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P. Chai · SciRah

Researcher profile · Semantic Scholar

P. Chai

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P. Chai — researcher profile on SciRah

h-index: 30
Works: 94
Citations: 4,107

Most-cited papers

Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma
Jie Yu, P. Chai, Minyue Xie, S. Ge +3 more
2021Genome Biology857 citations Open access
Semantic Scholar
Lactate and lactylation in cancer
Jie Chen, Ziyue Huang, Ya Chen, Hao Tian +6 more
2025Signal Transduction and Targeted Therapy511 citations
Semantic Scholar
Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation
Hanhan Shi, P. Chai, R. Jia, Xianqun Fan
2020Molecular Cancer215 citations Open access
Semantic Scholar
Crosstalk between metabolic reprogramming and epigenetics in cancer: updates on mechanisms and therapeutic opportunities
T. Ge, Xiang Gu, R. Jia, S. Ge +3 more
2022Cancer Communications184 citations Open access
Semantic Scholar
m6A modification suppresses ocular melanoma through modulating HINT2 mRNA translation
R. Jia, P. Chai, Shanzheng Wang, Baofa Sun +6 more
2019Molecular Cancer156 citations Open access
Semantic Scholar
Novel insights on m6A RNA methylation in tumorigenesis: a double-edged sword
Shaoyun Wang, P. Chai, R. Jia, Ren-Bing Jia
2018Molecular Cancer154 citations Open access
Semantic Scholar
Histone lactylation-boosted ALKBH3 potentiates tumor progression and diminished promyelocytic leukemia protein nuclear condensates by m1A demethylation of SP100A
Xiang Gu, Ai Zhuang, Jie Yu, Ludi Yang +5 more
2023Nucleic Acids Research140 citations Open access
Semantic Scholar
Emancipating Target‐Functionalized Carbon Dots from Autophagy Vesicles for a Novel Visualized Tumor Therapy
Ji-Peng Li, Siwei Yang, Yuan Deng, P. Chai +7 more
2018Advanced Functional Materials138 citations
Semantic Scholar
Genetic alteration, RNA expression, and DNA methylation profiling of coronavirus disease 2019 (COVID-19) receptor ACE2 in malignancies: a pan-cancer analysis
P. Chai, Jie-Fei Yu, S. Ge, R. Jia +1 more
2020Journal of Hematology & Oncology111 citations Open access
Semantic Scholar
Effects of cancer on patients with COVID-19: a systematic review and meta-analysis of 63,019 participants
Lu-Di Yang, P. Chai, Jie Yu, Xianqun Fan
2021Cancer Biology and Medicine105 citations Open access
Semantic Scholar
Extrachromosomal circular DNA: biogenesis, structure, functions and diseases
Lu-Di Yang, R. Jia, T. Ge, S. Ge +3 more
2022Signal Transduction and Targeted Therapy101 citations Open access
Semantic Scholar
Nuclear PD-L1 promotes EGR1-mediated angiogenesis and accelerates tumorigenesis
Jie Yu, Ai Zhuang, Xiang Gu, Y. Hua +6 more
2023Cell Discovery93 citations Open access
Semantic Scholar
The Evolving Functions of Autophagy in Ocular Health: A Double-edged Sword
P. Chai, Hongyan Ni, He Zhang, Xianqun Fan
2016International Journal on Biological Sciences86 citations Open access
Semantic Scholar
A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3
Xiaoyu He, P. Chai, Fang Li, Lei-Lei Zhang +9 more
2020Molecular Cancer68 citations Open access
Semantic Scholar
NSUN2‐mediated m5C RNA methylation dictates retinoblastoma progression through promoting PFAS mRNA stability and expression
Sipeng Zuo, Lin Li, Xu-Yang Wen, Xiang Gu +8 more
2023Clinical and Translational Medicine64 citations Open access
Semantic Scholar
Hijacking of the nervous system in cancer: mechanism and therapeutic targets
Yu Zhang, Qili Liao, Xu-Yang Wen, Jia-Yan Fan +5 more
2025Molecular Cancer62 citations Open access
Semantic Scholar
The m6A reading protein YTHDF3 potentiates tumorigenicity of cancer stem-like cells in ocular melanoma through facilitating CTNNB1 translation
Yangfan Xu, Xiaoyu He, Shanzheng Wang, Baofa Sun +8 more
2022Oncogene61 citations
Semantic Scholar
Regulation of epigenetic homeostasis in uveal melanoma and retinoblastoma.
