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W. Schwede · SciRah

Researcher profile · Semantic Scholar

W. Schwede

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W. Schwede — researcher profile on SciRah

h-index: 13
Works: 95
Citations: 762

Most-cited papers

Total synthesis and antitumor activity of ZK-EPO: the first fully synthetic epothilone in clinical development.
U. Klar, B. Buchmann, W. Schwede, W. Skuballa +2 more
2006Angewandte Chemie111 citations
Semantic Scholar
Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone.
J. Hoffmann, I. Vitale, B. Buchmann, L. Galluzzi +18 more
2008Cancer Research103 citations Open access
Semantic Scholar
Synthesis and biological activity of a novel, highly potent progesterone receptor antagonist.
U. Fuhrmann, Holger Hess-Stumpp, A. Cleve, G. Neef +4 more
2000Journal of Medicinal Chemistry94 citations
Semantic Scholar
Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance
M. Quanz, E. Bender, C. Kopitz, Sylvia Grünewald +13 more
2018Molecular Cancer Therapeutics93 citations
Semantic Scholar
BAY 1002670: a novel, highly potent and selective progesterone receptor modulator for gynaecological therapies.
A. Wagenfeld, W. Bone, W. Schwede, M. Fritsch +2 more
2013Human Reproduction42 citations Open access
Semantic Scholar
Subcellular distribution of epothilones in human tumor cells
Rosemarie Lichtner, A. Rotgeri, T. Bunte, B. Buchmann +4 more
2001Proceedings of the National Academy of Sciences of the United States of America41 citations Open access
Semantic Scholar
Global gene expression profiling of progesterone receptor modulators in T47D cells provides a new classification system.
Wiebke Afhüppe, A. Sommer, Jörg Müller, W. Schwede +2 more
2009Journal of Steroid Biochemistry and Molecular Biology34 citations
Semantic Scholar
Pharmacology and clinical use of sex steroid hormone receptor modulators.
A. Cleve, K. Fritzemeier, B. Haendler, N. Heinrich +3 more
2012Handbook of Experimental Pharmacology29 citations
Semantic Scholar
Discovery of Vilaprisan (BAY 1002670): A Highly Potent and Selective Progesterone Receptor Modulator Optimized for Gynecologic Therapies
Carsten Möller, W. Bone, A. Cleve, U. Klar +5 more
2018ChemMedChem28 citations Open access
Semantic Scholar
Efficient Chiral Pool Synthesis of the C1-C6 Fragment of Epothilones
U. Klar, Bodo Röhr, F. Kuczyński, W. Schwede +3 more
200519 citations
Semantic Scholar
Investigational developments for the treatment of progesterone-dependent diseases
Carsten Möller, J. Hoffmann, Thomas A. Kirkland, W. Schwede
2008Expert Opinion on Investigational Drugs18 citations
Semantic Scholar
11β-Aryl steroids in the androstene series. The role of the 11β-region in steroid progesterone receptor interaction
A. Cleve, K. Fritzemeier, N. Heinrich, U. Klar +4 more
199614 citations
Semantic Scholar
Safety Performance of Passenger Cars Designed to Accommodate Frontal impacts with Partial Barrier Overlap
L. Grosch, K. Baumann, H. Holtze, W. Schwede
198914 citations
Semantic Scholar
Beneficial effects of fluorine in the anti-progestin ZK 230211
A. Cleve, U. Klar, W. Schwede
200513 citations
Semantic Scholar
Synthesis of 14β-H antiprogestins
A. Cleve, G. Neef, Eckhard Ottow, S. Scholz +1 more
199513 citations
