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E. Kaffe · SciRah

Researcher profile · Semantic Scholar

E. Kaffe

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E. Kaffe — researcher profile on SciRah

h-index: 26
Works: 51
Citations: 3,031

Most-cited papers

Inflammasome activation in infected macrophages drives COVID-19 pathology
Esen Sefik, Rihao Qu, Caroline Junqueira, E. Kaffe +17 more
2021Nature462 citations Open access
Semantic Scholar
Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche
M. Roulis, Aimilios Kaklamanos, Marina Schernthanner, Piotr Bielecki +21 more
2020Nature261 citations Open access
Semantic Scholar
IL-10 constrains sphingolipid metabolism to limit inflammation
A. York, Mathias H. Skadow, Joonseok Oh, Rihao Qu +11 more
2024Nature241 citations Open access
Semantic Scholar
Lysoglycerophospholipids in chronic inflammatory disorders: the PLA(2)/LPC and ATX/LPA axes.
I. Sevastou, E. Kaffe, Marios-Angelos Mouratis, V. Aidinis
2013Biochimica et Biophysica Acta240 citations
Semantic Scholar
Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis.
N. Oikonomou, Marios-Angelos Mouratis, A. Tzouvelekis, E. Kaffe +6 more
2012American Journal of Respiratory Cell and Molecular Biology228 citations
Semantic Scholar
Hepatocyte autotaxin expression promotes liver fibrosis and cancer
E. Kaffe, A. Katsifa, N. Xylourgidis, I. Ninou +10 more
2017Hepatology174 citations
Semantic Scholar
Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation.
G. Park, Y. Lee, E. Berdyshev, S. Nyenhuis +23 more
2013American Journal of Respiratory and Critical Care Medicine132 citations Open access
Semantic Scholar
Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer.
Efrosini Barbayianni, E. Kaffe, V. Aidinis, G. Kokotos
2015Progress in lipid research120 citations
Semantic Scholar
A humanized mouse model of chronic COVID-19
Esen Sefik, B. Israelow, H. Mirza, Jun Zhao +10 more
2021Nature Biotechnology109 citations Open access
Semantic Scholar
Autotaxin and chronic inflammatory diseases.
C. Magkrioti, A. Galaris, P. Kanellopoulou, Elli-Anna Stylianaki +2 more
2019Journal of Autoimmunity101 citations
Semantic Scholar
Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis
M. Roulis, Christoforos Nikolaou, E. Kotsaki, E. Kaffe +11 more
2014Proceedings of the National Academy of Sciences of the United States of America88 citations Open access
Semantic Scholar
Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions
E. Kaffe, M. Roulis, Jun Zhao, Rihao Qu +11 more
2023Cell83 citations Open access
Semantic Scholar
Deregulated Lysophosphatidic Acid Metabolism and Signaling in Liver Cancer
E. Kaffe, C. Magkrioti, V. Aidinis
2019Cancers72 citations Open access
Semantic Scholar
The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life
A. Katsifa, E. Kaffe, N. Nikolaidou-Katsaridou, A. Economides +3 more
2015PLoS ONE66 citations Open access
Semantic Scholar
Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22
A. Giannou, Jan Kempski, A. Shiri, J. Lücke +71 more
2023Immunity60 citations Open access
Semantic Scholar
The Autotaxin-Lysophosphatidic Acid Axis Promotes Lung Carcinogenesis.
C. Magkrioti, N. Oikonomou, E. Kaffe, Marios-Angelos Mouratis +12 more
2018Cancer Research57 citations Open access
Semantic Scholar
Pathophysiologic implications of innate immunity and autoinflammation in the biliary epithelium
M. Strazzabosco, R. Fiorotto, M. Cadamuro, C. Spirli +4 more
2017Biochimica et Biophysica Acta - Molecular Basis of Disease51 citations Open access
Semantic Scholar
Oxidative stress and antioxidant status in patients with autoimmune liver diseases
