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J. Unitt · SciRah

Researcher profile · Semantic Scholar

J. Unitt

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J. Unitt — researcher profile on SciRah

h-index: 22
Works: 50
Citations: 3,500

Most-cited papers

Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression
D. E. Nelson, Adaoha Elizabeth Ihekwaba, M. Elliott, James R. Johnson +15 more
2004Science1,154 citations
Semantic Scholar
Pulsatile stimulation determines timing and specificity of NF-kappa B-dependent transcription
Louise Ashall, C. Horton, D. E. Nelson, P. Paszek +10 more
2009Science585 citations Open access
Semantic Scholar
Oscillations in NF-kappaB signaling control the dynamics of gene expression.
D. E. Nelson, Adaoha Elizabeth Ihekwaba, M. Elliott, J. R. Johnson +15 more
2004Science535 citations
Semantic Scholar
Multi-parameter analysis of the kinetics of NF-kappaB signalling and transcription in single living cells.
G. Nelson, L. Paraoan, D. Spiller, G. Wilde +6 more
2002Journal of Cell Science124 citations
Semantic Scholar
Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors.
A. Baxter, S. Brough, A. Cooper, Eike Floettmann +13 more
2004Bioorganic & Medicinal Chemistry Letters96 citations
Semantic Scholar
Potent Reversible Inhibition of Myeloperoxidase by Aromatic Hydroxamates*
L. V. Forbes, T. Sjögren, F. Auchère, D. Jenkins +8 more
2013Journal of Biological Chemistry95 citations Open access
Semantic Scholar
Plant lectins are novel Toll-like receptor agonists.
J. Unitt, D. Hornigold
2011Biochemical Pharmacology88 citations Open access
Semantic Scholar
Direct evidence for a role of intramitochondrial Ca2+ in the regulation of oxidative phosphorylation in the stimulated rat heart. Studies using 31P n.m.r. and ruthenium red.
J. Unitt, James G. McCormack, D. Reid, L. K. Maclachlan +1 more
1989Biochemical Journal86 citations Open access
Semantic Scholar
NF-κB signalling is inhibited by glucocorticoid receptor and STAT6 via distinct mechanisms
G. Nelson, G. Wilde, D. Spiller, Stephnie Kennedy +4 more
2003Journal of Cell Science84 citations Open access
Semantic Scholar
Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist.
H. Hunt, J. Belanoff, I. Walters, B. Gourdet +6 more
2017Journal of Medicinal Chemistry61 citations Open access
Semantic Scholar
Hit-to-Lead studies: the discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists.
A. Baxter, A. Cooper, E. Kinchin, Kerry Moakes +2 more
2006Bioorganic & Medicinal Chemistry Letters52 citations Open access
Semantic Scholar
An evaluation of fluorescence polarization and lifetime discriminated polarization for high throughput screening of serine/threonine kinases.
A. Fowler, D. Swift, E. Longman, A. Acornley +6 more
2002Analytical Biochemistry51 citations
Semantic Scholar
Rat skeletal muscle metabolism in experimental heart failure: effects of physical training.
F. Brunotte, Campbell H. Thompson, S. Adamopoulos, A. Coats +5 more
1995Acta Physiologica Scandinavica47 citations
Semantic Scholar
Dual D2-receptor and beta2-adrenoceptor agonists for the treatment of airway diseases. 1. Discovery and biological evaluation of some 7-(2-aminoethyl)-4-hydroxybenzothiazol-2(3H)-one analogues.
R. Bonnert, R. C. Brown, Dave Chapman, D. Cheshire +13 more
1998Journal of Medicinal Chemistry46 citations
Semantic Scholar
Hit-to-lead studies: the discovery of potent, orally bioavailable triazolethiol CXCR2 receptor antagonists.
A. Baxter, Colin Bennion, Janice Bent, Kerry L. Boden +8 more
2003Bioorganic & Medicinal Chemistry Letters41 citations Open access
Semantic Scholar
