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J. Siekierka · SciRah

Researcher profile · Semantic Scholar

J. Siekierka

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J. Siekierka — researcher profile on SciRah

h-index: 26
Works: 64
Citations: 2,858

Most-cited papers

A mechanism for the control of protein synthesis by adenovirus VA RNAI.
Robert P. O'Malley, T. M. Mariano, J. Siekierka, M. Mathews
1986Cell237 citations
Semantic Scholar
Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?
N. Sigal, F. Dumont, P. Durette, J. Siekierka +6 more
1991Journal of Experimental Medicine231 citations Open access
Semantic Scholar
Interleukin (IL)-1 Receptor–associated Kinase (IRAK) Requirement for Optimal Induction of Multiple IL-1 Signaling Pathways and IL-6 Production
Palanisamy Kanakaraj, P. Schafer, D. Cavender, Ying Wu +7 more
1998Journal of Experimental Medicine220 citations Open access
Semantic Scholar
Imidazopyrimidines, potent inhibitors of p38 MAP kinase.
K. Rupert, J. Henry, J. Dodd, S. Wadsworth +4 more
2003Bioorganic & Medicinal Chemistry Letters197 citations Open access
Semantic Scholar
Defective Interleukin (IL)-18–mediated Natural Killer and T Helper Cell Type 1 Responses in IL-1 Receptor–associated Kinase (IRAK)-deficient Mice
Palanisamy Kanakaraj, K. Ngo, Ying Wu, A. Angulo +5 more
1999Journal of Experimental Medicine196 citations Open access
Semantic Scholar
Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes.
W. Morice, G. Brunn, G. Wiederrecht, J. Siekierka +1 more
1993Journal of Biological Chemistry185 citations Open access
Semantic Scholar
RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase.
S. Wadsworth, D. Cavender, S. Beers, Praful Lalan +9 more
1999Journal of Pharmacology and Experimental Therapeutics174 citations
Semantic Scholar
Drug-eluting stents: sirolimus and paclitaxel differentially affect cultured cells and injured arteries.
T. Parry, R. Brosius, Rathna Thyagarajan, Demetrius Carter +3 more
2005European Journal of Pharmacology141 citations
Semantic Scholar
p38α Mitogen-Activated Protein Kinase Is Activated by CD28-Mediated Signaling and Is Required for IL-4 Production by Human CD4+CD45RO+ T Cells and Th2 Effector Cells
P. Schafer, S. Wadsworth, Liwen Wang, J. Siekierka
1999Journal of Immunology103 citations Open access
Semantic Scholar
Regulation of a protein synthesis initiation factor by adenovirus virus-associated RNAI
P. A. Reichel, W. Merrick, J. Siekierka, M. Mathews
1985Nature99 citations
Semantic Scholar
FK-506 and cyclosporin A: immunosuppressive mechanism of action and beyond.
J. Siekierka, N. Sigal
1992Current Opinion in Immunology92 citations
Semantic Scholar
Translational control by adenovirus: lack of virus-associated RNAI during adenovirus infection results in phosphorylation of initiation factor eIF-2 and inhibition of protein synthesis.
J. Siekierka, T. M. Mariano, P. A. Reichel, Michael B. Mathews
1985Proceedings of the National Academy of Sciences of the United States of America90 citations Open access
Semantic Scholar
FKBl encodes a nonessential FK 506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins
G. Wiederrecht, L. Brizuela, Keith Owen Elliston, N. Sigal +1 more
1991Proceedings of the National Academy of Sciences of the United States of America83 citations Open access
Semantic Scholar
T cell activation signals up-regulate p38 mitogen-activated protein kinase activity and induce TNF-alpha production in a manner distinct from LPS activation of monocytes.
P. Schafer, Liwen Wang, S. Wadsworth, Janet E. Davis +1 more
1999Journal of Immunology76 citations Open access
Semantic Scholar
Mechanism of polypeptide chain initiation in eukaryotes and its control by phosphorylation of the alpha subunit of initiation factor 2.
J. Siekierka, L. Mauser, Severo Ochoa
1982Proceedings of the National Academy of Sciences of the United States of America76 citations Open access
Semantic Scholar
