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C. Bewshea · SciRah

Researcher profile · Semantic Scholar

C. Bewshea

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C. Bewshea — researcher profile on SciRah

h-index: 19
Works: 95
Citations: 2,578

Most-cited papers

Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study.
N. Kennedy, G. Heap, Harry D. Green, B. Hamilton +25 more
2019The Lancet Gastroenterology and Hepatology534 citations Open access
Semantic Scholar
HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease.
Aleksejs Sazonovs, N. Kennedy, L. Moutsianas, G. Heap +16 more
2019Gastroenterology339 citations Open access
Semantic Scholar
Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD
N. Kennedy, Simeng Lin, J. Goodhand, N. Chanchlani +22 more
2021Gut263 citations Open access
Semantic Scholar
HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants
G. Heap, M. Weedon, C. Bewshea, Abhey Singh +52 more
2014Nature Genetics189 citations Open access
Semantic Scholar
Anti-SARS-CoV-2 antibody responses are attenuated in patients with IBD treated with infliximab
N. Kennedy, J. Goodhand, C. Bewshea, R. Nice +27 more
2021Gut166 citations Open access
Semantic Scholar
Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease
G. Walker, James W. Harrison, G. Heap, M. Voskuil +46 more
2019Journal of the American Medical Association (JAMA)144 citations Open access
Semantic Scholar
Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study.
N. Chanchlani, Simeng Lin, C. Bewshea, B. Hamilton +13 more
2024The Lancet Gastroenterology and Hepatology119 citations Open access
Semantic Scholar
COVID-19 vaccine-induced antibody responses in immunosuppressed patients with inflammatory bowel disease (VIP): a multicentre, prospective, case-control study
J. Alexander, N. Kennedy, H. Ibraheim, S. Anandabaskaran +58 more
2022The Lancet Gastroenterology and Hepatology110 citations Open access
Semantic Scholar
Clinical Features and HLA Association of 5-Aminosalicylate (5-ASA)-induced Nephrotoxicity in Inflammatory Bowel Disease.
G. Heap, K. So, M. Weedon, Naomi Edney +58 more
2016Journal of Crohn's & Colitis109 citations Open access
Semantic Scholar
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab
Simeng Lin, N. Kennedy, A. Saifuddin, D. M. Sandoval +28 more
2022Nature Communications74 citations Open access
Semantic Scholar
The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patients
J. Alexander, B. Mullish, Nathan P. Danckert, Zhigang Liu +23 more
2023EBioMedicine55 citations Open access
Semantic Scholar
COVID-19 vaccine-induced antibody and T-cell responses in immunosuppressed patients with inflammatory bowel disease after the third vaccine dose (VIP): a multicentre, prospective, case-control study
J. Alexander, Zhigang Liu, Diana Muñoz Sandoval, C. Reynolds +65 more
2022The Lancet Gastroenterology and Hepatology53 citations Open access
Semantic Scholar
Adalimumab and Infliximab Impair SARS-CoV-2 Antibody Responses: Results from a Therapeutic Drug Monitoring Study in 11 422 Biologic-Treated Patients
N. Chanchlani, Simeng Lin, D. Chee, B. Hamilton +21 more
2021Journal of Crohn's & Colitis44 citations Open access
Semantic Scholar
Vaccine escape, increased breakthrough and reinfection in infliximab-treated patients with IBD during the Omicron wave of the SARS-CoV-2 pandemic
N. Kennedy, M. Janjua, N. Chanchlani, Simeng Lin +19 more
2022Gut37 citations Open access
Semantic Scholar
Quality improvement project identifies factors associated with delay in IBD diagnosis
G. Walker, Simeng Lin, N. Chanchlani, A. Thomas +10 more
2020Alimentary Pharmacology and Therapeutics35 citations Open access
Semantic Scholar
Faecal calprotectin effectively excludes inflammatory bowel disease in 789 symptomatic young adults with/without alarm symptoms: a prospective UK primary care cohort study
G. Walker, L. Moore, N. Heerasing, P. Hendy +12 more
2018Alimentary Pharmacology and Therapeutics35 citations Open access
Semantic Scholar
Neutralising antibody potency against SARS-CoV-2 wild-type and omicron BA.1 and BA.4/5 variants in patients with inflammatory bowel disease treated with infliximab and vedolizumab after three doses of COVID-19 vaccine (CLARITY IBD): an analysis of a prospective multicentre cohort study
Zhigang Liu, K. Le, Xin Zhou, J. Alexander +18 more
2022The Lancet Gastroenterology and Hepatology29 citations Open access
Semantic Scholar
