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J. Castellano · SciRah

Researcher profile · Semantic Scholar

J. Castellano

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J. Castellano — researcher profile on SciRah

h-index: 48
Works: 96
Citations: 9,001

Most-cited papers

Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide.
V. Navarro, J. Castellano, R. Fernández-Fernández, M. Barreiro +6 more
2004Endocrinology725 citations Open access
Semantic Scholar
Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition.
J. Castellano, V. Navarro, R. Fernández-Fernández, R. Nogueiras +9 more
2005Endocrinology549 citations Open access
Semantic Scholar
Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54.
V. Navarro, J. Castellano, R. Fernández-Fernández, S. Tovar +10 more
2005Endocrinology470 citations Open access
Semantic Scholar
Advanced vaginal opening and precocious activation of the reproductive axis by KiSS‐1 peptide, the endogenous ligand of GPR54
V. Navarro, R. Fernández-Fernández, J. Castellano, J. Roa +7 more
2004Journal of Physiology458 citations
Semantic Scholar
Novel signals for the integration of energy balance and reproduction.
R. Fernández-Fernández, A. Martini, V. Navarro, J. Castellano +4 more
2006Molecular and Cellular Endocrinology354 citations
Semantic Scholar
Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat.
V. Navarro, J. Castellano, R. Fernández-Fernández, S. Tovar +8 more
2005Endocrinology326 citations Open access
Semantic Scholar
Epigenetic Control of Female Puberty
A. Lomniczi, A. Loche, J. Castellano, O. Rønnekleiv +6 more
2013Nature Neuroscience287 citations Open access
Semantic Scholar
Expression of Hypothalamic KiSS-1 System and Rescue of Defective Gonadotropic Responses by Kisspeptin in Streptozotocin-Induced Diabetic Male Rats
J. Castellano, V. Navarro, R. Fernández-Fernández, J. Roa +6 more
2006Diabetes264 citations
Semantic Scholar
Expression of KiSS-1 in rat ovary: putative local regulator of ovulation?
J. Castellano, M. Gaytán, J. Roa, E. Vigo +9 more
2006Endocrinology259 citations Open access
Semantic Scholar
Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat.
V. Navarro, J. Castellano, Sarah McConkey, R. Pineda +5 more
2011American Journal of Physiology. Endocrinology and Metabolism255 citations Open access
Semantic Scholar
The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system.
J. Roa, D. García-Galiano, L. Varela, M. Sánchez-Garrido +10 more
2009Endocrinology223 citations Open access
Semantic Scholar
Effects of Ghrelin upon Gonadotropin-Releasing Hormone and Gonadotropin Secretion in Adult Female Rats: In vivo and in vitro Studies
R. Fernández-Fernández, M. Tena-Sempere, V. Navarro, M. L. Barreiro +3 more
2006Neuroendocrinology221 citations
Semantic Scholar
Early metabolic programming of puberty onset: impact of changes in postnatal feeding and rearing conditions on the timing of puberty and development of the hypothalamic kisspeptin system.
J. Castellano, Agnete H. Bentsen, M. Sánchez-Garrido, F. Ruiz-Pino +7 more
2011Endocrinology196 citations
Semantic Scholar
Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat.
J. Castellano, V. Navarro, R. Fernández-Fernández, J. Castaño +6 more
2006Molecular and Cellular Endocrinology186 citations
Semantic Scholar
Kisspeptins: bridging energy homeostasis and reproduction.
J. Castellano, Agnete H. Bentsen, J. Mikkelsen, M. Tena-Sempere
2010Brain Research177 citations
Semantic Scholar
KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels in a rat model of ovulatory dysfunction.
F. Gaytán, M. Gaytán, J. Castellano, M. Romero +8 more
2009American Journal of Physiology. Endocrinology and Metabolism176 citations
Semantic Scholar
Hypothalamic expression of KiSS-1 system and gonadotropin-releasing effects of kisspeptin in different reproductive states of the female Rat.
J. Roa, E. Vigo, J. Castellano, V. Navarro +6 more
2006Endocrinology173 citations Open access
Semantic Scholar
Role of Neurokinin B in the Control of Female Puberty and Its Modulation by Metabolic Status
V. Navarro, F. Ruiz-Pino, M. Sánchez-Garrido, D. García-Galiano +9 more
2012Journal of Neuroscience172 citations Open access
Semantic Scholar
Metabolic control of puberty onset: new players, new mechanisms.
J. Roa, D. García-Galiano, J. Castellano, F. Gaytán +2 more
