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Derek A. Costello · SciRah

Researcher profile · Semantic Scholar

Derek A. Costello

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Derek A. Costello — researcher profile on SciRah

h-index: 16
Works: 21
Citations: 1,016

Most-cited papers

Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice
A. McIntosh, V. Mela, C. Harty, A. Minogue +3 more
2019Brain Pathology168 citations Open access
Semantic Scholar
Long Term Potentiation Is Impaired in Membrane Glycoprotein CD200-deficient Mice
Derek A. Costello, A. Lyons, Stephanie Denieffe, T. Browne +2 more
2011Journal of Biological Chemistry100 citations Open access
Semantic Scholar
Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli
James P. Barrett, Derek A. Costello, J. O'Sullivan, T. Cowley +1 more
2015Journal of Neuroinflammation75 citations Open access
Semantic Scholar
Brain Deletion of Insulin Receptor Substrate 2 Disrupts Hippocampal Synaptic Plasticity and Metaplasticity
Derek A. Costello, M. Claret, Hind Al‐Qassab, F. Plattner +5 more
2012PLoS ONE74 citations Open access
Semantic Scholar
Toll‐like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon‐β
Derek A. Costello, Marina A. Lynch
2013Hippocampus70 citations
Semantic Scholar
A beta 25-35-induced depression of long-term potentiation in area CA1 in vivo and in vitro is attenuated by verapamil.
D. B. Freir, Derek A. Costello, C. Herron
2003Journal of Neurophysiology70 citations
Semantic Scholar
Interleukin-1α and HMGB1 Mediate Hippocampal Dysfunction in SIGIRR-Deficient Mice
Derek A. Costello, Melanie B. Watson, T. Cowley, Niamh Murphy +3 more
2011Journal of Neuroscience63 citations Open access
Semantic Scholar
Palmitic Acid and Oleic Acid Differently Modulate TLR2-Mediated Inflammatory Responses in Microglia and Macrophages
A. Howe, Sinéad Burke, M. O'Reilly, F. McGillicuddy +1 more
2022Molecular Neurobiology60 citations Open access
Semantic Scholar
The role of c-Jun N-terminal kinase in the A beta-mediated impairment of LTP and regulation of synaptic transmission in the hippocampus.
Derek A. Costello, C. Herron
2004Neuropharmacology59 citations
Semantic Scholar
Dok2 mediates the CD200Fc attenuation of Aβ-induced changes in glia
A. Lyons, Eric J. Downer, Derek A. Costello, Niamh Murphy +1 more
2012Journal of Neuroinflammation51 citations Open access
Semantic Scholar
Agonists of peroxisome proliferator-activated receptor-γ attenuate the Aβ-mediated impairment of LTP in the hippocampus in vitro
Derek A. Costello, Deirdre M. O'Leary, C. Herron
200538 citations
Semantic Scholar
α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR.
Derek A. Costello, Dónal Carney, M. Lynch
2015Brain, behavior, and immunity36 citations Open access
Semantic Scholar
Glial Activation in AβPP/PS1 Mice is Associated with Infiltration of IFNγ-Producing Cells
R. Kelly, A. Minogue, A. Lyons, Raasay S. Jones +6 more
2013Journal of Alzheimer's Disease36 citations
Semantic Scholar
SIGIRR modulates the inflammatory response in the brain.
Melanie B. Watson, Derek A. Costello, Dónal Carney, Keith McQuillan +1 more
2010Brain, behavior, and immunity34 citations Open access
Semantic Scholar
The age-related neuroinflammatory environment promotes macrophage activation, which negatively impacts synaptic function.
Derek A. Costello, K. Keenan, R. McManus, A. Falvey +1 more
2016Neurobiology of Aging31 citations
Semantic Scholar
Inhibition of Urea Transporter (UT)-B Modulates LPS-Induced Inflammatory Responses in BV2 Microglia and N2a Neuroblastoma Cells
Aimée C. Jones, Farhana Pinki, G. Stewart, Derek A. Costello
2021Neurochemical Research19 citations
Semantic Scholar
Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro.
Derek A. Costello, Deirdre M. O'Leary, C. Herron
2005Neuropharmacology13 citations
Semantic Scholar
Characterising lipoteichoic acid as an in vitro model of acute neuroinflammation.
A. Howe, Aoife Cosgrave, Maitiú Ó'Murchú, Conor Britchfield +5 more
2020International Immunopharmacology12 citations Open access
Semantic Scholar
Long-term potentiation is impaired in CD 200-deficient mice : a role for Toll-like receptor activation
Derek A. Costello, A. Lyons, T. Browne, Stephanie Denieffe +2 more
20117 citations
Semantic Scholar
IL-1 α and HMGB 1 mediate hippocampal dysfunction in SIGIRR-deficient mice Abbreviated title : SIGIRR deficiency leads to hippocampal dysfunction
Derek A. Costello, Melanie B. Watson, T. Cowley, Niamh Murphy +3 more
20110 citations
Semantic Scholar
Aβ-mediated depression of hippocampal synaptic plasticity: mechanism of action?
Adrien W. Schmid, C. Herron, Derek A. Costello, D. B. Freir
20030 citations
Semantic Scholar

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M. Lynch×10
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M. Lynch — researcher profile on SciRah
C. Herron×5
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C. Herron — researcher profile on SciRah
A. Lyons×4
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A. Lyons — researcher profile on SciRah
Stephanie Denieffe×3
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T. Browne — researcher profile on SciRah

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T. Cowley — researcher profile on SciRah

Melanie B. Watson×3

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Melanie B. Watson — researcher profile on SciRah

Niamh Murphy×3

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Niamh Murphy — researcher profile on SciRah

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A. Minogue — researcher profile on SciRah

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Marina A. Lynch — researcher profile on SciRah

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D. B. Freir — researcher profile on SciRah