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Jun-Fang Zhou · SciRah

Researcher profile · Semantic Scholar

Jun-Fang Zhou

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Jun-Fang Zhou — researcher profile on SciRah

h-index: 27
Works: 61
Citations: 6,387

Most-cited papers

Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B
A. Nathwani, E. Tuddenham, S. Rangarajan, Cecilia Rosales +28 more
2011New England Journal of Medicine1,810 citations Open access
Semantic Scholar
Long-Term Safety and Efficacy of Factor IX Gene Therapy in Hemophilia B
A. Nathwani, U. Reiss, E. Tuddenham, Cecilia Rosales +26 more
2014New England Journal of Medicine1,152 citations Open access
Semantic Scholar
Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver.
A. Nathwani, J. Gray, C. Ng, Jun-Fang Zhou +8 more
2006Blood425 citations Open access
Semantic Scholar
Long-term safety and efficacy following systemic administration of a self-complementary AAV vector encoding human FIX pseudotyped with serotype 5 and 8 capsid proteins.
A. Nathwani, Cecilia Rosales, J. McIntosh, G. Rastegarlari +20 more
2011Molecular Therapy316 citations Open access
Semantic Scholar
Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant.
J. McIntosh, P. Lenting, Cecilia Rosales, Doyoung Lee +19 more
2013Blood279 citations Open access
Semantic Scholar
Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman primates.
A. Nathwani, J. Gray, J. McIntosh, C. Ng +6 more
2007Blood278 citations Open access
Semantic Scholar
Sex significantly influences transduction of murine liver by recombinant adeno-associated viral vectors through an androgen-dependent pathway.
A. Davidoff, C. Ng, Jun-Fang Zhou, Yunyu Spence +1 more
2003Blood246 citations Open access
Semantic Scholar
Comparison of the ability of adeno-associated viral vectors pseudotyped with serotype 2, 5, and 8 capsid proteins to mediate efficient transduction of the liver in murine and nonhuman primate models.
A. Davidoff, J. Gray, C. Ng, You-Bin Zhang +4 more
2005Molecular Therapy229 citations Open access
Semantic Scholar
Bone marrow-derived cells contribute to tumor neovasculature and, when modified to express an angiogenesis inhibitor, can restrict tumor growth in mice.
A. Davidoff, Catherine Y. C. Ng, P. Brown, Margaret A. Leary +5 more
2001Clinical Cancer Research206 citations
Semantic Scholar
Sustained high-level expression of human factor IX (hFIX) after liver-targeted delivery of recombinant adeno-associated virus encoding the hFIX gene in rhesus macaques.
A. Nathwani, A. Davidoff, H. Hanawa, Yunyu Hu +9 more
2002Blood181 citations Open access
Semantic Scholar
Factors influencing in vivo transduction by recombinant adeno-associated viral vectors expressing the human factor IX cDNA.
A. Nathwani, A. Davidoff, H. Hanawa, Jun-Fang Zhou +2 more
2001Blood157 citations Open access
Semantic Scholar
Adeno-Associated Mediated Gene Transfer for Hemophilia B:8 Year Follow up and Impact of Removing "Empty Viral Particles" on Safety and Efficacy of Gene Transfer
A. Nathwani, U. Reiss, E. Tuddenham, P. Chowdary +14 more
2018Blood110 citations Open access
Semantic Scholar
A Novel Mechanism of Cell Killing by Anti-topoisomerase II Bisdioxopiperazines*
L. Jensen, Karin C. Nitiss, Angela Rose, Jiao-Wang Dong +6 more
2000Journal of Biological Chemistry93 citations Open access
Semantic Scholar
ENHANCING TRANSDUCTION OF THE LIVER BY ADENO-ASSOCIATED VIRAL VECTORS
A. Nathwani, Melanie Cochrane, J. McIntosh, Catherine Y. C. Ng +3 more
2008Gene Therapy91 citations Open access
Semantic Scholar
Brain-derived Neurotrophic Factor Promotes Survival and Chemoprotection of Human Neuroblastoma Cells*
David S. Middlemas, Brenda K. Kihl, Jun-Fang Zhou, Xiao-Yan Zhu
1999Journal of Biological Chemistry81 citations Open access
Semantic Scholar
In vivo bioluminescence imaging for early detection and monitoring of disease progression in a murine model of neuroblastoma.
P. Dickson, Blair Hamner, C. Ng, M. Hall +4 more
2007Journal of Pediatric Surgery71 citations
Semantic Scholar
