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Melanie C. Zigler · SciRah

Researcher profile · Semantic Scholar

Melanie C. Zigler

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Melanie C. Zigler — researcher profile on SciRah

h-index: 11
Works: 30
Citations: 1,130

Most-cited papers

Mitochondria‐targeted antioxidant (MitoQ) ameliorates age‐related arterial endothelial dysfunction in mice
R. Gioscia-Ryan, T. LaRocca, Amy L. Sindler, Melanie C. Zigler +2 more
2014Journal of Physiology240 citations Open access
Semantic Scholar
Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans
Vienna E. Brunt, R. Gioscia-Ryan, Abigail G. Casso, Nicholas S. VanDongen +7 more
2020HYPERTENSION235 citations Open access
Semantic Scholar
Dietary rapamycin supplementation reverses age‐related vascular dysfunction and oxidative stress, while modulating nutrient‐sensing, cell cycle, and senescence pathways
L. Lesniewski, D. Seals, Ashley E. Walker, Grant D. Henson +7 more
2016Aging Cell160 citations Open access
Semantic Scholar
Suppression of the gut microbiome ameliorates age‐related arterial dysfunction and oxidative stress in mice
Vienna E. Brunt, R. Gioscia-Ryan, James J. Richey, Melanie C. Zigler +12 more
2019Journal of Physiology147 citations Open access
Semantic Scholar
The Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure with Aging in Mice and Humans
Vienna E. Brunt, Abigail G. Casso, R. Gioscia-Ryan, Zachary J. Sapinsley +10 more
2021HYPERTENSION88 citations Open access
Semantic Scholar
Sustained Activation of AMPK Ameliorates Age-Associated Vascular Endothelial Dysfunction via a Nitric Oxide-Independent Mechanism
L. Lesniewski, Melanie C. Zigler, J. Durrant, Anthony J. Donato +1 more
2012Mechanisms of Ageing and Development60 citations Open access
Semantic Scholar
Voluntary aerobic exercise increases arterial resilience and mitochondrial health with aging in mice
R. Gioscia-Ryan, Micah L. Battson, L. M. Cuevas, Melanie C. Zigler +2 more
2016Aging55 citations Open access
Semantic Scholar
Lifelong voluntary aerobic exercise prevents age- and Western diet- induced vascular dysfunction, mitochondrial oxidative stress, and inflammation in mice
R. Gioscia-Ryan, Zachary S. Clayton, Melanie C. Zigler, James J. Richey +7 more
2020Journal of Physiology47 citations Open access
Semantic Scholar
Short‐term interleukin‐37 treatment improves vascular endothelial function, endurance exercise capacity, and whole‐body glucose metabolism in old mice
D. Ballak, Vienna E. Brunt, Zachary J. Sapinsley, B. Ziemba +9 more
2019Aging Cell40 citations Open access
Semantic Scholar
Late-life voluntary wheel running reverses age-related aortic stiffness in mice: a translational model for studying mechanisms of exercise-mediated arterial de-stiffening
R. Gioscia-Ryan, Zachary S. Clayton, B. Fleenor, Jason S. Eng +5 more
2020GeroScience18 citations Open access
Semantic Scholar
Lifelong physical activity attenuates age- and Western-style diet-related declines in physical function and adverse changes in skeletal muscle mass and inflammation.
Zachary S. Clayton, R. Gioscia-Ryan, J. Justice, Kara L. Lubieniecki +4 more
2021Experimental Gerontology13 citations
Semantic Scholar
Female C57BL/6N mice are a viable model of aortic aging in women.
Abigail G. Longtine, Ravinandan Venkatasubramanian, Melanie C. Zigler, Alexandra Lindquist +7 more
2023American Journal of Physiology. Heart and Circulatory Physiology11 citations Open access
Semantic Scholar
The plasma metabolome is associated with preservation of physiological function following lifelong aerobic exercise in mice
Kevin O. Murray, Grace S. Maurer, R. Gioscia-Ryan, Melanie C. Zigler +6 more
2024GeroScience7 citations Open access
Semantic Scholar
Administration of anti‐inflammatory interleukin‐37 ameliorates age‐related vascular, metabolic and physical dysfunction in mice
Zachary J. Sapinsley, Dov B. Ballak, Vienna E. Brunt, Melanie C. Zigler +4 more
2017The FASEB Journal3 citations Open access
Semantic Scholar
Late-onset menopause and attenuated aortic stiffness
Sanna Darvish, Kevin O. Murray, Sophia A. Mahoney, Nicholas S. VanDongen +10 more
2026HYPERTENSION2 citations Open access
Semantic Scholar
Transfer of Young Gut Microbiota Ameliorates Age‐ and Western‐Style Diet‐Related Vascular Endothelial Dysfunction in Mice
Nicholas S. VanDongen, R. Gioscia-Ryan, Jacob N. Frye, Abigail G. Casso +3 more
2019The FASEB Journal2 citations
Semantic Scholar
Vascular Endothelial Dysfunction Induced by a Western‐Style Diet Can Be Transferred via Fecal Microbiota Transplant in Mice
