic transaminase and glutamic pyruvic transaminase, but enhances lactate dehydrogenase levels in normal mice in vivo
Ming-Yang Yeh, Yung-Lu-En Shih, Hsueh-Yu Chung, Jason Chou +7 more
2016Experimental and Therapeutic Medicine10 citations Open access
Semantic Scholar
Novel anti-leukemia activities of pipoxolan operate via the mitochondria-related pathway in human leukemia U937 cells and attenuate U937 cell growth in an animal model.
Yuh-Fung Chen, Jia-Sin Yang, Wen-Wen Huang, H. Tsai
2010Molecular Medicine Reports10 citations Open access
Semantic Scholar
Genistein enhances the effects of L‐asparaginase on inducing cell apoptosis in human leukemia cancer HL‐60 cells
Yin-Chen Hsiao, F. Chueh, Yi-Shih Ma, Jin-Cherng Lien +7 more
2020Environmental Toxicology9 citations
Semantic Scholar
The quinolone derivative CHM-1 inhibits murine WEHI-3 leukemia in BALB/c mice in vivo
T. Lai, Jai-Sing Yang, Ping-Ping Wu, Wen-Wen Huang +4 more
2010Leukemia and Lymphoma8 citations
Semantic Scholar
Allyl isothiocyanate induces DNA damage and inhibits DNA repair‐associated proteins in a human gastric cancer cells in vitro
Yung-Luen Shih, Sheng-Yao Hsu, Kuang-Chi Lai, F. Chueh +7 more
2023Environmental Toxicology7 citations
Semantic Scholar
Demethoxycurcumin Inhibits In Vivo Growth of Xenograft Tumors of Human Cervical Cancer Cells
F. Chueh, Jin-Cherng Lien, Yu-Cheng Chou, Wen-Wen Huang +8 more
2020In Vivo7 citations Open access
Semantic Scholar
Arsenic trioxide (As2O3) inhibits murine WEHI‐3 leukemia in BALB/c mice in vivo
T. Lai, Jen-Jyh Lin, Wen-Wen Huang, S. Kuo +5 more
2012Environmental Toxicology7 citations
Semantic Scholar
Bisdemethoxycurcumin induces DNA damage and inhibits DNA repair associated protein expressions in NCI‐H460 human lung cancer cells
Chien-Chih Yu, Su-Tso Yang, Wen-Wen Huang, Shu-Fen Peng +6 more
2016Environmental Toxicology6 citations
Semantic Scholar

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Jing-Gung Chung×39
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Jai-Sing Yang×29
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Jai-Sing Yang — researcher profile on SciRah
Shu-Fen Peng×23
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F. Chueh×16
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Po-Yuan Chen — researcher profile on SciRah

Jo-Hua Chiang×8

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Chao-Lin Kuo×8

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Chao-Lin Kuo — researcher profile on SciRah

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Hsu-Feng Lu — researcher profile on SciRah

Chi-Cheng Lu×7

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Yi-Ping Huang×7

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Kuang-Chi Lai×6

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Kuang-Chi Lai — researcher profile on SciRah