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P. Giastas · SciRah

Researcher profile · Semantic Scholar

P. Giastas

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P. Giastas — researcher profile on SciRah

h-index: 17
Works: 80
Citations: 923

Most-cited papers

A common SNP in ER aminopeptidase 2 induces a specificity switch that leads to altered antigen processing
Irini Evnouchidou, J. Birtley, S. Seregin, A. Papakyriakou +10 more
2012Journal of Immunology106 citations Open access
Semantic Scholar
Crystal structures of free and antagonist-bound states of human α9 nicotinic receptor extracellular domain
M. Zouridakis, P. Giastas, E. Zarkadas, Dafni Chroni-Tzartou +2 more
2014Nature Structural &Molecular Biology94 citations
Semantic Scholar
Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2*
A. Mpakali, P. Giastas, N. Mathioudakis, I. Mavridis +2 more
2015Journal of Biological Chemistry70 citations Open access
Semantic Scholar
Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1
P. Giastas, A. Mpakali, A. Papakyriakou, A. Lelis +6 more
2019Proceedings of the National Academy of Sciences of the United States of America53 citations Open access
Semantic Scholar
Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound α2 homopentamer
N. Kouvatsos, P. Giastas, Dafni Chroni-Tzartou, C. Poulopoulou +1 more
2016Proceedings of the National Academy of Sciences of the United States of America51 citations Open access
Semantic Scholar
Molecular Interaction of α-Conotoxin RgIA with the Rat α9α10 Nicotinic Acetylcholine Receptor
L. Azam, A. Papakyriakou, M. Zouridakis, P. Giastas +2 more
2015Molecular Pharmacology41 citations Open access
Semantic Scholar
Crystal Structure of the Monomeric Extracellular Domain of α9 Nicotinic Receptor Subunit in Complex With α-Conotoxin RgIA: Molecular Dynamics Insights Into RgIA Binding to α9α10 Nicotinic Receptors
M. Zouridakis, A. Papakyriakou, I. Ivanov, I. Kasheverov +3 more
2019Frontiers in Pharmacology40 citations Open access
Semantic Scholar
Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.
A. Mpakali, E. Saridakis, K. Harlos, Yu-Guang Zhao +5 more
2017Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor
P. Giastas, M. Neu, P. Rowland, E. Stratikos
2019ACS Medicinal Chemistry Letters35 citations Open access
Semantic Scholar
Understanding structure–function relationships of the human neuronal acetylcholine receptor: insights from the first crystal structures of neuronal subunits
P. Giastas, M. Zouridakis, S. Tzartos
2018British Journal of Pharmacology32 citations Open access
Semantic Scholar
The structure of the 2[4Fe–4S] ferredoxin from Pseudomonas aeruginosa at 1.32-Å resolution: comparison with other high-resolution structures of ferredoxins and contributing structural features to reduction potential values
P. Giastas, N. Pinotsis, Georgios Efthymiou, M. Wilmanns +3 more
2006JBIC Journal of Biological Inorganic Chemistry32 citations
Semantic Scholar
Insight into the protein and solvent contributions to the reduction potentials of [4Fe–4S]2+/+ clusters: crystal structures of the Allochromatium vinosum ferredoxin variants C57A and V13G and the homologous Escherichia coli ferredoxin
E. Saridakis, P. Giastas, Georgios Efthymiou, Vladimiros Thoma +3 more
2009JBIC Journal of Biological Inorganic Chemistry29 citations
Semantic Scholar
Two Putative Polysaccharide Deacetylases Are Required for Osmotic Stability and Cell Shape Maintenance in Bacillus anthracis
Sofia Arnaouteli, P. Giastas, A. Andreou, M. Tzanodaskalaki +5 more
2015Journal of Biological Chemistry28 citations Open access
Semantic Scholar
Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor.
A. Mpakali, E. Saridakis, P. Giastas, Z. Maben +4 more
2020ACS Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Structures of the Peptidoglycan N-Acetylglucosamine Deacetylase Bc1974 and Its Complexes with Zinc Metalloenzyme Inhibitors.
P. Giastas, A. Andreou, A. Papakyriakou, D. Koutsioulis +4 more
2018Biochemistry21 citations
Semantic Scholar
Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic-Target Guided Synthesis
V. Camberlein, Charlotte Fleau-Tabey, Pierre Sierocki, Le-Nong Li +25 more
2022Angewandte Chemie20 citations Open access
Semantic Scholar
Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency.
A. Mpakali, P. Giastas, R. Deprez-Poulain, A. Papakyriakou +7 more
2017ACS Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on α-Hydroxy-β-amino Acid Derivatives of Bestatin.
D. Vourloumis, Ioannis Mavridis, Alexandros Athanasoulis, Ioannis Temponeras +8 more
2022Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
Expression of human AChR extracellular domain mutants with improved characteristics.
K. Lazaridis, P. Zisimopoulou, P. Giastas, Kalliopi Bitzopoulou +3 more
2014International Journal of Biological Macromolecules17 citations Open access
Semantic Scholar
Molecular structures of the inclusion complexes β-cyclodextrin‒1,2-bis(4-aminophenyl)ethane and β-cyclodextrin‒4,4'-diaminobiphenyl; packing of dimeric β-cyclodextrin inclusion complexes
P. Giastas, K. Yannakopoulou, I. Mavridis
200317 citations
Semantic Scholar
Novel benzimidazole angiotensin receptor blockers with anti-SARS-CoV-2 activity equipotent to that of nirmatrelvir: computational and enzymatic studies
Harry Ridgway, Graham J. Moore, L. K. Gadanec, Anthony Zulli +17 more
2024Expert opinion on therapeutic targets16 citations
Semantic Scholar
Formation of a highly-ordered rigid multichromophoric 3D supramolecular network by combining ionic and coordination-driven self-assembly.
A. Kaloudi-Chantzea, Elisabeth Martinou, K. Seintis, N. Karakostas +5 more
2016Chemical Communications16 citations
Semantic Scholar
Structural and Evolutionary Insights within the Polysaccharide Deacetylase Gene Family of Bacillus anthracis and Bacillus cereus
A. Andreou, P. Giastas, Elias Christoforides, E. Eliopoulos
2018Genes14 citations Open access
Semantic Scholar
Synthesis of 6-mono-6-deoxy-beta-cyclodextrins substituted with isomeric aminobenzoic acids. Structural characterization, conformational preferences, and self-inclusion as studied by NMR spectroscopy in aqueous solution and by X-ray crystallography in the solid state.
Kyriaki Eliadou, P. Giastas, K. Yannakopoulou, I. Mavridis
2003Journal of Organic Chemistry13 citations
Semantic Scholar
Inclusion compounds of plant growth regulators in cyclodextrins. V. 4-Chlorophenoxyacetic acid encapsulated in β-cyclodextrin and heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin
Frantzeska Tsorteki, K. Bethanis, N. Pinotsis, P. Giastas +1 more
200512 citations
Semantic Scholar
Insights into the Protein Ruthenation Mechanism by Antimetastatic Metallodrugs: High-Resolution X-ray Structures of the Adduct Formed between Hen Egg-White Lysozyme and NAMI-A at Various Time Points.
L. Chiniadis, P. Giastas, I. Bratsos, A. Papakyriakou
2021Inorganic Chemistry9 citations
Semantic Scholar
Molecular recognition of N-acetyltryptophan enantiomers by β-cyclodextrin
S. Chatziefthimiou, Mario Inclán, P. Giastas, A. Papakyriakou +2 more
2017Beilstein Journal of Organic Chemistry9 citations Open access
Semantic Scholar
Synthesis of Chalcogenidoimidodiphosphinato–RhI Complexes and DFT Investigation of Their Catalytic Activation in Olefin Hydroformylation
A. Grigoropoulos, D. Maganas, D. Symeonidis, P. Giastas +3 more
20139 citations
Semantic Scholar
High-resolution crystal structures of a “half sandwich”-type Ru(II) coordination compound bound to hen egg-white lysozyme and proteinase K
L. Chiniadis, I. Bratsos, K. Bethanis, M. Karpusas +2 more
2020JBIC Journal of Biological Inorganic Chemistry7 citations Open access
Semantic Scholar
Control of differential inclusion complexation in the solid state by seed crystals.
Kazuhiro Yoshizawa, S. Toyota, F. Toda, S. Chatziefthimiou +3 more
2005Angewandte Chemie7 citations
Semantic Scholar
Pseudorotaxanes of β-Cyclodextrin with Diamino End-functionalized Oligo-phenyl and -benzyl Compounds in Solution and in the Solid State
P. Giastas, Nikolaos Mourtzis, K. Yannakopoulou, I. Mavridis
20026 citations
Semantic Scholar
Mechanisms of allosteric inhibition of Insulin-Regulated Aminopeptidase.
A. Mpakali, I. Barla, Liying Lu, Karthik M. Ramesh +4 more
2024Journal of Molecular Biology5 citations Open access
Semantic Scholar
X-ray crystallography and solution NMR spectroscopy characterization of heptakis(2,3-di-O-acetyl-6-bromo-6-deoxy)cyclomaltoheptaose.
P. Giastas, Kyriaki Eliadou, Zoi F. Plyta, K. Yannakopoulou +1 more
