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I. Critchley · SciRah

Researcher profile · Semantic Scholar

I. Critchley

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I. Critchley — researcher profile on SciRah

h-index: 44
Works: 160
Citations: 5,434

Most-cited papers

Integrated analysis of CANVAS 1 and 2: phase 3, multicenter, randomized, double-blind studies to evaluate the safety and efficacy of ceftaroline versus vancomycin plus aztreonam in complicated skin and skin-structure infection.
G. Corey, M. Wilcox, G. Talbot, H. D. Friedland +5 more
2010Clinical Infectious Diseases244 citations Open access
Semantic Scholar
FOCUS 1: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia.
T. File, D. Low, P. Eckburg, G. Talbot +5 more
2011Journal of Antimicrobial Chemotherapy210 citations
Semantic Scholar
Integrated analysis of FOCUS 1 and FOCUS 2: randomized, doubled-blinded, multicenter phase 3 trials of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in patients with community-acquired pneumonia.
T. File, Donald E. Low, P. Eckburg, G. Talbot +5 more
2010Clinical Infectious Diseases202 citations
Semantic Scholar
FOCUS 2: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia.
Donald E. Low, T. File, P. Eckburg, G. Talbot +122 more
2011Journal of Antimicrobial Chemotherapy185 citations
Semantic Scholar
The burden of antimicrobial resistance among urinary tract isolates of Escherichia coli in the United States in 2017
I. Critchley, N. Cotroneo, M. Pucci, R. Mendes
2019bioRxiv145 citations Open access
Semantic Scholar
Ceftaroline fosamil: a novel broad-spectrum cephalosporin with expanded anti-Gram-positive activity.
D. Biek, I. Critchley, Todd Riccobene, D. Thye
2010Journal of Antimicrobial Chemotherapy105 citations Open access
Semantic Scholar
Avibactam Pharmacokinetic/Pharmacodynamic Targets
W. Nichols, P. Newell, I. Critchley, Todd Riccobene +1 more
2018Antimicrobial Agents and Chemotherapy97 citations Open access
Semantic Scholar
Aminoacyl-tRNA synthetases: essential and still promising targets for new anti-infective agents
U. Ochsner, Xi-Cheng Sun, T. Jarvis, I. Critchley +1 more
2007Expert Opinion on Investigational Drugs94 citations
Semantic Scholar
Activity of chequerboard combinations of ceftaroline and NXL104 versus beta-lactamase-producing Enterobacteriaceae.
S. Mushtaq, M. Warner, G. Williams, I. Critchley +1 more
2010Journal of Antimicrobial Chemotherapy90 citations Open access
Semantic Scholar
Inhibitory effect of REP3123 on toxin and spore formation in Clostridium difficile, and in vivo efficacy in a hamster gastrointestinal infection model.
U. Ochsner, S. Bell, A. O'leary, T. Hoang +4 more
2009Journal of Antimicrobial Chemotherapy84 citations Open access
Semantic Scholar
Activity of Ceftaroline and Epidemiologic Trends in Staphylococcus aureus Isolates Collected from 43 Medical Centers in the United States in 2009
S. Richter, K. Heilmann, Cassie L. Dohrn, F. Riahi +6 more
2011Antimicrobial Agents and Chemotherapy80 citations Open access
Semantic Scholar
Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections.
I. Critchley, L. Green, C. Young, J. Bullard +6 more
2009Journal of Antimicrobial Chemotherapy79 citations Open access
Semantic Scholar
Activity of Ceftaroline against Recent Emerging Serotypes of Streptococcus pneumoniae in the United States
M. Jacobs, Caryn E. Good, A. Windau, S. Bajaksouzian +4 more
2010Antimicrobial Agents and Chemotherapy77 citations Open access
Semantic Scholar