FKBP5 mRNA Expression Is a Biomarker for GR Antagonism.
U. Bali, T. Phillips, H. Hunt, J. Unitt
2016Journal of Clinical Endocrinology and Metabolism35 citations Open access
Semantic Scholar
Key Aspects of Modern GPCR Drug Discovery.
P. Addis, U. Bali, F. Baron, A. Campbell +9 more
2023SLAS discovery : advancing life sciences R & D33 citations Open access
Semantic Scholar
Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists.
N. Kindon, G. Andrews, A. Baxter, D. Cheshire +14 more
2017ACS Medicinal Chemistry Letters31 citations Open access
Semantic Scholar
Discovery of small molecule human FPR1 receptor antagonists.
J. Unitt, Malbinder Fagura, T. Phillips, Sarah J. King +10 more
2009Bioorganic & Medicinal Chemistry Letters30 citations
Semantic Scholar
Determination of free creatine and phosphocreatine concentrations in the isolated perfused rat heart by 1H- and 31P-NMR.
J. Unitt, Jürgen Schrader, François Brunotte, G. Radda +1 more
1992Biochimica et Biophysica Acta28 citations
Semantic Scholar
A combinatorial biophysical approach; FTSA and SPR for identifying small molecule ligands and PAINs.
M. Redhead, R. Satchell, Vaida Morkūnaitė, D. Swift +5 more
2015Analytical Biochemistry26 citations
Semantic Scholar
1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile.
H. Hunt, J. Belanoff, E. Golding, B. Gourdet +5 more
2015Bioorganic & Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
Novel cobalt complex inhibitors of mitochondrial calcium uptake.
J. Unitt, Kerry L. Boden, A. Wallace, Anthony Howard Ingall +2 more
1999Bioorganic & Medicinal Chemistry17 citations
Semantic Scholar
Evaluation of the Biological Activity of Compounds: Techniques and Mechanism of Action Studies
I. Dougall, J. Unitt
201516 citations
Semantic Scholar
Thermal Shift as an Entropy-Driven Effect.
M. Redhead, R. Satchell, Ciara M. McCarthy, Scott R. Pollack +1 more
2017Biochemistry15 citations Open access
Semantic Scholar
Development of a high-throughput human rhinovirus infectivity cell-based assay for identifying antiviral compounds.
T. Phillips, Lesley Jenkinson, C. McCrae, B. Thong +1 more
2011Journal of Virological Methods15 citations
Semantic Scholar
Development and Validation of a Simple Cell-Based Fluorescence Assay for Dipeptidyl Peptidase 1 (DPP1) Activity
B. Thong, J. Pilling, E. Ainscow, R. Beri +1 more
2011Journal of biomolecular screening13 citations Open access
Semantic Scholar
Discovery of pyrazoles as novel FPR1 antagonists.
A. Morley, Andrew Cook, Sarah J. King, B. Roberts +8 more
2011Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
The acute effects of the creatine analogue, beta-guanidinopropionic acid, on cardiac energy metabolism and function.
J. Unitt, G. Radda, Anne-Marie L. Seymour
1993Biochimica et Biophysica Acta11 citations
Semantic Scholar
Intracellular [Ca2+] staircase in the isovolumic pressure--frequency relationship of Langendorff-perfused rat heart.
M. Field, A. Azzawi, J. Unitt, Anne-Marie L. Seymour +2 more
1996Journal of Molecular and Cellular Cardiology10 citations
Semantic Scholar
Fowler, A. et al. An evaluation of fluorescence polarization and lifetime discriminated polarization for high throughput screening of serine/threonine kinases. Anal. Biochem. 308, 223-231
A. Fowler, D. Swift, E. Longman, A. Acornley +6 more
20028 citations
Semantic Scholar
Dynamic analysis of STAT6 signalling in living cells
G. Nelson, G. Wilde, D. Spiller, E. Sullivan +2 more
2002FEBS Letters8 citations Open access
Semantic Scholar
Discovery and Optimization of Potent and Orally Available CTP Synthetase Inhibitors for Use in Treatment of Diseases Driven by Aberrant Immune Cell Proliferation.
