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C. Kloft · SciRah

Researcher profile · Semantic Scholar

C. Kloft

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C. Kloft — researcher profile on SciRah

h-index: 39
Works: 234
Citations: 5,276

Most-cited papers

Inhaled Therapy in Respiratory Disease: The Complex Interplay of Pulmonary Kinetic Processes
J. Borghardt, C. Kloft, Ashish Sharma
2018Canadian Respiratory Journal294 citations Open access
Semantic Scholar
Therapeutic drug monitoring of oral targeted antineoplastic drugs
Anna Mueller‐Schoell, S. Groenland, Oliver Scherf-Clavel, Madelé van Dyk +6 more
2020European Journal of Clinical Pharmacology179 citations Open access
Semantic Scholar
Pharmacy‐based interdisciplinary intervention for patients with chronic heart failure: results of the PHARM‐CHF randomized controlled trial
M. Schulz, Nina Griese-Mammen, S. Anker, Friedrich Koehler +21 more
2019European Journal of Heart Failure96 citations Open access
Semantic Scholar
Perspectives on Model‐Informed Precision Dosing in the Digital Health Era: Challenges, Opportunities, and Recommendations
Franziska Kluwe, R. Michelet, Anna Mueller‐Schoell, Corinna Maier +5 more
2020Clinical pharmacology and therapy76 citations Open access
Semantic Scholar
Novel insights into the complex pharmacokinetics of voriconazole: a review of its metabolism
Josefine Schulz, Franziska Kluwe, G. Mikus, R. Michelet +1 more
2019Drug metabolism reviews (Softcover ed.)72 citations
Semantic Scholar
Development of a dosing algorithm for meropenem in critically ill patients based on a population pharmacokinetic/pharmacodynamic analysis.
Lisa Ehmann, M. Zoller, Iris K. Minichmayr, C. Scharf +3 more
2019International Journal of Antimicrobial Agents63 citations
Semantic Scholar
Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells
Mareike Berlak, E. Tucker, Mathurin Dorel, A. Winkler +32 more
2022Molecular Cancer54 citations Open access
Semantic Scholar
Reinforcement learning and Bayesian data assimilation for model‐informed precision dosing in oncology
Corinna Maier, Niklas Hartung, C. Kloft, W. Huisinga +1 more
2020CPT: Pharmacometrics & Systems Pharmacology47 citations Open access
Semantic Scholar
Early Survival Prediction Framework in CD19-Specific CAR-T Cell Immunotherapy Using a Quantitative Systems Pharmacology Model
Anna Mueller‐Schoell, N. Puebla-Osorio, R. Michelet, Michael R. Green +7 more
2021Cancers41 citations Open access
Semantic Scholar
A continued learning approach for model‐informed precision dosing: Updating models in clinical practice
Corinna Maier, J. de Wiljes, Niklas Hartung, C. Kloft +1 more
2021CPT: Pharmacometrics & Systems Pharmacology39 citations Open access
Semantic Scholar
Bayesian Data Assimilation to Support Informed Decision Making in Individualized Chemotherapy
Corinna Maier, Niklas Hartung, J. de Wiljes, C. Kloft +1 more
2019CPT: Pharmacometrics & Systems Pharmacology36 citations Open access
Semantic Scholar
Does the cytokine adsorber CytoSorb® reduce vancomycin exposure in critically ill patients with sepsis or septic shock? a prospective observational study
C. Scharf, F. Weinelt, Ines Schroeder, M. Paal +6 more
2022Annals of Intensive Care33 citations Open access
Semantic Scholar
Integrated Data Analysis of Six Clinical Studies Points Toward Model-Informed Precision Dosing of Tamoxifen
L. Klopp-Schulze, Anna Mueller‐Schoell, P. Neven, S. Koolen +3 more
2020Frontiers in Pharmacology31 citations Open access
Semantic Scholar
No clinically relevant removal of meropenem by cytokine adsorber CytoSorb® in critically ill patients with sepsis or septic shock
U. Liebchen, C. Scharf, M. Zoller, F. Weinelt +9 more
2021Intensive Care Medicine29 citations Open access
Semantic Scholar
Linezolid Concentrations in Plasma and Subcutaneous Tissue are Reduced in Obese Patients, Resulting in a Higher Risk of Underdosing in Critically Ill Patients: A Controlled Clinical Pharmacokinetic Study
P. Simon, D. Busse, D. Petroff, C. Dorn +8 more
2020Journal of Clinical Medicine28 citations Open access
Semantic Scholar
Obesity alters endoxifen plasma levels in young breast cancer patients: A pharmacometric simulation approach.
Anna Mueller‐Schoell, L. Klopp-Schulze, W. Schroth, T. Mürdter +15 more
2020Clinical pharmacology and therapy24 citations Open access
Semantic Scholar
Acute-on-chronic liver failure alters meropenem pharmacokinetics in critically ill patients with continuous hemodialysis: an observational study
