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N. Geacintov · SciRah

Researcher profile · Semantic Scholar

N. Geacintov

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N. Geacintov — researcher profile on SciRah

h-index: 64
Works: 518
Citations: 16K

Most-cited papers

One-electron oxidation reactions of purine and pyrimidine bases in cellular DNA
J. Cadet, J. R. Wagner, V. Shafirovich, N. Geacintov
2014International Journal of Radiation Biology147 citations Open access
Semantic Scholar
PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells
Ayal Hendel, P. Krijger, Noam Diamant, Z. Goren +11 more
2011PLoS Genetics140 citations Open access
Semantic Scholar
Lifetimes and Reaction Pathways of Guanine Radical Cations and Neutral Guanine Radicals in an Oligonucleotide in Aqueous Solutions
Yekaterina Rokhlenko, N. Geacintov, V. Shafirovich
2012Journal of the American Chemical Society99 citations Open access
Semantic Scholar
Mechanistic Aspects of Hydration of Guanine Radical Cations in DNA
Yekaterina Rokhlenko, J. Cadet, N. Geacintov, V. Shafirovich
2014Journal of the American Chemical Society92 citations Open access
Semantic Scholar
The Chemical Biology of DNA Damage
N. Geacintov, S. Broyde
201077 citations
Semantic Scholar
Structural basis for the recognition of diastereomeric 5′,8-cyclo-2′-deoxypurine lesions by the human nucleotide excision repair system
Konstantin Kropachev, Shuang Ding, Michael A. Terzidis, A. Masi +7 more
2014Nucleic Acids Research74 citations Open access
Semantic Scholar
MOLECULAR BASIS FOR DAMAGE RECOGNITION AND VERIFICATION BY XPC-RAD23B AND TFIIH IN NUCLEOTIDE EXCISION REPAIR
Hong Mu, N. Geacintov, S. Broyde, J. Yeo +1 more
2018DNA Repair65 citations Open access
Semantic Scholar
Resistance of bulky DNA lesions to nucleotide excision repair can result from extensive aromatic lesion–base stacking interactions
Dara A. Reeves, Hong Mu, Konstantin Kropachev, Yuqin Cai +9 more
2011Nucleic Acids Research62 citations Open access
Semantic Scholar
Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability
P. Galanos, George Pappas, A. Polyzos, A. Kotsinas +17 more
2017Genome Biology59 citations Open access
Semantic Scholar
Repair-Resistant DNA Lesions
N. Geacintov, S. Broyde
2017Chemical Research in Toxicology58 citations Open access
Semantic Scholar
Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin
O. Ziv, A. Zeisel, Nataly Mirlas-Neisberg, Umakanta Swain +11 more
2014Nature Communications58 citations Open access
Semantic Scholar
Removal of oxidatively generated DNA damage by overlapping repair pathways
V. Shafirovich, N. Geacintov
2016Free Radical Biology & Medicine56 citations Open access
Semantic Scholar
Probing for DNA damage with β-hairpins: Similarities in incision efficiencies of bulky DNA adducts by prokaryotic and human nucleotide excision repair systems in vitro
Yang Liu, Dara A. Reeves, Konstantin Kropachev, Yuqin Cai +7 more
2011DNA Repair52 citations Open access
Semantic Scholar
5′,8-Cyclopurine Lesions in DNA Damage: Chemical, Analytical, Biological, and Diagnostic Significance
C. Chatgilialoglu, C. Ferreri, N. Geacintov, M. Krokidis +5 more
2019Cells50 citations Open access
Semantic Scholar
Base and Nucleotide Excision Repair of Oxidatively Generated Guanine Lesions in DNA*
V. Shafirovich, Konstantin Kropachev, T. Anderson, Zhi Liu +7 more
2016Journal of Biological Chemistry50 citations Open access
Semantic Scholar
Nucleotide excision repair of 2-acetylaminofluorene- and 2-aminofluorene-(C8)-guanine adducts: molecular dynamics simulations elucidate how lesion structure and base sequence context impact repair efficiencies
Hong Mu, Konstantin Kropachev, Li-Hua Wang, Lu Zhang +4 more
2012Nucleic Acids Research49 citations Open access
Semantic Scholar
Genomic assay reveals tolerance of DNA damage by both translesion DNA synthesis and homology-dependent repair in mammalian cells
Lior Izhar, O. Ziv, Isadora S. Cohen, N. Geacintov +1 more
2013Proceedings of the National Academy of Sciences of the United States of America46 citations Open access
Semantic Scholar