rAAV-mediated long-term liver-generated expression of an angiogenesis inhibitor can restrict renal tumor growth in mice.
A. Davidoff, A. Nathwani, W. Spurbeck, C. Ng +2 more
2002Cancer Research62 citations
Semantic Scholar
The bis(naphthalimide) DMP-840 causes cytotoxicity by its action against eukaryotic topoisomerase II.
J. Nitiss, Jun-Fang Zhou, Angela Rose, Y. Hsiung +2 more
1998Biochemistry55 citations
Semantic Scholar
Adeno-associated virus vector-mediated delivery of pigment epithelium-derived factor restricts neuroblastoma angiogenesis and growth.
C. Streck, You-Bin Zhang, Jun-Fang Zhou, C. Ng +2 more
2005Journal of Pediatric Surgery53 citations
Semantic Scholar
Targeting histone demethylases in MYC-driven neuroblastomas with ciclopirox
Jun J. Yang, S. Milasta, Dong-Li Hu, Alaa Altahan +27 more
2017Cancer Research47 citations Open access
Semantic Scholar
Adeno-Associated Virus Vector-Mediated Systemic Delivery of IFN-β Combined with Low-Dose Cyclophosphamide Affects Tumor Regression in Murine Neuroblastoma Models
C. Streck, P. Dickson, C. Ng, Jun-Fang Zhou +3 more
2005Clinical Cancer Research46 citations Open access
Semantic Scholar
GO-8: Preliminary Results of a Phase I/II Dose Escalation Trial of Gene Therapy for Haemophilia a Using a Novel Human Factor VIII Variant
A. Nathwani, E. Tuddenham, P. Chowdary, J. McIntosh +10 more
2018Blood43 citations Open access
Semantic Scholar
Restriction of neuroblastoma angiogenesis and growth by interferon-α/β
C. Streck, You-Bin Zhang, Ryan Miyamoto, Jun-Fang Zhou +3 more
200436 citations
Semantic Scholar
Liposome-Encapsulated Curcumin Suppresses Neuroblastoma Growth Through Nuclear Factor-κB Inhibition
W. Orr, J. Denbo, Karim R. Saab, Adrianne L. Myers +5 more
2012Surgery32 citations Open access
Semantic Scholar
2: Bortezomib inhibits angiogenesis and reduces tumor burden in a murine model of neuroblastoma
J. B. Hamner, P. Dickson, T. L. Sims, Jun-Fang Zhou +3 more
200732 citations
Semantic Scholar
Using Yeast to Understand Drugs that Target Topoisomerases a
J. Nitiss, Angela Rose, K. C. Sykes, J. Harris +1 more
1996Annals of the New York Academy of Sciences32 citations
Semantic Scholar
Interferon-mediated anti-angiogenic therapy for neuroblastoma.
C. Streck, C. Ng, You-Bin Zhang, Jun-Fang Zhou +2 more
2005Cancer Letters27 citations
Semantic Scholar
Preventing packaging of translatable P5-associated DNA contaminants in recombinant AAV vector preps
Mark A. Brimble, P. Cheng, Stephen M. Winston, I. Reeves +10 more
2022Molecular Therapy: Methods & Clinical Development25 citations Open access
Semantic Scholar
Interferon-β Sensitizes Neuroblastoma to the Anti-Tumor Activity of Temozolomide by Modulating O6-Methylguanine-DNA Methyltransferase Expression
Shannon F. Rosati, Regan F. Williams, Lindsey C Nunnally, M. McGee +9 more
2008Molecular Cancer Therapeutics24 citations Open access
Semantic Scholar
Careful decoy receptor titering is required to inhibit tumor angiogenesis while avoiding adversely altering VEGF bioavailability.
A. Davidoff, C. Ng, You-Bin Zhang, C. Streck +7 more
2005Molecular Therapy16 citations Open access
Semantic Scholar
Continuous Local Delivery of Interferon-β Stabilizes Tumor Vasculature in an Orthotopic Glioblastoma Xenograft Resection Model
J. Denbo, Regan F. Williams, W. S. Orr, T. L. Sims +8 more
2011Surgery15 citations Open access
Semantic Scholar
Endostatin-mediated concomitant resistance in neuroblastoma.
C. Streck, You-Bin Zhang, Jun-Fang Zhou, C. Ng +1 more
2004Journal of Pediatric Surgery15 citations
Semantic Scholar
GO-8: Stable Expression of Factor VIII over 5 Years Following Adeno-Associated Gene Transfer in Subjects with Hemophilia a Using a Novel Human Factor VIII Variant
P. Chowdary, U. Reiss, E. Tuddenham, Paul Batty +19 more
2023Blood14 citations
Semantic Scholar
Neural progenitor cell-mediated delivery of interferon-β improves neuroblastoma response to cyclophosphamide
T. L. Sims, J. B. Hamner, R. Bush, Regan F. Williams +5 more
2008Annals of Surgical Oncology14 citations Open access
Semantic Scholar