Whole Blood DNA Methylation Changes Are Associated with Anti-TNF Drug Concentration in Patients with Crohn’s Disease
Simeng Lin, E. Hannon, M. Reppell, J. Waring +10 more
2023medRxiv21 citations Open access
Semantic Scholar
Incidence and prevalence of inflammatory bowel disease in Devon, UK
B. Hamilton, Harry D. Green, N. Heerasing, P. Hendy +7 more
2020Frontline Gastroenterology21 citations Open access
Semantic Scholar
HLA-DQA1*05 is associated with the development of antibodies to anti-TNF therapy
Aleksejs Sazonovs, Nick Kennedy, L. Moutsianas, G. Heap +15 more
2018bioRxiv17 citations Open access
Semantic Scholar
Covid-19 vaccine-induced antibodies are attenuated and decay rapidly in infliximab treated patients
Simeng Lin, N. Kennedy, A. Saifuddin, D. M. Sandoval +28 more
202116 citations Open access
Semantic Scholar
Anti-TNF Biologicals Enhance the Anti-Inflammatory Properties of IgG N-Glycome in Crohn’s Disease
M. Hanić, F. Vučković, H. Deriš, C. Bewshea +7 more
2023Biomolecules14 citations Open access
Semantic Scholar
Validating the positivity thresholds of drug‐tolerant anti‐infliximab and anti‐adalimumab antibody assays
R. Nice, N. Chanchlani, Harry D. Green, C. Bewshea +5 more
2020Alimentary Pharmacology and Therapeutics14 citations Open access
Semantic Scholar
Understanding anti‐TNF treatment failure: does serum triiodothyronine‐to‐thyroxine (T3/T4) ratio predict therapeutic outcome to anti‐TNF therapies in biologic‐naïve patients with active luminal Crohn's disease?
Simeng Lin, N. Chanchlani, I. Carbery, M. Janjua +7 more
2022Alimentary Pharmacology and Therapeutics13 citations Open access
Semantic Scholar
Pretreatment Vitamin D Concentrations Do Not Predict Therapeutic Outcome to Anti-TNF Therapies in Biologic-Naïve Patients With Active Luminal Crohn’s Disease
N. Chanchlani, Simeng Lin, Rebecca Smith, C. Roberts +8 more
2023Crohn's & Colitis 36012 citations Open access
Semantic Scholar
Primary care faecal calprotectin testing in children with suspected inflammatory bowel disease: a diagnostic accuracy study
G. Walker, N. Chanchlani, A. Thomas, Simeng Lin +13 more
2020Archives of Disease in Childhood10 citations Open access
Semantic Scholar
OP013 HLA-DQA1 contributes to the development of antibodies to anti-TNF therapy in Crohn’s disease
Aleksejs Sazonovs, N. Kennedy, C. Bewshea, L. Moutsianas +6 more
201810 citations
Semantic Scholar
Infliximab and adalimumab are stable in whole blood clotted samples for seven days at room temperature
M. Perry, C. Bewshea, Richard J. Brown, K. So +2 more
2015Annals of Clinical Biochemistry10 citations Open access
Semantic Scholar
Clinical Utility and Cost‐Effectiveness of Pretreatment NUDT15 Pharmacogenetic Testing to Prevent Thiopurine‐Induced Myelosuppression: A Genotype‐First Reverse Phenotyping Cohort Study Within the UK NIHR Inflammatory Bowel Disease Bioresource
C. Roberts, Jaime L. Peters, Aleksejs Sazonvos, N. Goodman +31 more
2025Alimentary Pharmacology and Therapeutics9 citations Open access
Semantic Scholar
Antibody Responses to Influenza Vaccination are Diminished in Patients With Inflammatory Bowel Disease on Infliximab or Tofacitinib
Zhigang Liu, James L. Alexander, Yee-Eng Kai, H. Ibraheim +29 more
2023Journal of Crohn's & Colitis9 citations Open access
Semantic Scholar
Neutralising antibody responses against SARS-CoV-2 Omicron BA.4/5 and wild-type virus in patients with inflammatory bowel disease following three doses of COVID-19 vaccine (VIP): a prospective, multicentre, cohort study
Zhigang Liu, James L. Alexander, K. Le, Xin Zhou +68 more
2023EClinicalMedicine7 citations Open access
Semantic Scholar
Ethical issues and best practice in clinically based genomic research: Exeter Stakeholders Meeting Report
Daniele Carrieri, C. Bewshea, G. Walker, Tariq Ahmad +3 more
2016Journal of Medical Ethics7 citations Open access
Semantic Scholar
OP031 Clinical effectiveness, safety and immunogenicity of anti-TNF therapy in Crohn’s disease: 12-month data from the PANTS study
N. Kennedy, G. Heap, B. Hamilton, G. Walker +4 more
20186 citations
Semantic Scholar
OP035 NUDT15 variants contribute to thiopurine-induced myelosuppression in European populations
G. Walker, James W. Harrison, M. Voskuil, G. Heap +12 more
20185 citations Open access
Semantic Scholar
Baseline expression of immune gene modules in blood is associated with primary response to anti-TNF therapy in Crohn's disease patients
