Yumiko Isobe

Most-cited papers

1. Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway

   Takeshi Fujino, S. Goyama, Y. Sugiura, D. Inoue +21 more

   2021Nature Communications97 citations Open access

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2. Design, synthesis, and biological activity of novel factor Xa inhibitors: improving metabolic stability by S1 and S4 ligand modification.

   S. Komoriya, Shozo Kobayashi, K. Osanai, T. Yoshino +10 more

   2006Bioorganic & Medicinal Chemistry39 citations

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3. Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors.

   T. Nagata, T. Yoshino, N. Haginoya, K. Yoshikawa +3 more

   2007Bioorganic & Medicinal Chemistry Letters28 citations Open access

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4. Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites.

   S. Komoriya, N. Haginoya, Shozo Kobayashi, T. Nagata +8 more

   2005Bioorganic & Medicinal Chemistry24 citations

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5. Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses.

   M. Kubo, Ryuichi Nagashima, Etsuro Ohta, Tatsunori Maekawa +9 more

   2016Journal of Neuroimmunology19 citations

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6. von Willebrand factor type D domain mutant of SVS‐1/SUSD2, vWDm, induces apoptosis in HeLa cells

   T. Sugahara, Y. Yamashita, Masahito Shinomi, Yumiko Isobe +7 more

   200714 citations Open access

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7. Bromodomain protein BRD8 regulates cell cycle progression in colorectal cancer cells through a TIP60-independent regulation of the pre-RC complex

   K. Yamaguchi, S. Nakagawa, Akari Saku, Yumiko Isobe +17 more

   2023iScience9 citations Open access

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8. Identification of odontogenic ameloblast associated as a novel target gene of the Wnt/β‐catenin signaling pathway

   K. Yamaguchi, Chiaki Horie, Kiyoko Takane, T. Ikenoue +12 more

   2022Cancer Science6 citations Open access

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9. von Willebrand factor type D domain mutant of SVS-1/SUSD2, vWD(m), induces apoptosis in HeLa cells.

   T. Sugahara, Y. Yamashita, Masahito Shinomi, Yumiko Isobe +7 more

   2007Cancer Science6 citations

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10. Motile sperm domain containing 1 is upregulated by the Wnt/β-catenin signaling pathway in colorectal cancer.

    Chiaki Horie, Chi Zhu, K. Yamaguchi, S. Nakagawa +10 more

    2022Oncology Letters4 citations Open access

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11. BRD8 deficiency leads to progressive impairment of spermatogenesis in mice.

    S. Nakagawa, Manabu Ozawa, Teh-Wei Wang, T. Ikenoue +6 more

    2026Journal of Cell Science0 citations Open access

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12. FACTOR XA IN COMPLEX WITH THE INHIBITOR (-)-cis-N1-[(5-Chloroindol-2-yl)carbonyl]-N2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine

    T. Nagata, T. Yoshino, N. Haginoya, K. Yoshikawa +3 more

    20080 citations

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