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K. Yaku · SciRah

Researcher profile · Semantic Scholar

K. Yaku

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K. Yaku — researcher profile on SciRah

h-index: 22
Works: 56
Citations: 1,702

Most-cited papers

NAD metabolism: Implications in aging and longevity.
K. Yaku, Keisuke Okabe, T. Nakagawa
2018Ageing Research Reviews237 citations
Semantic Scholar
Implications of altered NAD metabolism in metabolic disorders
Keisuke Okabe, K. Yaku, K. Tobe, T. Nakagawa
2019Journal of Biomedical Sciences205 citations Open access
Semantic Scholar
NAD Metabolism in Cancer Therapeutics
K. Yaku, Keisuke Okabe, Keisuke Hikosaka, T. Nakagawa
2018Frontiers in Oncology194 citations Open access
Semantic Scholar
Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia
Mathieu Membrez, E. Migliavacca, Stefan Christen, K. Yaku +31 more
2024Nature Metabolism135 citations Open access
Semantic Scholar
Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects
Keisuke Okabe, K. Yaku, Yoshiaki Uchida, Yuichiro Fukamizu +4 more
2022Frontiers in Nutrition96 citations Open access
Semantic Scholar
Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men
Masaki Igarashi, Yoshiko Nakagawa-Nagahama, M. Miura, K. Kashiwabara +12 more
2022npj Aging86 citations Open access
Semantic Scholar
BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities
K. Yaku, Sailesh Palikhe, Hironori Izumi, T. Yoshida +10 more
2021Nature Communications72 citations Open access
Semantic Scholar
Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice
Sho Matsui, Tsutomu Sasaki, Daisuke Kohno, K. Yaku +10 more
2018Nature Communications63 citations Open access
Semantic Scholar
The enhancement of phase 2 enzyme activities by sodium butyrate in normal intestinal epithelial cells is associated with Nrf2 and p53
K. Yaku, Yuka Enami, Chika Kurajyo, I. Matsui-yuasa +2 more
2012Molecular and Cellular Biochemistry55 citations
Semantic Scholar
Implications of NAD metabolism in pathophysiology and therapeutics for neurodegenerative diseases
Keisuke Hikosaka, K. Yaku, Keisuke Okabe, T. Nakagawa
2019Nutritional neuroscience48 citations
Semantic Scholar
Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age‐associated insulin resistance
Maryam Gulshan, K. Yaku, Keisuke Okabe, A. Mahmood +7 more
2018Aging Cell45 citations Open access
Semantic Scholar
Simultaneous measurement of NAD metabolome in aged mice tissue using liquid chromatography tandem-mass spectrometry.
K. Yaku, Keisuke Okabe, T. Nakagawa
2018Biomedical chromotography43 citations
Semantic Scholar
Metabolism and biochemical properties of nicotinamide adenine dinucleotide (NAD) analogs, nicotinamide guanine dinucleotide (NGD) and nicotinamide hypoxanthine dinucleotide (NHD)
K. Yaku, Keisuke Okabe, Maryam Gulshan, K. Takatsu +2 more
2019Scientific Reports38 citations Open access
Semantic Scholar
Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD+ synthesis via enterohepatic circulation
K. Yaku, Sailesh Palikhe, Tooba Iqbal, Faisal Hayat +11 more
2025Science Advances35 citations Open access
Semantic Scholar
NAD+ Metabolism Regulates Preadipocyte Differentiation by Enhancing α-Ketoglutarate-Mediated Histone H3K9 Demethylation at the PPARγ Promoter
Keisuke Okabe, A. Nawaz, Yasuhiro Nishida, K. Yaku +3 more
2020Frontiers in Cell and Developmental Biology35 citations Open access
Semantic Scholar
The microRNAs miR-302b and miR-372 regulate mitochondrial metabolism via the SLC25A12 transporter, which controls MAVS-mediated antiviral innate immunity
K. Yasukawa, D. Kinoshita, K. Yaku, T. Nakagawa +1 more
2019Journal of Biological Chemistry34 citations Open access
Semantic Scholar
Food odor perception promotes systemic lipid utilization
H. Tsuneki, Masanori Sugiyama, Toshihiro Ito, Kiyofumi Sato +19 more
2022Nature Metabolism33 citations
Semantic Scholar
Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma
Miyuki Nomura, Mai Ohuchi, Yoshimi Sakamoto, Kei Kudo +25 more
2023Nature Communications31 citations Open access
Semantic Scholar
