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L. Young · SciRah

Researcher profile · Semantic Scholar

L. Young

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L. Young — researcher profile on SciRah

h-index: 31
Works: 62
Citations: 7,429

Most-cited papers

Large offspring syndrome in cattle and sheep.
L. Young, K. Sinclair, I. Wilmut
1998Reviews of reproduction950 citations Open access
Semantic Scholar
Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture
L. Young, Kenneth Fernandes, T. McEvoy, S. Butterwith +6 more
2001Nature Genetics860 citations
Semantic Scholar
DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status
K. Sinclair, C. Allegrucci, Ravinder Singh, D. Gardner +10 more
2007Proceedings of the National Academy of Sciences of the United States of America836 citations Open access
Semantic Scholar
Screening a large, ethnically diverse population of human embryonic stem cells identifies a chromosome 20 minimal amplicon that confers a growth advantage
K. Amps, P. Andrews, G. Anyfantis, L. Armstrong +121 more
2011Nature Biotechnology575 citations Open access
Semantic Scholar
Improved Human Embryonic Stem Cell Embryoid Body Homogeneity and Cardiomyocyte Differentiation from a Novel V‐96 Plate Aggregation System Highlights Interline Variability
P. Burridge, David A. Anderson, H. Priddle, Maria D. Barbadillo Muñoz +4 more
2007Stem Cells312 citations
Semantic Scholar
Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform
C. Denning, V. Borgdorff, James Crutchley, K. Firth +11 more
2016Biochimica et Biophysica Acta284 citations Open access
Semantic Scholar
Non-conservation of mammalian preimplantation methylation dynamics.
N. Beaujean, G. Hartshorne, J. Cavilla, Jane E. Taylor +4 more
2004Current Biology239 citations Open access
Semantic Scholar
Effect of Limited DNA Methylation Reprogramming in the Normal Sheep Embryo on Somatic Cell Nuclear Transfer1
N. Beaujean, Jane E. Taylor, J. Gardner, I. Wilmut +2 more
2004Biology of Reproduction236 citations Open access
Semantic Scholar
Differences between human embryonic stem cell lines.
C. Allegrucci, L. Young
2007Human Reproduction Update234 citations Open access
Semantic Scholar
Evaluation of Gestational Deficiencies in Cloned Sheep Fetuses and Placentae1
P. D. De Sousa, T. King, L. Harkness, L. Young +2 more
2001Biology of Reproduction226 citations
Semantic Scholar
Epigenetics and the germline.
C. Allegrucci, A. Thurston, E. Lucas, L. Young
2005Reproduction220 citations Open access
Semantic Scholar
Aberrant fetal growth and development after in vitro culture of sheep zygotes.
K. Sinclair, T. McEvoy, E. Maxfield, C. Maltin +4 more
1999Journal of Reproduction and Fertility217 citations Open access
Semantic Scholar
In-utero overgrowth in ruminants following embryo culture: lessons from mice and a warning to men.
K. Sinclair, L. Young, I. Wilmut, T. McEvoy
2000Human Reproduction207 citations
Semantic Scholar
N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells
Abdulkadir Abakir, Tom C. B. Giles, Agnese Cristini, J. Foster +18 more
2019Nature Genetics203 citations Open access
Semantic Scholar
Restriction landmark genome scanning identifies culture-induced DNA methylation instability in the human embryonic stem cell epigenome.
C. Allegrucci, Yue-Zhong Wu, A. Thurston, C. Denning +13 more
2007Human Molecular Genetics182 citations Open access
Semantic Scholar
DNA methylation in the preimplantation embryo: the differing stories of the mouse and sheep.
L. Young, N. Beaujean
2004Animal Reproduction Science167 citations
Semantic Scholar
The developmental origins of health and disease: current theories and epigenetic mechanisms.
K. D. Sinclair, R. Lea, W. Rees, L. Young
2019Society of Reproduction and Fertility supplement144 citations Open access
Semantic Scholar
The effect of interspecific oocytes on demethylation of sperm DNA.
N. Beaujean, J. E. Taylor, Michelle McGarry, J. Gardner +8 more
2004Proceedings of the National Academy of Sciences of the United States of America128 citations Open access
Semantic Scholar
Conservation of IGF2-H19 and IGF2R imprinting in sheep: effects of somatic cell nuclear transfer.
L. Young, A. Schnieke, K. McCreath, Sébastien Wieckowski +7 more
2003Mechanisms of Development122 citations Open access
Semantic Scholar
Large offspring syndrome and other consequences of ruminant embryo culture in vitro: Relevance to blastocyst culture in human ART
T. McEvoy, K. Sinclair, L. Young, I. Wilmut +1 more
2000Human Fertility113 citations
Semantic Scholar
Gene-specific vulnerability to imprinting variability in human embryonic stem cell lines.
Kee-Pyo Kim, A. Thurston, C. Mummery, Dorien Ward-van Oostwaard +4 more
2007Genome Research110 citations Open access
Semantic Scholar
Feeder-free culture of human embryonic stem cells in conditioned medium for efficient genetic modification
S. Braam, C. Denning, E. Matsa, L. Young +2 more
2008Nature Protocols87 citations
Semantic Scholar
Imprinting of Genes and the Barker Hypothesis
L. Young
2001Twin Research85 citations Open access
Semantic Scholar
Ovine fetal development is more sensitive to perturbation by the presence of serum in embryo culture before rather than after compaction.