Mechanism of translational control by partial phosphorylation of the alpha subunit of eukaryotic initiation factor 2.
J. Siekierka, Veeraswamy Manne, Severo Ochoa
1984Proceedings of the National Academy of Sciences of the United States of America67 citations Open access
Semantic Scholar
HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation.
K. Muthumani, A. Y. Choo, Daniel S. Hwang, A. Premkumar +6 more
2005Blood64 citations Open access
Semantic Scholar
Yeast FKBP-13 is a membrane-associated FK506-binding protein encoded by the nonessential gene FKB2.
J. Nielsen, F. Foor, J. Siekierka, Ming-Jo Hsu +6 more
1992Proceedings of the National Academy of Sciences of the United States of America46 citations Open access
Semantic Scholar
A Novel Role for the Immunophilin FKBP52 in Copper Transport*
R. Sanokawa-Akakura, H. Dai, S. Akakura, D. Weinstein +5 more
2004Journal of Biological Chemistry45 citations Open access
Semantic Scholar
Suppression of HIV-1 viral replication and cellular pathogenesis by a novel p38/JNK kinase inhibitor
K. Muthumani, S. Wadsworth, Nathanael S Dayes, Daniel S. Hwang +4 more
2004AIDS (London)44 citations Open access
Semantic Scholar
Inhibition of human T-cell activation by FK 506, rapamycin, and cyclosporine A.
N. Sigal, C. S. Lin, J. Siekierka
1991Transplantation Proceedings33 citations
Semantic Scholar
Drugs Designed To Inhibit Human p38 Mitogen-Activated Protein Kinase Activation Treat Toxoplasma gondii and Encephalitozoon cuniculi Infection
Shuang Wei, Benjamin J. Daniel, M. Brumlik, M. Burow +5 more
2007Antimicrobial Agents and Chemotherapy32 citations Open access
Semantic Scholar
Observations on the mechanism of action of FK-506. A pharmacologic probe of lymphocyte signal transduction.
N. Sigal, J. Siekierka, F. Dumont
1990Biochemical Pharmacology32 citations
Semantic Scholar
Human p38 mitogen-activated protein kinase inhibitor drugs inhibit Plasmodium falciparum replication
M. Brumlik, Standwell C. Nkhoma, Mark J. Kious, G. Thompson +4 more
2011Experimental parasitology31 citations Open access
Semantic Scholar
Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells.
L. Tao, S. Wadsworth, Jason C. Mercer, C. Mueller +3 more
2002Biochemical Journal29 citations Open access
Semantic Scholar
Regulation of a protein synthesis initiation factor by adenovirus virus-associated RNA.
P. A. Reichel, W. Merrick, J. Siekierka, M. Mathews
1985Nature27 citations
Semantic Scholar
Plasmodium falciparum cGMP-Dependent Protein Kinase – A Novel Chemotherapeutic Target
D. Rotella, J. Siekierka, P. Bhanot
2021Frontiers in Microbiology25 citations Open access
Semantic Scholar
The role of a Brugia malayi p38 MAP kinase ortholog (Bm-MPK1) in parasite anti-oxidative stress responses.
Akruti Patel, Agnieszka Chojnowski, Katie Gaskill, William De Martini +2 more
2011Molecular and biochemical parasitology (Print)20 citations
Semantic Scholar
Apicomplexa, trypanosoma and parasitic nematode protein kinases as antiparasitic therapeutic targets.
F. Liotta, J. Siekierka
2010Current opinion in investigational drugs18 citations
Semantic Scholar
The placental transfer of lead-chelate complexes in the rat.
R. Mcclain, J. Siekierka
1975Toxicology and Applied Pharmacology18 citations
Semantic Scholar
Inhibition of HeLa cell protein synthesis under heat shock conditions in the absence of initiation factor eIF-2 alpha phosphorylation.
T. M. Mariano, J. Siekierka
1986Biochemical and Biophysical Research Communications - BBRC17 citations
Semantic Scholar
Is FKBP involved in the immunosuppressive and/or toxic mechanism of action of FK 506?
N. Sigal, F. Dumont, J. Siekierka, G. Wiederrecht +2 more
1991Transplantation Proceedings12 citations
Semantic Scholar
The effects of various chelating agents on the teratogenicity of lead nitrate in rats.
R. Mcclain, J. Siekierka
1975Toxicology and Applied Pharmacology12 citations
Semantic Scholar
Probing T-cell signal transduction pathways with the immunosuppressive drugs, FK-506 and rapamycin
