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A. Ketkar · SciRah

Researcher profile · Semantic Scholar

A. Ketkar

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A. Ketkar — researcher profile on SciRah

h-index: 18
Works: 47
Citations: 755

Most-cited papers

Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
Che-Chia Hsu, Xian Zhang, Gui-Hua Wang, Weina Zhang +18 more
2021Molecules and Cells74 citations Open access
Semantic Scholar
Human Rev1 polymerase disrupts G-quadruplex DNA
Sarah Eddy, A. Ketkar, M. K. Zafar, Leena Maddukuri +2 more
2013Nucleic Acids Research71 citations Open access
Semantic Scholar
Kinetic Analysis of Human PrimPol DNA Polymerase Activity Reveals a Generally Error-Prone Enzyme Capable of Accurately Bypassing 7,8-Dihydro-8-oxo-2′-deoxyguanosine
M. K. Zafar, A. Ketkar, M. Lodeiro, C. Cameron +1 more
2014Biochemistry64 citations Open access
Semantic Scholar
Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4.
N. Madadi, N. Penthala, Kevin Howk, A. Ketkar +3 more
2015European journal of medicinal chemistry57 citations Open access
Semantic Scholar
Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA
Sarah Eddy, Leena Maddukuri, A. Ketkar, M. K. Zafar +3 more
2015Biochemistry43 citations Open access
Semantic Scholar
Human translesion polymerase kappa exhibits enhanced activity and reduced fidelity two nucleotides from G-quadruplex DNA
Sarah Eddy, Magdalena Tillman, Leena Maddukuri, A. Ketkar +2 more
2016Biochemistry38 citations Open access
Semantic Scholar
1-Benzyl-2-methyl-3-indolylmethylene barbituric acid derivatives: anti-cancer agents that target nucleophosmin 1 (NPM1)
N. Penthala, A. Ketkar, K. Sekhar, M. Freeman +3 more
2015Bioorganic & Medicinal Chemistry34 citations Open access
Semantic Scholar
A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
M. K. Zafar, Leena Maddukuri, A. Ketkar, N. Penthala +4 more
2018Biochemistry33 citations Open access
Semantic Scholar
Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin
N. Madadi, Hong-Liang Zong, A. Ketkar, Chen Zheng +6 more
2015MedChemComm31 citations Open access
Semantic Scholar
Proteomic identification of immunoproteasome accumulation in formalin-fixed rodent spinal cords with experimental autoimmune encephalomyelitis
M. Jain, Qing Li, Tong Liu, J. Rinaggio +5 more
2012Journal of Proteome Research27 citations Open access
Semantic Scholar
Residues in the RecQ C-terminal Domain of the Human Werner Syndrome Helicase Are Involved in Unwinding G-quadruplex DNA*
A. Ketkar, M. Voehler, Tresor Mukiza, R. Eoff
2017Journal of Biological Chemistry26 citations Open access
Semantic Scholar
N-Aroyl Indole Thiobarbituric Acids as Inhibitors of DNA Repair and Replication Stress Response Polymerases
G. Coggins, Leena Maddukuri, Narsima R. Penthala, Jessica H. Hartman +4 more
2013ACS Chemical Biology24 citations Open access
Semantic Scholar
Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents
N. Penthala, Hong-Liang Zong, A. Ketkar, N. Madadi +4 more
2014European journal of medicinal chemistry20 citations Open access
Semantic Scholar
The leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity
A. Ketkar, M. K. Zafar, Leena Maddukuri, Kinrin Yamanaka +5 more
2013Chemical Research in Toxicology20 citations Open access
Semantic Scholar
BIOTECHNOLOGICALLY RELEVANT ENZYMES AND PROTEINS A new DNA polymerase I from Geobacillus caldoxylosilyticus TK4: cloning, characterization, and mutational analysis of two aromatic residues
C. Sandalli, Kamalendra Singh, M. Modak, A. Ketkar +3 more
200920 citations
Semantic Scholar