E. Kaffe, E. Rigopoulou, G. Koukoulis, G. Dalekos +1 more
2015Redox Report47 citations Open access
Semantic Scholar
Autotaxin and Endotoxin-Induced Acute Lung Injury
Marios-Angelos Mouratis, C. Magkrioti, N. Oikonomou, A. Katsifa +3 more
2015PLoS ONE44 citations Open access
Semantic Scholar
β-catenin and IL-1β dependent CXCL10 production drives progression of disease in a mouse model of Congenital Hepatic Fibrosis
E. Kaffe, R. Fiorotto, F. Pellegrino, V. Mariotti +5 more
2018Hepatology42 citations Open access
Semantic Scholar
Pharmacologic targeting of the ATX/LPA axis attenuates bleomycin-induced pulmonary fibrosis.
I. Ninou, E. Kaffe, Stefan Müller, D. Budd +3 more
2018Pulmonary Pharmacology & Therapeutics41 citations
Semantic Scholar
Bioactive signaling lipids as drivers of chronic liver diseases.
E. Kaffe, A. Tisi, C. Magkrioti, V. Aidinis +3 more
2023Journal of Hepatology36 citations Open access
Semantic Scholar
A Metabolically-Stabilized Phosphonate Analog of Lysophosphatidic Acid Attenuates Collagen-Induced Arthritis
I. Nikitopoulou, E. Kaffe, I. Sevastou, Ivi Sirioti +4 more
2013PLoS ONE35 citations Open access
Semantic Scholar
Hydroxamic Acids Constitute a Novel Class of Autotaxin Inhibitors that Exhibit in Vivo Efficacy in a Pulmonary Fibrosis Model.
Aikaterini Nikolaou, I. Ninou, Maroula G. Kokotou, E. Kaffe +3 more
2018Journal of Medicinal Chemistry29 citations Open access
Semantic Scholar
A Treg-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liver
Chen-Bo Ding, Zhibin Yu, Esen Sefik, Jing Zhou +7 more
2023Nature Aging27 citations
Semantic Scholar
Notch signaling and progenitor/ductular reaction in steatohepatitis
C. Morell, R. Fiorotto, M. Meroni, A. Raizner +7 more
2017PLoS ONE27 citations Open access
Semantic Scholar
MAP3K8 Regulates Cox-2–Mediated Prostaglandin E2 Production in the Lung and Suppresses Pulmonary Inflammation and Fibrosis
M. Zannikou, Ilianna Barbayianni, Dionysios Fanidis, Theodora Grigorakaki +7 more
2020Journal of Immunology24 citations
Semantic Scholar
Animal models of cholangiocarcinoma: What they teach us about the human disease.
M. Cadamuro, S. Brivio, T. Stecca, E. Kaffe +6 more
2018Clinics And Research in Hepatology and Gastroenterology23 citations
Semantic Scholar
THE METABOTROPIC GLUTAMATE 2/3 RECEPTOR ANTAGONIST LY341495 DIFFERENTIALLY AFFECTS RECOGNITION MEMORY IN RATS
N. Pitsikas, E. Kaffe, A. Markou
2012Behavioural Brain Research22 citations Open access
Semantic Scholar
A humanized mouse model of chronic COVID-19 to evaluate disease mechanisms and treatment options
Esen Sefik, B. Israelow, Jun Zhao, Rihao Qu +10 more
2021Research Square20 citations Open access
Semantic Scholar
Genetic deletion of Autotaxin from CD11b+ cells decreases the severity of experimental autoimmune encephalomyelitis
I. Ninou, I. Sevastou, C. Magkrioti, E. Kaffe +6 more
2019bioRxiv18 citations Open access
Semantic Scholar
The Role of Autotaxin and LPA Signaling in Embryonic Development, Pathophysiology and Cancer
C. Magkrioti, E. Kaffe, V. Aidinis
2023International Journal of Molecular Sciences15 citations Open access
Semantic Scholar
Structure-Based Discovery of Novel Chemical Classes of Autotaxin Inhibitors
C. Magkrioti, E. Kaffe, Elli-Anna Stylianaki, Camelia Sidahmet +4 more
2020International Journal of Molecular Sciences14 citations Open access
Semantic Scholar
The fermented soy beverage Q-CAN® plus induces beneficial changes in the oral and intestinal microbiome
E. Dioletis, Ricardo Paiva, E. Kaffe, Eric R. Secor +4 more
2020BMC Nutrition9 citations Open access