National and Regional Assessment of Antimicrobial Resistance among Community-Acquired Respiratory Tract Pathogens Identified in a 2005-2006 U.S. Faropenem Surveillance Study
I. Critchley, S. Brown, M. Traczewski, G. Tillotson +1 more
2007Antimicrobial Agents and Chemotherapy77 citations Open access
Semantic Scholar
Pharmacodynamics of β-Lactamase Inhibition by NXL104 in Combination with Ceftaroline: Examining Organisms with Multiple Types of β-Lactamases
A. Louie, M. Castanheira, Wei-Guo Liu, C. Grasso +8 more
2011Antimicrobial Agents and Chemotherapy72 citations Open access
Semantic Scholar
Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris
G. Zhanel, I. Critchley, L. Lin, N. Alvandi
2018Antimicrobial Agents and Chemotherapy61 citations Open access
Semantic Scholar
Dose Selection and Validation for Ceftazidime-Avibactam in Adults with Complicated Intra-abdominal Infections, Complicated Urinary Tract Infections, and Nosocomial Pneumonia
Shampa Das, Jianguo Li, Todd Riccobene, T. Carrothers +5 more
2019Antimicrobial Agents and Chemotherapy59 citations Open access
Semantic Scholar
Oral Tebipenem Pivoxil Hydrobromide in Complicated Urinary Tract Infection.
P. Eckburg, L. Muir, I. Critchley, Susannah M. Walpole +8 more
2022New England Journal of Medicine58 citations Open access
Semantic Scholar
Susceptibility of Staphylococcus aureus isolated from skin and wound infections in the United States 2005-07: laboratory-based surveillance study.
G. Tillotson, D. Draghi, D. Sahm, K. Tomfohrde +2 more
2008Journal of Antimicrobial Chemotherapy54 citations Open access
Semantic Scholar
Serotype distribution and antimicrobial susceptibility of USA Streptococcus pneumoniae isolates collected prior to and post introduction of 13-valent pneumococcal conjugate vaccine.
R. Mendes, Andrew J. Costello, M. Jacobs, D. Biek +2 more
2014Diagnostic microbiology and infectious disease52 citations
Semantic Scholar
Randomized Trial of Ceftazidime-Avibactam vs Meropenem for Treatment of Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia (REPROVE): Analyses per US FDA–Specified End Points
A. Torres, Douglas R. Rank, D. Melnick, L. Rekeda +6 more
2019Open Forum Infectious Diseases47 citations Open access
Semantic Scholar
Review of ceftaroline fosamil microbiology: integrated FOCUS studies.
I. Critchley, P. Eckburg, A. Jandourek, D. Biek +2 more
2011Journal of Antimicrobial Chemotherapy45 citations
Semantic Scholar
Pharmacodynamics of Tebipenem: New Options for Oral Treatment of Multidrug-Resistant Gram-Negative Infections
L. McEntee, Adam Johnson, N. Farrington, J. Unsworth +9 more
2019Antimicrobial Agents and Chemotherapy44 citations Open access
Semantic Scholar
Dalbavancin Population Pharmacokinetic Modeling and Target Attainment Analysis
T. Carrothers, Jason T. Chittenden, I. Critchley
2019Clinical pharmacology in drug development42 citations Open access
Semantic Scholar
Resistance among urinary tract pathogens collected in Europe during 2018.
I. Critchley, N. Cotroneo, M. Pucci, Akash Jain +1 more
2020Journal of Global Antimicrobial Resistance38 citations Open access
Semantic Scholar
Prevalence of Serotype 19A Streptococcus pneumoniae among Isolates from U.S. Children in 2005-2006 and Activity of Faropenem
I. Critchley, M. Jacobs, S. Brown, M. Traczewski +2 more
2008Antimicrobial Agents and Chemotherapy38 citations Open access
Semantic Scholar
Fosfomycin and Comparator Activity Against Select Enterobacteriaceae, Pseudomonas, and Enterococcus Urinary Tract Infection Isolates from the United States in 2012
T. Keepers, M. Gómez, C. Celeri, K. Krause +2 more