Nathan T. Greenberg, Nicholas S. VanDongen, R. Gioscia-Ryan, Abigail G. Casso +7 more
2020The FASEB Journal1 citations
Semantic Scholar
YI 1.4 Increases in Circulating Trimethylamine-N-Oxide Contribute to the Development of Age-Related Aortic Stiffness in Humans and Mice
Abigail G. Casso, R. Gioscia-Ryan, Zachary J. Sapinsley, Nicholas S. VanDongen +6 more
2020Artery Research1 citations Open access
Semantic Scholar
Primary Prevention of Age‐ and Western Diet‐Associated Vascular Endothelial Dysfunction by Voluntary Aerobic Exercise in Mice: Role of Mitochondrial Oxidative Stress
Zachary S. Clayton, R. Gioscia-Ryan, Matthew J. Rossman, James J. Richey +4 more
2019The FASEB Journal1 citations
Semantic Scholar
LIFETIME EXERCISE ATTENUATES AGE- AND WESTERN DIET-RELATED DECLINES IN PHYSICAL FUNCTION IN MICE
Zachary S. Clayton, R. Gioscia-Ryan, J. Justice, Kara L. Lubieniecki +3 more
2019Innovation in aging1 citations Open access
Semantic Scholar
Mitochondria‐targeted antioxidant therapy with MitoQ ameliorates age‐related vascular endothelial dysfunction
R. Gioscia-Ryan, T. LaRocca, Melanie C. Zigler, M. Murphy +1 more
20131 citations
Semantic Scholar
Female C57Bl/6N mice are a viable model of human aortic aging: Aortic stiffness and structure and systemic inflammation
Abigail G. Longtine, Ravinandan Venkatasubramanian, Melanie C. Zigler, Alexandra Lindquist +7 more
2023Physiology0 citations
Semantic Scholar
Lifelong voluntary aerobic exercise-mediated preservation of physical function is related to changes in the plasma metabolome in aged mice
Grace S. Maurer, K. Murray, R. Gioscia-Ryan, J. Justice +6 more
2023Physiology0 citations
Semantic Scholar
Late-life voluntary wheel running reverses age-related aortic stiffness in mice: a translational model for studying mechanisms of exercise-mediated arterial de-stiffening
R. Gioscia-Ryan, Zachary S. Clayton, B. Fleenor, Jason S. Eng +5 more
2020GeroScience0 citations Open access
Semantic Scholar
Supplementation with the Gut Microbiome‐Derived Metabolite Trimethylamine N‐Oxide Induces Aortic Stiffening in Young Mice
Abigail G. Casso, R. Gioscia-Ryan, Zachary J. Sapinsley, James J. Richey +7 more
2019The FASEB Journal0 citations
Semantic Scholar
Suppression of the Gut Microbiome‐Derived Metabolite Trimethylamine N‐oxide Prevents Western Diet‐Induced Arterial Dysfunction
Vienna E. Brunt, Zachary J. Sapinsley, R. Gioscia-Ryan, James J. Richey +2 more
20180 citations
Semantic Scholar
Angiotensin II receptor signaling modulates vascular smooth muscle sensitivity to nitric oxide in an adiposity‐specific manner in healthy adults
Demetra D. Christou, Moon-Hyon Hwang, Ashley E. Walker, Melanie C. Zigler +1 more
20130 citations
Semantic Scholar
Age‐related cerebrovascular endothelial dysfunction is associated with cognitive impairment in C57BL/6 mice
S. Asano, D. Seals, Melanie C. Zigler, J. Justice +3 more
20130 citations
Semantic Scholar
Sodium nitrite treatment restores vascular endothelial function in old mice with CKD
Amy L. Sindler, Melanie C. Zigler, M. Yoshizawa, C. Baylis +1 more
20120 citations
Semantic Scholar
Polyamine supplementation reduces oxidative stress and reverses vascular endothelial dysfunction with aging
R. Gioscia-Ryan, Melanie C. Zigler, D. Seals, Amy L. Sindler +1 more
20120 citations
Semantic Scholar

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D. Seals×30
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R. Gioscia-Ryan×22
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R. Gioscia-Ryan — researcher profile on SciRah
Vienna E. Brunt×10
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Vienna E. Brunt — researcher profile on SciRah
Nicholas S. VanDongen×10
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Nicholas S. VanDongen — researcher profile on SciRah

James J. Richey

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Zachary S. Clayton×8

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Zachary S. Clayton — researcher profile on SciRah

Matthew J. Rossman×6

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Matthew J. Rossman — researcher profile on SciRah

Amy L. Sindler×5

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Amy L. Sindler — researcher profile on SciRah

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Zachary S. Clayton×5

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T. LaRocca — researcher profile on SciRah

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B. Ziemba — researcher profile on SciRah