Longterm recombinant adeno-associated, virus-mediated, liver-generated expression of an angiogenesis inhibitor improves survival in mice with disseminated neuroblastoma.
C. Streck, Jun-Fang Zhou, C. Ng, You-Bin Zhang +2 more
2004Journal of the American College of Surgeons14 citations
Semantic Scholar
Stable Therapeutic Transgenic FIX Levels for More Than 10 Years in Subjects with Severe Hemophilia B Who Received scAAV2/8-LP1-Hfixco Adeno-Associated Virus Gene Therapy
U. Reiss, A. Davidoff, E. Tuddenham, P. Chowdary +16 more
2023Blood13 citations Open access
Semantic Scholar
RAPAMYCIN-INDUCED TUMOR VASCULATURE REMODELING IN RHABDOMYOSARCOMA XENOGRAFTS INCREASES THE EFFECTIVENESS OF ADJUVANT IONIZING RADIATION
Adrianne L. Myers, Shannon Orr, J. Denbo, C. Ng +4 more
2012Journal of Pediatric Surgery12 citations Open access
Semantic Scholar
expression of human FIX in nonhuman primates of self-complementary AAV vector results in stable therapeutic Safe and efficient transduction of the liver after peripheral vein infusion
Melanie Cochrane, E. Gray, E. Tuddenham, A. Davidoff +6 more
20138 citations
Semantic Scholar
transduction of murine and nonhuman primate liver efficient liver-specific human factor IX expression cassette enable highly Self-complementary adeno-associated virus vectors containing a novel
K. Mertens, E. Tuddenham, G. Kemball-Cook, J. McIntosh +5 more
20137 citations
Semantic Scholar
Adeno-Associated Viral Vector Mediated Gene Transfer for Hemophilia B
A. Nathwani, E. Tuddenham, S. Rangarajan, Cecilia Rosales +28 more
20116 citations
Semantic Scholar
547. AAV Preparations Contain Contamination from DNA Sequences in Production Plasmids Directly Outside of the ITRs
Mark A. Brimble, Jun-Fang Zhou, Christopher L. Morton, M. Meagher +3 more
20165 citations Open access
Semantic Scholar
Pre-Existing Immunity to a Nucleic Acid Contaminant-Derived Antigen Mediates Transaminitis and Resultant Diminished Transgene Expression in a Mouse Model of Hepatic Recombinant Adeno-Associated Virus-Mediated Gene Transfer
Mark A. Brimble, Christopher L. Morton, Stephen M. Winston, I. Reeves +7 more
2024Human Gene Therapy3 citations Open access
Semantic Scholar
Stable Factor IX Activity Following AAV-Mediated Gene Transfer in Patients with Severe Hemophilia B
A. Davidoff, E. Tuddenham, S. Rangarajan, Cecilia Rosales +19 more
20123 citations
Semantic Scholar
In vivo bioluminescent imaging for early detection and monitoring of disease progression in a murine model of neuroblastoma
P. Dickson, C. Ng, Jun-Fang Zhou, B. McCarville +1 more
20053 citations
Semantic Scholar
Restriction of neuroblastoma angiogenesis and growth by interferon-alpha/beta.
C. Streck, Youbin Zhang, Ryan Miyamoto, Jun-Fang Zhou +3 more
2004Surgery3 citations
Semantic Scholar
A phase i/ii clinical trial entailing peripheral vein administration of a novel self complementary adeno-associated viral vector encoding human fix for haemophilia b gene therapy
A. Nathwani, E. Tuddenham, Cecilia Rosales, J. Macintosh +19 more
20111 citations
Semantic Scholar
Continuous delivery of IFN-beta sensitizes human gliomas to ionizing radiation
J. B. Hamner, P. Dickson, M. Gaber, C. Ng +2 more
20061 citations
Semantic Scholar
Liver targeted delivery of recombinant adeno-associated virus (rAAV) serotype 5 vectors leads to sustained therapeutic expression of human factor IX (hFIX) in non-human primates previously sensitized to rAAV2 vectors.
A. Nathwani, C. Ng, Jun-Fang Zhou, Yunyu Spence +2 more
20031 citations
Semantic Scholar
SUSTAINED HIGH LEVEL EXPRESSION OF HUMAN FIX FOLLOWING LIVER TARGETED DELIVERY OF RECOMBINANT ADENO-ASSOCIATED VIRUS ENCODING THE HUMAN FIX GENE IN RHESUS MACAQUES
A. Nathwani, A. Davidoff, H. Hanawa, Yunyu Hu +10 more
20021 citations
Semantic Scholar
Retraction notice to "Liposome-encapsulated curcumin suppresses neuroblastoma growth through nuclear factor-kB inhibition" [j.surg 151 (2012) 736-744].
W. S. Orr, J. Denbo, Karim R. Saab, Adrianne L. Myers +5 more
2016Surgery0 citations Open access
Semantic Scholar

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