NAD+ Precursors in Human Health and Disease: Current Status and Future Prospects
K. Yaku, T. Nakagawa
2023Antioxidants and Redox Signaling25 citations
Semantic Scholar
Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men
Masaki Igarashi, M. Miura, YoshikoNakagawa, Nagahama +14 more
2021npj Aging24 citations Open access
Semantic Scholar
AMPK synergizes with the combined treatment of 1'-acetoxychavicol acetate and sodium butyrate to upregulate phase II detoxifying enzyme activities.
K. Yaku, I. Matsui-yuasa, Y. Konishi, A. Kojima-Yuasa
2013Molecular Nutrition & Food Research24 citations
Semantic Scholar
1'-acetoxychavicol acetate inhibits adipogenesis in 3T3-L1 adipocytes and in high fat-fed rats.
Rieko Ohnishi, I. Matsui-yuasa, Yohei Deguchi, K. Yaku +4 more
2012The American Journal of Chinese Medicine24 citations
Semantic Scholar
Simultaneous Measurement of Amino Acid Enantiomers in Aged Mouse Brain Samples by LC/MS/MS Combined with Derivatization Using Nα-(5-Fluoro-2,4-dinitrophenyl)-l-leucinamide (l-FDLA)
Taiji Yamamoto, K. Yaku, T. Nakagawa
2021Metabolites17 citations Open access
Semantic Scholar
Deletion of PHGDH in adipocytes improves glucose intolerance in diet-induced obese mice.
Keisuke Okabe, I. Usui, K. Yaku, Y. Hirabayashi +2 more
2018Biochemical and Biophysical Research Communications - BBRC15 citations
Semantic Scholar
Regional contributions of D-serine to Alzheimer’s disease pathology in male AppNL–G–F/NL–G–F mice
Xiance Ni, Ran Inoue, Yi Wu, T. Yoshida +6 more
2023Frontiers in Aging Neuroscience13 citations Open access
Semantic Scholar
1'-Acetoxychavicol acetate enhances the phase II enzyme activities via the increase in intranuclear Nrf2 level and cytosolic p21 level.
K. Yaku, I. Matsui-yuasa, H. Azuma, A. Kojima-Yuasa
2011The American Journal of Chinese Medicine12 citations
Semantic Scholar
1'-Acetoxychavicol acetate ameliorates age-related spatial memory deterioration by increasing serum ketone body production as a complementary energy source for neuronal cells.
A. Kojima-Yuasa, Tomiya Yamamoto, K. Yaku, Shiori Hirota +3 more
2016Chemico-Biological Interactions11 citations Open access
Semantic Scholar
Deletion of the GAPDH gene contributes to genome stability in Saccharomyces cerevisiae
Miki Hanasaki, K. Yaku, Motohiro Yamauchi, T. Nakagawa +1 more
2020Scientific Reports8 citations Open access
Semantic Scholar
1′-Acetoxychavicol Acetate Increases Proteasome Activity by Activating cAMP-PKA Signaling
K. Yaku, I. Matsui-yuasa, A. Kojima-Yuasa
2017Planta Medica8 citations Open access
Semantic Scholar
Novel role of serine racemase in anti-apoptosis and metabolism.
G. Talukdar, Ran Inoue, T. Yoshida, Tetsuya Ishimoto +3 more
2017Biochimica et Biophysica Acta - General Subjects8 citations
Semantic Scholar
Blood levels of nicotinic acid negatively correlate with hearing ability in healthy older men
Yoshiko Nakagawa-Nagahama, Masaki Igarashi, M. Miura, K. Kashiwabara +7 more
2023BMC Geriatrics7 citations Open access
Semantic Scholar
Adipocyte NMNAT1 expression is essential for nuclear NAD+ biosynthesis but dispensable for regulating thermogenesis and whole-body energy metabolism
Shintaro Yamaguchi, Daiki Kojima, Tooba Iqbal, Shotaro Kosugi +10 more
2023Biochemical and Biophysical Research Communications - BBRC7 citations Open access
Semantic Scholar
Loss of hepatic Nmnat1 has no impact on diet-induced fatty liver disease.
Tooba Iqbal, A. Nawaz, M. Karim, K. Yaku +3 more
2022Biochemical and Biophysical Research Communications - BBRC7 citations Open access
Semantic Scholar
Deletion of Nmnat1 in Skeletal Muscle Leads to the Reduction of NAD+ Levels but Has No Impact on Skeletal Muscle Morphology and Fiber Types.
Mariam Karim, Tooba Iqbal, A. Nawaz, K. Yaku +1 more
2023Journal of Nutritional Science and Vitaminology4 citations Open access
Semantic Scholar
Aberrant humoral immune responses and intestinal homeostasis in Cd38 Bst1 double knockout mice
A. Yahagi, Masanori Iseki, K. Yaku, Takashi Nakagawa +3 more
2025ImmunoHorizons3 citations Open access
Semantic Scholar