Andrew Novak, D. Laughton, R. Lane, Emma E. Blackham +20 more
2022Journal of Medicinal Chemistry5 citations Open access
Semantic Scholar
Effect of lipophilicity modulation on inhibition of human rhinovirus capsid binders.
A. Morley, N. Tomkinson, Andrew Cook, Cathy MacDonald +6 more
2011Bioorganic & Medicinal Chemistry Letters4 citations Open access
Semantic Scholar
Abstract 1631: GPR65 is a critical mediator of low pH induced immunosuppressive signalling in tumor associated macrophages: Human target validation of GPR65 as a novel innate immune checkpoint and discovery of potent, selective GPR65 antagonists
B. Cipriani, A. Naylor, G. Milne, Barbara Young +13 more
2021Immunology3 citations
Semantic Scholar
Discovery of small molecule human C5a receptor antagonists.
H. Sanganee, A. Baxter, Simon Barber, Alastair J. H. Brown +8 more
2009Bioorganic & Medicinal Chemistry Letters3 citations Open access
Semantic Scholar
Acute replacement of phosphocreatine in the isolated rat heart by perfusion with the creatine analogue beta-guanidinopropionic acid.
J. Unitt, G. Radda, Anne-Marie L. Seymour
1990Biochemical Society Transactions3 citations
Semantic Scholar
Age-dependent changes in cardiac muscle metabolism upon replacement of creatine by ß- guanidinopropionic acid
M. Field, J. Unitt, G. Radda, C. Henderson +1 more
19912 citations
Semantic Scholar
Age-dependent changes in cardiac muscle metabolism upon replacement of creatine by beta- guanidinopropionic acid.
M. Field, J. Unitt, G. Radda, C. Henderson +1 more
1991Biochemical Society Transactions2 citations
Semantic Scholar
PSS288 - Potent Reversible Inhibition of Myeloperoxidase by Aromatic Hydroxamates
L. V. Forbes, T. Sjögren, F. Auchere, B. Thong +3 more
20131 citations Open access
Semantic Scholar
From Large to Small Cytokine Receptor Antagonists.
Pawel Leznicki, K. Deacon, B. Waszkowycz, J. Unitt
2025SLAS discovery : advancing life sciences R & D0 citations Open access
Semantic Scholar
Abstract 5317: A high throughput screen of the novel immuno-oncology target HPK1 identifies a range of chemical starting points for the development of potent and selective inhibitors
D. Swift, Samantha Hitchin, C. Tomlinson, A. Sengupta +6 more
2020Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract 1757: Developing sensitive assays to facilitate hit identification of RNA modifying enzymes
C. Tomlinson, Rachel Lawrence, S. Best, G. Boden +8 more
2020Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Hydroxamates Myeloperoxidase by Aromatic Potent Reversible Inhibition of Enzymology
J. Unitt, A. Kettle, R. Turner, H. Eriksson +6 more
20140 citations
Semantic Scholar
Myeloperoxidase in complex with the revesible inhibitor HX1
L. V. Forbes, T. Sjogren, F. Auchère, D. Jenkins +7 more
20130 citations
Semantic Scholar
Cardiac hypertrophy and the control of glycogen metabolism
J. Unitt, L. Arnolda, G. Radda, A. Seymour
19900 citations
Semantic Scholar
Effects of Ruthenium Red on O2 uptake and lactate and CO2 production by the perfused rat heart in the absence and presence of isoprenaline
J. Unitt, J. Mccormack, P. England
19880 citations
Semantic Scholar
The effects of ruthenium red on Ca2+-handling and energy metabolism in the rat and guinea pig heart
J. Unitt, J. Mccormack, P. England
19880 citations
Semantic Scholar
The effects of Ruthenium Red on Ca2+ handling by the heart
J. Unitt, J. Mccormack, P. England
19870 citations
Semantic Scholar
A Cost Analysis Model for Programs in French as a Second Language.
G. Macnab, J. Unitt
19780 citations
Semantic Scholar

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