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A. Rowan · SciRah

Researcher profile · Semantic Scholar

A. Rowan

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A. Rowan — researcher profile on SciRah

h-index: 42
Works: 114
Citations: 5,696

Most-cited papers

Synergistic interactions of proinflammatory cytokines with oncostatin M: implications for joint destruction
T. Cawston, H. Wang, Carl D. Richards, A. Rowan
2003Arthritis Research & Therapy604 citations Open access
Semantic Scholar
Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines
P. Koshy, N. Henderson, C. Logan, P. Life +2 more
2002Annals of the Rheumatic Diseases230 citations Open access
Semantic Scholar
Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases
Wang Hui, G. Litherland, M. Elias, G. Kitson +3 more
2011Annals of the Rheumatic Diseases224 citations Open access
Semantic Scholar
The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: a time-course study using real-time quantitative reverse transcription-polymerase chain reaction.
P. Koshy, Caroline J. Lundy, A. Rowan, S. Porter +4 more
2002Arthritis & Rheumatism220 citations Open access
Semantic Scholar
Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage
W. Hui, D. Young, A. Rowan, Xin Xu +2 more
2014Annals of the Rheumatic Diseases189 citations Open access
Semantic Scholar
The Comparative Role of Activator Protein 1 and Smad Factors in the Regulation of Timp-1 and MMP-1 Gene Expression by Transforming Growth Factor- (cid:1) 1*
M. Hall, D. Young, J. Waters, A. Rowan +3 more
2003185 citations
Semantic Scholar
Activity of matrix metalloproteinase‐9 against native collagen types I and III
Heather F. Bigg, A. Rowan, M. D. Barker, T. Cawston
2007The FEBS Journal164 citations Open access
Semantic Scholar
Synergistic effects of glycoprotein 130 binding cytokines in combination with interleukin-1 on cartilage collagen breakdown.
A. Rowan, P. Koshy, W. Shingleton, B. Degnan +6 more
2001Arthritis & Rheumatism151 citations Open access
Semantic Scholar
An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathies.
B. Vaidya, Simon H. S. Pearce, S. Charlton, N. Marshall +5 more
2002Rheumatology141 citations Open access
Semantic Scholar
The Mammalian Chitinase-like Lectin, YKL-40, Binds Specifically to Type I Collagen and Modulates the Rate of Type I Collagen Fibril Formation*
H. Bigg, R. Wait, A. Rowan, T. Cawston
2006Journal of Biological Chemistry140 citations Open access
Semantic Scholar
Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: implications for cartilage degradation in arthritis.
H. E. Barksby, J. Milner, A. Patterson, N. Peake +7 more
2006Arthritis & Rheumatism137 citations Open access
Semantic Scholar
Oncostatin M in combination with tumor necrosis factor alpha induces cartilage damage and matrix metalloproteinase expression in vitro and in vivo.
Wang Hui, A. Rowan, Carl D. Richards, T. Cawston
2003Arthritis & Rheumatism125 citations Open access
Semantic Scholar
cAMP response element‐binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis
C. Bui, M. Barter, J. Scott, Yao-Bo Xu +4 more
2012The FASEB Journal122 citations Open access
Semantic Scholar
Gain‐of‐function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC)
Jie Zheng, F. L. van de Veerdonk, K. Crossland, S. Smeekens +9 more
2015European Journal of Immunology118 citations Open access
Semantic Scholar
Interleukin-1 in combination with oncostatin M up-regulates multiple genes in chondrocytes: implications for cartilage destruction and repair.
H. E. Barksby, Wang Hui, I. Wappler, Heiko Peters +4 more
2006Arthritis & Rheumatism105 citations Open access
Semantic Scholar
Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology
C. Huesa, A. Ortiz, L. Dunning, Laura McGavin +11 more
2015Annals of the Rheumatic Diseases98 citations Open access
Semantic Scholar
Macrophage Migration and Invasion Is Regulated by MMP10 Expression