Semantic Scholar
Synthesis of 11α-methyl-11β-(arylethynyl) substituted steroids of the estrane series
W. Schwede, A. Cleve, E. Ottow, R. Wiechert
199310 citations
Semantic Scholar
Frontal Offset Crash Testing for Approx. 15 Years: Results, Experiences and Consequences
K. Baumann, L. Groesch, H. Holtze, W. Schwede
199010 citations
Semantic Scholar
New synthetic Epothilone Derivative ZK-EPO inhibits breast cancer metastasis
J. Hoffmann, B. Buchmann, W. Schwede, W. Skuballa +3 more
20059 citations
Semantic Scholar
Identification of the Highly Active, Species Cross-Reactive Complex I Inhibitor BAY-179.
J. Mowat, A. Ehrmann, Sven Christian, C. Sperl +5 more
2022ACS Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
7α,15α-Ethano bridged steroids. Synthesis and progesterone receptor interaction
U. Egner, K. Fritzemeier, W. Halfbrodt, N. Heinrich +5 more
19998 citations
Semantic Scholar
Synthesis of 11β-(alkynyl)substituted 19-norsteroids
Eckhard Ottow, R. Rohde, W. Schwede, R. Wiechert
19938 citations
Semantic Scholar
VEHICLE CRASHWORTHINESS AND OCCUPANT PROTECTION IN FRONTAL COLLISIONS. FRONTAL OFFSET CRASH TESTING FOR APPROX. 15 YEARS: RESULTS, EXPERIENCES AND CONSEQUENCES. SAE INTERNATIONAL CONGRESS AND EXPOSITION, FEBRUARY 26-MARCH 2, 1990, DETROIT, MICHIGAN
K. Baumann, L. Groesch, H. Holtze, W. Schwede
19908 citations
Semantic Scholar
A facile construction of the 17α-fluoroprogesterone side chain
G. Neef, G. Ast, G. Michl, W. Schwede +1 more
19945 citations
Semantic Scholar
Synthesis and Biological Activity of Epothilones
U. Klar, W. Skuballa, B. Buchmann, W. Schwede +3 more
20104 citations
Semantic Scholar
Highly diastereoselective synthesis of 11β,17β‐diaryl‐18a‐homo‐19‐nor steroids
Eckhard Ottow, A. Cleve, G. Neef, W. Schwede
19974 citations
Semantic Scholar
Synthesis and biological activity of 17-chloro-16(17) unsaturated D-homo antiprogestins.
W. Schwede, A. Cleve, G. Neff, E. Ottow +2 more
1994Steroids4 citations
Semantic Scholar
THE DEFORMABLE BARRIER, A REALISTIC EXTENSION OF OFFSET TESTING
D. Scheunert, R. Justen, R. Herrmann, F. Zeidler +1 more
19934 citations
Semantic Scholar
Abstract 1126: Differential effects of metformin and phenformin vs. other complex 1 inhibitors in vitro and in vivo
Carolyn Algire, A. Ehrmann, Sven Christian, R. Neuhaus +4 more
20153 citations
Semantic Scholar
631 POSTER Comparative antiproliferative activities and cellular distribution of the third-generation epothilone ZK-EPO and texanes
J. Hoffman, S. Winsel, S. Hammer, K. Mittelstaedt +6 more
20062 citations
Semantic Scholar
7α,15α‐Ethano Bridged Steroids. Synthesis and Progesterone Receptor Interaction.
U. Egner, K. Fritzemeier, W. Halfbrodt, N. Heinrich +5 more
20002 citations
Semantic Scholar
Abstract 223: Comparison of human-specific versus cross-reactive Complex I inhibitor for in vivo tumor efficacy
Sven Christian, Carolyn Algire, W. Schwede, J. Mowat +4 more
20161 citations
Semantic Scholar
Abstract 317: 3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions
Carsten Wenzel, Sven Christian, Carolyn Algire, W. Schwede +7 more
20151 citations
Semantic Scholar
Inhibition of Proliferation and Fibrosis by Vitamin D Agonists—Impact for Uterine Leiomyoma.
A. Wagenfeld, C. Moeller, P. Sandner, W. Schwede +2 more
