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S. Colombetti · SciRah

Researcher profile · Semantic Scholar

S. Colombetti

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S. Colombetti — researcher profile on SciRah

h-index: 22
Works: 74
Citations: 2,942

Most-cited papers

Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation
R. Palumbo, M. Sampaolesi, Francesco de Marchis, R. Tonlorenzi +4 more
2004Journal of Cell Biology497 citations Open access
Semantic Scholar
Dendritic cells dictate responses to PD-L1 blockade cancer immunotherapy
M. Mayoux, A. Roller, V. Pulko, S. Sammicheli +18 more
2020Science Translational Medicine378 citations
Semantic Scholar
A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors
M. Bacac, T. Fauti, Johannes Sam, S. Colombetti +24 more
2016Clinical Cancer Research302 citations
Semantic Scholar
PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells
Laura Codarri Deak, V. Nicolini, Masao Hashimoto, M. Karagianni +31 more
2022Nature247 citations Open access
Semantic Scholar
Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy
C. Claus, C. Ferrara, Wei Xu, Johannes Sam +53 more
2019Science Translational Medicine236 citations Open access
Semantic Scholar
CD20-TCB with Obinutuzumab Pretreatment as Next-Generation Treatment of Hematologic Malignancies
M. Bacac, S. Colombetti, S. Herter, Johannes Sam +19 more
2018Clinical Cancer Research192 citations Open access
Semantic Scholar
Prolonged TCR/CD28 Engagement Drives IL-2-Independent T Cell Clonal Expansion through Signaling Mediated by the Mammalian Target of Rapamycin1
S. Colombetti, V. Basso, D. Mueller, A. Mondino
2006Journal of Immunology149 citations
Semantic Scholar
Simlukafusp alfa (FAP-IL2v) immunocytokine is a versatile combination partner for cancer immunotherapy
I. Waldhauer, V. Gonzalez‐Nicolini, A. Freimoser-Grundschober, T. Nayak +25 more
2021mAbs106 citations Open access
Semantic Scholar
IL-7 adjuvant treatment enhances long-term tumor-antigen-specific CD8+ T-cell responses after immunization with recombinant lentivector.
S. Colombetti, F. Lévy, Laurence Chapatte
2009Blood69 citations
Semantic Scholar
In Vivo Fluorescence Imaging of the Activity of CEA TCB, a Novel T-Cell Bispecific Antibody, Reveals Highly Specific Tumor Targeting and Fast Induction of T-Cell–Mediated Tumor Killing
Steffi Lehmann, Ramanil Perera, H. Grimm, Johannes Sam +12 more
2016Clinical Cancer Research66 citations Open access
Semantic Scholar
Clonal Anergy Is Maintained Independently of T Cell Proliferation1
S. Colombetti, F. Benigni, V. Basso, A. Mondino
2002Journal of Immunology57 citations
Semantic Scholar
Xotx5b, a new member of the Otx gene family, may be involved in anterior and eye development in Xenopus laevis.
R. Vignali, S. Colombetti, G. Lupo, Wenge Zhang +3 more
2000Mechanisms of Development56 citations Open access
Semantic Scholar
Efficient induction of tumor antigen-specific CD8+ memory T cells by recombinant lentivectors.
Laurence Chapatte, S. Colombetti, J. Cerottini, F. Lévy
2006Cancer Research52 citations Open access
Semantic Scholar
Extracellular HMGB 1 , a signal of tissue damage , induces mesoangioblast migration and proliferation
R. Palumbo, M. Sampaolesi, Francesco de Marchis, R. Tonlorenzi +4 more
200451 citations
Semantic Scholar
Combination of T-Cell Bispecific Antibodies With PD-L1 Checkpoint Inhibition Elicits Superior Anti-Tumor Activity
Johannes Sam, S. Colombetti, T. Fauti, A. Roller +13 more
2020Frontiers in Oncology47 citations Open access
Semantic Scholar
Multi-Parameter Quantitative Imaging of Tumor Microenvironments Reveals Perivascular Immune Niches Associated With Anti-Tumor Immunity
Caleb R. Stoltzfus, R. Sivakumar, L. Kunz, Brandy E. Olin Pope +7 more
2021bioRxiv42 citations Open access
Semantic Scholar
CD19-CD28: an affinity-optimized CD28 agonist for combination with glofitamab (CD20-TCB) as off-the-shelf immunotherapy
Johannes Sam, Thomas Hofer, Christine Kuettel, Christina Claus +35 more
2024Blood41 citations Open access
Semantic Scholar
Cross-linking of T cell to B cell lymphoma by the T cell bispecific antibody CD20-TCB induces IFNγ/CXCL10-dependent peripheral T cell recruitment in humanized murine model
F. Cremasco, E. Menietti, D. Speziale, Johannes Sam +8 more
2020bioRxiv36 citations Open access
Semantic Scholar
Application of a MABEL Approach for a T-Cell-Bispecific Monoclonal Antibody: CEA TCB