J. Grensemann, D. Busse, Christina König, K. Roedl +7 more
2020Annals of Intensive Care24 citations Open access
Semantic Scholar
Perioperative administration of cefazolin and metronidazole in obese and non-obese patients: a pharmacokinetic study in plasma and interstitial fluid.
C. Dorn, D. Petroff, Melanie Stoelzel, M. G. Kees +7 more
2021Journal of Antimicrobial Chemotherapy23 citations Open access
Semantic Scholar
Plasma and tissue pharmacokinetics of fosfomycin in morbidly obese and non-obese surgical patients: a controlled clinical trial.
C. Dorn, D. Petroff, N. Neumann, A. Kratzer +8 more
2019Journal of Antimicrobial Chemotherapy22 citations Open access
Semantic Scholar
Towards the Elucidation of the Pharmacokinetics of Voriconazole: A Quantitative Characterization of Its Metabolism
Josefine Schulz, A. Thomas, A. Saleh, G. Mikus +2 more
2022Pharmaceutics21 citations Open access
Semantic Scholar
Meropenem Plasma and Interstitial Soft Tissue Concentrations in Obese and Nonobese Patients—A Controlled Clinical Trial
P. Simon, D. Petroff, D. Busse, Jana Heyne +8 more
2020Antibiotics19 citations Open access
Semantic Scholar
Pharmacokinetic/pharmacodynamic evaluation of hydrocortisone therapy in pediatric patients with congenital adrenal hyperplasia.
J. Melin, Z. Parra-Guillén, R. Michelet, T. Truong +4 more
2020Journal of Clinical Endocrinology and Metabolism19 citations Open access
Semantic Scholar
High voriconazole target‐site exposure after approved sequence dosing due to nonlinear pharmacokinetics assessed by long‐term microdialysis
Claudia Kirbs, Franziska Kluwe, F. Drescher, E. Lackner +4 more
2019European Journal of Pharmaceutical Sciences18 citations
Semantic Scholar
Infliximab clearance decreases in the second and third trimesters of pregnancy in inflammatory bowel disease
Ana-Marija Grisic, M. Dorn-Rasmussen, B. Ungar, J. Brynskov +8 more
2020United European Gastroenterology journal17 citations Open access
Semantic Scholar
Developing a Nationwide Infrastructure for Therapeutic Drug Monitoring of Targeted Oral Anticancer Drugs: The ON-TARGET Study Protocol
Anna M. Mc Laughlin, E. Schmulenson, O. Teplytska, S. Zimmermann +15 more
2021Cancers16 citations Open access
Semantic Scholar
Drug combinations and impact of experimental conditions on relative recovery in in vitro microdialysis investigations
Daniela Burau, D. Petroff, P. Simon, Lisa Ehmann +5 more
2019European Journal of Pharmaceutical Sciences16 citations
Semantic Scholar
Role of TDM‐based dose adjustments for taxane anticancer drugs
M. Muth, F. W. Ojara, C. Kloft, M. Joerger
2020British Journal of Clinical Pharmacology15 citations
Semantic Scholar
Development and validation of a bioanalytical method for the quantification of axitinib from plasma and capillary blood using volumetric absorptive microsampling (VAMS) and on-line solid phase extraction (SPE) LC-MS.
P. Opitz, S. Zimmermann, Anna M. Mc Laughlin, L. Müller +5 more
2022Journal of Pharmaceutical and Biomedical Analysis14 citations
Semantic Scholar
Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
Johanna Seeger, S. Guenther, K. Schaufler, Stefan E. Heiden +2 more
2021Antibiotics14 citations Open access
Semantic Scholar
Target Site Pharmacokinetics of Meropenem: Measurement in Human Explanted Lung Tissue by Bronchoalveolar Lavage, Microdialysis, and Homogenized Lung Tissue
M. Paal, C. Scharf, Annika Denninger, L. Ilia +12 more
2021Antimicrobial Agents and Chemotherapy14 citations Open access
Semantic Scholar
Towards Model-Informed Precision Dosing of Voriconazole: Challenging Published Voriconazole Nonlinear Mixed-Effects Models with Real-World Clinical Data
Franziska Kluwe, R. Michelet, W. Huisinga, M. Zeitlinger +2 more
2023Clinical Pharmacokinetics13 citations Open access
Semantic Scholar
Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion
Y. M. Nassar, N. Hohmann, R. Michelet, Katharina Gottwalt +6 more
2022Clinical Pharmacokinetics13 citations Open access
Semantic Scholar
Constitutive Cell Proliferation Regulating Inhibitor of Protein Phosphatase 2A (CIP2A) Mediates Drug Resistance to Erlotinib in an EGFR Activating Mutated NSCLC Cell Line
H. Saafan, Ahmad Alahdab, R. Michelet, Linus Gohlke +8 more
2021Cells12 citations Open access
Semantic Scholar
Quantification of microdialysis related variability in humans: Clinical trial design recommendations.
D. Busse, P. Simon, R. Michelet, Lisa Ehmann +7 more
2020European Journal of Pharmaceutical Sciences12 citations