Benjamin Y. H. Bai, M. Reppell, N. Smaoui, J. Waring +10 more
2023medRxiv4 citations Open access
Semantic Scholar
OTU-002 HLA-DQA1 contributes to the development of antibodies to anti-TNF therapy in crohn’s disease
Aleksejs Sazonovs, N. Kennedy, C. Bewshea, L. Moutsianas +6 more
2018IBD4 citations Open access
Semantic Scholar
638 5-Aminosalicylate (5-ASA) Induced Nephrotoxicity in Inflammatory Bowel Disease
K. So, C. Bewshea, G. Heap, A. Muller +25 more
20134 citations
Semantic Scholar
Baseline Expression of Immune Gene Modules in Blood is Associated With Primary Response to Anti-TNF Therapy in Crohn’s Disease Patients
Benjamin Y. H. Bai, M. Reppell, N. Smaoui, J. Waring +9 more
2023Journal of Crohn's & Colitis3 citations Open access
Semantic Scholar
OP21 COVID-19 vaccine-induced antibody responses are impaired in Inflammatory Bowel Disease patients treated with infliximab, ustekinumab or tofacitinib, but not thiopurines or vedolizumab
J. Alexander, N. Kennedy, H. Ibraheim, S. Anandabaskaran +27 more
2022Journal of Crohn's & Colitis3 citations Open access
Semantic Scholar
159 - Clinical Effectiveness, Safety and Immunogenicity of Anti-TNF Therapy in Crohn's Disease: 12 Month Data from the Pants Study
N. Kennedy, G. Heap, B. Hamilton, G. Walker +4 more
20183 citations
Semantic Scholar
6 thiopurine induced pancreatitis in inflammatory bowel disease : clinical features and genetic determinants
G. Heap, Abhey Singh, C. Bewshea, M. Weedon +31 more
20143 citations Open access
Semantic Scholar
HLA-DRB1*01:03 in patients with inflammatory bowel disease: a genotype-phenotype association study.
Qian Zhang, E. Shakweh, M. Sharip, B. Zare +34 more
2026The Lancet Gastroenterology and Hepatology2 citations Open access
Semantic Scholar
OC4 Understanding anti-TNF treatment failure in Crohn’s disease: mechanisms and management of loss of response to anti-TNF therapy, three-year data from the PANTS study
Neil Chanchlani, Simeng Lin, C. Bewshea, B. Hamilton +13 more
2024Abstracts2 citations
Semantic Scholar
DOP88 Understanding the molecular mechanisms of anti-TNF treatment failure: Whole blood DNA methylation changes associated with primary non-response to anti-TNF treatment in patients with Crohn’s disease
S. Lin, E. Hannon, J. Waring, M. Reppell +10 more
2023Journal of Crohn's & Colitis2 citations Open access
Semantic Scholar
OP24 Neutralising antibody potency against SARS-CoV-2 wild-type and Omicron BA.1 and BA.4/5 variants in infliximab and vedolizumab treated patients with Inflammatory Bowel Disease after three doses of COVID-19 vaccine: a prospective multicentre cohort study
Z. Liu, K. Le, X. Zhou, J. Alexander +18 more
2023Journal of Crohn's & Colitis2 citations Open access
Semantic Scholar
472 - NUDT15 Variants Contribute to Thiopurine-Induced Myelosuppression in European Populations
G. Walker, James W. Harrison, M. Voskuil, G. Heap +12 more
20182 citations Open access
Semantic Scholar
PTU-010 Prevalence and phenotype of IBD across primary and secondary care: implications for colorectal cancer surveillance
B. Hamilton, N. Heerasing, P. Hendy, L. Moore +5 more
2018IBD2 citations Open access
Semantic Scholar
Prevalence and factors associated with obesity in patients with inflammatory bowel disease (IBD) treated with infliximab and vedolizumab across the UK
C. Roberts, Phoebe Hodges, F. Badrulhisham, Rebecca Smith +9 more
2026Frontline Gastroenterology1 citations Open access
Semantic Scholar
O18 Prevalence and factors associated with obesity in patients with IBD treated with infliximab and vedolizumab across the United Kingdom (UK)
C. Roberts, Phoebe Hodges, Fakhirah Badrelhisham, Rebecca Smith +7 more
2025Oral Presentations1 citations
Semantic Scholar
Understanding Anti-TNF Treatment Failure: Pre-Existing Antidrug Antibodies Are Common but Do Not Neutralize Drug Activity In Vitro or Influence Clinical Response to Infliximab or Adalimumab in Patients with Crohn Disease.
R. Nice, Simeng Lin, Neil Chanchlani, C. Bewshea +5 more
2025The Journal of Applied Laboratory Medicine1 citations Open access
Semantic Scholar

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N. Kennedy×29
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C. Lees×23
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T. Ahmad×22
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Simeng Lin — researcher profile on SciRah

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G. Heap — researcher profile on SciRah