P. Chai, R. Jia, Yong-Yun Li, Chuan-Di Zhou +10 more
2021Progress in retinal and eye research50 citations
Semantic Scholar
CANT1 lncRNA Triggers Efficient Therapeutic Efficacy by Correcting Aberrant lncing Cascade in Malignant Uveal Melanoma.
Yue Xing, Xu-Yang Wen, Xia Ding, Jia-Yan Fan +6 more
2017Molecular Therapy49 citations Open access
Semantic Scholar
Recent progress in Retinoblastoma: Pathogenesis, Presentation, Diagnosis and Management.
Min Zhou, Jie-Ling Tang, Jia-Yan Fan, Xu-Yang Wen +4 more
2024Asia - Pacific Journal of Ophthalmology46 citations Open access
Semantic Scholar
Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment
Nan-Nan Xu, Ye-Min Zhu, Yi-Chao Han, Qi Liu +20 more
2025Nature Metabolism42 citations
Semantic Scholar
Dynamic chromosomal tuning of a novel GAU1 lncing driver at chr12p13.32 accelerates tumorigenesis
P. Chai, R. Jia, R. Jia, Hui Pan +8 more
2018Nucleic Acids Research42 citations Open access
Semantic Scholar
Recent Understandings Toward Coronavirus Disease 2019 (COVID-19): From Bench to Bedside
Jie-Fei Yu, P. Chai, S. Ge, Xianqun Fan
2020Frontiers in Cell and Developmental Biology40 citations Open access
Semantic Scholar
Targeting histone deacetylase suppresses tumor growth through eliciting METTL14‐modified m6A RNA methylation in ocular melanoma
Ai Zhuang, Xiang Gu, T. Ge, Shaoyun Wang +4 more
2023Cancer Communications38 citations Open access
Semantic Scholar
Mohs micrographic surgery for eyelid sebaceous carcinoma: A multicenter cohort of 360 patients.
Chuan-Di Zhou, Fan Wu, P. Chai, Ying-Yun Shi +8 more
2019Journal of American Academy of Dermatology37 citations
Semantic Scholar
Novel insights into chromosomal conformations in cancer
R. Jia, P. Chai, He Zhang, Xianqun Fan
2017Molecular Cancer37 citations Open access
Semantic Scholar
m6A RNA hypermethylation-induced BACE2 boosts intracellular calcium release and accelerates tumorigenesis of ocular melanoma.
Fang-Lin He, Jie Yu, Jie Yang, Shaoyun Wang +6 more
2021Molecular Therapy34 citations Open access
Semantic Scholar
In vivo prime editing rescues photoreceptor degeneration in nonsense mutant retinitis pigmentosa
Yidian Fu, Xiaoyu He, Liang Ma, Xin D. Gao +8 more
2025Nature Communications32 citations Open access
Semantic Scholar
Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
P. Chai, P. Lan, Shao-Bai Li, D. Yao +7 more
2022Molecules and Cells32 citations Open access
Semantic Scholar
LncRNA CANT1 suppresses retinoblastoma progression by repellinghistone methyltransferase in PI3Kγ promoter
Hongyan Ni, P. Chai, Jie Yu, Yue Xing +6 more
2020Cell Death and Disease31 citations Open access
Semantic Scholar
FTO elicits tumor neovascularization in cancer-associated fibroblasts through eliminating m6A modifications of multiple pro-angiogenic factors.
Qili Liao, Hanhan Shi, Jie Yang, Sheng-Fang Ge +4 more
2024Cancer Letters30 citations
Semantic Scholar
Novel insights into histone lysine methyltransferases in cancer therapy: From epigenetic regulation to selective drugs
Qili Liao, Jie Yang, S. Ge, P. Chai +2 more
2022Journal of Pharmaceutical Analysis30 citations Open access
Semantic Scholar
A novel MYCN-YTHDF1 cascade contributes to retinoblastoma tumor growth by eliciting m^6A -dependent activation of multiple oncogenes
Yingxiu Luo, Mengjia He, Jie Yang, Feifei Zhang +6 more
2023Science China Life Sciences27 citations
Semantic Scholar
Novel insights into extrachromosomal DNA: redefining the onco-drivers of tumor progression
Xiang Gu, Jie Yu, P. Chai, S. Ge +1 more
2020Journal of experimental & clinical cancer research : CR27 citations Open access
Semantic Scholar
Generation of onco-enhancer enhances chromosomal remodeling and accelerates tumorigenesis
P. Chai, Jie Yu, R. Jia, Xu-Yang Wen +7 more
2020Nucleic Acids Research23 citations Open access
Semantic Scholar
Contemporary update of overall prognosis and nomogram to predict individualized survival for Chinese patients with eyelid sebaceous carcinoma
