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M. Fitzgerald · SciRah

Researcher profile · Semantic Scholar

M. Fitzgerald

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M. Fitzgerald — researcher profile on SciRah

h-index: 11
Works: 46
Citations: 781

Most-cited papers

Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases.
R. Russell, A. Thorley, S. V. Culpitt, S. Dodd +4 more
2002American Journal of Physiology - Lung cellular and Molecular Physiology296 citations
Semantic Scholar
Phosphodiesterase 4 inhibitors for the treatment of COPD.
G. Sturton, M. Fitzgerald
2002Chest112 citations
Semantic Scholar
p38α-Selective Mitogen-Activated Protein Kinase Inhibitor SD-282 Reduces Inflammation in a Subchronic Model of Tobacco Smoke-Induced Airway Inflammation
S. Medicherla, M. Fitzgerald, Dianne Spicer, P. Woodman +6 more
2008Journal of Pharmacology and Experimental Therapeutics91 citations
Semantic Scholar
Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases
F. von Nussbaum, V. Li, S. Allerheiligen, S. Anlauf +18 more
2015ChemMedChem60 citations Open access
Semantic Scholar
Emerging trends in the therapy of COPD: bronchodilators as mono- and combination therapies.
M. Fitzgerald, J. C. Fox
2007Drug Discovery Today43 citations
Semantic Scholar
Emerging trends in the therapy of COPD: novel anti-inflammatory agents in clinical development.
M. Fitzgerald, J. C. Fox
2007Drug Discovery Today36 citations
Semantic Scholar
Human lung tissue provides highly relevant data about efficacy of new anti-asthmatic drugs
O. Danov, Sharon Melissa Jiménez Delgado, H. Obernolte, S. Seehase +12 more
2018PLoS ONE28 citations Open access
Semantic Scholar
The role of animal models in the pharmacological evaluation of emerging anti-inflammatory agents for the treatment of COPD.
J. C. Fox, M. Fitzgerald
2009Current opinion in pharmacology (Print)16 citations
Semantic Scholar
Models of chronic obstructive pulmonary disease: a review of current status
J. C. Fox, M. Fitzgerald
200416 citations
Semantic Scholar
Elarekibep (PRS-060/AZD1402): a new class of inhaled Anticalin medicine targeting IL-4Ra for T2 endotype asthma.
G. Matschiner, M. Fitzgerald, U. Moebius, A. Hohlbaum +15 more
2022Journal of Allergy and Clinical Immunology14 citations Open access
Semantic Scholar
A phase 2 study to evaluate the safety, efficacy and pharmacokinetics of DP2 antagonist GB001 and to explore biomarkers of airway inflammation in mild‐to‐moderate asthma
H. Ortega, M. Fitzgerald, K. Raghupathi, Cindy‐ann Tompkins +4 more
2019Clinical and Experimental Allergy13 citations Open access
Semantic Scholar
Design, Synthesis, and Biological Characterization of Inhaled p38α/β MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases.
E. Armani, Carmelida Capaldi, V. Bagnacani, F. Saccani +21 more
2022Journal of Medicinal Chemistry8 citations Open access
Semantic Scholar
Phase 1 evaluation of the inhaled IL-4Ra antagonist, AZD1402/PRS-060, a potent and selective blocker of IL-4Ra
I. Bruns, M. Fitzgerald, Katerina Pardali, Gardiner Philip +5 more
2019Airway pharmacology and treatment7 citations
Semantic Scholar
The safety, PK and PD profile of ADC3680, a potent and selective CRTh2 antagonist, in healthy volunteers and partly controlled atopic asthmatic subjects
M. Fitzgerald, S. Snape, S. Febbraro, David Singh +3 more
2013European Respiratory Journal6 citations
Semantic Scholar
Late Breaking Abstract - Multiple ascending dose study of the inhaled IL-4Ra antagonist, AZD1402/PRS-060, in mild asthmatics demonstrates robust FeNO reduction and a promising clinical profile for the treatment of asthma
I. Bruns, M. Fitzgerald, George Mensing, Tsung Mei +11 more
2019Airway pharmacology and treatment5 citations
Semantic Scholar
p 38 α Selective MAP kinase inhibitor , SD-282 , reduces inflammation in a sub-chronic model of tobacco smoke-induced airway inflammation
S. Medicherla, M. Fitzgerald, Dianne Spicer, P. Woodman +4 more
20075 citations
Semantic Scholar
The Discovery and Development of AZD1402/PRS-060, an Inhaled, Potent and Selective Antagonist of the IL-4 Receptor Alpha
G. Matschiner, Song Huang, S. Constant, Barbara Rattenstetter +5 more
2018Airway pharmacology and treatment4 citations
Semantic Scholar
The in vitro profile of ADC3680, a potent and selective CRTh2 antagonist for the treatment of inadequately controlled asthma
M. Fitzgerald, M. Whitmarsh, J. Prosser, A. Banyard +1 more
2013European Respiratory Journal4 citations
Semantic Scholar
AZD1402/PRS-060, an inhaled Anticalin® IL-4Ra antagonist, potently inhibits IL-4 induced functional effects in human whole blood, which can be employed translationally in clinical studies
Katerina Pardali, Fanyi Jiang, M. Fitzgerald, G. Matschiner +1 more
2018Airway pharmacology and treatment3 citations
Semantic Scholar
Pharmacological characterization of CHI25243, a novel potent inhaled inhibitor of neutrophil elastase
D. Miglietta, C. Carnini, Veronica Puviani, H. Finch +5 more
20163 citations
Semantic Scholar
Effects Of Low Dose Inhaled Theophylline (ADC4022) Co-administered With Budesonide On Inflammatory Markers And Lung Function In Patients With COPD
N. Barnes, S. Snape, J. C. Fox, M. Fitzgerald +7 more