2010Molecular and Cellular Endocrinology165 citations Open access
Semantic Scholar
KiSS-1/kisspeptins and the metabolic control of reproduction: physiologic roles and putative physiopathological implications.
J. Castellano, J. Roa, R. Luque, C. Diéguez +3 more
2009Peptides162 citations
Semantic Scholar
The Anorexigenic Neuropeptide, Nesfatin-1, Is Indispensable for Normal Puberty Onset in the Female Rat
D. García-Galiano, V. Navarro, J. Roa, F. Ruiz-Pino +9 more
2010Journal of Neuroscience157 citations Open access
Semantic Scholar
Persistent impairment of hypothalamic KiSS-1 system after exposures to estrogenic compounds at critical periods of brain sex differentiation.
V. Navarro, M. Sánchez-Garrido, J. Castellano, J. Roa +5 more
2009Endocrinology138 citations Open access
Semantic Scholar
Effects of single or repeated intravenous administration of kisspeptin upon dynamic LH secretion in conscious male rats.
S. Tovar, M. J. Vazquez, V. Navarro, R. Fernández-Fernández +8 more
2006Endocrinology125 citations
Semantic Scholar
Ghrelin inhibits the proliferative activity of immature Leydig cells in vivo and regulates stem cell factor messenger ribonucleic acid expression in rat testis.
M. Barreiro, F. Gaytán, J. Castellano, J. Suominen +6 more
2004Endocrinology116 citations
Semantic Scholar
Loss-of-function mutations in PNPLA6 encoding neuropathy target esterase underlie pubertal failure and neurological deficits in Gordon Holmes syndrome.
A. Topaloğlu, A. Lomniczi, D. Kretzschmar, G. Dissen +15 more
2014Journal of Clinical Endocrinology and Metabolism114 citations Open access
Semantic Scholar
SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression
M. J. Vázquez, C. A. Toro, J. Castellano, F. Ruiz-Pino +13 more
2018Nature Communications111 citations Open access
Semantic Scholar
Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2/nesfatin-1, in the testis.
D. García-Galiano, R. Pineda, T. Ilhan, J. Castellano +9 more
2012Endocrinology110 citations
Semantic Scholar
Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states.
J. Roa, E. Vigo, D. García-Galiano, J. Castellano +6 more
2008American Journal of Physiology. Endocrinology and Metabolism104 citations
Semantic Scholar
Kisspeptins and the control of gonadotropin secretion in male and female rodents.
J. Roa, J. Castellano, V. Navarro, David Handelsman +2 more
2009Peptides100 citations
Semantic Scholar
Kisspeptin receptor haplo-insufficiency causes premature ovarian failure despite preserved gonadotropin secretion.
F. Gaytán, D. García-Galiano, M. Dorfman, M. Manfredi-Lozano +4 more
2014Endocrinology99 citations Open access
Semantic Scholar
Metabolic programming of puberty: sexually dimorphic responses to early nutritional challenges.
M. Sánchez-Garrido, J. Castellano, F. Ruiz-Pino, D. García-Galiano +6 more
2013Endocrinology98 citations Open access
Semantic Scholar
Opposite roles of estrogen receptor (ER)-alpha and ERbeta in the modulation of luteinizing hormone responses to kisspeptin in the female rat: implications for the generation of the preovulatory surge.
J. Roa, E. Vigo, J. Castellano, F. Gaytán +7 more
2008Endocrinology95 citations Open access
Semantic Scholar
Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression
A. Lomniczi, Hollis Wright, J. Castellano, V. Matagne +4 more
2015Nature Communications94 citations Open access
Semantic Scholar
Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences.
J. Castellano, V. Navarro, J. Roa, R. Pineda +7 more
2009Endocrinology94 citations
Semantic Scholar
Neuroendocrine factors in the initiation of puberty: The emergent role of kisspeptin
V. Navarro, J. Castellano, D. García-Galiano, M. Tena-Sempere
2007Reviews in Endocrine & Metabolic Disorders92 citations
Semantic Scholar
Pattern of orexin expression and direct biological actions of orexin-a in rat testis.
M. Barreiro, R. Pineda, F. Gaytán, Marta Archanco +9 more
2005Endocrinology89 citations
Semantic Scholar
Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty.
V. Heras, J. Castellano, D. Fernandois, I. Velasco +16 more
2020Cell Metabolism86 citations Open access
Semantic Scholar
Development and validation of a method for precise dating of female puberty in laboratory rodents: The puberty ovarian maturation score (Pub-Score)
F. Gaytán, C. Morales, S. León, V. Heras +6 more
