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S. Miknyoczki · SciRah

Researcher profile · Semantic Scholar

S. Miknyoczki

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S. Miknyoczki — researcher profile on SciRah

h-index: 14
Works: 22
Citations: 1,317

Most-cited papers

Animal models of disease: pre-clinical animal models of cancer and their applications and utility in drug discovery.
B. Ruggeri, Faye Camp, S. Miknyoczki
2014Biochemical Pharmacology341 citations
Semantic Scholar
Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor.
S. Miknyoczki, S. Jones-Bolin, S. Pritchard, K. Hunter +9 more
2003Molecular Cancer Therapeutics214 citations
Semantic Scholar
Discovery of small molecule c-Met inhibitors: Evolution and profiles of clinical candidates.
T. Underiner, T. Herbertz, S. Miknyoczki
2010Anti-Cancer Agents in Medicinal Chemistry130 citations
Semantic Scholar
The neurotrophin-trk receptor axes are critical for the growth and progression of human prostatic carcinoma and pancreatic ductal adenocarcinoma xenografts in nude mice.
S. Miknyoczki, Wei-Hua Wan, Hong Chang, P. Dobrzanski +3 more
2002Clinical Cancer Research94 citations
Semantic Scholar
The selective poly(ADP-ribose) polymerase-1(2) inhibitor, CEP-8983, increases the sensitivity of chemoresistant tumor cells to temozolomide and irinotecan but does not potentiate myelotoxicity
S. Miknyoczki, Hong Chang, Jennifer V. Grobelny, S. Pritchard +9 more
2007Molecular Cancer Therapeutics90 citations Open access
Semantic Scholar
Pan-trk inhibition decreases metastasis and enhances host survival in experimental models as a result of its selective induction of apoptosis of prostate cancer cells.
A. Weeraratna, Susan L. Dalrymple, J. Lamb, S. Denmeade +3 more
2001Clinical Cancer Research89 citations
Semantic Scholar
The Trk tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits significant antitumor efficacy in preclinical xenograft models of human pancreatic ductal adenocarcinoma.
S. Miknyoczki, H. Chang, Andres J Klein-Szanto, C. Dionne +1 more
1999Clinical Cancer Research87 citations
Semantic Scholar
Stable reintroduction of wild-type P53 (MTmp53ts) causes the induction of apoptosis and neuroendocrine-like differentiation in human ductal pancreatic carcinoma cells
D. Lang, S. Miknyoczki, Lingyi Huang, B. Ruggeri
1998Oncogene56 citations
Semantic Scholar
Synthesis and biological profile of the pan-vascular endothelial growth factor receptor/tyrosine kinase with immunoglobulin and epidermal growth factor-like homology domains 2 (VEGF-R/TIE-2) inhibitor 11-(2-methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-c]
R. Hudkins, Nadine C. Becknell, A. Zulli, T. Underiner +12 more
2012Journal of Medicinal Chemistry45 citations Open access
Semantic Scholar
The Novel Trk Receptor Tyrosine Kinase Inhibitor CEP‐701 (KT‐5555) Exhibits Antitumor Efficacy against Human Pancreatic Carcinoma (Panc1) Xenograft Growth and In Vivo Invasiveness
S. Miknyoczki, C. Dionne, Andres J Klein-Szanto, B. Ruggeri
1999Annals of the New York Academy of Sciences40 citations
Semantic Scholar
Vascular endothelial growth factor mediates vasogenic edema in acute lead encephalopathy
Mir Ahamed Hossain, Juliet C. Russell, S. Miknyoczki, B. Ruggeri +2 more
2004Annals of Neurology36 citations
Semantic Scholar
The development and pharmacology of proteasome inhibitors for the management and treatment of cancer.
B. Ruggeri, S. Miknyoczki, B. Dorsey, A. Hui
2009Advances in Pharmacology32 citations
Semantic Scholar
Neurotrophin-Trk receptor interactions in neoplasia: a possible role in interstitial and perineural invasion in ductal pancreatic cancer.
S. Miknyoczki, Andres J Klein-Szanto, B. Ruggeri
1996Critical reviews in oncogenesis18 citations
Semantic Scholar
Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group.
Karen L. Milkiewicz, L. Aimone, M. Albom, T. Angeles +12 more
2011Bioorganic & Medicinal Chemistry14 citations Open access
Semantic Scholar
2,4-Diaminopyrimidine inhibitors of c-Met kinase bearing benzoxazepine anilines.
C. A. Zificsak, Jay P Theroff, L. Aimone, M. Albom +16 more
2011Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Design and synthesis of dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole oximes as potent dual inhibitors of TIE-2 and VEGF-R2 receptor tyrosine kinases.
R. Dandu, A. Zulli, E. Bacon, T. Underiner +10 more
2008Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
The Development and Pharmacology of Proteasome Inhibitors for the Management and Treatment of Cancer
B. Ruggeri, S. Miknyoczki, B. Dorsey, A. Hui
20103 citations
Semantic Scholar
Abstract C272: Antitumor activity of the dual AXL/c-Met inhibitor CEP-40783 in Champions primary TumorGraft™ models of human non-small cell lung cancer (NSCLC).
J. Friedman, R. Donaldson, S. Miknyoczki, M. Cheng +6 more
20131 citations
Semantic Scholar
Abstract C275: CEP-40783: A potent and selective AXL/c-Met inhibitor for use in breast, non-small cell lung (NSCLC), and pancreatic cancers.
S. Miknyoczki, M. Cheng, R. Hudkins, T. Angeles +12 more
20130 citations
Semantic Scholar
A process for the radiosensitization of tumors with a radiation-sensitizing agent
James L. Diebold, R. Hudkins, S. Miknyoczki, B. Ruggeri
20070 citations
Semantic Scholar
Method for cancer-treatment with anti-neurotrophin agent
K. Buchkovich, C. Dionne, S. Miknyoczki, B. Ruggeri
20010 citations
Semantic Scholar
The role of neurotrophin-trk receptor interactions in the development of pancreatic ductal adenocarcinoma
S. Miknyoczki
0 citations
Semantic Scholar

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