Identification of a New Motif Required for the 3′–5′ Exonuclease Activity of Escherichia coli DNA Polymerase I (Klenow Fragment)
Pinky Kukreti, Kamalendra Singh, A. Ketkar, M. Modak
2008Journal of Biological Chemistry20 citations Open access
Semantic Scholar
Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms
A. Ketkar, Leena Maddukuri, N. Penthala, Megan R. Reed +3 more
2019ACS Chemical Biology18 citations Open access
Semantic Scholar
A structural basis for the role of nucleotide specifying residues in regulating the oligomerization of the Rv1625c adenylyl cyclase from M. tuberculosis.
A. Ketkar, A. Shenoy, U. Ramagopal, S. Visweswariah +1 more
2006Journal of Molecular Biology18 citations
Semantic Scholar
Enhancement of Human DNA Polymerase η Activity and Fidelity Is Dependent Upon a Bipartite Interaction with the Werner Syndrome Protein*
Leena Maddukuri, A. Ketkar, Sarah Eddy, M. K. Zafar +2 more
2012Journal of Biological Chemistry17 citations Open access
Semantic Scholar
Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
A. Ketkar, Lane Smith, Callie Johnson, Alyssa Richey +7 more
2021Nucleic Acids Research15 citations Open access
Semantic Scholar
Antinociceptive effects of the 6-O-sulfate ester of morphine in normal and diabetic rats: Comparative role of mu- and delta-opioid receptors
J. Yadlapalli, Benjamin M. Ford, A. Ketkar, Anqi Wan +5 more
2016Pharmacological Research15 citations Open access
Semantic Scholar
Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
Megan R. Reed, Leena Maddukuri, A. Ketkar, S. Byrum +4 more
2020bioRxiv13 citations Open access
Semantic Scholar
The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa
Leena Maddukuri, A. Ketkar, Sarah Eddy, M. K. Zafar +1 more
2014Nucleic Acids Research13 citations Open access
Semantic Scholar
Purification, crystallization and preliminary X-ray diffraction analysis of the catalytic domain of adenylyl cyclase Rv1625c from Mycobacterium tuberculosis.
A. Ketkar, A. Shenoy, M. M. Kesavulu, S. Visweswariah +1 more
2004Acta Crystallographica Section D: Biological Crystallography11 citations
Semantic Scholar
Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer Agents
N. Madadi, N. Penthala, A. Ketkar, R. Eoff +3 more
2018Anti-Cancer Agents in Medicinal Chemistry8 citations Open access
Semantic Scholar
A nucleotide analogue induced gain of function corrects the error-prone nature of human DNA polymerase iota
A. Ketkar, M. K. Zafar, Surajit Banerjee, V. Márquez +2 more
2012Journal of the American Chemical Society8 citations Open access
Semantic Scholar
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells
N. Madadi, A. Ketkar, N. Penthala, April C. L. Bostian +2 more
2016Bioorganic & Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Differential furanose selection in the active sites of archaeal DNA polymerases probed by fixed-conformation nucleotide analogues
A. Ketkar, M. K. Zafar, Surajit Banerjee, V. Márquez +2 more
2012Biochemistry5 citations Open access
Semantic Scholar
Site-Specific Synthesis of Oligonucleotides Containing 6-Oxo-M1dG, the Genomic Metabolite of M1dG, and LC-MS/MS Analysis of Its In Vitro Bypass by Human Polymerase ι
P. Christov, Robyn Richie-Jannetta, Philip J. Kingsley, Anoop Vemulapalli +7 more
2021Chemical Research in Toxicology3 citations Open access
Semantic Scholar
A structural basis for the role of nucleotide specifying residues in regulating the Rv1625c adenylyl cyclase oligomerization of the from M-tuberculosis
A. Ketkar, A. Shenoy, U. Ramagopal, S. Visweswariah +1 more
20063 citations
Semantic Scholar
Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis
