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R. Havelek · SciRah

Researcher profile · Semantic Scholar

R. Havelek

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R. Havelek — researcher profile on SciRah

h-index: 22
Works: 97
Citations: 1,350

Most-cited papers

Gamma radiation induces senescence in human adult mesenchymal stem cells from bone marrow and periodontal ligaments
J. Čmielová, R. Havelek, T. Soukup, A. Jiroutová +9 more
2012International Journal of Radiation Biology88 citations
Semantic Scholar
Effective Method of Purification of Betulin from Birch Bark: The Importance of Its Purity for Scientific and Medicinal Use
P. Šiman, A. Filipová, A. Tichá, M. Niang +2 more
2016PLoS ONE78 citations Open access
Semantic Scholar
The effect of Amaryllidaceae alkaloids haemanthamine and haemanthidine on cell cycle progression and apoptosis in p53-negative human leukemic Jurkat cells.
R. Havelek, M. Seifrtová, K. Královec, L. Brůčková +6 more
2014Phytomedicine69 citations
Semantic Scholar
Irradiation of Adult Human Dental Pulp Stem Cells Provokes Activation of p53, Cell Cycle Arrest, and Senescence but Not Apoptosis
D. Muthná, T. Soukup, J. Vávrová, J. Mokry +8 more
2010Stem Cells and Development59 citations
Semantic Scholar
The effect of sodium butyrate and cisplatin on expression of EMT markers
A. Mrkvicová, M. Chmelarova, E. Peterova, R. Havelek +4 more
2019PLoS ONE47 citations Open access
Semantic Scholar
Anticancer potential of Amaryllidaceae alkaloids evaluated by screening with a panel of human cells, real-time cellular analysis and Ehrlich tumor-bearing mice.
R. Havelek, D. Muthná, P. Tomšík, K. Královec +7 more
2017Chemico-Biological Interactions47 citations
Semantic Scholar
The Biological Activity of Alkaloids from the Amaryllidaceae: From Cholinesterases Inhibition to Anticancer Activity
K. Habartová, L. Cahlíková, M. Řezáčová, R. Havelek
2016Natural Product Communications42 citations Open access
Semantic Scholar
The cytotoxic effect of α-tomatine in MCF-7 human adenocarcinoma breast cancer cells depends on its interaction with cholesterol in incubation media and does not involve apoptosis induction
L. Suchá, M. Hroch, M. Řezáčová, E. Rudolf +6 more
2013Oncology Report41 citations Open access
Semantic Scholar
Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity
M. Safratova, A. Hošťálková, D. Hulcová, K. Breiterová +13 more
2017Archives of pharmacal research39 citations
Semantic Scholar
The response of human ectomesenchymal dental pulp stem cells to cisplatin treatment.
M. Seifrtová, R. Havelek, J. Čmielová, A. Jiroutová +5 more
2012International Endodontic Journal39 citations
Semantic Scholar
Comparative cytotoxicity of chelidonine and homochelidonine, the dimethoxy analogues isolated from Chelidonium majus L. (Papaveraceae), against human leukemic and lung carcinoma cells.
R. Havelek, M. Seifrtová, K. Královec, Eliška Kročová +8 more
2016Phytomedicine36 citations
Semantic Scholar
The Amaryllidaceae alkaloids haemanthamine, haemanthidine and their semisynthetic derivatives as potential drugs
L. Cahlíková, Ippei Kawano, M. Řezáčová, G. Blunden +2 more
2020Phytochemistry Reviews34 citations
Semantic Scholar
Differences in vanadocene dichloride and cisplatin effect on MOLT-4 leukemia and human peripheral blood mononuclear cells.
R. Havelek, P. Šiman, J. Čmielová, A. Stoklasová +4 more
2012Medicinal chemistry34 citations
Semantic Scholar
Study of antitumor effect of selected vanadium and molybdenum organometallic complexes in human leukemic T-cells.
Lucie Šebestová, R. Havelek, M. Řezáčová, J. Honzíček +2 more
2015Chemico-Biological Interactions30 citations
Semantic Scholar
Amaryllidaceae Alkaloids of Different Structural Types from Narcissus L. cv. Professor Einstein and Their Cytotoxic Activity
K. Breiterová, Darja Koutová, J. Maříková, R. Havelek +7 more
2020Plants29 citations Open access
Semantic Scholar
Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells
K. Habartová, R. Havelek, M. Seifrtová, K. Královec +8 more
2018Scientific Reports29 citations Open access
Semantic Scholar
Chemical and Biological Aspects of Montanine-Type Alkaloids Isolated from Plants of the Amaryllidaceae Family