Megan Y. Murray, T. Birkland, J. D. Howe, A. Rowan +3 more
2013PLoS ONE95 citations Open access
Semantic Scholar
Adenoviral gene transfer of interleukin-1 in combination with oncostatin M induces significant joint damage in a murine model.
A. Rowan, W. Hui, T. Cawston, C. Richards
2003American Journal of Pathology87 citations Open access
Semantic Scholar
Synergistic induction of matrix metalloproteinase 1 by interleukin-1alpha and oncostatin M in human chondrocytes involves signal transducer and activator of transcription and activator protein 1 transcription factors via a novel mechanism.
J. B. Catterall, S. Carrère, P. Koshy, B. Degnan +5 more
2001Arthritis & Rheumatism86 citations Open access
Semantic Scholar
HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes.
M. Barter, Leon P. Pybus, G. Litherland, A. Rowan +4 more
2010Matrix Biology84 citations Open access
Semantic Scholar
Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation.
K. Culley, Wang Hui, M. Barter, R. Davidson +8 more
2013Arthritis & Rheumatism83 citations Open access
Semantic Scholar
Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis.
J. Milner, Amit Patel, R. Davidson, T. Swingler +11 more
2010Arthritis & Rheumatism81 citations Open access
Semantic Scholar
Metalloproteases as potential therapeutic targets in arthritis treatment
A. Rowan, G. Litherland, W. Hui, J. Milner
2008Expert opinion on therapeutic targets80 citations Open access
Semantic Scholar
Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis
J. Milner, A. Rowan, T. Cawston, D. Young
2006Arthritis Research & Therapy74 citations Open access
Semantic Scholar
Emerging roles of serine proteinases in tissue turnover in arthritis.
Jm Milner, Amit Patel, A. Rowan
2008Arthritis & Rheumatism71 citations Open access
Semantic Scholar
Insulin-like growth factor 1 blocks collagen release and down regulates matrix metalloproteinase-1, -3, -8, and -13 mRNA expression in bovine nasal cartilage stimulated with oncostatin M in combination with interleukin 1α
Hui Wang, A. Rowan, T. Cawston
200166 citations Open access
Semantic Scholar
Synergistic Collagenase Expression and Cartilage Collagenolysis Are Phosphatidylinositol 3-Kinase/Akt Signaling-dependent*
G. Litherland, C. Dixon, R. Lakey, T. Robson +4 more
2008Journal of Biological Chemistry64 citations Open access
Semantic Scholar
Levels of matrix metalloproteinase (MMP)-1 in paired sera and synovial fluids of juvenile idiopathic arthritis patients: relationship to inflammatory activity, MMP-3 and tissue inhibitor of metalloproteinases-1 in a longitudinal study.
N. Peake, K. Khawaja, A. Myers, D. Jones +3 more
2005Rheumatology63 citations Open access
Semantic Scholar
Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis
J. Milner, L. Kevorkian, D. Young, D. Jones +9 more
2006Arthritis Research & Therapy60 citations Open access
Semantic Scholar
Matrix metalloproteinase‐13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha‐1 antitrypsin: Implications for osteoarthritis
David J. Wilkinson, Adrian M. D. Falconer, H. L. Wright, Hua Lin +9 more
2021The FEBS Journal57 citations Open access
Semantic Scholar
Development of a novel 2D proteomics approach for the identification of proteins secreted by primary chondrocytes after stimulation by IL-1 and oncostatin M.
J. B. Catterall, A. Rowan, S. Sarsfield, J. Saklatvala +2 more
2006Rheumatology57 citations Open access
Semantic Scholar
Modulation of the expression of matrix metalloproteinase and tissue inhibitors of metalloproteinases by TGF-beta1 and IGF-1 in primary human articular and bovine nasal chondrocytes stimulated with TNF-alpha.
W. Hui, A. Rowan, T. Cawston
2001Cytokine57 citations Open access
Semantic Scholar
Protein Kinase C Isoforms ζ and ι Mediate Collagenase Expression and Cartilage Destruction via STAT3- and ERK-dependent c-fos Induction*
G. Litherland, M. Elias, W. Hui, Christopher D. Macdonald +5 more