J. Siekierka
1994Immunologic research11 citations
Semantic Scholar
Inhibition of protein synthesis in vesicular stomatitis virus infected Chinese hamster ovary cells: role of virus mRNA-ribonucleoprotein particle.
C. A. Rosen, J. Siekierka, H. Ennis, Paul S. Cohen
1984Biochemistry10 citations
Semantic Scholar
Effects of drug combinations on smooth muscle cell proliferation: an isobolographic analysis.
T. Parry, Rathna Thyagarajan, D. Argentieri, R. Falotico +2 more
2006European Journal of Pharmacology9 citations
Semantic Scholar
Purification and properties of the guanine nucleotide exchange factor (GEF) from HeLa cells and its role in the initiation of protein synthesis.
T. M. Mariano, J. Siekierka, S. Ochoa
1986Biochemical and Biophysical Research Communications - BBRC9 citations
Semantic Scholar
Discovery of isoxazolyl-based inhibitors of Plasmodium falciparum cGMP-dependent protein kinase.
S. Mahmood, Huimin Cheng, Sreedhar R. Tummalapalli, R. Chakrasali +6 more
2020RSC Medicinal Chemistry7 citations Open access
Semantic Scholar
Discovery of a Stress-Activated Protein Kinase Inhibitor for Lymphatic Filariasis.
Sreedhar R. Tummalapalli, R. Bhat, Agnieszka Chojnowski, Monika Prorok +9 more
2018ACS Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Inhibitors of unactivated p38 MAP kinase.
J. Bullington, D. Argentieri, K. Averill, Demetrius Carter +19 more
2006Bioorganic & Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Alkyl ether derivatives of the FK-506 related, immunosuppressive macrolide L-683,742 (C31-O-desmethyl ascomycin)
Mark T. Goulet, Derek W. Hodkey, M. Staruch, F. Dumont +4 more
19947 citations
Semantic Scholar
Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization
Natalie A. Hawryluk, Zhiru Li, C. Carlow, Suzanne Gokool +17 more
2022International Journal for Parasitology: Drugs and Drug Resistance6 citations Open access
Semantic Scholar
Discovery of Imidazole-Based Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase.
Rammohan R. Yadav Bheemanaboina, M. D. de Souza, M. González, S. Mahmood +12 more
2021ACS Medicinal Chemistry Letters6 citations Open access
Semantic Scholar
Initiation of protein synthesis in eukaryotes. Nature of ternary complex dissociation factor.
J. Siekierka, Asis Datta, Ljubica Mauser, Severo Ochoa
1982Journal of Biological Chemistry5 citations Open access
Semantic Scholar
Phosphatidylserine-Targeting Monoclonal Antibodies Exhibit Distinct Biochemical and Cellular Effects on Anti-CD3/CD28–Stimulated T Cell IFN-γ and TNF-α Production
D. Calianese, Tamara Kreiss, Canan Kasikara, Viralkumar Davra +15 more
2021Journal of Immunology4 citations Open access
Semantic Scholar
Role of phosphorylation-dephosphorylation cycles in the control of protein synthesis in eukaryotes.
Severo Ochoa, C. de Haro, J. Siekierka, Haim Grosfeld
1981Current Topics in Cellular Regulation2 citations
Semantic Scholar
A novel series of putative Brugia malayi histone demethylase inhibitors as potential anti-filarial drugs
Tamara Kreiss, Tyler Eck, Brittany M. Hart, Sreedhar R. Tummalapalli +2 more
2022PLoS Neglected Tropical Diseases1 citations Open access
Semantic Scholar
Characterization of novel competitive inhibitors of P. falciparum cGMP-dependent protein kinase
Tyler Eck, M. D. de Souza, Rammohan R. Yadav Bheemanaboina, R. Chakrasali +5 more
2021bioRxiv0 citations Open access
Semantic Scholar
Discovery of imidazole-based inhibitors of P. falciparum cGMP-dependent protein kinase
Rammohan R. Yadav Bheemanaboina, M. D. de Souza, Mariana Lozano Gonzalez, S. Mahmood +12 more
20210 citations Open access
Semantic Scholar
Discovery of novel potent, cell-permeable inhibitors of P. falciparum cGMP-dependent protein kinase
Rammohan R. Yadav Bheemanaboina, Mariana Lozano Gonzalez, S. Mahmood, Tyler Eck +12 more
2021bioRxiv0 citations Open access
Semantic Scholar

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