Nucleotide excision repair efficiencies of bulky carcinogen-DNA adducts are governed by a balance between stabilizing and destabilizing interactions
Yuqin Cai, N. Geacintov, S. Broyde
2012Biochemistry46 citations Open access
Semantic Scholar
Oxidative Modification of Guanine Bases Initiated by Oxyl Radicals Derived From Photolysis of Azo Compounds
J. Shao, N. Geacintov, V. Shafirovich
2010Journal of Physical Chemistry B41 citations Open access
Semantic Scholar
Adenine-DNA adducts derived from the highly tumorigenic dibenzo[a,l]pyrene are resistant to nucleotide excision repair while guanine adducts are not
Konstantin Kropachev, Marina Kolbanovskiy, Zhi Liu, Yuqin Cai +7 more
2013Chemical Research in Toxicology40 citations Open access
Semantic Scholar
Generation of Guanine – Thymidine Cross-links in DNA by Peroxynitrite/Carbon Dioxide
B. Yun, N. Geacintov, V. Shafirovich
2011Chemical Research in Toxicology40 citations Open access
Semantic Scholar
Generation of Guanine -Thymine Crosslinks in Human Cells by One-Electron Oxidation Mechanisms
Guru S. Madugundu, R. Wagner, J. Cadet, Konstantin Kropachev +3 more
2013Chemical Research in Toxicology38 citations Open access
Semantic Scholar
The relationships between XPC binding to conformationally diverse DNA adducts and their excision by the human NER system: is there a correlation?
Yuan-Cho Lee, Yuqin Cai, Hong Mu, S. Broyde +4 more
2014DNA Repair37 citations Open access
Semantic Scholar
Nucleotide Excision Repair Lesion-Recognition Protein Rad4 Captures a Pre-Flipped Partner Base in a Benzo[a]pyrene-Derived DNA Lesion: How Structure Impacts the Binding Pathway
Hong Mu, N. Geacintov, Jung-Hyun Min, Ying-Kai Zhang +1 more
2017Chemical Research in Toxicology35 citations Open access
Semantic Scholar
Preferred WMSA catalytic mechanism of the nucleotidyl transfer reaction in human DNA polymerase κ elucidates error-free bypass of a bulky DNA lesion
Lee Lior-Hoffmann, Li-Hua Wang, Sheng-Long Wang, N. Geacintov +2 more
2012Nucleic Acids Research33 citations Open access
Semantic Scholar
Characterization of the interactions of PARP-1 with UV-damaged DNA in vivo and in vitro
Nupur K. Purohit, Mihaela-Alina Robu, R. Shah, N. Geacintov +1 more
2016Scientific Reports27 citations Open access
Semantic Scholar
Recognition of Damaged DNA for Nucleotide Excision Repair: A Correlated Motion Mechanism with a Mismatched cis-syn Thymine Dimer Lesion
Hong Mu, N. Geacintov, Ying-Kai Zhang, S. Broyde
2015Biochemistry27 citations Open access
Semantic Scholar
Thermodynamic Profiles and NMR Studies of Oligonucleotide Duplexes Containing Single Diastereomeric Spiroiminodihydantoin Lesions
Irine G. Khutsishvili, Na Zhang, L. Marky, Conor W. Crean +3 more
2013Biochemistry27 citations Open access
Semantic Scholar
Structural, energetic and dynamic properties of guanine(C8)–thymine(N3) cross-links in DNA provide insights on susceptibility to nucleotide excision repair
Shuang Ding, Konstantin Kropachev, Yuqin Cai, Marina Kolbanovskiy +5 more
2011Nucleic Acids Research26 citations Open access
Semantic Scholar
DNA lesion identity drives choice of damage tolerance pathway in murine cell chromosomes
Isadora S. Cohen, Carmit Bar, Tamar Paz-Elizur, E. Ainbinder +4 more
2015Nucleic Acids Research25 citations Open access
Semantic Scholar
Ribonucleotides as nucleotide excision repair substrates
Yuqin Cai, N. Geacintov, S. Broyde
2013DNA Repair24 citations Open access
Semantic Scholar
Nucleotide Excision Repair and Transcription-coupled DNA Repair Abrogate the Impact of DNA Damage on Transcription
Aditi Nadkarni, John A. Burns, A. Gandolfi, Moinuddin A. Chowdhury +4 more
2015Journal of Biological Chemistry23 citations Open access
Semantic Scholar
Intercalative Conformations of the 14R (+)- and 14S (–)-trans-anti-DB[a,l]P-N6-dA Adducts: Molecular Modeling and MD Simulations
Yuqin Cai, Shuang Ding, N. Geacintov, S. Broyde
2011Chemical Research in Toxicology23 citations Open access
Semantic Scholar
Nucleotide Excision Repair and Impact of Site-Specific 5’,8-Cyclopurine and Bulky DNA Lesions on the Physical Properties of Nucleosomes
V. Shafirovich, Marina Kolbanovskiy, Konstantin Kropachev, Zhi Liu +8 more