Semantic Scholar
Dysregulation of the Scribble/YAP/β-catenin axis sustains the fibroinflammatory response in a PKHD1−/− mouse model of Congenital Hepatic Fibrosis
L. Fabris, Chiara Milani, R. Fiorotto, V. Mariotti +5 more
2022The FASEB Journal8 citations Open access
Semantic Scholar
IL-10 constrains sphingolipid metabolism via fatty acid desaturation to limit inflammation
A. York, Mathias H. Skadow, Rihao Qu, Joonseok Oh +9 more
2023bioRxiv3 citations Open access
Semantic Scholar
An aerosolized dual-action autotaxin inhibitor-PPARγ agonist for the treatment of pulmonary fibrosis
A. Matralis, Elli-Anna Stylianaki, E. Ladopoulou, P. Kanellopoulou +19 more
2026Cell Reports Medicine2 citations Open access
Semantic Scholar
Amplex red assay, a standardized in vitro protocol to quantify the efficacy of autotaxin inhibitors
Elli-Anna Stylianaki, C. Magkrioti, E. Kaffe, A. Matralis +1 more
2025STAR Protocols2 citations Open access
Semantic Scholar
The Fermented Soy Beverage Q-CAN® Plus Induces Bene cial Changes in the Oral and Intestinal Microbiome
Ricardo Paiva, E. Kaffe, Eric R. Secor, R. Theresa +3 more
20202 citations
Semantic Scholar
Inhibition of IL-1b/STAT3/β-catenin-dependent stimulation of the CXCL10/CXCR3 axis prevents macrophage recruitment and progression of the disease in Pkhd1del4/del4 mice, a model of congenital hepatic fibrosis
E. Kaffe, F. Pellegrino, V. Mariotti, L. Fabris +5 more
20172 citations
Semantic Scholar
Computer Aided Drug Design Approaches for Identification of Novel Autotaxin (ATX) Inhibitors.
E. Vrontaki, G. Melagraki, E. Kaffe, T. Mavromoustakos +3 more
2016Current Medicinal Chemistry2 citations
Semantic Scholar
Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche
M. Roulis, Aimilios Kaklamanos, Marina Schernthanner, Piotr Bielecki +21 more
2020Nature1 citations Open access
Semantic Scholar
Author Correction: A Treg-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liver
Chen-Bo Ding, Zhibin Yu, Esen Sefik, Jing Zhou +7 more
2026Nature Aging0 citations Open access
Semantic Scholar
THU-062 A preclinical model of acute alcoholic hepatitis (AAH) in humanized liver mice
E. Kaffe, Negin Farzad, Rui-Qi Li, Y. Kluger +3 more
2026Journal of Hepatology0 citations
Semantic Scholar
An aerosolised dual-action Autotaxin inhibitor-PPARγ agonist for the treatment of pulmonary fibrosis
A. Matralis, Elli-Anna Stylianaki, E. Ladopoulou, P. Kanellopoulou +17 more
2025bioRxiv0 citations
Semantic Scholar
THU-493-Reciprocal changes in ARID1A and EZH2 are associated with cholangiocarcinoma development in a mouse model of caroli disease with high Yap expression
E. Kaffe, C. Spirli, R. Fiorotto, V. Mariotti +3 more
2019Journal of Hepatology0 citations
Semantic Scholar
Peer Review #2 of "Hepatic autotaxin overexpression in infants with biliary atresia (v0.1)"
W. Udomsinprasert, P. Vejchapipat, N. Klaikeaw, V. Chongsrisawat +197 more
20180 citations Open access
Semantic Scholar
Inhibition of YAP activation induces cell senescence and autophagy while blocking cell proliferation in cholangiocarcinoma (CCA)
M. Cadamuro, G. Casati, T. Stecca, S. Brivio +10 more
20180 citations
Semantic Scholar
β-catenin and IL-1β dependent CXCL10 production drives progression of disease in a mouse model of Congenital Hepatic Fibrosis
E. Kaffe, R. Fiorotto, F. Pellegrino, V. Mariotti +5 more
20170 citations
Semantic Scholar
Faculty Opinions recommendation of TLR4 enhances TGF-beta signaling and hepatic fibrosis.
V. Aidinis, E. Kaffe
20130 citations
Semantic Scholar

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