S. Dudal, Heather Hinton, A. Giusti, M. Bacac +11 more
2016Journal of immunotherapy33 citations
Semantic Scholar
A novel EGFRvIII-T cell bispecific antibody for the treatment of glioblastoma.
R. Iurlaro, I. Waldhauer, E. Planas-Rigol, Ester Bonfill-Teixidor +31 more
2022Molecular Cancer Therapeutics29 citations Open access
Semantic Scholar
Lentivector immunization induces tumor antigen‐specific B and T cell responses in vivo
Javier Garcia Casado, J. Janda, Joe Wei, Laurence Chapatte +7 more
2008European Journal of Immunology25 citations Open access
Semantic Scholar
Rapamycin‐sensitive signals control TCR/CD28‐driven Ifng, Il4 and Foxp3 transcription and promoter region methylation
Romana Tomasoni, V. Basso, Karolina Pilipow, G. Sitia +6 more
2011European Journal of Immunology23 citations Open access
Semantic Scholar
International Consensus on Minimum Preclinical Testing Requirements for the Development of Innovative Therapies For Children and Adolescents with Cancer
G. Vassal, P. Houghton, S. Pfister, Malcolm A. Smith +8 more
2021Molecular Cancer Therapeutics22 citations Open access
Semantic Scholar
CD20 Tcb (RG6026), a Novel 2:1 T Cell Bispecific Antibody for the Treatment of B Cell Malignancies
M. Bacac, P. Umaña, S. Herter, S. Colombetti +9 more
201622 citations
Semantic Scholar
Breast cancer suppressor candidate‐1 (BCSC‐1) is a melanoma tumor suppressor that down regulates MITF
S. Anghel, Rafael Correa‐Rochal, E. Budinská, Kayluz F. Boliganl +10 more
2012Pigment Cell & Melanoma Research20 citations Open access
Semantic Scholar
Constitutive active p21ras enhances primary T cell responsiveness to Ca2+ signals without interfering with the induction of clonal anergy
D. Crespi, S. Massa, V. Basso, S. Colombetti +2 more
2002European Journal of Immunology18 citations Open access
Semantic Scholar
Promises and Limitations of Murine Models in the Development of Anticancer T-Cell Vaccines
F. Lévy, S. Colombetti
2006International Reviews of Immunology17 citations
Semantic Scholar
Abstract 2270: RG7769 (PD1-TIM3), a novel heterodimeric avidity-driven T cell specific PD-1/TIM-3 bispecific antibody lacking Fc-mediated effector functions for dual checkpoint inhibition to reactivate dysfunctional T cells
L. C. Deak, S. Seeber, M. Perro, P. Weber +25 more
2020Immunology14 citations
Semantic Scholar
Preclinical advances in glofitamab combinations: a new frontier for non-Hodgkin lymphoma
Johannes Sam, G. Leclercq-Cohen, Samuel Gebhardt, M. Surowka +20 more
2025Blood13 citations Open access
Semantic Scholar
Combining venetoclax and azacytidine with T-cell bispecific antibodies for treatment of acute myeloid leukemia: a preclinical assessment
G. Hänel, A. Schönle, Anne-Sophie Neumann, D. Nixdorf +14 more
2024Leukemia9 citations Open access
Semantic Scholar
Optimizing efficacy and safety of T cell bispecific antibodies: the interdependence of CD3 and tumor antigen binder affinities in FOLR1 and CEACAM5 2 + 1 TCBs
O. Abdelmotaleb, A. Schneider, I. Waldhauer, Johannes Sam +14 more
2025mAbs8 citations Open access
Semantic Scholar
RG6333 (CD19-CD28), a CD19-Targeted Affinity-Optimized CD28 Bispecific Antibody, Enhances and Prolongs the Anti-Tumor Activity of Glofitamab (CD20-TCB) in Preclinical Models
Johannes Sam, T. Hofer, Christine Kuettel, C. Claus +18 more
2022Blood7 citations Open access
Semantic Scholar
Abstract LB-389: Combination of TYRP1-TCB, a novel T cell bispecific antibody for the treatment of melanoma, with immunomodulatory agents
V. Nicolini, I. Waldhauer, A. Freimoser-Grundschober, M. Richard +14 more
2020Bioinformatics, Convergence Science, and Systems Biology7 citations
Semantic Scholar
Impact of Orthologous Melan-A Peptide Immunizations on the Anti-Self Melan-A/HLA-A2 T Cell Cross-Reactivity1
S. Colombetti, T. Fagerberg, Petra Baumgärtner, Laurence Chapatte +4 more
2006Journal of Immunology7 citations Open access
Semantic Scholar
ROCKETS – a novel one-for-all toolbox for light sheet microscopy in drug discovery
J. Müller, Michael Dobosz, Nils O'Brien, Nassri Abdoush +13 more
2022bioRxiv5 citations Open access
Semantic Scholar
Differentiating PD-1+ stem-like CD8 T cells towards distinct effectors with enhanced therapeutic potential by an engineered IL-2 cis-targeted to PD-1
P. Umaña, L. C. Deak, Masao Hashimoto, R. Ahmed +22 more
20214 citations Open access
Semantic Scholar
Mammalian Target of Rapamycin through Signaling Mediated by the IL-2-Independent T Cell Clonal Expansion Prolonged TCR / CD 28 Engagement Drives