A. Ketkar, Reham S Sewilam, Mason McCrury, Jaycelyn S. Hall +5 more
2023RSC Chemical Biology2 citations Open access
Semantic Scholar
Human REV1 interacts with DHX36 to promote replication and tolerance of G-quadruplex DNA
A. Ketkar, Bethany C. Paxton, O. Zúñiga, Reham S Sewilam +15 more
2026Nucleic Acids Research0 citations Open access
Semantic Scholar
Abstract 4350 Investigation of REV1-DHX36 interactions and the impact on G4 replisome dynamics
Rowan McCollum, A. Ketkar, Julie E C Gunderson, R. Eoff
2026Journal of Biological Chemistry0 citations Open access
Semantic Scholar
Selective Binding Of Human Rev1 With G‐Quadruplex DNA Is Determined By A Region Unique to Higher Eukaryotes
A. Ketkar, Lane Smith, Callie Johnson, Alyssa Richey +7 more
2021The FASEB Journal0 citations Open access
Semantic Scholar
Deletion of putative xenobiotic response elements (XREs) in hpol κ alters the replication stress response and overall genomic instability in glioblastoma cells
Leena Maddukuri, Megan R. Reed, A. Ketkar, J. W. Leung +1 more
2021The FASEB Journal0 citations
Semantic Scholar
DNA Polymerase Kappa Acts as a Barrier to Unrestrained Replication in Glioblastoma
Megan R. Reed, Leena Maddukuri, A. Ketkar, M. K. Zafar +3 more
2021The FASEB Journal0 citations
Semantic Scholar
A Novel Small Molecule Inhibitor of Human DNA Polymerase Eta Modulates the Efficacy of Cisplatin in Cancer Cells
M. K. Zafar, Leena Maddukuri, Narsima R. Penthala, A. Ketkar +4 more
2017The FASEB Journal0 citations Open access
Semantic Scholar
Biochemical and Biological Investigation of Human Polymerase Kappa Activity on G‐Quadruplex DNA
Sarah Eddy, Leena Maddukuri, Magdalena Tillman, Rachel Smith +3 more
2016The FASEB Journal0 citations Open access
Semantic Scholar
Investigation of Structure‐Activity Relationships for Small‐Molecule Inhibitors of Human DNA Polymerase Eta
M. K. Zafar, Leena Maddukuri, Sarah Eddy, A. Ketkar +3 more
2016The FASEB Journal0 citations Open access
Semantic Scholar
Mutations in The RQC Domain of Human WRN Helicase Compromise It's Ability To Unwind G‐Quadruplex DNA
A. Ketkar, M. Voehler, Tresor Mukiza, R. Eoff
2016The FASEB Journal0 citations Open access
Semantic Scholar
Participation of Distal RRRY Motif in Strand Displacement DNA synthesis by A‐Family DNA Polymerases
M. Modak, A. Ketkar, Kamal Singh
2016The FASEB Journal0 citations Open access
Semantic Scholar
Mechanism of hRev1 polymerase action on G‐quadruplex DNA (927.3)
Sarah Eddy, M. K. Zafar, A. Ketkar, Leena Maddukuri +1 more
20140 citations
Semantic Scholar
Identification and characterization of novel small molecule inhibitors of the human Y‐family DNA polymerases
A. Ketkar, M. K. Zafar, Leena Maddukuri, N. Penthala +4 more
20130 citations
Semantic Scholar
Crystal structure of Dpo4 in complex with N-MC-dAMP opposite dT
R. Eoff, A. Ketkar, S. Banerjee, M. K. Zafar
20120 citations
Semantic Scholar
Conformationally Restrained North-methanocarba-2'-deoxyadenosine Corrects the Error-Prone Nature of Human DNA Polymerase Iota
R. Eoff, A. Ketkar, Surajit Banerjee
20120 citations
Semantic Scholar
IDENTIFICATION OF A NEW MOTIF REQUIRED FOR THE 3’ – 5’ EXONUCLEASE ACTIVITY OF E. COLI DNA POLYMERASE I (KLENOW FRAGMENT): RRRY MOTIF IS NECESSARY FOR THE BINDING OF SSDNA SUBSTRATE AND THE TEMPLATE STRAND OF THE MISMATCHED DUPLEX
Pinky Kukreti, Kamalendra Singh, A. Ketkar, M. Modak
20080 citations
Semantic Scholar
Crystal structure of a mutant form of the mycobacterial adenylyl cyclase Rv1625c
A. Ketkar, A. Shenoy, U. A. Ramagopal, S. Visweswariah +1 more
20060 citations
Semantic Scholar

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