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David C. Mikles · SciRah

Researcher profile · Semantic Scholar

David C. Mikles

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David C. Mikles — researcher profile on SciRah

h-index: 15
Works: 30
Citations: 566

Most-cited papers

Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors
Yan Chen, Jin-Yi Zhu, K. Hong, David C. Mikles +4 more
2018ACS Chemical Biology78 citations Open access
Semantic Scholar
Species-Specific Effects of Herbivory on the Oviposition Behavior of the Moth Manduca sexta
C. Reisenman, J. Riffell, Kristin Duffy, Adrien Pesque +2 more
2012Journal of Chemical Ecology65 citations
Semantic Scholar
General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases
A. Tichá, S. Stanchev, K. Vinothkumar, David C. Mikles +11 more
2017Cell Chemical Biology44 citations Open access
Semantic Scholar
Biophysical Analysis of the Binding of WW Domains of YAP2 Transcriptional Regulator to PPXY Motifs within WBP1 and WBP2 Adaptors
Caleb B. McDonald, Samantha K. N. McIntosh, David C. Mikles, V. Bhat +7 more
2011Biochemistry43 citations Open access
Semantic Scholar
Biophysical Basis of the Binding of WWOX Tumor Suppressor to WBP1 and WBP2 Adaptors
Caleb B. McDonald, L. Buffa, T. Bar-Mag, Z. Salah +9 more
2012Journal of Molecular Biology39 citations Open access
Semantic Scholar
Molecular Origin of the Binding of WWOX Tumor Suppressor to ErbB4 Receptor Tyrosine Kinase
Brett J. Schuchardt, V. Bhat, David C. Mikles, Caleb B. McDonald +2 more
2013Biochemistry27 citations Open access
Semantic Scholar
Structural and Thermodynamic Consequences of the Replacement of Zinc with Environmental Metals on ERα-DNA Interactions
Brian J. Deegan, Anna M. Bona, V. Bhat, David C. Mikles +3 more
2011Journal of Molecular Recognition27 citations Open access
Semantic Scholar
Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors.
Parul Goel, T. Jumpertz, A. Tichá, Isabella Ogorek +6 more
2018Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
pH Modulates the Binding of EGR1 Transcription Factor to DNA
David C. Mikles, V. Bhat, Brett J. Schuchardt, Brian J. Deegan +3 more
2013The FEBS Journal18 citations Open access
Semantic Scholar
Molecular Basis of the Binding of YAP Transcriptional Regulator to the ErbB4 Receptor Tyrosine Kinase
Brett J. Schuchardt, V. Bhat, David C. Mikles, Caleb B. McDonald +2 more
2014Biochimie17 citations Open access
Semantic Scholar
Bivalent Binding Drives the Formation of Grb2-Gab1 Signaling Complex in a Non-Cooperative Manner
Caleb B. McDonald, V. Bhat, David C. Mikles, Brian J. Deegan +2 more
2012The FEBS Journal17 citations Open access
Semantic Scholar
Ligand Binding and Membrane Insertion Compete with Oligomerization of the BclXL Apoptotic Repressor
V. Bhat, Caleb B. McDonald, David C. Mikles, Brian J. Deegan +3 more
2011Journal of Molecular Biology17 citations Open access
Semantic Scholar
Energetic Coupling Along an Allosteric Communication Channel Drives the Binding of Jun-Fos Heterodimeric Transcription Factor to DNA
K. Seldeen, Brian J. Deegan, V. Bhat, David C. Mikles +2 more
2011The FEBS Journal17 citations Open access
Semantic Scholar
Ligand Binding to WW Tandem Domains of YAP2 Transcriptional Regulator Is Under Negative Cooperativity
Brett J. Schuchardt, David C. Mikles, Lawrence M. Hoang, V. Bhat +3 more
2014The FEBS Journal16 citations Open access
Semantic Scholar