2004Carbohydrate Research4 citations
Semantic Scholar
Photoreactions of 2- and 4- Pyridones in Their Inclusion Crystal with a Host Compound
F. Toda, M. Yagi, Shinya Hirano, S. Toyota +2 more
20034 citations Open access
Semantic Scholar
Inhibitor-Dependent Usage of the S1' Specificity Pocket of ER Aminopeptidase 2.
A. Mpakali, D. Georgiadis, E. Stratikos, P. Giastas
2022ACS Medicinal Chemistry Letters2 citations Open access
Semantic Scholar
Structural Insights into the Role of β3 nAChR Subunit in the Activation of Nicotinic Receptors
P. Giastas, A. Papakyriakou, George Tsafaras, S. Tzartos +1 more
2022Molecules2 citations Open access
Semantic Scholar
The putative polysaccharide deacetylase Ba0331: cloning, expression, crystallization and structure determination.
A. Andreou, P. Giastas, Sofia Arnaouteli, M. Tzanodaskalaki +4 more
2019Acta Crystallographica Section F Structural Biology Communications2 citations Open access
Semantic Scholar
Inclusion compounds of plant growth regulators in cyclodextrins. V. 4-Chlorophenoxyacetic acid encapsulated in beta-cyclodextrin and heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin.
Frantzeska Tsorteki, K. Bethanis, N. Pinotsis, P. Giastas +1 more
2005Acta Crystallographica Section B Structural Science2 citations Open access
Semantic Scholar
Stabilization of the open conformation οf insulin‐regulated aminopeptidase by a novel substrate‐selective small‐molecule inhibitor
A. Mpakali, Galateia Georgaki, Alberto Buson, A. Findlay +6 more
2024bioRxiv1 citations Open access
Semantic Scholar
Corrigendum: Crystal structure of the monomeric extracellular domain of α9 nicotinic receptor subunit in complex with α-conotoxin RgIA: Molecular dynamics insights into RgIA binding to α9α10 nicotinic receptors
M. Zouridakis, A. Papakyriakou, I. Ivanov, I. Kasheverov +3 more
2022Frontiers in Pharmacology1 citations Open access
Semantic Scholar
Non-contact Current Transfer Induces the Formation and Improves the X-ray Diffraction Quality of Protein Crystals
Ilias Boltsis, George Lagoumintzis, D. Chatzileontiadou, P. Giastas +3 more
20141 citations
Semantic Scholar
Altered Antigen Processing Induces a Specificity Switch That Leads to in Endoplasmic Reticulum Aminopeptidase 2 A Common Single Nucleotide Polymorphism
Irini Evnouchidou, J. Birtley, S. Seregin, A. Papakyriakou +10 more
20121 citations
Semantic Scholar
Molecular structures of the inclusion complexes beta-cyclodextrin-1,2-bis(4-aminophenyl)ethane and beta-cyclodextrin-4,4'-diaminobiphenyl; packing of dimeric beta-cyclodextrin inclusion complexes.
P. Giastas, K. Yannakopoulou, I. Mavridis
2003Acta Crystallographica Section B Structural Science1 citations
Semantic Scholar
Structural insights into allosteric regulation and conformational dynamics of ACE2 in catalysis and SARS-CoV-2 binding
P. Giastas, O. Kupreienko, N. Alevizopoulos, M. A. Balachouti +4 more
2026Acta Crystallographica Section A: Foundations and Advances0 citations
Semantic Scholar
High-resolution crystal structures of ER aminopeptidase 1 with bound antigenic peptide precursor analogues
P. Giastas, A. Lelis, Paraskevi Kokkala, D. Georgiadis +1 more
2022Molecular Immunology0 citations
Semantic Scholar
The adduct of NAMI-A with Hen Egg White Lysozyme at 1.5 hours.
L. Chiniadis, P. Giastas, I. Bratsos, A. Papakyriakou
20210 citations
Semantic Scholar
The adduct of NAMI-A with Hen Egg White Lysozyme at 26 hours.
L. Chiniadis, P. Giastas, I. Bratsos, A. Papakyriakou
20210 citations
Semantic Scholar
The adduct of NAMI-A with Hen Egg White Lysozyme at 8 hours.
L. Chiniadis, P. Giastas, I. Bratsos, A. Papakyriakou
20210 citations
Semantic Scholar
The adduct of NAMI-A with Hen Egg White Lysozyme at 98 hours.
L. Chiniadis, P. Giastas, I. Bratsos, A. Papakyriakou
20210 citations
Semantic Scholar
Proteinase K in complex with a "half sandwich"-type Ru(II) coordination compound
L. Chiniadis, P. Giastas, I. Bratsos, A. Papakyriakou
20200 citations
Semantic Scholar

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A. Papakyriakou×19
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E. Stratikos×14
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I. Mavridis×13
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