A Combination of Oxidative Stress-Induced DNA Damage and NAD+ Synthesis Inhibition Induces Synthetic Lethality in A549 Cells.
Yasuhito Nitta, Masashi Yamamoto, K. Yaku, Hitoshi Uchida +2 more
2026Journal of Nutritional Science and Vitaminology1 citations Open access
Semantic Scholar
The Mitochondrial NAD Transporter SLC25A51 in Adipocytes Regulates Adipose Tissue Mitochondrial Function and Systemic Metabolism During Aging
Daiki Kojima, K. Yaku, Shotaro Kosugi, Ryunosuke Mitsuno +16 more
2026Aging Cell1 citations Open access
Semantic Scholar
Early-life NAD+ deficiency programs skeletal muscle aging by sustained suppression of hyaluronic acid synthesis beginning in childhood.
Mariam Karim, K. Yaku, Jun-Dal Kim, Akira Okekawa +9 more
2026Cell Reports1 citations Open access
Semantic Scholar
Conditional deletion of glutaminase 1 in Tnfrsf11a-expressing cells reduces bone mass and induces postnatal growth retardation in mice.
Shintaro Terashita, Yasuhito Yahara, Jun-Dal Kim, Amane Mizutani +5 more
2025Biochemical and Biophysical Research Communications - BBRC1 citations Open access
Semantic Scholar
Metabolic remodeling and cardiac dysfunction in left ventricular noncompaction: Insights from the MYH7 Q315R model
S. Takarada, Y. Hata, K. Yaku, Hironori Izumi +18 more
2025PLoS ONE1 citations Open access
Semantic Scholar
Mitochondrial Redox Status Regulates Glycogen Metabolism via Glycogen Phosphorylase Activity
Ikko Sakamoto, S. Shibuya, H. Nojiri, Kotaro Takeno +5 more
2024Antioxidants1 citations
Semantic Scholar
Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle motility in healthy old men
Masaki Igarashi, M. Miura, Yoshiko Nakagawa-Nagahama, K. Yaku +12 more
20211 citations Open access
Semantic Scholar
The enhancement of phase 2 enzyme activities by sodium butyrate in normal intestinal epithelial cells is associated with Nrf2 and p53
K. Yaku, Yuka Enami, Chika Kurajyo, I. Matsui-yuasa +2 more
2012Molecular and Cellular Biochemistry1 citations
Semantic Scholar
Epidermal NAD+ deficiency induces IL-36–mediated skin inflammation and acanthosis
Taiki Seki, Jun-Dal Kim, Yasuhito Yahara, Hitoshi Uchida +5 more
2026JCI Insight0 citations Open access
Semantic Scholar
Sustained NAD⁺ augmentation by high-dose nicotinamide mononucleotide supplementation in older adults: a 24-week randomized, double-blind, placebo-controlled trial
Masaki Igarashi, Kyoko Naruse, Yuriko Takaoka, M. Miura +10 more
2026npj Aging0 citations Open access
Semantic Scholar
CGK733 binds to adenine nucleotide translocator 2 and modulates mitochondrial function and protein translation
Daisuke Kaida, Yuta Inagaki, K. Yaku, Kazuki Sasaki +9 more
2025bioRxiv0 citations Open access
Semantic Scholar
Combination of oxidative stress and NAD+ synthesis inhibition induces synthetic lethality in cancer cell
Yasuhito Nitta, Keisuke Hikosaka, K. Yaku, Takashi Nakagawa
2023Proceedings for Annual Meeting of The Japanese Pharmacological Society0 citations Open access
Semantic Scholar
1628-P: Role of CD38 in the Regulation of Muscle Stem Cell Functions in Aged Mice
A. Nawaz, K. Yaku, I. Jeelani, Kazuyuki Tobe +1 more
2023Diabetes0 citations
Semantic Scholar
Nmnat3 deficiency in hemolytic anemia exacerbates malaria infection.
A. Mahmood, K. Yaku, Keisuke Hikosaka, Maryam Gulshan +3 more
2022Biochemical and Biophysical Research Communications - BBRC0 citations Open access
Semantic Scholar
Acetoxychavicol acetate ameliorates age-related spatial memory deterioration by enhancing of proteasome activity and increasing serum ketone body production in neuronal cells
A. Kojima-Yuasa, K. Yaku, Tomiya Yamamoto, Shiori Hirota +3 more
20170 citations
Semantic Scholar

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T. Nakagawa×26
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Keisuke Okabe×10
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Takashi Nakagawa×10
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I. Matsui-yuasa×8
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A. Kojima-Yuasa

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