S. Colombetti, V. Basso, D. Mueller, A. Mondino
20064 citations
Semantic Scholar
Pathological insights of human CD34+ hematopoietic stem cell-engrafted NSG mice: Implications for the safety assessment of cancer immunotherapy drugs
Anna Maria Giusti, Johannes Sam, S. Colombetti, I. Veiga +1 more
2026Veterinary Pathology-Supplement3 citations Open access
Semantic Scholar
Abstract 3571: The ITCC-P4 sustainable platform of fully characterized PDXs supports the preclinical proof-of-concept drug testing of high-risk pediatric tumor models
A. Federico, Apurva Gopisetty, D. Surdez, Y. Iddir +45 more
2023Cancer Research3 citations
Semantic Scholar
CD20-TCB with obinutuzumab pretreatment as next generation treatment of hematological malignancies
M. Bacac, S. Colombetti, S. Herter, Johannes Sam +18 more
20183 citations
Semantic Scholar
Abstract 3634: A novel tumor-targeted 4-1BB agonist and its combination with T-cell bispecific antibodies: an off-the-shelf cancer immunotherapy alternative to CAR T-cells
C. Claus, C. Ferrara, Sabine Lang, Rosmarie Albrecht +8 more
20173 citations
Semantic Scholar
Abstract 3629: Engineering a novel asymmetric head-to-tail 2+1 T-cell bispecific (2+1 TCB) IgG antibody platform with superior T-cell killing compared to 1+1 asymmetric TCBs
C. Klein, C. Neumann, T. Fauti, Tina Weinzierl +18 more
20173 citations
Semantic Scholar
Abstract LB-236: M4-3-ML2, a novel glycoengineered humanized IgG1 antibody, targeting a membrane-proximal epitope of MCSP/CSPG4 exhibits potent ADCC inductionin vitroandin vivoanti-tumoral efficacy in disseminated melanoma models
Ekkehard Mössner, Gérald Tuffin, S. Colombetti, Olivier Freytag +18 more
20123 citations
Semantic Scholar
FAP-CD40 and PD1-IL2v combination therapy reprograms immunologically cold tumors through de novo intratumoral T cell-dendritic cell clusters
Thuy Trinh Nguyen, H. Gómez, Mechthild Lutge, E. Yángüez +9 more
2026Journal for ImmunoTherapy of Cancer2 citations Open access
Semantic Scholar
T cell margination: investigating the detour of T cells following forimtamig treatment in humanized mice
Nils O'Brien, Joerg P J Mueller, Ann-Marie E. Bröske, Jan Attig +11 more
2024mAbs2 citations Open access
Semantic Scholar
Abstract 5621: FAP-4-1BBL: A novel versatile tumor-stroma targeted 4-1BB agonist for combination immunotherapy with checkpoint inhibitors, T-cell bispecific antibodies, and ADCC-mediating antibodies
Johannes Sam, C. Claus, C. Ferrara, Sabine Lang +7 more
2018Clinical research2 citations
Semantic Scholar
Abstract 2579: Combination with the novel tumor-targeted CEA-IL2v immunocytokine enhances the activity of ADCC-competent and glycoengineered antibodies in vitro and in vivo
G. NicoliniValeria, I. Waldhauer, A. Freimoser, S. Colombetti +5 more
20142 citations
Semantic Scholar
Modular engineered colorectal tumor microenvironments for immuno-oncology research and drug development
Adrian M. Filip, Barbora Lavickova, Aurélie Hérault, Irineja Cubela +18 more
2026bioRxiv1 citations Open access
Semantic Scholar
CEA-4-1BBL: CEACAM5-Targeted 4-1BB Ligand Fusion Proteins for Cis Co-Stimulation with CEA-TCB
Christina Claus, Claudia Ferrara-Koller, Johannes Sam, Sabine Lang +9 more
2025Antibodies1 citations Open access
Semantic Scholar
Abstract 1235: Impact of anti-CD3 and tumor-target binder affinities on in-vitro potency, in-vivo efficacy, and cytokine release
O. Abdelmotaleb, A. Schneider, Thomas Hofer, Johannes Sam +10 more
2024Cancer Research1 citations
Semantic Scholar

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P. Umaña×28
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P. Umaña — researcher profile on SciRah
M. Bacac×24
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M. Bacac — researcher profile on SciRah
Johannes Sam×23
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Johannes Sam — researcher profile on SciRah
C. Klein×20
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C. Klein — researcher profile on SciRah

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V. Nicolini — researcher profile on SciRah

A. Freimoser-Grundschober×13

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S. Herter — researcher profile on SciRah

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M. Perro — researcher profile on SciRah

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T. Fauti — researcher profile on SciRah