Acidic pH Promotes Oligomerization and Membrane Insertion of the BclXL Apoptotic Repressor
V. Bhat, Dmitry Kurouski, Max B. Olenick, Caleb B. McDonald +5 more
2012Archives of Biochemistry and Biophysics16 citations Open access
Semantic Scholar
Allostery Mediates Ligand Binding to Grb2 Adaptor in a Mutually Exclusive Manner
Caleb B. McDonald, Jimmy A. El Hokayem, Nawal Zafar, Jordan E. Balke +5 more
2013Journal of Molecular Recognition15 citations Open access
Semantic Scholar
Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases
Parul Goel, T. Jumpertz, David C. Mikles, Anezžka Tichá +10 more
2017Biochemistry14 citations Open access
Semantic Scholar
Multivalent Binding and Facilitated Diffusion Account for the Formation of Grb2-Sos1 Signaling Complex in a Cooperative Manner
Caleb B. McDonald, Jordan E. Balke, V. Bhat, David C. Mikles +3 more
2012Biochemistry14 citations Open access
Semantic Scholar
Biophysical Basis of the Promiscuous Binding of Bcl2 Apoptotic Repressor to BH3 Ligands
V. Bhat, Max B. Olenick, Brett J. Schuchardt, David C. Mikles +2 more
2013Journal of Molecular Recognition10 citations Open access
Semantic Scholar
Effect of Osmolytes on the Binding of EGR1 Transcription Factor to DNA
David C. Mikles, V. Bhat, Brett J. Schuchardt, Caleb B. McDonald +1 more
2015Biopolymers9 citations Open access
Semantic Scholar
Structural Landscape of the Proline-Rich Domain of Sos1 Nucleotide Exchange Factor
Caleb B. McDonald, V. Bhat, Dmitry Kurouski, David C. Mikles +4 more
2013Biophysical Chemistry9 citations Open access
Semantic Scholar
Interplay between HGAL and Grb2 proteins regulates B-cell receptor signaling.
Xiao-Yu Jiang, Xiao-Qing Lu, Yu Zhang, L. Lacaria +10 more
2019Blood Advances8 citations Open access
Semantic Scholar
Allostery Mediates Ligand Binding to WWOX Tumor Suppressor via a Conformational Switch
Brett J. Schuchardt, David C. Mikles, V. Bhat, Caleb B. McDonald +2 more
2015Journal of Molecular Recognition7 citations Open access
Semantic Scholar
Role of Promoter DNA Sequence Variations on the Binding of EGR1 Transcription Factor
David C. Mikles, Brett J. Schuchardt, V. Bhat, Caleb B. McDonald +1 more
2014Archives of Biochemistry and Biophysics6 citations Open access
Semantic Scholar
Heat-Induced Fibrillation of BclXL Apoptotic Repressor
V. Bhat, Max B. Olenick, Brett J. Schuchardt, David C. Mikles +9 more
2013Biophysical Chemistry6 citations Open access
Semantic Scholar
Molecular Determinants of the Binding Specificity of BH3 Ligands to BclXL Apoptotic Repressor
V. Bhat, Max B. Olenick, Brett J. Schuchardt, David C. Mikles +2 more
2014Biopolymers5 citations Open access
Semantic Scholar
Enthalpic Factors Override the Polyelectrolyte Effect in the Binding of EGR1 Transcription Factor to DNA
David C. Mikles, V. Bhat, Brett J. Schuchardt, Caleb B. McDonald +1 more
2014Journal of Molecular Recognition2 citations Open access
Semantic Scholar
Grb2 Directly Interacts with HGAL and Ameliorates Its Effects on B-Cell Receptor Signaling
Xiao-Yu Jiang, Xiao-Qing Lu, Brett J. Schuchardt, David C. Mikles +3 more
20150 citations
Semantic Scholar
Physicochemical insights into the EGR1-DNA interaction
David C. Mikles
20140 citations
Semantic Scholar
Species-Specific Effects of Herbivory on the Oviposition Behavior of the Moth Manduca sexta
C. Reisenman, J. Riffell, Kristin Duffy, Adrien Pesque +2 more
2012Journal of Chemical Ecology0 citations
Semantic Scholar

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