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G. Hirokane · SciRah

Researcher profile · Semantic Scholar

G. Hirokane

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G. Hirokane — researcher profile on SciRah

h-index: 13
Works: 41
Citations: 448

Most-cited papers

The Impact of CYP2C19 and CYP2D6 Genotypes on Metabolism of Amitriptyline in Japanese Psychiatric Patients
K. Shimoda, T. Someya, Aya Yokono, Sachiyo Morita +3 more
2002Journal of Clinical Psychopharmacology63 citations
Semantic Scholar
Lower plasma levels of haloperidol in smoking than in nonsmoking schizophrenic patients.
K. Shimoda, Toshiyuki Someya, Sachiyo Morita, G. Hirokane +4 more
1999Therapeutic Drug Monitoring54 citations
Semantic Scholar
The impact of CYP2D6 genotypes on the plasma concentration of paroxetine in Japanese psychiatric patients.
M. Ueda, G. Hirokane, Sachiyo Morita, M. Okawa +3 more
2006Progress in Neuro-psychopharmacology and Biological Psychiatry45 citations
Semantic Scholar
The Effect of CYP2C19 and CYP2D6 Genotypes on the Metabolism of Clomipramine in Japanese Psychiatric Patients
Aya Yokono, Sachiyo Morita, T. Someya, G. Hirokane +2 more
2001Journal of Clinical Psychopharmacology44 citations
Semantic Scholar
Lack of impact of CYP1A2 genetic polymorphism (C/A polymorphism at position 734 in intron 1 and G/A polymorphism at position -2964 in the 5'-flanking region of CYP1A2) on the plasma concentration of haloperidol in smoking male Japanese with schizophrenia.
K. Shimoda, T. Someya, Sachiyo Morita, G. Hirokane +3 more
2002Progress in Neuro-psychopharmacology and Biological Psychiatry42 citations
Semantic Scholar
The effect of cytochrome P450 2D6 genotypes on haloperidol metabolism: A preliminary study in a psychiatric population
T. Someya, Yutaro Suzuki, K. Shimoda, G. Hirokane +4 more
1999Psychiatry and Clinical Neurosciences35 citations Open access
Semantic Scholar
Metabolism of desipramine in Japanese psychiatric patients: the impact of CYP2D6 genotype on the hydroxylation of desipramine.
K. Shimoda, Sachiyo Morita, G. Hirokane, Aya Yokono +2 more
2000Acta Pharmacologica et Toxicologica27 citations Open access
Semantic Scholar
Interindividual variation of plasma haloperidol concentrations and the impact of concomitant medications: the analysis of therapeutic drug monitoring data.
G. Hirokane, T. Someya, Saburo Takahashi, Sachiyo Morita +1 more
1999Therapeutic Drug Monitoring26 citations
Semantic Scholar
Effect of CYP2D6 Genotypes on the Metabolism of Haloperidol in a Japanese Psychiatric Population
T. Someya, K. Shimoda, Yutaro Suzuki, Satoshi Sato +5 more
2003Neuropsychopharmacology25 citations
Semantic Scholar
CYP2D6*10 alleles are not the determinant of the plasma haloperidol concentrations in Asian patients.
K. Shimoda, Sachiyo Morita, Aya Yokono, T. Someya +3 more
2000Therapeutic Drug Monitoring25 citations
Semantic Scholar
Importance of the Cytochrome P450 2D6 Genotype for the Drug Metabolic Interaction Between Chlorpromazine and Haloperidol
Yutaro Suzuki, T. Someya, K. Shimoda, G. Hirokane +4 more
2001Therapeutic Drug Monitoring19 citations
Semantic Scholar
Interindividual variation in bromperidol metabolism and relationship to therapeutic effects.
Toshiyuki Someya, T. Muratake, G. Hirokane, M. Shibasaki +2 more
2000Journal of Clinical Psychopharmacology15 citations
Semantic Scholar
Genetic and pharmacokinetic factors affecting the initial pharmacotherapeutic effect of paroxetine in Japanese patients with panic disorder
Y. Saeki, Takashi Watanabe, M. Ueda, Atsushi Saito +6 more
2009European Journal of Clinical Pharmacology13 citations
Semantic Scholar
High Plasma Concentrations of Paroxetine Impede Clinical Response in Patients With Panic Disorder
Takashi Watanabe, M. Ueda, Y. Saeki, G. Hirokane +4 more
2007Therapeutic Drug Monitoring7 citations
Semantic Scholar
Plasma concentrations of timiperone and its reduced metabolite in the patients on timiperone
K. Shimoda, T. Someya, Sachiyo Morita, G. Hirokane +3 more
1998Psychiatry and Clinical Neurosciences6 citations
Semantic Scholar
A comparison of haloperidol plasma levels among Japanese, Korean and Swedish psychiatric patients
Sachiyo Morita, H. Roh, K. Shimoda, T. Someya +4 more
20101 citations Open access
Semantic Scholar
P.4.e.008 The factors that influence the therapeutic response to paroxetine in patients with panic disorder: longitudinal study
M. Ueda, Takashi Watanabe, Y. Saeki, Atsushi Saito +6 more
20090 citations
Semantic Scholar
P.4.a.005 An investigation of clinical factors influence the therapeutic response of paroxetine in patients with panic disorder
T. Ayugase, Shin Ishiguro, Takashi Watanabe, M. Ueda +6 more
20080 citations
Semantic Scholar
An association between paroxetine serum concentrations in panic disorder patients and response to initial treatment
Takashi Watanabe, M. Ueda, Y. Saeki, G. Hirokane +4 more
20060 citations
Semantic Scholar
Influence of the serotonergic gene polymorphisms on gastrointestinal adverse effects of paroxetine in Japanese depressive patients
G. Hirokane, Sachiyo Morita, M. Ueda, M. Okawa +1 more
20050 citations
Semantic Scholar
Influence of the serotonin transporter gene polymorphism on therapeutic response and adverse effects of paroxetine in Japanese depressive patients