Darja Koutová, N. Maafi, R. Havelek, L. Opletal +3 more
2020Molecules27 citations Open access
Semantic Scholar
Regulation and role of endoglin in cholesterol‐induced endothelial and vascular dysfunction in vivo and in vitro
M. Vicen, B. Vitverová, R. Havelek, Katerina Blazickova +8 more
2019The FASEB Journal26 citations Open access
Semantic Scholar
Synthesis, structural characterisation, docking, lipophilicity and cytotoxicity of 1-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-alkyl carbamates, novel acetylcholinesterase and butyrylcholinesterase pseudo-irreversible inhibitors
Šárka Štěpánková, M. Pejchalová, K. Královec, R. Havelek +4 more
201626 citations
Semantic Scholar
Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer’s Disease
Eliška Kohelová, R. Peřinová, N. Maafi, J. Korábečný +10 more
2019Molecules25 citations Open access
Semantic Scholar
Alpha-tomatine activates cell cycle checkpoints in the absence of DNA damage in human leukemic MOLT-4 cells
J. Kudelova, M. Seifrtová, L. Suchá, P. Tomšík +2 more
201322 citations Open access
Semantic Scholar
The effect of ATM and ERK1/2 inhibition on mitoxantrone-induced cell death of leukaemic cells.
M. Seifrtová, R. Havelek, M. Chmelarova, J. Čmielová +4 more
2011Folia biologica22 citations Open access
Semantic Scholar
Silica-coated manganite and Mn-based ferrite nanoparticles: a comparative study focused on cytotoxicity
O. Kaman, T. Dědourková, J. Koktan, J. Kuličková +8 more
2016Journal of nanoparticle research21 citations
Semantic Scholar
Disruption of Cell Adhesion and Cytoskeletal Networks by Thiol-Functionalized Silica-Coated Iron Oxide Nanoparticles
K. Královec, Lucie Melounková, M. Slováková, N. Mannová +3 more
2020International Journal of Molecular Sciences20 citations Open access
Semantic Scholar
Accumulation of DNA Damage and Cell Death after Fractionated Irradiation
M. Řezáčová, Gabriela Rudolfová, A. Tichý, Alena Bačı́ková +6 more
2011Radiation Research20 citations
Semantic Scholar
Boldine Inhibits Mouse Mammary Carcinoma In Vivo and Human MCF-7 Breast Cancer Cells In Vitro
P. Tomšík, S. Mičuda, D. Muthná, E. Cermakova +7 more
2016Planta Medica17 citations
Semantic Scholar
Lymphocyte subsets and their H2AX phosphorylation in response to in vivo irradiation in rats
L. Zárybnická, J. Vávrová, R. Havelek, A. Tichý +2 more
2013International Journal of Radiation Biology17 citations
Semantic Scholar
Alkaloid Profiling of Hippeastrum Cultivars by GC-MS, Isolation of Amaryllidaceae Alkaloids and Evaluation of Their Cytotoxicity
L. Al Shammari, A. Mamun, Darja Koutová, M. Majorošová +6 more
201916 citations Open access
Semantic Scholar
Vanadocene complexes bearing N,N'-chelating ligands: Synthesis, structures and in vitro cytotoxic studies on the A549 lung adenocarcinoma cell line.
Lucie Melounková, Aneta Machálková, R. Havelek, J. Honzíček +4 more
2019Journal of Inorganic Biochemistry15 citations
Semantic Scholar
Haemanthamine alters sodium butyrate-induced histone acetylation, p21WAF1/Cip1 expression, Chk1 and Chk2 activation and leads to increased growth inhibition and death in A2780 ovarian cancer cells.
M. Seifrtová, R. Havelek, L. Cahlíková, D. Hulcová +2 more
2017Phytomedicine15 citations
Semantic Scholar
Specific inhibition of Wee1 kinase and Rad51 recombinase: a strategy to enhance the sensitivity of leukemic T-cells to ionizing radiation-induced DNA double-strand breaks.
R. Havelek, J. Čmielová, K. Královec, L. Brůčková +5 more
2014Biochemical and Biophysical Research Communications - BBRC14 citations
Semantic Scholar
Magnetic nanoparticles of Ga-substituted ε-Fe2 O3 for biomedical applications: magnetic properties, transverse relaxivity and effects of silica-coated particles on cytoskeletal networks.
K. Královec, R. Havelek, Darja Koutová, P. Veverka +6 more
2020Journal of Biomedical Materials Research. Part A13 citations Open access
Semantic Scholar
LC-MS/MS method for the determination of haemanthamine in rat plasma, bile and urine and its application to a pilot pharmacokinetic study.
M. Hroch, S. Mičuda, R. Havelek, J. Cermanová +4 more
2016Biomedical chromotography13 citations