2010Asian Test Symposium3 citations
Semantic Scholar
Small-molecule neutrophil elastase inhibitors as therapies for respiratory disease
M. Fitzgerald
20103 citations
Semantic Scholar
O66. The highly selective iNOS inhibitor BYK402750 exerts potent anti-inflammatory effects in a mouse model of cigarette smoke-induced inflammation
Christian Hesslinger, M. Lehner, A. Strub, R. Boer +8 more
20082 citations
Semantic Scholar
Reduction of Exhaled Nitric Oxide by the DP2 antagonist GB001 in Patients with Mild Atopic Asthma.: 311
H. Ortega, M. Fitzgerald, N. Bhakta, K. Raghupathi +1 more
2019Journal of Allergy and Clinical Immunology1 citations Open access
Semantic Scholar
CHI25243, a novel potent inhaled inhibitor of neutrophil elastase for the treatment of bronchiectasis and other chronic inflammatory lung disease
C. Carnini, D. Miglietta, Veronica Puviani, M. Calderazzo +6 more
20161 citations
Semantic Scholar
The effect of glucocorticoids on lyso-PAF formationin vitro andin vivo
L. Parente, M. Fitzgerald, R. Flower, G. Nucci
2005Agents and Actions1 citations
Semantic Scholar
Imidazopyridinone as p38 map kinase inhibitors
C. Alonso-Alija, Martin Michels, H. Schirok, K. Schlemmer +4 more
20021 citations
Semantic Scholar
Markers of eosinophilic inflammation are associated with response to the DP2 antagonist GB001 in patients with mild atopic asthma
H. Ortega, M. Fitzgerald, K. Raghupathi, Cindyann Tompinks +1 more
2019Airway pharmacology and treatment0 citations
Semantic Scholar
In vitropharmacological characterization of a novel p38α (MAPK14) inhibitor designed for inhaled delivery
Nadia Moretto, Carmelida Capaldi, E. Armani, M. Fitzgerald +6 more
20160 citations
Semantic Scholar
Cover Picture: Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85‐8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases (ChemMedChem 7/2015)
F. von Nussbaum, V. Li, S. Allerheiligen, S. Anlauf +18 more
20150 citations
Semantic Scholar
Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor
F. vonNussbaum, V. Li, S. Allerheiligen, S. Anlauf +18 more
20150 citations
Semantic Scholar
Reducing Central Line-Associated Blood Stream Infection And Ventilator-Associated Pneumonia In An Academic Community Hospital
V. D. de Palo, M. Fitzgerald, Khalid Alhourani, Taro Minami +2 more
2012Asian Test Symposium0 citations
Semantic Scholar
Combination of methylxanthine and steroid for the treatment of chronic respiratory diseases.
H. Finch, M. Fitzgerald, J. C. Fox
20060 citations
Semantic Scholar
Combination of methyl xanthine compounds and steroids for the treatment of chronic airway diseases
J. C. Fox, M. Fitzgerald, H. Finch
20060 citations
Semantic Scholar
Multimers of pyrimidinonderivaten and their use as inhibitors of human neutrophil elastase
H. Finch, C. Edwards, Ray, Charles Nicholas +2 more
20060 citations
Semantic Scholar
Dihydropyridinonderivate as wages inhibitors
Heike Gielen-Haertwig, Li Min-jian, U. Rosentreter, K. Schlemmer +8 more
20030 citations
Semantic Scholar
Dihydropyridine derivatives for use as inhibitors of human neutrophil elastase
Heike Gielen-Haertwig, Li Min-jian, U. Rosentreter, K. Schlemmer +8 more
20030 citations
Semantic Scholar
Derives de dihydropyridinone
Heike Gielen-Haertwig, V. Li, U. Rosentreter, K. Schlemmer +8 more
20030 citations
Semantic Scholar
Effects of endotoxin on surfactant function & lung mechanics in the rabbit
M. Freeman, H. L. McMath, M. Fitzgerald
20020 citations
Semantic Scholar
Derives de 1,4-dihydro-1,4-diphenylpyridine
H. Gielen, V. Li, U. Rosentreter, K. Schlemmer +3 more
20020 citations
Semantic Scholar
Imidazopyridinones en tant qu'inhibiteurs de proteine-kinase associee aux membranes (map kinase) p38
C. Alonso-Alija, Martin Michels, H. Schirok, K. Schlemmer +4 more
20020 citations
Semantic Scholar
Oxalyl-benzofuran and Benzothienylderivate
G. Braeunlich, R. Fischer, M. Es-Sayed, R. Hanko +5 more
19950 citations
Semantic Scholar
Oxalylamino-benzofuran and benzothienyl
Gabriele Dr Brounlich, R. Fischer, M. Es-Sayed, R. Hanko +5 more
19950 citations
Semantic Scholar
Amino-benzofuryl- and thienyl
Gabriele Dr Brounlich, Trevor Dr Abram, R. Fischer, M. Es-Sayed +5 more
19950 citations
Semantic Scholar
Aminobenzofuryl- and -thienylderivate
G. Braeunlich, R. Fischer, M. Es-Sayed, R. Hanko +5 more
19950 citations
Semantic Scholar
Pharmacological modulation of guinea-pig bronchospasm induced by PAF-acether aerosol in vivo
M. Fitzgerald, L. Parente, A. Payne
19850 citations
Semantic Scholar

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S. Allerheiligen×7
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S. Allerheiligen — researcher profile on SciRah
U. Rosentreter×7
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Heike Gielen-Haertwig×6
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Leila A. Telan — researcher profile on SciRah

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K. Schlemmer×6

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G. Sturton — researcher profile on SciRah

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V. Li — researcher profile on SciRah

G. Matschiner×4

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