2017Infectious Disease and Therapy33 citations Open access
Semantic Scholar
Quinazolin-2-ylamino-quinazolin-4-ols as novel non-nucleoside inhibitors of bacterial DNA polymerase III.
J. Guiles, Xi-Cheng Sun, I. Critchley, U. Ochsner +9 more
2009Bioorganic & Medicinal Chemistry Letters31 citations
Semantic Scholar
Ceftazidime–avibactam for the treatment of complicated urinary tract infections and complicated intra-abdominal infections
Y. Mawal, I. Critchley, Todd Riccobene, A. Talley
2015Expert Review of Clinical Pharmacology30 citations
Semantic Scholar
Panton-Valentine Leukocidin Is Not the Primary Determinant of Outcome for Staphylococcus aureus Skin Infections: Evaluation from the CANVAS Studies
Amy Tong, Steven Y. C. Tong, Yurong Zhang, S. Lamlertthon +9 more
2012PLoS ONE30 citations Open access
Semantic Scholar
Pharmacokinetic-Pharmacodynamic Target Attainment Analyses To Evaluate In Vitro Susceptibility Test Interpretive Criteria for Ceftaroline against Staphylococcus aureus and Streptococcus pneumoniae
S. Van Wart, P. Ambrose, C. Rubino, T. Khariton +4 more
2013Antimicrobial Agents and Chemotherapy29 citations Open access
Semantic Scholar
In Vitro and In Vivo Characterization of Tebipenem, an Oral Carbapenem
N. Cotroneo, A. Rubio, I. Critchley, C. Pillar +1 more
2020Antimicrobial Agents and Chemotherapy28 citations Open access
Semantic Scholar
Ceftazidime-Avibactam Susceptibility Breakpoints against Enterobacteriaceae and Pseudomonas aeruginosa
W. Nichols, G. Stone, P. Newell, H. Broadhurst +6 more
2018Antimicrobial Agents and Chemotherapy28 citations Open access
Semantic Scholar
Recent advances in the preclinical evaluation of the topical antibacterial agent REP8839.
I. Critchley, U. Ochsner
2008Current Opinion in Chemical Biology22 citations
Semantic Scholar
Decreased Ceftriaxone Susceptibility in Emerging (35B and 6C) and Persisting (19A) Streptococcus pneumoniae Serotypes in the United States, 2011-2012: Ceftaroline Remains Active In Vitro among β-Lactam Agents
R. Mendes, D. Biek, I. Critchley, D. Farrell +2 more
2014Antimicrobial Agents and Chemotherapy20 citations Open access
Semantic Scholar
In Vitro Resistance against DNA Gyrase Inhibitor SPR719 in Mycobacterium avium and Mycobacterium abscessus
W. W. Aragaw, N. Cotroneo, S. Stokes, M. Pucci +3 more
2022Microbiology spectrum19 citations Open access
Semantic Scholar
Evolution of Ceftaroline-Resistant Mrsa in a Child with Cystic Fibrosis Following Repeated Antibiotic Exposure
C. Cannavino, R. Mendes, H. Sader, D. Farrell +6 more
2016The Pediatric Infectious Disease Journal18 citations
Semantic Scholar
Evaluation of Tebipenem Hydrolysis by β-Lactamases Prevalent in Complicated Urinary Tract Infections
Zhi-Zeng Sun, Lynn H. Su, N. Cotroneo, I. Critchley +3 more
2022Antimicrobial Agents and Chemotherapy16 citations Open access
Semantic Scholar
Efficacy of SPR720 in murine models of non-tuberculous mycobacterial pulmonary infection
N. Cotroneo, S. Stokes, Michael J. Pucci, A. Rubio +2 more
2024Journal of Antimicrobial Chemotherapy15 citations
Semantic Scholar
Activity of Faropenem against Middle Ear Fluid Pathogens from Children with Acute Otitis Media in Costa Rica and Israel
K. Stone, R. Dagan, A. Arguedas, E. Leibovitz +4 more
2007Antimicrobial Agents and Chemotherapy14 citations Open access
Semantic Scholar
Contemporary Evaluation of Tebipenem In Vitro Activity against Enterobacterales Clinical Isolates Causing Urinary Tract Infections in US Medical Centers (2019–2020)
R. Mendes, S. J. Ryan Arends, J. Streit, I. Critchley +2 more