20111 citations
Semantic Scholar
SAGOPILONE, A NOVEL EPOTHILONE, INHIBITS TUMOR CELL GROWTH IN PRECLINICAL MODELS OF UROLOGICAL CANCER
S. Winsel, S. Hammer, B. Buchmann, W. Schwede +4 more
20081 citations
Semantic Scholar
Beneficial Effects of Fluorine in the anti‐Progestin ZK 230211.
A. Cleve, U. Klar, W. Schwede
20051 citations
Semantic Scholar
Synthesis and biological activity of 11,19-bridged progestins.
W. Schwede, K. Fritzemeier, W. Halfbrodt, R. Krattenmacher +4 more
1998Steroids1 citations
Semantic Scholar
11β-Aryl Steroids in the Androstene Series. The Role of the 11. beta.-Region in Steroid Progesterone Receptor Interaction.
A. Cleve, K. Fritzemeier, N. Heinrich, U. Klar +4 more
19961 citations
Semantic Scholar
Synthesis of 14β-H Antiprogestins.
A. Cleve, G. Neef, E. Ottow, S. Scholz +1 more
19951 citations
Semantic Scholar
Abstract 2682: Small molecule targeting the lipoic acid post-translational modification impacts proliferation of colorectal and PIK3CA-mutant cell lines
L. Doherty, T. Sangpo, P. Tsvetkov, John F. Davis +15 more
2022Cancer Research0 citations
Semantic Scholar
Front Cover: Discovery of Vilaprisan (BAY 1002670): A Highly Potent and Selective Progesterone Receptor Modulator Optimized for Gynecologic Therapies (ChemMedChem 21/2018)
Carsten Möller, W. Bone, A. Cleve, U. Klar +5 more
2018ChemMedChem0 citations Open access
Semantic Scholar
Abstract 3248: Identification and optimization of a highly active, cross reactive Complex-1 inhibitor
J. Mowat, Sven Christian, C. Sperl, A. Ehrmann +6 more
20170 citations
Semantic Scholar
Abstract 4989: 3D spheroid screen yields SCD1 pathway inhibitors for the treatment of cancer
Sylvia Gruenewald, C. Sperl, Patrick Steigemann, Alexander Walter +7 more
20170 citations
Semantic Scholar
Composés 2-(1h-pyrazol-1-yl)-1h-benzimidazole substitués
K. Thede, Ludwig Zorn, Patrick Steigemann, Sylvia Grünewald +6 more
20160 citations
Semantic Scholar
Design rules for structural safety of passenger–car bodies
H. Gotz, W. Schwede, M. Muller
20140 citations
Semantic Scholar
Profiling of a novel, highly potent and selective progesetrone receptor modulator for gynecological therapies
A. Wagenfeld, W. Bone, M. Fritsch, W. Schwede +2 more
20130 citations Open access
Semantic Scholar
Receptor antagonists progesterone
W. Schwede, U. Klar, Carsten Möller, A. Rotgeri +2 more
20110 citations
Semantic Scholar
17-hydroxy-17-ethyl pentanoic fluoro-estra-4,9 (10) -diene-11-aryl derivative, process for their preparation and their use for the treatment of diseases
W. Schwede, U. Klar, C. Moeller, A. Rotgeri +1 more
20100 citations
Semantic Scholar
Progesterone receptor antagonist
W. Bone, Christoph M. Huwe, U. Klar, C. Moeller +2 more
20100 citations
Semantic Scholar
Synthesis of 11α-Methyl-11β-(arylethynyl)-Substituted Steroids (I) of the Estrane Series.
W. Schwede, A. Cleve, E. Ottow, R. Wiechert
20100 citations
Semantic Scholar
Derivatives of 17-hydroxy-17-pentafluoroethyl-estra-4,9 (10) -diene-11-metilenoxialquilenarílicos, process for their preparation and their use for treating diseases
U. Klar, W. Schwede, Carsten Möller, A. Rotgeri +1 more
20100 citations
Semantic Scholar

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