2010Journal of Biological Chemistry50 citations Open access
Semantic Scholar
A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL
W. Hui, T. Cawston, C. Richards, A. Rowan
2004Arthritis Research & Therapy50 citations Open access
Semantic Scholar
Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway.
W. Hui, G. Litherland, M. Jefferson, M. Barter +4 more
2010Rheumatology49 citations Open access
Semantic Scholar
Matrix metalloproteinases and TIMPs: properties and implications for the treatment of chronic obstructive pulmonary disease.
T. Cawston, S. Carrère, J. B. Catterall, R. Duggleby +3 more
2001Novartis Foundation symposium44 citations Open access
Semantic Scholar
Interleukin 13 blocks the release of collagen from bovine nasal cartilage treated with proinflammatory cytokines
C. Cleaver, A. Rowan, T. Cawston
2001Annals of the Rheumatic Diseases42 citations Open access
Semantic Scholar
Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: implications for therapeutics
David J. Wilkinson, Maria del Carmen Arques, C. Huesa, A. Rowan
2019British Journal of Pharmacology41 citations Open access
Semantic Scholar
Collagenase gene regulation by pro-inflammatory cytokines in cartilage.
A. Rowan, D. Young
2007Frontiers in Bioscience41 citations Open access
Semantic Scholar
Transforming growth factor beta 1 and insulin-like growth factor 1 block collagen degradation induced by oncostatin M in combination with tumour necrosis factor alpha from bovine cartilage.
Wang Hui, T. Cawston, A. Rowan
2003Annals of the Rheumatic Diseases41 citations Open access
Semantic Scholar
Inhibition of furin-like enzymes blocks interleukin-1alpha/oncostatin M-stimulated cartilage degradation.
Jm Milner, A. Rowan, Sarah Elliott, T. Cawston
2003Arthritis & Rheumatism40 citations Open access
Semantic Scholar
The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover
David J. Wilkinson, A. Désilets, Hua Lin, S. Charlton +16 more
2017Scientific Reports37 citations Open access
Semantic Scholar
Oncostatin M in combination with tumour necrosis factor α induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2
Wang Hui, H. E. Barksby, David A. Young, T. Cawston +2 more
2005Annals of the Rheumatic Diseases37 citations Open access
Semantic Scholar
Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts
Rachel C. Williams, A. Skelton, S. Todryk, A. Rowan +2 more
2016PLoS ONE35 citations Open access
Semantic Scholar
Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination
M. Radwan, David J. Wilkinson, W. Hui, Auriane P M Destrument +7 more
2014Annals of the Rheumatic Diseases35 citations Open access
Semantic Scholar
Human nasal cartilage responds to oncostatin M in combination with interleukin 1 or tumour necrosis factor α by the release of collagen fragments via collagenases
Tanya G. Morgan, A. Rowan, S. Dickinson, D. Jones +3 more
2005Annals of the Rheumatic Diseases34 citations Open access
Semantic Scholar
Interleukin-6 signalling in juvenile idiopathic arthritis is limited by proteolytically cleaved soluble interleukin-6 receptor.
N. Peake, K. Khawaja, A. Myers, M. Nowell +4 more
2006Rheumatology31 citations Open access
Semantic Scholar
Novel Gain-of-Function Mutation in Stat1 Sumoylation Site Leads to CMC/CID Phenotype Responsive to Ruxolitinib
T. Alshehri, K. Gilmour, F. Gothe, S. Loughlin +9 more
2019Journal of Clinical Immunology30 citations
Semantic Scholar
Assessment of the clinical significance of gelatinase activity in patients with juvenile idiopathic arthritis using quantitative protein substrate zymography
N. Peake, H. E. Foster, K. Khawaja, T. Cawston +1 more
2005Annals of the Rheumatic Diseases30 citations Open access
Semantic Scholar
Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis
G. Litherland, W. Hui, M. Elias, David J. Wilkinson +4 more
2014Arthritis & Rheumatology27 citations Open access
Semantic Scholar

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