Chuan-Di Zhou, Ying-Yun Shi, P. Chai, Fan Wu +6 more
2018EBioMedicine23 citations Open access
Semantic Scholar
Lactate/lactylation in ocular development and diseases.
P. Chai, Fei Zhao, R. Jia, Xiang-Tian Zhou +1 more
2024Trends in Molecular Medicine21 citations
Semantic Scholar
Metformin promotes histone deacetylation of optineurin and suppresses tumour growth through autophagy inhibition in ocular melanoma
Ai Zhuang, P. Chai, Shaoyun Wang, Sipeng Zuo +9 more
2022Clinical and Translational Medicine21 citations Open access
Semantic Scholar
SKP2 targeted inhibition suppresses human uveal melanoma progression by blocking ubiquitylation of p27
Hong-Bo Zhao, Hui Pan, Huixue Wang, P. Chai +3 more
2019OncoTargets and Therapy21 citations Open access
Semantic Scholar
Clinical characteristics and germline mutation spectrum of RB1 in Chinese patients with retinoblastoma: A dual-center study of 145 patients.
P. Chai, Yingxiu Luo, Jie Yu, Yong-Yun Li +5 more
2021Experimental Eye Research20 citations
Semantic Scholar
Single-cell sequencing depicts tumor architecture and empowers clinical decision in metastatic conjunctival melanoma
Hanhan Shi, Hao Tian, Tian-Yu Zhu, Qili Liao +12 more
2024Cell Discovery19 citations Open access
Semantic Scholar
Functional Analysis of a Novel FOXL2 Indel Mutation in Chinese Families with Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Type I
P. Chai, Fang Li, Jia-Yan Fan, R. Jia +2 more
2017International Journal on Biological Sciences14 citations Open access
Semantic Scholar
RNA Methylation Homeostasis in Ocular Diseases: All Eyes on Me.
Jie-Ling Tang, Chuan-Di Zhou, Fuxiang Ye, Sipeng Zuo +4 more
2025Progress in retinal and eye research13 citations
Semantic Scholar
Orbital involvement by NUT midline carcinoma: new presentation and encouraging outcome managed by radiotherapy combined with tyrosine kinase inhibitor: a case report
P. Chai, Chuan-Di Zhou, R. Jia, Ye-Fei Wang
2020Diagnostic Pathology13 citations Open access
Semantic Scholar
The Use of rAAV2-RB1–Mediated Gene Therapy in Retinoblastoma
Hanhan Shi, Xiaoyu He, Zhi Yang, Qili Liao +7 more
2023Investigative Ophthalmology and Visual Science12 citations Open access
Semantic Scholar
Epigenetic drug library screening reveals targeting DOT1L abrogates NAD+ synthesis by reprogramming H3K79 methylation in uveal melanoma
Xiang Gu, Y. Hua, Jie Yu, Lu-Di Yang +5 more
2022Journal of Pharmaceutical Analysis12 citations Open access
Semantic Scholar
Phase separation drives tumor pathogenesis and evolution: all roads lead to Rome
Xiang Gu, Ai Zhuang, Jie Yu, P. Chai +2 more
2022Oncogene12 citations
Semantic Scholar
BMP9 promotes cutaneous wound healing by activating Smad1/5 signaling pathways and cytoskeleton remodeling
P. Chai, Jie Yu, Xi Wang, S. Ge +1 more
2021Clinical and Translational Medicine12 citations Open access
Semantic Scholar
Lactylation-boosted Polycomb Repression of KLF4 Elicits Glycolysis in Retinoblastoma: A Positive Feedback Circuit between Histone Modifications.
Ludi Yang, Sipeng Zuo, R. Jia, Xiang Gu +11 more
2025Cancer Letters11 citations Open access
Semantic Scholar
Clinical characteristics and mutation Spectrum of NF1 in 12 Chinese families with orbital/periorbital plexiform Neurofibromatosis type 1
P. Chai, Yingxiu Luo, Chuan-Di Zhou, Ye-Fei Wang +2 more
2019BMC Medical Genetics11 citations Open access
Semantic Scholar

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Xianqun Fan×31
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S. Ge×24
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Jie Yu×14
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Jia-Yan Fan×11

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Chuan-Di Zhou×8

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Xu-Yang Wen — researcher profile on SciRah

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Hanhan Shi — researcher profile on SciRah