2023Microbiology spectrum12 citations Open access
Semantic Scholar
Assessment of 30/20-Microgram Disk Content versus MIC Results for Ceftazidime-Avibactam Tested against Enterobacteriaceae and Pseudomonas aeruginosa
H. Sader, P. Rhomberg, M. Huband, I. Critchley +3 more
2018Journal of Clinical Microbiology11 citations Open access
Semantic Scholar
Pharmacokinetic-Pharmacodynamic Assessment of Faropenem in a Lethal Murine Bacillus anthracis Inhalation Postexposure Prophylaxis Model
S. Gill, C. Rubino, J. Bassett, L. Miller +8 more
2010Antimicrobial Agents and Chemotherapy10 citations Open access
Semantic Scholar
New agents for Clostridium difficile-associated disease
J. Guiles, I. Critchley, Xi-Cheng Sun
2008Expert Opinion on Investigational Drugs9 citations
Semantic Scholar
In Vitro Activity of Tebipenem against Various Resistant Subsets of Escherichia coli Causing Urinary Tract Infections in the United States (2018 to 2020)
R. Mendes, Cory M. Hubler, J. Kimbrough, Valerie Kantro +3 more
2022Antimicrobial Agents and Chemotherapy8 citations Open access
Semantic Scholar
Eradication of MRSA nasal colonization as a strategy for infection prevention
I. Critchley
20068 citations
Semantic Scholar
Agar Dilution and Disk Diffusion Susceptibility Testing of Campylobacter spp.
Sonya M. Bodeis, F. Aarestrup, S. Brown, M. Traczewski +17 more
20077 citations
Semantic Scholar
Phase 3, Randomized, Double-blind Noninferiority (NI) Study of Ceftazidime–Avibactam (CAZ-AVI) vs. Meropenem (MER) in the Treatment of Patients with Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia (HABP/VABP): Analyses of the REPROVE Study per US FDA Endpoints
A. Torres, Douglas R. Rank, L. Rekeda, Xiang Chen +8 more
20176 citations Open access
Semantic Scholar
Effect of In Vitro Testing Parameters on Ceftazidime-Avibactam Minimum Inhibitory Concentrations
T. Keepers, M. Gómez, D. Biek, I. Critchley +1 more
2015International Scholarly Research Notices6 citations Open access
Semantic Scholar
Impact of antibiotic pharmacokinetics in urine on recurrent bacteriuria following treatment of complicated urinary tract infections
David Melnick, Angela K. Talley, Vipul K. Gupta, I. Critchley +8 more
2023Antimicrobial Agents and Chemotherapy5 citations Open access
Semantic Scholar

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D. Biek×10
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D. Biek — researcher profile on SciRah
N. Cotroneo×9
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N. Cotroneo — researcher profile on SciRah
N. Janjić×8
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N. Janjić — researcher profile on SciRah
D. Thye×7
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D. Thye — researcher profile on SciRah

×7

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R. Mendes — researcher profile on SciRah

Ronald N. Jones×7

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Ronald N. Jones — researcher profile on SciRah

H. D. Friedland×6

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H. D. Friedland — researcher profile on SciRah

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P. Eckburg — researcher profile on SciRah

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M. Pucci — researcher profile on SciRah

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Todd Riccobene — researcher profile on SciRah

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U. Ochsner — researcher profile on SciRah

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G. Talbot — researcher profile on SciRah