2018Biochemistry22 citations Open access
Semantic Scholar
Nucleosome histone tail conformation and dynamics: impacts of lysine acetylation and a nearby minor groove benzo[a]pyrene-derived lesion
Iwen Fu, Yuqin Cai, N. Geacintov, Ying-Kai Zhang +1 more
2017Biochemistry22 citations Open access
Semantic Scholar
Excision of Oxidatively Generated Guanine Lesions by Competing Base and Nucleotide Excision Repair Mechanisms in Human Cells
V. Shafirovich, Konstantin Kropachev, Marina Kolbanovskiy, N. Geacintov
2019Chemical Research in Toxicology21 citations Open access
Semantic Scholar
5-Formylcytosine-induced DNA–peptide cross-links reduce transcription efficiency, but do not cause transcription errors in human cells
Shao-Fei Ji, D. Park, Konstantin Kropachev, Marina Kolbanovskiy +5 more
2019Journal of Biological Chemistry20 citations Open access
Semantic Scholar
Lesion Sensing during Initial Binding by Yeast XPC/Rad4: Toward Predicting Resistance to Nucleotide Excision Repair
Hong Mu, Ying-Kai Zhang, N. Geacintov, S. Broyde
2018Chemical Research in Toxicology20 citations Open access
Semantic Scholar
Generation of Guanine – Amino Acid Cross-Links by a Free Radical Combination Mechanism
Yuriy Uvaydov, N. Geacintov, V. Shafirovich
2014Physical Chemistry, Chemical Physics - PCCP20 citations Open access
Semantic Scholar
Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase
O. Rechkoblit, Alexander Kolbanovskiy, H. Landes, N. Geacintov +1 more
2017Nature Communications19 citations Open access
Semantic Scholar
Resistance to Nucleotide Excision Repair of Bulky Guanine Adducts Opposite Abasic Sites in DNA Duplexes and Relationships between Structure and Function
Zhi Liu, Shuang Ding, Konstantin Kropachev, Jia Lei +3 more
2015PLoS ONE19 citations Open access
Semantic Scholar
Human DNA polymerase λ catalyzes lesion bypass across benzo[a]pyrene-derived DNA adduct during base excision repair.
L. V. Skosareva, N. Lebedeva, N. Rechkunova, Alexander Kolbanovskiy +2 more
2012DNA Repair19 citations
Semantic Scholar
Structural and Dynamic Characterization of Polymerase κ’s Minor Groove Lesion Processing Reveals How Adduct Topology Impacts Fidelity
Lee Lior-Hoffmann, Shuang Ding, N. Geacintov, Ying-Kai Zhang +1 more
2014Biochemistry18 citations Open access
Semantic Scholar
The role of structural and energetic factors in regulating repair of a bulky DNA lesion with different opposite partner bases
Hong Mu, Konstantin Kropachev, Ying Chen, Hong Zhang +3 more
2013Biochemistry18 citations Open access
Semantic Scholar
Mechanism of lesion verification by the human XPD helicase in nucleotide excision repair
Iwen Fu, Hong Mu, N. Geacintov, S. Broyde
2022Nucleic Acids Research17 citations Open access
Semantic Scholar
Free energy profiles of base flipping in intercalative polycyclic aromatic hydrocarbon-damaged DNA duplexes: Energetic and structural relationships to nucleotide excision repair susceptibility
Yuqin Cai, Han Zheng, Shuang Ding, Konstantin Kropachev +7 more
2013Chemical Research in Toxicology17 citations Open access
Semantic Scholar
The Non-Bulky DNA Lesions Spiroiminodihydantoin and 5-Guanidinohydantoin Significantly Block Human RNA Polymerase II Elongation in vitro
Marina Kolbanovskiy, Moinuddin A. Chowdhury, Aditi Nadkarni, S. Broyde +3 more
2017Biochemistry16 citations Open access
Semantic Scholar
Differences in the Access of Lesions to the Nucleotide Excision Repair Machinery in Nucleosomes
Yuqin Cai, Konstantin Kropachev, Michael A. Terzidis, A. Masi +4 more
2015Biochemistry16 citations Open access
Semantic Scholar
Molecular dynamics simulations reveal how H3K56 acetylation impacts nucleosome structure to promote DNA exposure for lesion sensing.
Iwen Fu, N. Geacintov, S. Broyde
2021DNA Repair15 citations Open access
Semantic Scholar
Oxidatively Generated Guanine(C8)-Thymine(N3) Intrastrand Cross-links in Double-stranded DNA Are Repaired by Base Excision Repair Pathways*
I. Talhaoui, V. Shafirovich, Zhi Liu, C. Saint-Pierre +5 more
2015Journal of Biological Chemistry15 citations Open access
Semantic Scholar

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