J. Rooke, T. McEvoy, C. Ashworth, J. Robinson +3 more
2007Theriogenology71 citations
Semantic Scholar
Monoallelic expression of nine imprinted genes in the sheep embryo occurs after the blastocyst stage.
A. Thurston, Jane E. Taylor, J. Gardner, K. Sinclair +1 more
2008Reproduction65 citations Open access
Semantic Scholar
Human embryonic stem cell methyl cycle enzyme expression: modelling epigenetic programming in assisted reproduction?
William Steele, C. Allegrucci, Ravinder Singh, E. Lucas +4 more
2005Reproductive Biomedicine Online60 citations Open access
Semantic Scholar
5-hydroxymethyl-cytosine enrichment of non-committed cells is not a universal feature of vertebrate development
Rimple D. Almeida, M. Loose, V. Sottile, E. Matsa +5 more
2012Epigenetics48 citations Open access
Semantic Scholar
Stem-cell consequences of embryo epigenetic defects.
C. Allegrucci, C. Denning, H. Priddle, L. Young
2004The Lancet39 citations
Semantic Scholar
Zygote donor nitrogen metabolism and in vitro embryo culture perturbs in utero development and IGF2R expression in ovine fetal tissues.
K. Powell, J. Rooke, T. McEvoy, C. Ashworth +4 more
2006Theriogenology38 citations
Semantic Scholar
Molecular and phenotypic analyses of human embryonic stem cell-derived cardiomyocytes
G. Goh, T. Self, Maria D. Barbadillo Muñoz, I. Hall +2 more
2005Thrombosis and Haemostasis34 citations
Semantic Scholar
Epigenetic reprogramming: how now, cloned cow?
H. Fairburn, L. Young, B. Hendrich
2002Current Biology32 citations Open access
Semantic Scholar
Two new protocols to enhance the production and isolation of human induced pluripotent stem cell lines.
E. Dick, E. Matsa, J. Bispham, M. Reza +8 more
2011Stem Cell Research31 citations Open access
Semantic Scholar
Human embryonic stem cells as a model for nutritional programming: an evaluation.
C. Allegrucci, C. Denning, P. Burridge, William Steele +2 more
2005Reproductive Toxicology27 citations
Semantic Scholar
New opportunities in animal breeding and production - an introductory remark.
I. Wilmut, L. Young, P. DeSousa, T. King
2000Animal Reproduction Science26 citations
Semantic Scholar
Cloning and expression of sheep DNA methyltransferase 1 and its development‐specific isoform
Jane E. Taylor, H. Moore, N. Beaujean, J. Gardner +3 more
2009Molecular Reproduction and Development25 citations
Semantic Scholar
Faster generation of hiPSCs by coupling high-titer lentivirus and column-based positive selection
E. Dick, E. Matsa, L. Young, D. Darling +1 more
2011Nature Protocols21 citations
Semantic Scholar
Altered IGF binding protein expression is associated with large offspring syndrome in fetal sheep
L. Young, C. Guttierez, S. Butterwith, J. Robinson +4 more
199921 citations
Semantic Scholar
Scientific hazards of human reproductive ‘cloning˚s
L. Young
200318 citations
Semantic Scholar
Identification of polymer surface adsorbed proteins implicated in pluripotent human embryonic stem cell expansion
M. Hammad, Wei Rao, James G. W. Smith, Daniel G. Anderson +6 more
2016Biomaterials Science17 citations Open access
Semantic Scholar
Region-specific DNA methylation in the preimplantation embryo as a target for genomic plasticity.
A. Thurston, E. Lucas, C. Allegrucci, William Steele +1 more
2007Theriogenology17 citations
Semantic Scholar
Bioluminescence Imaging of Human Embryonic Stem Cells Transplanted In Vivo in Murine and Chick Models
H. Priddle, A. Grabowska, T. Morris, P. Clarke +5 more
2009Cloning and Stem Cells16 citations
Semantic Scholar
Evaluation of gestational deficiencies in cloned sheep.
D. Pa, S. Walker, T. King, L. Young +5 more
200013 citations
Semantic Scholar
Increased ovine foetal weight following transient asynchronous embryo transfer is not associated with increased placental weight at day 21 of gestation
L. Young, S. Butterwith, I. Wilmut
199613 citations
Semantic Scholar
Derivation and characterisation of the human embryonic stem cell lines, NOTT1 and NOTT2
H. Priddle, C. Allegrucci, P. Burridge, Maria B Munoz +7 more
2010In Vitro Cellular & Developmental Biology - Animal11 citations
Semantic Scholar
Gene expression in the developing embryo and fetus.
J. Taylor, H. Fairburn, N. Beaujean, R. Meehan +1 more
2019Reproduction (Cambridge, England) Supplement9 citations Open access
Semantic Scholar
Methylation-sensitive polymerase chain reaction.
H. Moore, R. Meehan, L. Young
2006Methods in molecular biology6 citations
Semantic Scholar
Scientific hazards of human reproductive 'cloning'.
L. Young
2003Human Fertility6 citations
Semantic Scholar
Ovine fetal development following different periods of in vitro culture
M. Kuran, T. McEvoy, L. Young, P. Broadbent +2 more
20006 citations
Semantic Scholar
A novel method for quantifying mRNA levels in single embryos
L. Young, S. Butterwith, I. Wilmut
19986 citations
Semantic Scholar
Programming in the pre-implantation embryo.
L. Young, W. D. Rees, K. Sinclair, S. Langley-Evans
20045 citations
Semantic Scholar

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K. Sinclair×13
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C. Allegrucci×11
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