Researcher profile · Semantic Scholar

O. Defert

h-index: 9
Works: 23
Citations: 809

Most-cited papers

Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential.
Yang-Bo Feng, P. Lograsso, O. Defert, Rong-Shi Li
2016Journal of Medicinal Chemistry341 citations Open access
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Treatment of Intestinal Fibrosis in Experimental Inflammatory Bowel Disease by the Pleiotropic Actions of a Local Rho Kinase Inhibitor.
T. Holvoet, S. Devriese, K. Castermans, S. Boland +14 more
2017Gastroenterology129 citations Open access
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AMA0076, a novel, locally acting Rho kinase inhibitor, potently lowers intraocular pressure in New Zealand white rabbits with minimal hyperemia.
S. M. Van de Velde, T. Van Bergen, D. Sijnave, K. Hollanders +6 more
2014Investigative Ophthalmology and Visual Science89 citations Open access
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Rho kinase inhibitors: a patent review (2014 – 2016)
O. Defert, S. Boland
2017Expert Opinion on Therapeutic Patents75 citations
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Design, synthesis, and biological evaluation of novel, highly active soft ROCK inhibitors.
S. Boland, A. Bourin, J. Alen, Jacques Geraets +10 more
2015Journal of Medicinal Chemistry45 citations Open access
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3-[2-(Aminomethyl)-5-[(pyridin-4-yl)carbamoyl]phenyl] benzoates as soft ROCK inhibitors.
S. Boland, O. Defert, J. Alen, A. Bourin +7 more
2013Bioorganic & Medicinal Chemistry Letters34 citations Open access
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Novel Roflumilast analogs as soft PDE4 inhibitors.
S. Boland, J. Alen, A. Bourin, K. Castermans +5 more
2014Bioorganic & Medicinal Chemistry Letters33 citations Open access
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Design, synthesis and biological characterization of selective LIMK inhibitors.
S. Boland, A. Bourin, J. Alen, Jacques Geraets +9 more
2015Bioorganic & Medicinal Chemistry Letters32 citations Open access
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Kinase profiling in early stage drug discovery: sorting things out.
O. Defert, S. Boland
2015Drug Discovery Today : Technologies9 citations
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Design and synthesis of water-soluble prodrugs of rifabutin for intraveneous administration.
K. Antraygues, Mathieu Maingot, B. Schellhorn, V. Trebosc +7 more
2022European journal of medicinal chemistry8 citations Open access
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PhAc-ALGP-Dox, a Novel Anticancer Prodrug with Targeted Activation and Improved Therapeutic Index
Andrea Casazza, Lawrence Van Helleputte, Britt Van Renterghem, P. Pokreisz +12 more
2022Molecular Cancer Therapeutics4 citations Open access
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Tetrahydro-pyrimido-indoles as selective LIMK inhibitors: synthesis, selectivity profiling and structure–activity studies
J. Alen, A. Bourin, S. Boland, Jacques Geraets +2 more
20163 citations
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Mo1762 Soft Rock Inhibition Prevents Intestinal Fibrosis in a Murine Colitis Model
T. Holvoet, S. Devriese, K. Castermans, S. Boland +5 more
20153 citations
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Structure-activity relationships of actively FhuE transported rifabutin derivatives with potent activity against Acinetobacter baumannii.
M. Maingot, M. Bourotte, A. Vetter, B. Schellhorn +10 more
2023European journal of medicinal chemistry2 citations Open access
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P016 GI restricted ROCK inhibitors show potential to treat fibrosis and stenosis associated with inflammatory bowel disease
C. Jones, P. Bunyard, K. Eckersley, N. Hawkins +21 more
20182 citations
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In Vitro Hydrolysis of Latanoprost by Human Ocular Tissues
Fany L. Guerra, J. Rager, S. Bhoopathy, I. Hidalgo +3 more
20122 citations
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Heterocyclic amides as inhibitors of ROCK
Dirk Leysen, O. Defert, Nadzeya Kaval, Petra Blom +1 more
20111 citations
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Peer Review #1 of "Designing of the N-ethyl-4-(pyridin-4-yl)benzamide based potent ROCK1 inhibitors using docking, molecular dynamics, and 3D-QSAR (v0.1)"
Suparna Ghosh, S. Keretsu, Seunghyeon Joo, Cho Corresp +198 more
20210 citations Open access
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Soft ROCK Inhibition as Novel Treatment Mechanism for Glaucoma
N. Kindt, S. M. Van de Velde, K. Castermans, S. Boland +1 more
20150 citations
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Angiostatic Activity of the Novel Rho Kinase Inhibitor AMA 0428
K. Castermans, K. Hollanders, S. Boland, L. Panitti +6 more
20150 citations
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ROCK2 IN COMPLEX WITH 1426382-07-1
M. Augustin, S. Krapp, S. Boland, O. Defert +3 more
20150 citations
Semantic Scholar
Locally-acting ROCK Inhibitor AMA0076 Improves Corneal Wound Healing in Rabbit Ethanol/Mechanical Corneal Epithelial Debridement Model
O. Defert, G. Gum, K. Castermans, Steve Pakola +3 more
20150 citations
Semantic Scholar
New rock inhibitors
A. Bourin, Dirk Leysen, O. Defert, S. Boland
20130 citations
Semantic Scholar

J. Alen

×6

N. Kindt×6

N. Boumans×5

L. Panitti×5

S. M. Van de Velde×4

J. Vanormelingen×4

T. Holvoet×3

S. Devriese×3