G. Hirokane, Sachiyo Morita, M. Ueda, M. Okawa +1 more
20040 citations
Semantic Scholar
Phenytoin intoxication following coadministration of clobazam in the patient with cytochrome P450(CYP)2C19*1/*3 genotype. A case report
Sachiyo Morita, G. Hirokane, M. Ueda, M. Okawa +1 more
20040 citations
Semantic Scholar
Severe adverse effects following selective serotonin reuptake inhibitor, paroxetine administration, hyponatremia, atrial fibrillation and delirium: case reports
Sachiyo Morita, Mai Ichimura, Masahiro Matsuo, Kazuhide Tanaka +4 more
20040 citations
Semantic Scholar
P.1.091 Influence of the serotonergic gene polymorphism on clinical response and adverse effects of paroxetine in Japanese depressive patients
G. Hirokane, Sachiyo Morita, M. Ueda, M. Okawa +1 more
20040 citations
Semantic Scholar
Impact of CYP2D6 genotypes on the steady-state plasma concentrations of paroxetine in Japanese psychiatric patients
M. Ueda, G. Hirokane, Sachiyo Morita, M. Okawa +1 more
20040 citations
Semantic Scholar
[Butyrophenone derivatives].
G. Hirokane, K. Shimoda
2004Nihon rinsho. Japanese journal of clinical medicine0 citations
Semantic Scholar
The relationship between plasma concentration of paroxetine and CYP2D6 genotype in Japanese psychiatric patients
M. Ueda, G. Hirokane, Sachiyo Morita, Masako Okawa +1 more
20030 citations
Semantic Scholar
The impact of G-2964A and C734A polymorphism of CYP1A2 on the metabolism of clomipramine
G. Hirokane, M. Ueda, Sachiyo Morita, Aya Yokono +2 more
20030 citations
Semantic Scholar
The relationship between plasma concentration of paroxetine and CYP2D6 genotype in Japanese psychiatric patients
M. Ueda, G. Hirokane, Sachiyo Morita, Aya Yokono +2 more
20020 citations
Semantic Scholar
The impact of G-2694A and C734A polymorphism of CYP1A2 on the metabolism of clomipramine in Japanese depressive patients
G. Hirokane, M. Ueda, Sachiyo Morita, Aya Yokono +2 more
20020 citations
Semantic Scholar
The impact of genetic polymorphism of CYP1A2 inducibility on the steady state plasma haloperidol levels in smokers
G. Hirokane, Sachiyo Morita, Aya Yokono, T. Someya +2 more
20010 citations
Semantic Scholar
喫煙者におけるHaloperidol血中濃度とCytochrome P450 (CYP) 1A2遺伝子C→A多型との関連
G. Hirokane
20010 citations Open access
Semantic Scholar
Oral presentation: Relationship between plasma concentration of haloperidol and cytochrome P4502D6 genotypes
Aya Yokono, K. Shimoda, T. Someya, Sachiyo Morita +4 more
19990 citations
Semantic Scholar
Oral presentation: Effect of coadministraion of chlorpromazine on the plasma concentration of haloperidol
Y. Suzuk, K. Shimoda, T. Someya, T. Shimoda +8 more
19990 citations
Semantic Scholar
Relation between the change of blood haloperidol concentration by combined use of carbamazepine and CYP2D6 genotype .
G. Hirokane
19990 citations Open access
Semantic Scholar
Oral presentation: Relationship between the change of plasma haloperidol concentrations caused by coadministration of carbamazepine and CYP2D6 genotype
G. Hirokane, K. Shimoda, T. Someya, Sachiyo Morita +4 more
19990 citations
Semantic Scholar
Oral presentation: The effect of smoking on plasma haloperidol concentrations
K. Shimoda, T. Someya, G. Hirokane, Sachiyo Morita +6 more
19990 citations
Semantic Scholar
Relationship between the plasma concentration of bromperidol and the cytochrome P4502D6 genotype
G. Hirokane, T. Someya, K. Shimoda, Sachiyo Morita +2 more
19980 citations
Semantic Scholar
The effect of CYP2D6Ch on the hydroxylation of nortriptyline in Japanese patients
K. Shimoda, T. Someya, G. Hirokane, M. Shibasaki +4 more
19980 citations
Semantic Scholar
Effects of coadministration of carbamazepine. levomepromazine and perphenazine on the plasma concentration of haloperidol
T. Someya, G. Hirokane, T. Yashiki, A. Shirai +3 more
19980 citations
Semantic Scholar
Some crucial aspects of therapeutic drug monitoring and therapeutic range of bromperidol
G. Hirokane
19970 citations
Semantic Scholar

Frequent co-authors

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Sachiyo Morita×36
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Sachiyo Morita — researcher profile on SciRah
K. Shimoda×28
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K. Shimoda — researcher profile on SciRah
Aya Yokono×19
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Aya Yokono — researcher profile on SciRah
T. Someya×18
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T. Someya — researcher profile on SciRah

×16

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M. Ueda — researcher profile on SciRah

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M. Okawa — researcher profile on SciRah

Saburo Takahashi×10

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Saburo Takahashi — researcher profile on SciRah

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K. Shimoda — researcher profile on SciRah

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Y. Inoue — researcher profile on SciRah

Takashi Watanabe×6

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Takashi Watanabe — researcher profile on SciRah

Kazufumi Akiyama×6

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Kazufumi Akiyama — researcher profile on SciRah

M. Shibasaki×5

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M. Shibasaki — researcher profile on SciRah