Semantic Scholar
The circadian rhythm of corticosteroid‐binding globulin has little impact on cortisol exposure after hydrocortisone dosing
J. Melin, Niklas Hartung, Z. Parra-Guillén, Martin J. Whitaker +2 more
2019Clinical Endocrinology12 citations Open access
Semantic Scholar
Deriving mechanism‐based pharmacodynamic models by reducing quantitative systems pharmacology models: An application to warfarin
Undine Falkenhagen, Jane Knöchel, C. Kloft, W. Huisinga
2023CPT: Pharmacometrics & Systems Pharmacology11 citations Open access
Semantic Scholar
Evaluating prediction methods for glomerular filtration to optimise drug doses in obese and nonobese patients
D. Busse, J. Borghardt, D. Petroff, A. Pevzner +6 more
2021British Journal of Clinical Pharmacology11 citations Open access
Semantic Scholar
Which Analysis Approach Is Adequate to Leverage Clinical Microdialysis Data? A Quantitative Comparison to Investigate Exposure and Response Exemplified by Levofloxacin
D. Busse, A. Schaeftlein, A. Solms, L. Ilia +4 more
2021Pharmaceutical Research10 citations Open access
Semantic Scholar
Comparative Plasma and Interstitial Tissue Fluid Pharmacokinetics of Meropenem Demonstrate the Need for Increasing Dose and Infusion Duration in Obese and Non-obese Patients
D. Busse, P. Simon, L. Schmitt, D. Petroff +7 more
2021Clinical Pharmacokinetics10 citations Open access
Semantic Scholar
Rationale of a lower dexamethasone dose in prenatal congenital adrenal hyperplasia therapy based on pharmacokinetic modelling.
V. Stachanow, Uta Neumann, O. Blankenstein, U. Fuhr +4 more
2021European Journal of Endocrinology10 citations Open access
Semantic Scholar
Paediatric population pharmacokinetic modelling to assess hydrocortisone replacement dosing regimens in young children.
R. Michelet, J. Melin, Z. Parra-Guillén, Uta Neumann +7 more
2020European Journal of Endocrinology10 citations
Semantic Scholar
PBTK modeling of the pyrrolizidine alkaloid retrorsine to predict liver toxicity in mouse and rat
Anja Lehmann, I. Geburek, A. These, S. Hessel-Pras +7 more
2023Archives of Toxicology9 citations Open access
Semantic Scholar
Microdialysis sampling to monitor target-site vancomycin concentrations in septic infants - a feasible way to close the knowledge gap.
Sebastian Schroepf, Daniela Burau, Hans-Georg Muench, H. Derendorf +4 more
2021International Journal of Antimicrobial Agents9 citations
Semantic Scholar
Quantification of persister formation of Escherichia coli leveraging electronic cell counting and semi-mechanistic pharmacokinetic/pharmacodynamic modelling.
Johanna Seeger, R. Michelet, C. Kloft
2021Journal of Antimicrobial Chemotherapy9 citations
Semantic Scholar
Quantitative relationship between infliximab exposure and inhibition of C‐reactive protein synthesis to support inflammatory bowel disease management
Ana-Marija Grisic, A. Eser, W. Huisinga, W. Reinisch +1 more
2020British Journal of Clinical Pharmacology9 citations Open access
Semantic Scholar
A rapid, simple and sensitive liquid chromatography tandem mass spectrometry assay to determine amoxicillin concentrations in biological matrix of little volume.
Sebastian Franck, T. Fuhrmann-Selter, J. Joseph, R. Michelet +4 more
2019Talanta: The International Journal of Pure and Applied Analytical Chemistry9 citations
Semantic Scholar
Barriers to global pharmacometrics: educational challenges and opportunities across the globe
R. Michelet, L. Aulin, J. Borghardt, T. D. Costa +8 more
2023CPT: Pharmacometrics & Systems Pharmacology8 citations Open access
Semantic Scholar
Ulcerative Colitis and Acute Severe Ulcerative Colitis Patients Are Overlooked in Infliximab Population Pharmacokinetic Models: Results from a Comprehensive Review
A. Démaris, E. Widigson, J. Ilvemark, C. Steenholdt +5 more
2022Pharmaceutics8 citations Open access
Semantic Scholar
A versatile high-performance LC-MS/MS assay for the quantification of voriconazole and its N-oxide metabolite in small sample volumes of multiple human matrices for biomedical applications.
Josefine Schulz, R. Michelet, J. Joseph, M. Zeitlinger +3 more
2021Journal of Pharmaceutical and Biomedical Analysis8 citations
Semantic Scholar
The Biosynthetic Monophosphoryl Lipid A Enhances the Therapeutic Outcome of Antibiotic Therapy in Pneumococcal Pneumonia.
Fiordiligie Casilag, Laura Matarazzo, Sebastian Franck, M. Figeac +4 more
2021ACS Infectious Diseases8 citations
Semantic Scholar

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