Semantic Scholar
The effect of ATM kinase inhibition on the initial response of human dental pulp and periodontal ligament mesenchymal stem cells to ionizing radiation
J. Čmielová, R. Havelek, R. Kohlerova, T. Soukup +5 more
2013International Journal of Radiation Biology13 citations
Semantic Scholar
Bersavine: A Novel Bisbenzylisoquinoline Alkaloid with Cytotoxic, Antiproliferative and Apoptosis-Inducing Effects on Human Leukemic Cells
Darja Koutová, M. Kulhavá, R. Havelek, M. Majorošová +6 more
2020Molecules12 citations Open access
Semantic Scholar
Amaryllidaceae family alkaloids as potential drugs for cancer treatment
M. Dalecká, R. Havelek, K. Královec, L. Brůčková +1 more
201312 citations
Semantic Scholar
The anticancer properties of harmine and its derivatives
Abdul Aziz Timbilla, R. Vrabec, R. Havelek, M. Řezáčová +3 more
2024Phytochemistry Reviews11 citations Open access
Semantic Scholar
Silica coated iron oxide nanoparticles-induced cytotoxicity, genotoxicity and its underlying mechanism in human HK-2 renal proximal tubule epithelial cells.
K. Královec, R. Havelek, Eliška Kročová, L. Kučírková +4 more
2019Mutation research11 citations Open access
Semantic Scholar
New Light on An Old Friend: Targeting PUMA in Radioprotection and Therapy of Cardiovascular and Neurodegenerative Diseases.
A. Tichý, J. Marek, R. Havelek, J. Pejchal +5 more
2018Current Drug Targets11 citations
Semantic Scholar
Substituted Piperazines as Novel Potential Radioprotective Agents
A. Filipová, J. Marek, R. Havelek, J. Pejchal +12 more
2020Molecules10 citations Open access
Semantic Scholar
Ionizing radiation increases primary cilia incidence and induces multiciliation in C2C12 myoblasts
A. Filipová, Daniel Díaz-García, A. Bezrouk, D. Čížková +4 more
2015Cell Biology International10 citations
Semantic Scholar
Ionizing Radiation Induces Senescence and Differentiation of Human Dental Pulp Stem Cells (dentalpulpstemcells/ionizingradiation/radiation-inducedprematuredifferentiation/dentinogenesis/ osteogenesis)
R. Havelek, T. Soukup, J. Čmielová, M. Seifrtová +4 more
201310 citations
Semantic Scholar
Mn–Zn Ferrite Nanoparticles With Silica and Titania Coatings: Synthesis, Transverse Relaxivity, and Cytotoxicity
O. Kaman, J. Kuličková, M. Maryško, P. Veverka +7 more
2017IEEE transactions on magnetics9 citations Open access
Semantic Scholar
In-vitro and in-vivo evaluation of the anticancer activity of diruthenium-2, a new trithiolato arene ruthenium complex [(&eegr;6-p-MeC6H4Pri)2Ru2(&mgr;-S-p-C6H4OH)3]Cl
D. Muthná, P. Tomšík, R. Havelek, R. Köhlerova +5 more
2016Anti-Cancer Drugs9 citations
Semantic Scholar
Flubendazole exhibits anti-glioblastoma effect by inhibiting STAT3 and promoting cell cycle arrest
B. Vítovcová, V. Skarkova, R. Havelek, J. Soukup +3 more
2023Scientific Reports8 citations Open access
Semantic Scholar
Antiproliferative activity and apoptosis-inducing mechanism of Amaryllidaceae alkaloid montanine on A549 and MOLT-4 human cancer cells.
Darja Koutová, N. Maafi, D. Muthná, K. Královec +7 more
2023Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie8 citations Open access
Semantic Scholar
Monoclonal anti-endoglin antibody TRC105 (carotuximab) prevents hypercholesterolemia and hyperglycemia-induced endothelial dysfunction in human aortic endothelial cells
K. Tripská, I. C. Igreja Sá, M. Vašinová, M. Vicen +7 more
2022Frontiers in Medicine8 citations Open access
Semantic Scholar
A novel class of small molecule inhibitors with radioprotective properties.
J. Marek, A. Tichý, R. Havelek, M. Seifrtová +8 more
2019European journal of medicinal chemistry8 citations
Semantic Scholar
Chelidonine and Homochelidonine Induce Cell Death through Cell Cycle Checkpoints and MAP Kinase Pathways
R. Havelek, M. Seifrtová, K. Královec, K. Habartová +2 more
20178 citations Open access
Semantic Scholar
Phosphorylation of histone H2AX in peripheral blood mononuclear cells after thoracic irradiation of rats
R. Havelek, M. Řezáčová, Z. Sinkorova, L. Zárybnická +2 more
20118 citations Open access
Semantic Scholar

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L. Cahlíková×18
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