2017Scientific Reports77 citations Open access
Semantic Scholar
Metabolic regulation of female puberty via hypothalamic AMPK–kisspeptin signaling
J. Roa, Alexia Barroso, F. Ruiz-Pino, M. J. Vazquez +15 more
2018Proceedings of the National Academy of Sciences of the United States of America76 citations Open access
Semantic Scholar
Loss of Ntrk2/Kiss1r signaling in oocytes causes premature ovarian failure.
M. Dorfman, C. Garcia-Rudaz, Zefora Alderman, B. Kerr +8 more
2014Endocrinology75 citations Open access
Semantic Scholar
Obesity-induced hypogonadism in the male: premature reproductive neuroendocrine senescence and contribution of Kiss1-mediated mechanisms.
M. Sánchez-Garrido, F. Ruiz-Pino, M. Manfredi-Lozano, S. León +8 more
2014Endocrinology74 citations
Semantic Scholar
Activation of Microglia in Specific Hypothalamic Nuclei and the Cerebellum of Adult Rats Exposed to Neonatal Overnutrition
S. Tapia-González, L. M. García-Segura, M. Tena-Sempere, L. Frago +5 more
2011Journal of neuroendocrinology69 citations Open access
Semantic Scholar
Acute inflammation reduces kisspeptin immunoreactivity at the arcuate nucleus and decreases responsiveness to kisspeptin independently of its anorectic effects.
J. Castellano, Agnete H. Bentsen, M. Romero, R. Pineda +6 more
2010American Journal of Physiology. Endocrinology and Metabolism66 citations
Semantic Scholar
Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3
V. Heras, S. Sangiao-Alvarellos, M. Manfredi-Lozano, María J Sánchez-Tapia +16 more
2019PLoS Biology59 citations Open access
Semantic Scholar
Metabolic control of female puberty: potential therapeutic targets
J. Castellano, M. Tena-Sempere
2016Expert opinion on therapeutic targets59 citations
Semantic Scholar
Intergenerational Influence of Paternal Obesity on Metabolic and Reproductive Health Parameters of the Offspring: Male-Preferential Impact and Involvement of Kiss1-Mediated Pathways
M. Sánchez-Garrido, F. Ruiz-Pino, I. Velasco, Alexia Barroso +8 more
2018Endocrinology55 citations Open access
Semantic Scholar
Direct stimulatory effect of ghrelin on pituitary release of LH through a nitric oxide-dependent mechanism that is modulated by estrogen.
R. Fernández-Fernández, M. Tena-Sempere, J. Roa, J. Castellano +3 more
2007Reproduction55 citations Open access
Semantic Scholar
Environmentally Relevant Perinatal Exposures to Bisphenol A Disrupt Postnatal Kiss1/NKB Neuronal Maturation and Puberty Onset in Female Mice
F. Ruiz-Pino, D. Miceli, D. Franssen, M. J. Vazquez +4 more
2019Environmental Health Perspectives48 citations Open access
Semantic Scholar
A System Biology Approach to Identify Regulatory Pathways Underlying the Neuroendocrine Control of Female Puberty in Rats and Nonhuman Primates
A. Lomniczi, Hollis Wright, J. Castellano, K. Sonmez +1 more
2013Hormones and Behavior48 citations Open access
Semantic Scholar
Follicle-stimulating hormone responses to kisspeptin in the female rat at the preovulatory period: modulation by estrogen and progesterone receptors.
J. Roa, E. Vigo, J. Castellano, F. Gaytán +8 more
2008Endocrinology47 citations Open access
Semantic Scholar

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M. Tena-Sempere×42
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M. Tena-Sempere — researcher profile on SciRah
L. Pinilla×32
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L. Pinilla — researcher profile on SciRah
J. Roa×28
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J. Roa — researcher profile on SciRah
V. Navarro×23
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V. Navarro — researcher profile on SciRah

×18

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F. Gaytán — researcher profile on SciRah

D. García-Galiano×17

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D. García-Galiano — researcher profile on SciRah

F. Ruiz-Pino×15

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E. Aguilar — researcher profile on SciRah

C. Diéguez×13

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C. Diéguez — researcher profile on SciRah

R. Fernández-Fernández×12

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R. Pineda — researcher profile on SciRah

M. Sánchez-Garrido×11

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M. Sánchez-Garrido — researcher profile on SciRah